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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Nov 23, 2024 | 4:31 PM IST
Kryxana 200 mg Tablet is used to treat breast cancer. It contains Ribociclib, which works by slowing down the growth of cancer cells and delaying the progression of cancer. In some cases, this medicine may cause side effects such as diarrhoea, nausea, vomiting, constipation, hair loss, fatigue, dizziness, back pain, and headache. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Prescription drug

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Composition

RIBOCICLIB-200MG

Manufacturer/Marketer

Novartis India Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Kryxana 200 mg Tablet

Kryxana 200 mg Tablet belongs to the group of anti-cancer medicines called cyclin-dependent kinase (CDK) inhibitors used to treat a type of breast cancer that is locally advanced or metastatic (has spread to other parts of the body). Breast cancer is a type of cancer that develops in the breast when the breast cells begin to grow abnormally.
 
Kryxana 200 mg Tablet contains ‘Ribociclib’, which works by blocking cyclin-dependent kinase 4 and 6 proteins, which are necessary for the growth and division of the cells. Thereby, slows down the growth of cancer cells and delays the progression of cancer.
 
You are advised to take Kryxana 200 mg Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as diarrhoea, nausea, vomiting, constipation, hair loss, fatigue, dizziness, back pain, and headache. Do not be reluctant to talk with your doctor if you experience any of these side effects persistently.
 
Avoid taking Kryxana 200 mg Tablet if you are pregnant or breastfeeding. Kryxana 200 mg Tablet may cause tiredness and dizziness, so drive only if you are alert. Kryxana 200 mg Tablet should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol with Kryxana 200 mg Tablet as it could lead to increased dizziness. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Uses of Kryxana 200 mg Tablet

Treatment of Breast cancer

Medicinal Benefits

Kryxana 200 mg Tablet belongs to the group of anti-cancer medicines called cyclin-dependent kinase (CDK) inhibitors used to treat a type of breast cancer that is locally advanced or metastatic (has spread to other parts of the body). Kryxana 200 mg Tablet works by blocking cyclin-dependent kinase 4 and 6 proteins, which are necessary for the growth and division of the cells. Thereby, slows down the growth of cancer cells and delays the progression of cancer.

Directions for Use

Swallow Kryxana 200 mg Tablet as a whole with a glass of water; do not chew or break it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Kryxana 200 mg Tablet

  • Stomach upset
  • Diarrhoea
  • Nausea
  • Vomiting
  • Tiredness
  • Constipation
  • Hair loss
  • Weakness
  • Dizziness/light-headedness
  • Headache
  • Cough
  • Reduced appetite
  • Painful and frequent urination
  • Fever

Drug Warnings

Do not take Kryxana 200 mg Tablet if you are allergic to any of its components. Talk to your doctor if you have a fever, sore throat, mouth ulcers due to infections, liver problems, heart/heart rhythm disorders, or low levels of electrolytes. Avoid taking Kryxana 200 mg Tablet if you are pregnant or breastfeeding. Kryxana 200 mg Tablet may cause dizziness, so drive only if you are alert. Kryxana 200 mg Tablet should not be given to children as safety has not been established. Avoid consuming alcohol with Kryxana 200 mg Tablet as it could lead to increased dizziness. Inform your doctor about your health condition and medications before taking Kryxana 200 mg Tablet to rule out any side effects/interactions.

Drug Interactions

Drug-Drug Interactions: Kryxana 200 mg Tablet may interact with chemotherapy agents (paclitaxel, doxorubicin), sedative (zolpidem), opiate analgesic (oxycodone), anti-arrhythmic agent (sotalol). 

Drug-Food Interactions: Avoid pomegranate/pomegranate juice and grapefruit/grapefruit juice while taking Kryxana 200 mg Tablet as these might increase the amount of Kryxana 200 mg Tablet in blood.

Drug-Disease Interactions: Inform your doctor if you have heart/heart rhythm problems, neutropenia (low levels of white blood cells), lung, liver or kidney impairment.

