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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Mext F 7.5 Tablet is used to treat rheumatoid arthritis, psoriatic arthritis, juvenile idiopathic arthritis, psoriasis, and cancer. It contains Methotrexate and Folic acid which works by reducing inflammation and preventing cancer cell growth. In some cases, this medicine may cause side effects such as nausea, vomiting, diarrhoea, fatigue, dizziness, headache, loss of appetite, and stomach upset. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Manufacturer/Marketer :

Wallace Pharmaceuticals Pvt Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Mext F 7.5 Tablet

Mext F 7.5 Tablet belongs to the class of 'antimetabolite agents' primarily used to treat rheumatoid arthritis, psoriasis and juvenile idiopathic arthritis. Mext F 7.5 Tablet is also used to treat leukaemia (blood cancer), Non-Hodgkin's lymphoma (cancer of the lymphatic system), soft tissue and bone cancer and certain types of cancer/tumours breast, skin, head and neck, lung or uterus. Mext F 7.5 Tablet reduces the immune system's strength to treat conditions of autoimmune diseases. Arthritis is an autoimmune disease which leads to joint pain and damage.

Mext F 7.5 Tablet contains Methotrexate (immunosuppressant/antimetabolite) and Folic acid (vitamin). Methotrexate works by reducing the function of the cells that cause inflammation in the joint tissues. It is also an anticancer drug that prevents cancer cells' growth and spread by blocking their access to folate (a form of vitamin B9). Folic acid is the synthetic form of folate. It prevents and treats low blood levels of folate (folate deficiency) caused due to Methotrexate during chemotherapy.

Your doctor will decide the dosage based on your medical condition. In some cases, you may experience common side effects, such as nausea, vomiting, diarrhoea, fatigue, dizziness, headache, loss of appetite, increase in liver enzymes, lowered resistance to infections, tingling sensation, stomach upset, stomach pain, leukopenia (decreased number of white blood cells) and soreness of mouth and lips. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

If you are known to be allergic to Mext F 7.5 Tablet or its inactive components, please inform your doctor. Do not take Mext F 7.5 Tablet if you are pregnant or planning for pregnancy, as Mext F 7.5 Tablet causes serious congenital disabilities. Mext F 7.5 Tablet should not be taken by breastfeeding mothers as it passes into breast milk. Mext F 7.5 Tablet can cause dizziness and drowsiness; hence drive with caution. Mext F 7.5 Tablet should not be given to children below three years of age, as safety and efficacy have not been established. Avoid consuming alcohol along with Mext F 7.5 Tablet as it could lead to increased dizziness. 

Uses of Mext F 7.5 Tablet

Treatment of Rheumatoid arthritis, Psoriatic arthritis, Juvenile idiopathic arthritis, Psoriasis, and Cancer.

Directions for Use

Swallow Mext F 7.5 Tablet as a whole with a glass of water. Take Mext F 7.5 Tablet one hour after food, once every week. Take Mext F 7.5 Tablet on the same day each week. Do not crush, chew or break it.

Medicinal Benefits

Mext F 7.5 Tablet treats rheumatoid arthritis, psoriasis, juvenile idiopathic arthritis, leukaemia and cancer/tumours of the breast, skin, head and neck, lung, or uterus. It contains Methotrexate (immunosuppressant/antimetabolite) and Folic acid (vitamin B9). Methotrexate works by reducing the function of the cells that cause inflammation in the joint tissues. It reduces pain and inflammation and slows down joint damage and disease progression over time. Hence, it is also known as a disease-modifying anti-rheumatic drug (DMARD). It also acts as an anticancer drug that prevents cancer cells' growth and spread by blocking their access to folate (a form of vitamin B9). Folic acid is a water-soluble Vitamin B. It helps in the formation of red blood cells and prevents DNA changes that may lead to cancer. It prevents and treats low blood levels of folate (folate deficiency) caused due to Methotrexate during chemotherapy. 

How Mext F 7.5 Tablet Works

Mext F 7.5 Tablet contains Methotrexate (immunosuppressant/antimetabolite) and Folic acid (vitamin). Methotrexate works by reducing the function of the cells that cause inflammation in the joint tissues. It is also an anticancer drug that prevents cancer cells' growth and spread by blocking their access to folate (a form of vitamin B9). Folic acid is the synthetic form of folate. It prevents and treats low blood levels of folate (folate deficiency) caused due to Methotrexate during chemotherapy.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Mext F 7.5 Tablet

  • Nausea
  • Vomiting
  • Diarrhoea
  • Fatigue
  • Dizziness
  • Headache
  • Loss of appetite 
  • Increase in liver enzymes
  • Lowered resistance to infections
  • Tingling sensation
  • Stomach upset
  • Stomach pain
  • Leukopenia (decreased number of white blood cells)
  • Soreness of mouth and lips

What if I have taken an overdose of Mext F 7.5 Tablet

Avoid exceeding the recommended dose as it might cause an overdose. Seek immediate medical attention if you experience any unusual symptoms.

