Fossamart Injection

Fossamart Injection belongs to a class of drugs called anti-emetics. It is used in combination with other medicines to prevent nausea and vomiting caused by chemotherapy (anti-cancer medicines). Nausea is a feeling of uneasiness in the stomach that often comes before vomiting. On the other hand, vomiting is the forcible voluntary or involuntary emptying of stomach contents through the mouth.

Fossamart Injection contains Fosaprepitant, a neurokinin 1 (NK1) receptor antagonist which is converted to aprepitant in the body. It works by blocking neurokinin 1 receptors (causes a feeling of sickness) present in the vomiting centre in the brain. Thus, it helps prevent nausea and vomiting. 

Fossamart Injection will be administered by a healthcare professional; do not self-administer. In some cases, Fossamart Injection may cause common side effects such as headache, hiccups, tiredness, loss of appetite, indigestion, and constipation. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, consult your doctor immediately. 

If you are allergic to Fosaprepitant or other medicines, please tell your doctor. If you are pregnant or breastfeeding, please inform your doctor before receiving Fossamart Injection. Drive only if you are alert after receiving Fossamart Injection. If you are taking other prescription or non-prescription medicines, inform your doctor before receiving Fossamart Injection.

Fossamart Injection contains Fosaprepitant, an anti-emetic (a drug used to treat nausea and vomiting) which is converted to aprepitant in the body. It works by blocking the action of a natural substance in the brain called neurokinin that causes nausea and vomiting. Thus, it helps prevent nausea and vomiting caused by anti-cancer medicines.

• Headache
• Hiccups
• Tiredness
• Loss of appetite
• Indigestion
• Constipation

If you are allergic to Fosaprepitant or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, please inform your doctor before receiving Fossamart Injection. Drive only if you are alert after receiving Fossamart Injection. If you are taking any other prescription or non-prescription medicines, inform your doctor before receiving Fossamart Injection. If you are using warfarin (blood thinner), your doctor may recommend blood tests after you receive Fossamart Injection to check your blood clotting.

Drug-Drug Interactions: Avoid using Fossamart Injection with antipsychotics (pimozide), anti-allergic drugs (astemizole, terfenadine), and gastroprokinetic agents (cisapride). Fossamart Injection may interact with immunosuppressants (tacrolimus, everolimus, cyclosporine, sirolimus), pain killers (fentanyl, alfentanil), a medicine used to treat an irregular heartbeat (quinidine), anticancer medicines (etoposide, vinorelbine, irinotecan, ifosfamide), blood thinners (acenocoumarol, warfarin), antibiotics (clarithromycin, telithromycin, rifampicin), anticonvulsants (phenytoin, carbamazepine), medicines used to produce calmness or help you sleep (triazolam, phenobarbital, midazolam), antifungals (ketoconazole, voriconazole, posaconazole, itraconazole), antidepressants (nefazodone), a medicine used to treat high blood pressure (diltiazem), corticosteroids (dexamethasone), anti-anxiety medicines (alprazolam), antidiabetic agent (tolbutamide) and medicines used to treat migraines and HIV infections.

Drug-Food Interactions: Fossamart Injection may interact with St. John’s Wort (herbal preparation used to treat depression).

Drug-Disease Interactions: If you have any liver problems, inform your doctor before receiving Fossamart Injection.

• PIMOZIDE
• ASTEMIZOLE
• TERFENADINE
• CISAPRIDE
• TACROLIMUS
• EVEROLIMUS
• CYCLOSPORINE
• SIROLIMUS
• FENTANYL
• ALFENTANIL
• QUINIDINE
• ETOPOSIDE
• IRINOTECAN
• IFOSFAMIDE
• ACENOCOUMAROL
• WARFARIN
• CLARITHROMYCIN
• TELITHROMYCIN
• RIFAMPICIN
• PHENYTOIN
• CARBAMAZEPINE
• TRIAZOLAM
• PHENOBARBITAL
• MIDAZOLAM
• KETOCONAZOLE
• VORICONAZOLE
• POSACONAZOLE
• ITRACONAZOLE
• NEFAZODONE
• DILTIAZEM
• DEXAMETHASONE
• ALPRAZOLAM
• TOLBUTAMIDE

• Eat a healthy and low-fat diet that includes lots of fruits and vegetables, skinless poultry, lean meats, nuts, fish, whole grains, and plant-based oils, especially in small portions, as it will be easy for digestion.
• Avoid eating over-sweet food and include more salty food, especially if you have been vomiting. 
• Increase the intake of fluids. Drink a small amount of water after small intervals to stay hydrated. 
• Avoid taking greasy or oily foods, as these foods trigger nausea and vomiting. 
• If the smell of food makes you feel sick (vomit), do not cook food, as it may worsen your condition. Let someone else do the cooking or use prepared food from the freezer.

Nausea and vomiting: Nausea is an uneasiness in the stomach that usually precedes vomiting. Vomiting, on the other hand, is a normal bodily response in which a person desires to evacuate stomach contents from the mouth aggressively. In brief, nausea and vomiting are symptoms of a variety of disorders, including infections, motion sickness, an early stage of pregnancy, and gastroparesis (slow stomach emptying). Vomiting is controlled by a receptor in the brain known as the chemoreceptor trigger zone (CTZ). After chemotherapy and radiation therapy, nausea and vomiting are common side effects. It can also arise as a side effect of an operation or surgery. Controlling vomiting and nausea in cancer patients is critical for conducting daily tasks. It can cause mental abnormalities, lack of appetite, malnutrition, and dehydration if not managed.