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Negaflox 400mg Tablet

Negaflox 400mg Tablet

Prescription drug
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Consult Doctor

Manufacturer/Marketer

Cadila Pharmaceuticals Ltd

Consume Type

ORAL

Return Policy

Not Returnable

for this medicine

About Negaflox 400mg Tablet

Negaflox 400mg Tablet belongs to the group of quinolones antibiotics used to treat bacterial infections caused by susceptible bacteria. It is indicated in the treatment of urinary tract infections, prostatitis (prostate inflammation) and gonorrhoea (sexually transmitted disease). Additionally, Negaflox 400mg Tablet is used to treat infections of the stomach and intestine like traveller’s diarrhoea. 

Negaflox 400mg Tablet contains Norfloxacin which inhibits the synthesis of an enzyme called DNA gyrase. Thereby kills the bacteria and treats bacterial infections. Negaflox 400mg Tablet has a broad spectrum antibacterial activity against gram-positive and gram-negative aerobic bacteria.

Take Negaflox 400mg Tablet as prescribed. In some cases, Negaflox 400mg Tablet may cause common side-effects such as abdominal cramps, nausea, headache, and dizziness. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if the side-effects persist or worsen.

Inform your doctor if you experience pain in tendons, swelling, or inflammation as Negaflox 400mg Tablet is associated with an increased risk of tendon rupture and tendonitis; this risk is higher in patients older than 60years, in people taking steroids, or who have had kidney, heart or lung transplant. Negaflox 400mg Tablet may cause dizziness and light-headedness, so drive only if you are alert. Avoid alcohol consumption while taking Negaflox 400mg Tablet as it may cause increased dizziness.

Uses of Negaflox 400mg Tablet

Treatment of Bacterial infections, Traveller's diarrhoea

Medicinal Benefits

Negaflox 400mg Tablet belongs to the group of medicines called quinolones antibiotics used to treat bacterial infections of the prostate, urinary tract and gonorrhoea (sexually transmitted disease). Additionally, Negaflox 400mg Tablet is also used to treat traveller’s diarrhoea. Negaflox 400mg Tablet is bactericidal in nature. It works by inhibiting the synthesis of bacterial DNA gyrase; this prevents the bacteria from repairing and multiplying. Thereby, kills the bacteria and treats infections. Negaflox 400mg Tablet is a broad-spectrum antibiotic effective against a wide range of gram-positive and gram-negative bacteria.

Directions for Use

Tablet/Capsule: Swallow it as a whole with water; do not crush or chew the tablet/capsule. Take it on an empty stomach, i.e., one hour before food or two hours after food. Suspension: Shake the bottle well before use. Take the prescribed dose by mouth using the measuring cup provided by the pack.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Negaflox 400mg Tablet

  • Nausea
  • Heartburn
  • Headache
  • Dizziness
  • Abdominal cramps

Drug Warnings

Do not take Negaflox 400mg Tablet if you are allergic to any of its contents; if you had swelling or tearing of tendons while taking quinolone antibiotics. Negaflox 400mg Tablet is associated with an increased risk of tendon rupture and tendonitis in all age groups; this risk is higher in patients older than 60 years, people taking corticosteroids, who have had kidney, heart or lung transplants. Consult your doctor immediately if you experience tendon pain, swelling or inflammation while taking Negaflox 400mg Tablet. Do not take Negaflox 400mg Tablet if you have myasthenia gravis, as it may cause increased muscle weakness. Talk to your doctor if you have epilepsy, low levels of potassium, nervous or muscle problems, head injury or brain tumour, diabetes,  rheumatoid arthritis, heart, kidney or liver problems. Consult your doctor if you are pregnant or breastfeeding. Avoid alcohol consumption while taking Negaflox 400mg Tablet as it may cause increased dizziness. Negaflox 400mg Tablet may cause dizziness and vision problems, so be cautious while driving.

Drug Interactions

Drug-Drug Interactions: Negaflox 400mg Tablet may interact with pain killers (aspirin, ibuprofen), anti-coagulant/blood thinner (warfarin), anti-gout (probenecid), antibiotic (azithromycin, sulfamethoxazole, trimethoprim, metronidazole, nitrofurantoin, erythromycin), and calcium supplements (calcium/vitamin D).

Drug-Food Interactions: Avoid dairy products such as milk and yoghurt while taking Negaflox 400mg Tablet as they might decrease the effectiveness of Negaflox 400mg Tablet. Avoid consuming caffeine products along with Negaflox 400mg Tablet as it might increase the effects of caffeine.

Drug-Disease Interactions: Inform your doctor if you have colitis (inflammation in the lining of the colon), tendonitis (inflammation in tendons), CNS disorders, myasthenia gravis (neuromuscular disease), peripheral neuropathy (nerve pain), crystalluria (cloudy urine), diabetes, kidney, liver or heart problems.