Drug Warnings

If you are known to be allergic to Mext F 7.5 Tablet or its inactive components, please inform your doctor. Brief your medical history if you have any liver or kidney diseases, lung diseases (pulmonary fibrosis), alcohol use, suppressed immune system, blood cell/bone marrow disorders, gastrointestinal diseases (peptic ulcer, ulcerative colitis), and active infections (including chickenpox). Mext F 7.5 Tablet is contraindicated during pregnancy since it has harmful effects on the foetus. Please get a pregnancy test done before starting Mext F 7.5 Tablet . You should get a negative pregnancy test for sure before using Mext F 7.5 Tablet . Use reliable forms of birth control if you are undergoing treatment with Mext F 7.5 Tablet to avoid pregnancy. Mext F 7.5 Tablet should not be taken by breastfeeding mothers since it is excreted into the breast milk. Mext F 7.5 Tablet can cause dizziness and drowsiness; hence drive with caution. Avoid consuming alcohol along with Mext F 7.5 Tablet as it could lead to increased dizziness. Mext F 7.5 Tablet should not be given to children below three years of age, as safety and efficacy have not been established. 

Drug-Drug Interactions

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MethotrexateEtretinate
Critical
MethotrexateAcitretin
Severe

Drug-Drug Interactions

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MethotrexateEtretinate
Critical
How does the drug interact with Mext F 7.5 Tablet 28's:
Co-administration of Etretinate with Mext F 7.5 Tablet 28's may increase the risk or severity of liver problems.

How to manage the interaction:
Taking Etretinate with Mext F 7.5 Tablet 28's is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.
MethotrexateAcitretin
Severe
How does the drug interact with Mext F 7.5 Tablet 28's:
Co-administration of Acitretin with Mext F 7.5 Tablet 28's may increase the risk or severity of liver problems.

How to manage the interaction:
Although there is a possible interaction between Acitretin with Mext F 7.5 Tablet 28's, you can take these medicines together if only when prescribed by a doctor. Do not discontinue any medications without talking to a doctor.
MethotrexateEsomeprazole
Severe
How does the drug interact with Mext F 7.5 Tablet 28's:
Co-administration of Mext F 7.5 Tablet 28's and esomeprazole can increase the blood levels and side effects of Mext F 7.5 Tablet 28's.

How to manage the interaction:
Although taking Esomeprazole with Mext F 7.5 Tablet 28's can result in an interaction, they can be taken together if prescribed by a doctor. However, contact your doctor if you experience headache, dizziness, nausea and vomiting. Do not discontinue any medications without consulting a doctor.
MethotrexateProcaine benzylpenicillin
Severe
How does the drug interact with Mext F 7.5 Tablet 28's:
Coadministration of Mext F 7.5 Tablet 28's with procaine benzyl penicillin can increase the levels and side effects of Mext F 7.5 Tablet 28's.

How to manage the interaction:
Although there is a possible interaction between procaine benzyl penicillin and Mext F 7.5 Tablet 28's, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, mouth ulcers, paleness, fatigue, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, body aches, or other flu-like symptoms, consult your doctor. Do not stop using any medications without consulting to a doctor.
MethotrexateDexlansoprazole
Severe
How does the drug interact with Mext F 7.5 Tablet 28's:
Co-administration of Mext F 7.5 Tablet 28's with Dexlansoprazole can increase the levels and side effects of Mext F 7.5 Tablet 28's.

How to manage the interaction:
Although there is a possible interaction between Mext F 7.5 Tablet 28's and Dexlansoprazole, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as tiredness, dizziness, fainting, unusual bleeding or bruising, chills, fever, sore throat, or body pains. Consult a doctor immediately. Do not stop using medications without a doctor's advice.
MethotrexateTacrolimus
Severe
How does the drug interact with Mext F 7.5 Tablet 28's:
Taking tacrolimus with Mext F 7.5 Tablet 28's may increase the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between tacrolimus and Mext F 7.5 Tablet 28's, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, dizziness. Consult your doctor. Do not stop using any medications without consulting to a doctor.
MethotrexateTolmetin
Severe
How does the drug interact with Mext F 7.5 Tablet 28's:
Coadministration of Mext F 7.5 Tablet 28's with tolmetin can increase the levels and side effects of Mext F 7.5 Tablet 28's.

How to manage the interaction:
Although there is a possible interaction between tolmetin and Mext F 7.5 Tablet 28's, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as mouth ulcers or sores, vomiting, fever, chills, body aches, sore throat, muscle weakness, diarrhea, rash, loss of appetite, joint pain or swelling, yellow discoloration of skin and eyes, dark urine, breathing difficulty, dry cough, paleness, dizziness or fainting, unusual bruising or bleeding, seizures(fits), Consult a doctor. Do not stop using any medications without consulting a doctor.
MethotrexateDicloxacillin
Severe
How does the drug interact with Mext F 7.5 Tablet 28's:
Co-administration of Mext F 7.5 Tablet 28's with dicloxacillin can increase the levels and effects of Mext F 7.5 Tablet 28's. This can increase the risk or severity of serious infections.

