Itorebe 20 mg/150 mg Capsule SR is used to lower the increased level of stomach acid. It treats GERD (gastro-oesophagal reflux disease), and peptic ulcers. Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the food pipe (oesophagus). Peptic ulcers are sores that develop on the inner lining of the intestine and stomach.

Itorebe 20 mg/150 mg Capsule SR is a combination of two drugs: Rabeprazole and Itopride. Rabeprazole is a proton pump inhibitor (PPI) that works by blocking the action of an enzyme called gastric proton pump, which is responsible for acid production. It minimizes the release of acid from the stomach, which provides relief from heartburn and acid-related digestion. While Itopride works on the part of the brain that is responsible for controlling vomiting.  It increases gastric emp undying improves gastric sensitivity and tension by increasing the stomach's movement and intestines in the upper digestive tract. It also has anti-emetic action. Together, Itorebe 20 mg/150 mg Capsule SR helps prevent acid reflux, thereby relieving acidity.

Take Itorebe 20 mg/150 mg Capsule SR 30-60 minutes before food. Do not chew or break the tablet; swallow it as a whole with a glass of water. You are advised to take Itorebe 20 mg/150 mg Capsule SR for as long as your doctor has prescribed it for you, depending on your medical condition. Sometimes, you may experience common side effects such as headache, nausea, stomach pain, dizziness, and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Inform your doctor before taking Itorebe 20 mg/150 mg Capsule SR if you have a history of gastrointestinal bleeding, mechanical perforation/obstruction, or movement disorder. On long-term treatment, Itorebe 20 mg/150 mg Capsule SR may cause osteoporosis and hypomagnesemia (low levels of magnesium). Do not take Itorebe 20 mg/150 mg Capsule SR if you are pregnant or breastfeeding unless prescribed by the doctor. Itorebe 20 mg/150 mg Capsule SR causes drowsiness, so drive only if you are alert. Itorebe 20 mg/150 mg Capsule SR should not be given to children as safety has not been established. Avoid consuming alcohol with Itorebe 20 mg/150 mg Capsule SR as it can lead to increased drowsiness and increased acid production. 

Itorebe 20 mg/150 mg Capsule SR is a combination of two drugs:  Rabeprazole and Itopride. Rabeprazole is a proton pump inhibitor (PPI) that works by blocking the action of an enzyme called gastric proton pump, which is responsible for acid production. It minimizes the release of acid from the stomach, which provides relief from heartburn and acid-related digestion. While Itopride works on the part of the brain responsible for controlling vomiting.  It increases gastric emptying and improves gastric sensitivity and tension by increasing the stomach's movement and intestines in the upper digestive tract. It also has anti-emetic action. Together, Itorebe 20 mg/150 mg Capsule SR helps prevent acid reflux, thereby relieving acidity.
 

• Nausea
• Dizziness
• Diarrhoea 
• Headache
• Stomach pain

Do not take Itorebe 20 mg/150 mg Capsule SR if you are allergic to any of its contents. Inform your doctor before taking Itorebe 20 mg/150 mg Capsule SR if you have a history of gastrointestinal bleeding, mechanical perforation/obstruction, or movement disorder. Itorebe 20 mg/150 mg Capsule SR may cause osteoporosis on long-term treatment. Itorebe 20 mg/150 mg Capsule SR may also cause hypomagnesemia (low magnesium). Do not take Itorebe 20 mg/150 mg Capsule SR if you are pregnant or breastfeeding unless prescribed by the doctor. Itorebe 20 mg/150 mg Capsule SR causes dizziness, so drive only if you are alert. Itorebe 20 mg/150 mg Capsule SR should not be given to children as safety has not been established. Avoid consuming alcohol along with Itorebe 20 mg/150 mg Capsule SR as it could lead to increased drowsiness and elevate stomach acid production. Keep your doctor informed about all the medicines and your health condition to rule out any side effects.  Consult your doctor if you experience unexplained weight loss, stomach pain, indigestion, vomit food or blood, or if you pass black stools. On long-term treatment, Itorebe 20 mg/150 mg Capsule SR may cause osteoporosis and hypomagnesemia (low levels of magnesium), and may reduce the absorption of vitamin B12.

DRUG-DRUG INTERACTIONS: Itorebe 20 mg/150 mg Capsule SR may have interaction with pain killers (aspirin, naproxen), an antidepressant (duloxetine), hypothyroidism (levothyroxine), statins (atorvastatin), blood thinner (clopidogrel), and vitamin (vitamin b12).

FOOD-DRUG INTERACTIONS: Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.

DRUG-DISEASE INTERACTION: Itorebe 20 mg/150 mg Capsule SR may have interactions with gastrointestinal bleeding, mechanical obstruction or perforation, Clostridium difficile-associated diarrhoea (CDAD), liver disease, bone fractures, hypomagnesemia (low levels of magnesium).

• ASPIRIN
• NAPROXEN
• DULOXETINE
• LEVOTHYROXINE SODIUM
• ATORVASTATIN
• CLOPIDOGREL
• CYANOCOBALAMIN

• Eat smaller meals more often.
• Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
• Maintain a healthy weight by regular exercising.
• Avoid lying down after eating.
• Avoid tight-fitting clothes.
• Maintain a healthy weight by regular exercising.
• Practice relaxation techniques and avoid stress by doing yoga or meditation.
• Avoid foods such as high-fat, spicy chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea and soda. 
• Avoid sitting continuously, as it may trigger acidity. Take a break of 5minutes break every hour by doing brisk walking or stretching.

• Inform your doctor before taking Itorebe 20 mg/150 mg Capsule SR if you are due to have Chromogranin A test.
• Regular tests of magnesium and calcium are suggested if you are regularly taking prescribed Itorebe 20 mg/150 mg Capsule SR. 

Gastroesophageal reflux disease (GERD): The stomach is usually protected from acid by a mucous layer. In some cases, the mucous layer gets eroded due to excess acid production, which leads to complications like GERD, acidity, and peptic ulcers. Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn. Symptoms include heartburn, a sour or bitter taste, and difficulty swallowing. Peptic ulcers are sores that develop on the stomach and intestine lining due to erosion of the stomach's protective lining. Symptoms include nausea, changes in appetite, bloody or dark stools, unexplained weight loss, vomiting, and indigestion.