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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Dec 7, 2024 | 2:25 PM IST
Harmless Plus Suspension is used to treat bacterial infections. It contains Colistin Sulphate which works by killing infection-causing bacteria. In some cases, this medicine may cause side effects such as dizziness, upset stomach, rash, diarrhoea, vertigo (spinning sensation), paresthesia (tingling or pricking sensation) and slurred speech. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Prescription drug

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Synonym

COLISTIN

Consume Type

ORAL

Return Policy

Not Returnable

for this medicine

About Harmless Plus Suspension

Harmless Plus Suspension belongs to the class of medications called ‘antibiotics’ used to treat bacterial infections caused by susceptible Gram-negative bacteria. Bacterial infections are caused by the multiplication of harmful bacteria inside or on the body. These harmful bacteria produce chemicals known as toxins, which can damage tissue and make you sick. Symptoms of bacterial infection vary depending on the organ affected by bacteria.

Harmless Plus Suspension contains Colistin Sulphate. Colistin effectively solubilizes the bacterial cell membrane, resulting in bacterial cell death. As a result, Harmless Plus Suspension destroys the bacteria and successfully treats the infection.

Take Harmless Plus Suspension as prescribed by your doctor. Depending on your medical condition, you are advised to take Harmless Plus Suspension for as long as your doctor prescribes it. Sometimes, you may experience common side effects like dizziness, upset stomach, rash, diarrhoea, vertigo (spinning sensation), paresthesia (tingling or pricking sensation) and slurred speech. But these side effects are usually in the initial phase and resolve over time. However, if these side effects persist, let your doctor know.

Before receiving Harmless Plus Suspension, let your doctor know about all your medical conditions, sensitivities, and all medications you are using. And also, inform your doctor if you are pregnant, planning pregnancy, or breastfeeding. Harmless Plus Suspension can cause blurred vision and dizziness in some people; if this occurs, do not drive or operate tools or machinery. It is recommended not to consume any alcoholic beverages while on treatment with this medicine.

Uses of Harmless Plus Suspension

Treatment of Severe bacterial infections

Medicinal Benefits

Harmless Plus Suspension contains Colistin Sulphate, which is used for treating acute or chronic infections due to sensitive strains of certain gram-negative bacilli, particularly Pseudomonas aeruginosa. Colistin sulphate effectively solubilizes the bacterial cell membrane, resulting in bacterial cell death. As a result, Harmless Plus Suspension destroys the bacteria and successfully treats the infection.

Directions for Use

Shake the bottle well before each use. Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Harmless Plus Suspension

  • Dizziness
  • Upset stomach
  • Rash
  • Diarrhoea
  • Kidney damage
  • Vertigo (Spinning sensation)
  • Paresthesia (tingling or pricking sensation)
  • Slurred speech

Drug Warnings

Before taking the Harmless Plus Suspension, let your doctor know about all your medical conditions, sensitivities, and all medications you are using. Inform your doctor if you are pregnant, planning to become pregnant, or are breastfeeding before receiving Harmless Plus Suspension. Also, inform your doctor if you have chronic kidney disease, myasthenia gravis (muscle disorder), and porphyria (a blood disorder). Do not abruptly discontinue taking the prescription since this may result in antibiotic resistance, a condition in which bacteria develop resistance to antibiotics.

Drug Interactions

Drug-Drug Interactions: Harmless Plus Suspension is known to interact with selective skeletal muscle relaxants (e.g. cyclobenzaprine, metaxalone), antifungals (e.g. amphotericin B) and aminoglycosides (e.g. capreomycin, vancomycin)

Drug-Food Interactions: Harmless Plus Suspension is known to interact with alcohol and Grapefruit.

Drug-Disease Interactions: Harmless Plus Suspension is known to interact with disease conditions, including kidney problems, myasthenia gravis (a muscle disorder), and porphyria (a blood disorder).

Drug-Drug Interactions Checker List

  • AZITHROMYCIN
  • CLARITHROMYCIN
  • ERYTHROMYCIN
  • OFLOXACIN
  • NORFLOXACIN
  • CIPROFLOXACIN
  • NETILIMICIN
  • GENTAMICIN
  • AMIKACIN
  • TOBRAMYCIN
  • ATRACURIUM
  • CISATRACURIUM
  • VECURONIUM

Habit Forming

No

Diet & Lifestyle Advise

  • After taking the full course of Harmless Plus Suspension, probiotics should be taken to restore some of the healthy bacteria in the intestine that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yoghurt, cheese, sauerkraut and kimchi can restore the intestine's good bacteria stink.
  • Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria, which helps stimulate their growth. Thus fibre foods may help restore healthy gut bacteria after taking a course of antibiotics. Whole grains, like whole-grain bread and brown rice, should be included in your diet.
  • Avoid taking many calcium-enriched foods and drinks as it might affect the working of Harmless Plus Suspension.
  • Avoid intake of alcoholic beverages with Harmless Plus Suspension as it can make you dehydrated and affect your sleep. This can make it harder for your body to aid the Harmless Plus Suspension in fighting off infections.