Drug-Drug Interactions Checker List

  • ASPIRIN
  • IBUPROFEN
  • WARFARIN
  • PROBENECID
  • AZITHROMYCIN
  • TRIMETHOPRIM+SULFAMETHOXAZOLE
  • METRONIDAZOLE
  • NITROFURANTOIN
  • ERYTHROMYCIN
  • CALCIUM CARBONATE+CHOLECALCIFEROL

Habit Forming

No

Diet & Lifestyle Advise

  • Antibiotics can alter the useful bacteria in the stomach, which help in digestion. Therefore, you are advised to take foods rich in probiotics, such as yoghurt/curd, kefir, sauerkraut, tempeh, kimchi, miso, kombucha, buttermilk, natto and cheese.

  • Eat fibre-rich food like whole grains, beans, lentils, berries, broccoli, peas and bananas.

  • Avoid foods rich in calcium, grapefruit and grapefruit juice, as they might hinder the absorption of antibiotics.

  • Avoid consumption of alcohol and usage of tobacco.

Special Advise

Negaflox 400mg Tablet may cause changes in liver function tests and prothrombin time (time taken for blood clotting). Inform the person doing the tests that you are taking Negaflox 400mg Tablet.

Disease/Condition Glossary

Bacterial infections: A bacterial infection is a condition in which harmful bacteria enter, multiply, and infect the body. These harmful bacteria produce chemicals known as toxins, which can damage tissue and make you sick. It can target any body part and multiply very quickly. Symptoms include fever, chills, and fatigue. Anyone can become infected with a bacterial infection. But, people with a weak immune system or taking immunosuppressive medicines are more prone to bacterial infection.

Traveller’s diarrhoea: It is a digestive tract disorder that commonly occurs due to the consumption of contaminated food and water that the body is not familiar with. Symptoms include gas, bloating, abdominal cramps, nausea, vomiting, and loose stools.

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Alcohol

Unsafe

Avoid consuming alcohol while taking Negaflox 400mg Tablet as it may cause increased dizziness.

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Pregnancy

Caution

Negaflox 400mg Tablet belongs to pregnancy category C. Please consult your doctor if you are pregnant, your doctor will prescribe Negaflox 400mg Tablet only if the benefits outweigh the risks.

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Breast Feeding

Caution

It is unknown if Negaflox 400mg Tablet passes into breastmilk. Consult your doctor if you are breastfeeding.

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Driving

Caution

Negaflox 400mg Tablet may cause dizziness and light-headedness. So, drive only if you are alert.

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Liver

Caution

Dose adjustment may be needed. Please consult your doctor if you have liver impairment/liver disease.

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Kidney

Caution

Dose adjustment may be needed. Please consult your doctor if you have any concerns regarding this or if you have kidney impairment/kidney disease.

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Children

Unsafe

Negaflox 400mg Tablet is not recommended for children below 18 years as safety and effectiveness have not been established.

Other Info - NE67222

Author Details

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FAQs

Negaflox 400mg Tablet is used to treat bacterial infections caused by susceptible bacteria. It is indicated in the treatment of urinary tract infections, prostatitis (prostate inflammation) and gonorrhoea (sexually transmitted disease). Additionally, Negaflox 400mg Tablet is used to treat infections of the stomach and intestine like traveller’s diarrhoea.
Negaflox 400mg Tablet works by inhibiting the synthesis of bacterial DNA gyrase; this prevents the bacteria from repairing and multiplying. Thereby, helps in treating the infections.
Negaflox 400mg Tablet may cause photosensitivity (sensitivity to sunlight) and can make you sunburn easily. Avoid prolonged exposure to sunlight or tanning beds. Always wear protective clothing and sunscreen with SPF 30 or higher before going out.
It is recommended to complete the course of Negaflox 400mg Tablet even if you feel better as it is an antibiotic, and leaving it in between may lead to even severe infection. To treat your condition effectually, continue taking Negaflox 400mg Tablet for as long as your doctor has prescribed it.
Avoid consuming dairy products such as milk and yoghurt along with Negaflox 400mg Tablet as they may decrease the effectiveness of Negaflox 400mg Tablet.
Do not take Negaflox 400mg Tablet on your own, as self-medication may lead to antibiotic-resistance in which antibiotics fail to act against specific bacterial infections.
Maintain a minimum gap of two hours between Negaflox 400mg Tablet and antacid, anti-ulcer (sucralfate), anti-HIV (didanosine), vitamin and mineral medicines. However, consult your doctor before taking other medicines with Negaflox 400mg Tablet.
Consult your doctor before taking Negaflox 400mg Tablet if you have diabetes, as Negaflox 400mg Tablet may cause hypoglycaemia (low blood sugar levels). Regularly monitor blood sugar levels while taking Negaflox 400mg Tablet to avoid hypoglycaemic events.
Negaflox 400mg Tablet may cause changes in liver function tests and prothrombin time (time taken for blood clotting). Inform the person doing the tests that you are taking Negaflox 400mg Tablet.

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