Negaflox 400mg Tablet belongs to the group of quinolones antibiotics used to treat bacterial infections caused by susceptible bacteria. It is indicated in the treatment of urinary tract infections, prostatitis (prostate inflammation) and gonorrhoea (sexually transmitted disease). Additionally, Negaflox 400mg Tablet is used to treat infections of the stomach and intestine like traveller’s diarrhoea. 

Negaflox 400mg Tablet contains Norfloxacin which inhibits the synthesis of an enzyme called DNA gyrase. Thereby kills the bacteria and treats bacterial infections. Negaflox 400mg Tablet has a broad spectrum antibacterial activity against gram-positive and gram-negative aerobic bacteria.

Take Negaflox 400mg Tablet as prescribed. In some cases, Negaflox 400mg Tablet may cause common side-effects such as abdominal cramps, nausea, headache, and dizziness. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if the side-effects persist or worsen.

Inform your doctor if you experience pain in tendons, swelling, or inflammation as Negaflox 400mg Tablet is associated with an increased risk of tendon rupture and tendonitis; this risk is higher in patients older than 60years, in people taking steroids, or who have had kidney, heart or lung transplant. Negaflox 400mg Tablet may cause dizziness and light-headedness, so drive only if you are alert. Avoid alcohol consumption while taking Negaflox 400mg Tablet as it may cause increased dizziness.

Negaflox 400mg Tablet belongs to the group of medicines called quinolones antibiotics used to treat bacterial infections of the prostate, urinary tract and gonorrhoea (sexually transmitted disease). Additionally, Negaflox 400mg Tablet is also used to treat traveller’s diarrhoea. Negaflox 400mg Tablet is bactericidal in nature. It works by inhibiting the synthesis of bacterial DNA gyrase; this prevents the bacteria from repairing and multiplying. Thereby, kills the bacteria and treats infections. Negaflox 400mg Tablet is a broad-spectrum antibiotic effective against a wide range of gram-positive and gram-negative bacteria.

• Nausea
• Heartburn
• Headache
• Dizziness
• Abdominal cramps

Do not take Negaflox 400mg Tablet if you are allergic to any of its contents; if you had swelling or tearing of tendons while taking quinolone antibiotics. Negaflox 400mg Tablet is associated with an increased risk of tendon rupture and tendonitis in all age groups; this risk is higher in patients older than 60 years, people taking corticosteroids, who have had kidney, heart or lung transplants. Consult your doctor immediately if you experience tendon pain, swelling or inflammation while taking Negaflox 400mg Tablet. Do not take Negaflox 400mg Tablet if you have myasthenia gravis, as it may cause increased muscle weakness. Talk to your doctor if you have epilepsy, low levels of potassium, nervous or muscle problems, head injury or brain tumour, diabetes,  rheumatoid arthritis, heart, kidney or liver problems. Consult your doctor if you are pregnant or breastfeeding. Avoid alcohol consumption while taking Negaflox 400mg Tablet as it may cause increased dizziness. Negaflox 400mg Tablet may cause dizziness and vision problems, so be cautious while driving.

Drug-Drug Interactions: Negaflox 400mg Tablet may interact with pain killers (aspirin, ibuprofen), anti-coagulant/blood thinner (warfarin), anti-gout (probenecid), antibiotic (azithromycin, sulfamethoxazole, trimethoprim, metronidazole, nitrofurantoin, erythromycin), and calcium supplements (calcium/vitamin D).

Drug-Food Interactions: Avoid dairy products such as milk and yoghurt while taking Negaflox 400mg Tablet as they might decrease the effectiveness of Negaflox 400mg Tablet. Avoid consuming caffeine products along with Negaflox 400mg Tablet as it might increase the effects of caffeine.

Drug-Disease Interactions: Inform your doctor if you have colitis (inflammation in the lining of the colon), tendonitis (inflammation in tendons), CNS disorders, myasthenia gravis (neuromuscular disease), peripheral neuropathy (nerve pain), crystalluria (cloudy urine), diabetes, kidney, liver or heart problems.

• ASPIRIN
• IBUPROFEN
• WARFARIN
• PROBENECID
• AZITHROMYCIN
• TRIMETHOPRIM+SULFAMETHOXAZOLE
• METRONIDAZOLE
• NITROFURANTOIN
• ERYTHROMYCIN
• CALCIUM CARBONATE+CHOLECALCIFEROL

• Antibiotics can alter the useful bacteria in the stomach, which help in digestion. Therefore, you are advised to take foods rich in probiotics, such as yoghurt/curd, kefir, sauerkraut, tempeh, kimchi, miso, kombucha, buttermilk, natto and cheese.

• Eat fibre-rich food like whole grains, beans, lentils, berries, broccoli, peas and bananas.

• Avoid foods rich in calcium, grapefruit and grapefruit juice, as they might hinder the absorption of antibiotics.

• Avoid consumption of alcohol and usage of tobacco.

Negaflox 400mg Tablet may cause changes in liver function tests and prothrombin time (time taken for blood clotting). Inform the person doing the tests that you are taking Negaflox 400mg Tablet.

Bacterial infections: A bacterial infection is a condition in which harmful bacteria enter, multiply, and infect the body. These harmful bacteria produce chemicals known as toxins, which can damage tissue and make you sick. It can target any body part and multiply very quickly. Symptoms include fever, chills, and fatigue. Anyone can become infected with a bacterial infection. But, people with a weak immune system or taking immunosuppressive medicines are more prone to bacterial infection.

Traveller’s diarrhoea: It is a digestive tract disorder that commonly occurs due to the consumption of contaminated food and water that the body is not familiar with. Symptoms include gas, bloating, abdominal cramps, nausea, vomiting, and loose stools.