How to manage the interaction:
Although there is a possible interaction between Mext F 7.5 Tablet 28's and dicloxacillin, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, mouth ulcers, paleness, fatigue, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, body aches. Consult a doctor immediately. Do not stop using medications without a doctor's advice.
MethotrexateEverolimus
Severe
How does the drug interact with Mext F 7.5 Tablet 28's:
Coadministration of Everolimus with Mext F 7.5 Tablet 28's can increase the risk or severity of kidney disorders.

How to manage the interaction:
Taking Everolimus with Mext F 7.5 Tablet 28's together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not stop using any medications without talking to a doctor.
MethotrexatePiroxicam
Severe
How does the drug interact with Mext F 7.5 Tablet 28's:
Coadministration of Mext F 7.5 Tablet 28's with piroxicam can increase the levels and side effects.

How to manage the interaction:
Although there is a possible interaction between piroxicam and Mext F 7.5 Tablet 28's, it can be taken if prescribed by a doctor. However, if you experience any symptoms such as mouth ulcers or sores, vomiting, fever, chills, body aches, sore throat, muscle weakness, diarrhea, rash, loss of appetite, joint pain or swelling, yellow discoloration of skin and eyes, dark urine, breathing difficulty, dry cough, paleness, dizziness or fainting, unusual bruising or bleeding, seizures(fits), Consult a doctor. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps strengthen muscles and relieves joint stiffness. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.
  • Follow heat or cold therapy, and apply a cold or hot compress on the joints for 15-20 minutes regularly.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants, such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTIRHEUMATICS

Mext F 7.5 Tablet Substitute

Substitutes safety advice
  • Fotrex Combikit Tablet 24+4's

    169.75per tablet
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Mext F 7.5 Tablet . It could lead to increased dizziness and drowsiness.

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Pregnancy

Unsafe

Mext F 7.5 Tablet is not recommended and unsafe in pregnancy. It can affect and harm the developing baby. You are advised to get a pregnancy test done before starting Mext F 7.5 Tablet . You should get a negative pregnancy test for sure before using Mext F 7.5 Tablet . Also, please use reliable forms of birth control if you are undergoing treatment with Mext F 7.5 Tablet to avoid pregnancy.

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Breast Feeding

Unsafe

Mext F 7.5 Tablet is excreted into the breast milk and is not recommended during breastfeeding. Please consult your doctor before taking Mext F 7.5 Tablet if you are a breastfeeding mother.

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Driving

Caution

Mext F 7.5 Tablet may sometimes make you feel dizzy. Do not drive or operate machinery if you are not mentally alert and focused.

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Liver

Caution

Let your doctor know if you have any history of liver diseases before taking Mext F 7.5 Tablet . Your dosage may be adjusted in case of liver impairment.

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Kidney

Caution

Let your doctor know if you have any history of kidney diseases before taking Mext F 7.5 Tablet . Your dosage may be adjusted in case of renal impairment.

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Children

Caution

Mext F 7.5 Tablet may be given to children for psoriasis treatment. However, it should not be used by children under three years of age, as efficacy and safety have not been established.

FAQs

Mext F 7.5 Tablet is used to treat rheumatoid arthritis, psoriatic arthritis, juvenile idiopathic arthritis, psoriasis, and cancer.
Mext F 7.5 Tablet contains Methotrexate and Folic acid. Methotrexate acts as an immunosuppressant and works by suppressing the overactive immune system that causes inflammation in the cells and tissues, thus preventing various autoimmune diseases. Folic acid is used to replace the folic acid deficiency caused by Methotrexate.
Mext F 7.5 Tablet works by suppressing the overactive immune system responsible for causing psoriasis. Mext F 7.5 Tablet interferes with the synthesis of genetic material (DNA) and the growth of cells that multiply faster than usual, thereby helping in treating psoriasis and psoriatic arthritis.
Diarrhoea might be a side-effect of Mext F 7.5 Tablet . Drink lots of fluids and eat foods rich in fibre if you experience diarrhoea. If you find blood in your stools (tarry stools) or experience excess diarrhoea, consult your doctor. Do not take anti-diarrhoeal medicine on your own.
Methotrexate in Mext F 7.5 Tablet causes leukopenia (decreased number of white blood cells) and may make you more susceptible to infections. Stay away from people with active infections. Consult your doctor if you develop any signs of infections, such as fever, sore throat, breathlessness, jaundice and unexplained bleeding or bruising.
Mext F 7.5 Tablet should be used with caution if you have a medical history of liver or kidney diseases, lung diseases (pulmonary fibrosis), alcohol use, suppressed immune system, blood cell/bone marrow disorders, gastrointestinal diseases (peptic ulcer, ulcerative colitis) and active infections (including chickenpox).

Country of origin

INDIA

Manufacturer/Marketer address

Wallace Pharmaceuticals Pvt. Ltd., 3rd Floor, Dempo Trade Centre Bldg., Patto Plaza, EDC Complex, Panaji 403001, Goa, India.
Other Info - MEX0010

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