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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 9, 2024 | 12:36 PM IST
Nicostar Iv 48Mg Inj prevents or treats angina pectoris (heart-related chest pain). It contains Nicorandil, a potassium-channel activator that opens potassium channels present on the muscle cells within the walls of blood vessels, relaxes these muscle cells, and widens blood vessels. Thus, it reduces the heart's workload by making it easier for the heart to pump blood around the body and does not require much oxygen. Also, it helps to prevent angina by increasing oxygen and blood supply to the heart muscle by widening coronary arteries within the heart.
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Prescription drug

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Prescription drug
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Composition

NICORANDIL-48MG

Manufacturer/Marketer

Lupin Ltd

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Nicostar Iv 48Mg Inj

Nicostar Iv 48Mg Inj belongs to a class of medication called 'vasodilators' used to prevent or treat angina pectoris (heart-related chest pain) in adults who cannot take beta-blockers (blood pressure-lowering pills). Angina pectoris is a kind of chest pain due to decreased blood flow to the heart. It is a symptom of coronary artery disease.

Nicostar Iv 48Mg Inj contains Nicorandil, a potassium-channel activator that opens potassium channels present on the muscle cells within the walls of blood vessels and relaxes these muscle cells and widens blood vessels. Thereby, Nicostar Iv 48Mg Inj reduces the heart's workload by making it easier for the heart to pump blood around the body and does not require much oxygen. Also, Nicostar Iv 48Mg Inj helps to prevent angina by increasing oxygen and blood supply to the heart muscle by widening coronary arteries within the heart.

Nicostar Iv 48Mg Inj will be administered by a healthcare professional; do not self-administer. Some people may experience headache, nausea, vomiting, dizziness, weakness or flushing (reddening of the skin). Most of these side effects of Nicostar Iv 48Mg Inj do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.

If you are allergic to Nicorandil or any other medicines, inform your doctor. If you are pregnant or breastfeeding, please inform your doctor before taking Nicostar Iv 48Mg Inj. Drive only if you are alert as Nicostar Iv 48Mg Inj may cause dizziness or weakness. Avoid alcohol consumption with Nicostar Iv 48Mg Inj as it may cause severely low blood pressure. Avoid taking vardenafil, sildenafil, tadalafil and riociguat with Nicostar Iv 48Mg Inj as it may affect blood pressure.

Uses of Nicostar Iv 48Mg Inj

Treatment of Angina pectoris (heart-related chest pain)

Medicinal Benefits

Nicostar Iv 48Mg Inj contains Nicorandil, a potassium-channel activator used to prevent or treat angina pectoris (chest pain). Nicostar Iv 48Mg Inj works by opening potassium channels present on the muscle cells within the blood vessels' walls and relaxing these muscle cells and widening blood vessels. Thereby, Nicostar Iv 48Mg Inj reduces the heart's workload by making it easier for the heart to pump blood around the body and does not require much oxygen. Also, Nicostar Iv 48Mg Inj helps to prevent angina by increasing oxygen and blood supply to the heart muscle by widening coronary arteries within the heart. Nicostar Iv 48Mg Inj is given to adults who cannot tolerate other heart medicines such as calcium antagonists or beta-blockers. 

Directions for Use

Nicostar Iv 48Mg Inj will be administered by a healthcare professional; do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Nicostar Iv 48Mg Inj

  • Headache
  • Nausea
  • Vomiting
  • Dizziness
  • Weakness
  • Flushing (reddening of the skin)

Drug Warnings

If you are allergic to Nicorandil or any other medicines, please tell your doctor. Avoid taking Nicostar Iv 48Mg Inj if you have hypotension (severe low blood pressure), low blood volume, pulmonary oedema (accumulation of fluid in the lungs) or any heart problems. If you are pregnant or breastfeeding, please consult a doctor. Nicostar Iv 48Mg Inj is not recommended for children as safety and effectiveness were not established. Drive only if you are alert as Nicostar Iv 48Mg Inj may cause dizziness or weakness. Avoid alcohol consumption with Nicostar Iv 48Mg Inj as it may cause severely low blood pressure. Avoid taking vardenafil, sildenafil, tadalafil and riociguat with Nicostar Iv 48Mg Inj as it may affect blood pressure. If you notice in blood in stools while taking Nicostar Iv 48Mg Inj, inform your doctor immediately as it may be due to ulcers in the stomach, intestines or back passage. 

Drug Interactions

Drug-Drug Interaction: Nicostar Iv 48Mg Inj may interact with medicines used to treat erectile dysfunction (vardenafil, sildenafil, tadalafil), drugs to treat pulmonary hypertension (riociguat), medicine to treat premature ejaculation (dapoxetine), pain reliever (aspirin), steroids (prednisolone), high blood pressure-lowering medicines (lisinopril, ramipril, losartan, valsartan, candesartan).