Special Advise

 

Disease/Condition Glossary

Bacterial infections: A bacterial infection is a condition in which harmful bacteria enter, multiply and infect the body. It can target any organ of the body and multiply very quickly. Many give off chemicals called toxins, which can damage tissue and make you sick. Bacterial infections vary from minor illnesses (like sore throat and ear infections) to severe brain infections (like meningitis and encephalitis). When you get infected with bacteria, you can experience generalized symptoms like fevers, chills and fatigue. A few harmful bacteria commonly cause infections, including Streptococcus, Staphylococcus and E. coli. Anyone can get a bacterial infection, but people with a weak immune system or taking immunosuppressive medicines like steroids are more prone to infections.

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Alcohol

Caution

Harmless Plus Suspension is known to cause drowsiness. Taking alcohol along with it may increase drowsiness and cause excessive sleepiness.

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Pregnancy

Caution

Harmless Plus Suspension should not be used in pregnancy unless necessary. Inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Harmless Plus Suspension.

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Breast Feeding

Caution

Harmless Plus Suspension should not be used in breastfeeding unless necessary. Inform your doctor if you are a breastfeeding mother. Your doctor will weigh the benefits and potential risks before prescribing Harmless Plus Suspension.

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Driving

Caution

Harmless Plus Suspension may cause dizziness, so do not drive or operate heavy machinery if you feel dizzy.

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Liver

Consult your doctor

Harmless Plus Suspension should be used with caution if you have liver disease. Your doctor may adjust the dose based on your condition.

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Kidney

Consult your doctor

Harmless Plus Suspension should be used with caution if you have kidney disease. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Caution

Harmless Plus Suspension is probably safe when used in children who are above 40 kgs in weight. However, your child's doctor will adjust the dose based on the age, body weight and health condition of your child.

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FAQs

Harmless Plus Suspension is used to treat bacterial infections.
Harmless Plus Suspension contains Colistin Sulphate, an anti-bacterial medicine used to treat severe bacterial infections. It works by stopping the growth of bacterial cell walls, which is required for bacteria's growth and multiplication.
Before taking Harmless Plus Suspension, let your doctor know if you have or ever had any problems related to your kidneys/liver or lungs (such as asthma). Also, mention all the other medicines you are taking to avoid any drug interaction.
No, Harmless Plus Suspension does not treat cold and flu infections. It is used to treat severe bacterial infections and should be taken only if prescribed by a doctor.
After taking Harmless Plus Suspension, you may have diarrhoea. Harmless Plus Suspension is an antibiotic that kills or prevents bacterial growth. Some good intestinal bacteria that aid digestion might also be killed. So, drink plenty of fluids and take probiotics to prevent excessive loss of fluids from the body (dehydration). Consult the doctor if diarrhoea worsens, and never take anti-diarrhoea medication without consulting a doctor.
Harmless Plus Suspension is safe for the elderly population, but if you have any kidney problem, then Harmless Plus Suspension should be used with caution as it might lead to kidney complications and slow overall body processes. In such cases, inform your doctor before starting Harmless Plus Suspension so that dose adjustment can be made.
Harmless Plus Suspension may cause live bacterial vaccines (such as typhoid vaccine) not to work either. Do not have immunizations/vaccinations while using this medication unless your doctor tells you to.
Yes, Harmless Plus Suspension is effective in the treatment of bacterial infections of the stomach, bowel, intestines, and diarrhoea.
If you forget to take a dose of Harmless Plus Suspension, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and continue with your regular schedule.
Harmless Plus Suspension should not be used in people who are allergic to any of its components. Consult the doctor if you have any concerns.
Harmless Plus Suspension should be used during pregnancy only if advised by the doctor. You are recommended to consult your doctor before taking Harmless Plus Suspension if you are pregnant.
Yes, Harmless Plus Suspension is safe when used as prescribed by your doctor. However, it may cause some side effects like nausea, vomiting, loss of appetite, and stomach upset while using it.
The common side effects of Harmless Plus Suspension may include nausea, vomiting, loss of appetite and stomach upset. Most of these side effects of Harmless Plus Suspension do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

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