Drug-Drug Interactions Checker List

  • PACLITAXEL
  • DOXORUBICIN
  • ZOLPIDEM
  • OXYCODONE
  • SOTALOL

Habit Forming

No

Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs and spices in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep; rest well.

Special Advise

  • To monitor liver functioning, amount of blood cells, and electrolytes, your doctor might advise regular blood tests before and during the treatment with Kryxana 200 mg Tablet .
  • Regular monitoring of heart activity before and during treatment with Kryxana 200 mg Tablet is advised.
  • Kryxana 200 mg Tablet might cause heart rhythm problems, liver problems and neutropenia (low white blood cell count); therefore, regular tests are recommended while taking Kryxana 200 mg Tablet .
  • If you are a woman of childbearing potential, use effective contraception while taking Kryxana 200 mg Tablet and for at least 21 days after the last dose.

Disease/Condition Glossary

Breast cancer: It is a type of cancer that develops in the breast when the breast cells begin to grow abnormally. Breast cancer may form in lobules (glands that produce milk), ducts of the breast (the pathway that brings milk from glands to the nipple), in the fatty tissue or the fibrous connective tissue within the breast. The tumour cells invade other healthy breast cells and can travel to lymph nodes which are a primary pathway for the cancer cells to move to other parts of the body. Symptoms of breast cancer include a lump in the breast or tissue thickening which feels different than the normal surrounding tissues, breast pain, redness, swelling, nipple discharge other than breast milk, bloody discharge, unexplained change in shape, size or appearance of the breast, peeling, flaking or scaling of the skin, and a lump or swelling under the arm.

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Alcohol

Caution

Avoid alcohol consumption while taking Kryxana 200 mg Tablet as it might cause increased dizziness.

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Pregnancy

Unsafe

Kryxana 200 mg Tablet should not be taken during pregnancy as it might harm the unborn baby. If you are a woman of childbearing potential, use effective contraception while taking Kryxana 200 mg Tablet and for at least 21 days after the last dose.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Kryxana 200 mg Tablet and for at least 21days after the last dose.

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Driving

Unsafe

Kryxana 200 mg Tablet may cause dizziness, tiredness, or spinning sensation. Drive or operate heavy machinery only if you are alert.

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Liver

Caution

Dose adjustment may be necessary. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be necessary. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Kryxana 200 mg Tablet is not recommended for children below 18 years as safety and effectiveness have not been established.

Country of origin

Switzerland

Manufacturer/Marketer address

Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India
Other Info - KRY0003

Author Details

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FAQs

Kryxana 200 mg Tablet is used to treat breast cancer.
Kryxana 200 mg Tablet works by blocking cyclin-dependent kinase 4 and 6 proteins, which are necessary for the growth and division of the cells. Thereby, slows down the growth of cancer cells and delays the progression of cancer.
Kryxana 200 mg Tablet might cause fertility problems and may affect your ability to father a child. Talk to your doctor if you have any concerns regarding this.
Avoid pomegranate/pomegranate juice and grapefruit/grapefruit juice while taking Kryxana 200 mg Tablet as these might increase the amount of Kryxana 200 mg Tablet in blood.
Kryxana 200 mg Tablet may cause a heart problem called QT prolongation, which causes abnormal heartbeat. Inform your doctor if you have/had any heart problems, heart failure, irregular heartbeat, or QT prolongation. Regular monitoring of heart activity before and during treatment with Kryxana 200 mg Tablet is advised.
Do not stop taking Kryxana 200 mg Tablet on your own. You are advised to take Kryxana 200 mg Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Kryxana 200 mg Tablet .
Dry mouth could be a side-effect of Kryxana 200 mg Tablet . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol; drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.
The common side effects of Kryxana 200 mg Tablet include diarrhoea, nausea, vomiting, constipation, hair loss, fatigue, dizziness, back pain, and headache. If you experience any side effects persistently, it's essential to discuss them with your doctor.
Kryxana 200 mg Tablet should be taken as advised by the doctor. Take it at the same time daily to help you remember to take the medicine. It can be taken with or without food. Always follow the doctor’s instructions.

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