Drug-Food Interaction: Nicostar Iv 48Mg Inj may interact with alcohol. Therefore, avoid alcohol intake while taking Nicostar Iv 48Mg Inj as it may cause severe low blood pressure.

Drug-Disease Interaction: Avoid taking Nicostar Iv 48Mg Inj if you have hypotension (severe low blood pressure), low blood volume, pulmonary oedema (build-up of fluid in the lungs) or any heart problems.

Drug-Drug Interactions Checker List

  • VARDENAFIL
  • SILDENAFIL
  • TADALAFIL
  • RIOCIGAUT
  • DAPOXETINE
  • ASPIRIN
  • PREDNISOLONE
  • LISINOPRIL
  • RAMIPRIL
  • LOSARTAN
  • VALSARTAN
  • CANDESARTAN

Habit Forming

No

Diet & Lifestyle Advise

  • Follow a cholesterol-lowering diet.
  • Consume low-salt and a low-fat diet.
  • Exercise regularly. It helps in maintaining proper weight and lowers cholesterol.
  • Limit salt and sugar intake.
  • Avoid smoking and alcohol consumption.
  • Choose healthy fats and cut down on trans fat.
  • Include omega-3 fatty acids, fibre-rich food, fruits and vegetables.
  • Get active by doing any physical activity such as swimming, brisk walking or jogging. Take the stairs instead of elevators/lifts.

Disease/Condition Glossary

Angina pectoris: Angina pectoris is a type of chest pain caused by decreased blood flow to the heart, resulting in inadequate oxygen supply to the heart muscle. Emotional stress or physical activity are common causes of chest pain. Angina is a sign that you have coronary artery disease. Angina symptoms include dizziness, shortness of breath, nausea, fatigue, anxiety, or excessive sweating. Smoking, diabetes, being overweight, high blood pressure, high cholesterol, not exercising, or a family history of heart disease are all risk factors for angina.

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Alcohol

Unsafe

You are recommended to avoid consumption of alcohol with Nicostar Iv 48Mg Inj as it may cause severely low blood pressure.

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Pregnancy

Consult your doctor

There is limited information on the use of Nicostar Iv 48Mg Inj in pregnant women. Usually, it is not recommended for pregnant women. Therefore, if you are pregnant or planning pregnancy, please inform your doctor.

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Breast Feeding

Consult your doctor

There is limited information on the use of Nicostar Iv 48Mg Inj in breastfeeding mothers. Therefore, please inform your doctor if you are a breastfeeding mother.

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Driving

Caution

Nicostar Iv 48Mg Inj may cause dizziness or weakness in some people. Therefore, avoid driving if you feel dizzy or weak after taking Nicostar Iv 48Mg Inj.

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Liver

Caution

Take Nicostar Iv 48Mg Inj with caution, especially if you have a history of liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Nicostar Iv 48Mg Inj with caution, especially if you have a history of kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Consult your doctor

Nicostar Iv 48Mg Inj is not recommended for children as safety and effectiveness were not established. However, please consult a doctor if you have any concerns regarding this.

Country of origin

India

Manufacturer/Marketer address

Lupin Ltd, 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India Country of Origin: India
Other Info - NIC0216

Author Details

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FAQs

Nicostar Iv 48Mg Inj is used to treat Angina pectoris (heart-related chest pain).
Nicostar Iv 48Mg Inj contains Nicorandil which works by relaxing and widening blood vessels. Thereby, Nicostar Iv 48Mg Inj reduces the workload of the heart by making it easier for the heart to pump blood around the body and does not require much oxygen. Also, Nicostar Iv 48Mg Inj helps to prevent angina by increasing oxygen and blood supply to the heart muscle by widening coronary arteries within the heart.
Nicostar Iv 48Mg Inj may cause headache as a common side effect, especially in the first few days of treatment. However, if the condition persists or worsens, please consult a doctor so that the dose may be reduced initially.
Nicostar Iv 48Mg Inj is not recommended for patients with severe hypotension (low blood pressure) as it may increase the risk of worsening the condition. Therefore, inform your doctor if you have low blood pressure before taking Nicostar Iv 48Mg Inj.
You are not recommended to take aspirin (pain reliever) with Nicostar Iv 48Mg Inj as co-administration of these two medicines may increase the risk of ulcers or other adverse effects. However, please consult a doctor before taking other medicines with Nicostar Iv 48Mg Inj.
You are recommended to avoid taking Nicostar Iv 48Mg Inj if you have hypotension (severe low blood pressure), low blood volume, pulmonary oedema (accumulation of fluid in the lungs) or any heart problems such as left ventricular failure with low filling pressure, cardiac decompensation or cardiogenic shock.
You are not recommended to take more than the prescribed dose of Nicostar Iv 48Mg Inj as it may cause Nicostar Iv 48Mg Inj overdose resulting in symptoms such as weakness, dizziness (signs of low blood pressure), and fast or irregular heartbeat. However, if you experience any of these symptoms while taking Nicostar Iv 48Mg Inj, please consult a doctor immediately.

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