Megatas Plus 50 Combikit

Megatas Plus 50 Combikit is a combination medicine used to treat overactive bladder (OAB) with symptoms of urinary incontinence (urine leakage), urgent or frequent urination, increased night-time urination, and dysuria (painful or difficult urination). Overactive bladder is a condition in which there is a problem with bladder function, which causes a sudden urge to urinate that might be difficult to control.
 
Megatas Plus 50 Combikit contains Solifenacin (anti-cholinergic) and Mirabegron (beta-3 adrenergic agonist). Solifenacin reduces the undesirable contractions of the bladder, thereby increasing the amount of urine that the bladder can hold. This decreases the urgency for urination. Mirabegron relaxes the muscles of the bladder; this prevents frequent, uncontrolled, or urgent urination. Together, Megatas Plus 50 Combikit helps in treating overactive bladder.
 
You are advised to take Megatas Plus 50 Combikit for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience common side-effects such as dry mouth, constipation, headache, high blood pressure, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Consult your doctor if you are pregnant or breastfeeding. Megatas Plus 50 Combikit is not recommended for children as safety and efficacy have not been established. Megatas Plus 50 Combikit may cause blurred vision, so drive with caution. Avoid or limit alcohol consumption along with Megatas Plus 50 Combikit as it could lead to increased dizziness. Inform your doctor about your health condition and medications before taking Megatas Plus 50 Combikit to rule out any side effects/interactions.

Megatas Plus 50 Combikit is a combination of two drugs, namely: Solifenacin and Mirabegron. Megatas Plus 50 Combikit is a combination medicine used to treat overactive bladder (OAB) with symptoms of urinary incontinence (urine leakage), urgent or frequent urination, increased night-time urination, dysuria (painful or difficult urination). Solifenacin is an anti-cholinergic that reduces the undesirable contractions of the bladder, thereby increasing the amount of urine that the bladder can hold. This decreases the urgency for urination. Mirabegron is a beta-3 adrenergic agonist which relaxes the muscles of the bladder; this prevents frequent, uncontrolled, or urgent urination. Together, Megatas Plus 50 Combikit helps in treating an overactive bladder.

• Constipation
• Headache 
• Dry mouth
• Blurred vision
• Vomiting
• High blood pressure
• Urinary tract infection

Do not take Megatas Plus 50 Combikit if you are allergic to any of its contents. Inform your doctor if you have glaucoma, myasthenia gravis, ulcerative colitis, urinary retention, high blood pressure, angioedema, kidney or liver problems. Consult your doctor if you are pregnant or breastfeeding. Megatas Plus 50 Combikit is not recommended for children. Megatas Plus 50 Combikit may cause blurred vision, so drive with caution. Avoid or limit alcohol consumption with Megatas Plus 50 Combikit as it could lead to increased dizziness. 

Drug-Drug Interactions: Megatas Plus 50 Combikit may interact with antihistamine (diphenhydramine), analgesic (acetaminophen), bronchodilator (albuterol), beta-blocker (metoprolol).

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform your doctor if you have glaucoma, urinary obstruction/retention, high blood pressure, kidney or liver problems.

• DIPHENHYDRAMINE
• METOPROLOL
• ACETAMINOPHEN
• ALBUTEROL

• Pelvic floor exercises would be helpful in treating bladder spasms.

• Avoid foods like sugars, carbonated beverages, tea, citrus fruits, tomatoes, spicy foods, chocolate and tea. 

• Avoid drinking excess alcohol or caffeinated drinks, as they can worsen the symptoms.

• Maintain a healthy weight, and exercise regularly.

• Quit smoking.

• Take 6-8glasses of liquids every day.

• Avoid processed foods. Instead, choose whole, unprocessed foods.

• Include fruits, vegetables, and fibre-rich food in your diet.

Overactive bladder (OAB): Overactive bladder is a condition in which there is a problem with bladder function, which causes a sudden urge to urinate that might be difficult to control. The contraction or tightening of bladder muscles causes bladder spasms. Continuous contractions may cause an urge to urinate. Overactive bladder is characterised by involuntary leakage of urine, excessive urination, and urgent need to urinate. The common causes of bladder spasms are urinary tract infections, drinking too much caffeine or alcohol, diabetes, constipation, impaired kidney function, bladder stones, enlarged prostate, or neurological disorders. Symptoms of overactive bladder include urinating more than 8 times a day and more than 2 times at night, strong and sudden need to urinate, leakage of urine, and loss of bladder control.