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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 11, 2024 | 2:34 PM IST

Eplerenone 25mg Tablet is used to treat hypertension (high blood pressure). It also maintains the bloodstream's potassium level, removes excess water from the body, and prevents hypertension (high blood pressure) due to oedema (fluid retention). It contains Eplerenone, which works by increasing the amount of urine that is passed out from the kidneys. It effectively reduces excess fluid levels in the body and the heart's workload, making it more efficient at pumping blood throughout the body. Thus, it also helps lower high blood pressure, reducing the chances of any future heart attack, stroke, or angina (chest pain) in the future. In some cases, you may experience dehydration, electrolyte disturbances (calcium, magnesium, and sodium), constipation, itching, and increased uric acid.

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Composition

EPLERENONE-25MG

Consume Type

ORAL

Return Policy

Not Returnable

for this medicine

About Eplerenone 25mg Tablet

Eplerenone 25mg Tablet is used to treat hypertension (high blood pressure). It also maintains the bloodstream's potassium level, removes excess water from the body, and prevents hypertension (high blood pressure) due to oedema (fluid retention). Blood pressure measures the force our heart uses to pump blood to all body parts. Hypertension is a chronic condition when blood pressure is too high. This condition can lead to hardened arteries (blood vessels), decreasing the blood and oxygen flow to the heart.

Eplerenone 25mg Tablet contains Eplerenone, which is prescribed for the treatment of hypertension. Eplerenone 25mg Tablet works by increasing the amount of urine passed out from the kidneys. It effectively reduces excess fluid levels in the body and the heart's workload, making it more efficient at pumping blood throughout the body. Thus, it also helps lower high blood pressure, reducing the chances of any future heart attack, stroke, or angina (chest pain).

Take Eplerenone 25mg Tablet as prescribed by your doctor. Depending upon your medical condition, you are advised to take Eplerenone 25mg Tablet for as long as your doctor has prescribed it for you. In some cases, you may experience dehydration, electrolyte disturbances (calcium, magnesium, and sodium), constipation, itching, and increased uric acid. Most of these side effects of Eplerenone 25mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Try not to stop taking a Eplerenone 25mg Tablet of your own, as doing so may raise your blood pressure, thereby increasing the risk of heart disease and stroke. Inform your doctor if you have any kidney disease (with creatinine clearance less than 30 mL/min), liver disease, high serum potassium (hyperkalemia), diabetes mellitus type 2, and patients with nil urine output (anuria). If you are pregnant or breastfeeding, please tell your doctor so that the dosage of Eplerenone 25mg Tablet can be prescribed accordingly. Please tell your doctor if you are taking any other medicines or are allergic to the Eplerenone 25mg Tablet. Reducing the amount of table salt (sodium chloride) in your food often relieves the body's swelling. Please take Eplerenone 25mg Tablet at least 4 hours before sleeping to avoid frequent urination at night. Also, do not take Eplerenone 25mg Tablet along with lithium to prevent serious side effects.

Uses of Eplerenone 25mg Tablet

Treatment of Hypertension (high blood pressure) and oedema.

Medicinal Benefits

Eplerenone 25mg Tablet primarily used to treat hypertension (high blood pressure) and heart failure. It also treats edema (reduces swelling) caused due to other conditions. Eplerenone 25mg Tablet works by increasing the amount of urine passing from the kidneys. It effectively reduces excess fluid levels in the body, reduces the heart's workload, and makes the heart more efficient at pumping blood throughout the body. Thus, it also helps lower high blood pressure, reducing the chances of any future heart attack, stroke, or angina (chest pain) in the future.

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Eplerenone 25mg Tablet

  • Dizziness
  • Nausea
  • Dizziness
  • Headache
  • Cough
  • Increased creatinine and potassium in the blood
  • Fatigue

Drug Warnings

Eplerenone 25mg Tablet should not be given to the people allergic to Eplerenone 25mg Tablet, have low blood pressure (less than 90 mm of Hg), have had a heart attack, kidney disease (with creatinine clearance less than 30 mL/min), liver disease, high serum potassium (hyperkalemia), diabetes mellitus type 2 and patients with nil urine output (anuria), pregnant women, planning to get pregnant and breastfeeding women. Eplerenone 25mg Tablet can pass into breast milk, but its effect on the baby is unknown, so it is better to tell your doctor if you are taking Eplerenone 25mg Tablet and breastfeeding. Dehydration with electrolyte and acid-base disturbances must be corrected before using Eplerenone 25mg Tablet. Do not take extra potassium supplements or potassium-rich foods such as bananas and broccoli with Eplerenone 25mg Tablet. It may lead to an excessive increase in blood potassium levels (hyperkalemia). Please take Eplerenone 25mg Tablet at least 4 hours before sleeping to avoid frequent urination at night. Also, do not take Eplerenone 25mg Tablet along with lithium to prevent serious side effects.

Drug Interactions

Drug-Drug Interactions: Eplerenone 25mg Tablet may interact with other high blood pressure-lowering pills (metoprolol, ramipril, hydrochlorothiazide), blood thinners (aspirin, warfarin), anti-epilepsy medicines (carbamazepine, phenobarbital), immune-suppressing drugs (cyclosporine), painkillers (ibuprofen), anti-fungal medicines (itraconazole, ketoconazole), HIV medicines (ritonavir, nelfinavir), anti-bacterial medicines (clarithromycin, telithromycin), anti-depressants (lithium).

Drug-Food Interactions: You are recommended not to consume alcohol with Eplerenone 25mg Tablet to avoid unpleasant side effects. Also, St. John's wort plant (natural remedy to treat depression) is known to interact with Eplerenone 25mg Tablet.

Drug-Disease Interactions: Eplerenone 25mg Tablet should not be given to people with low blood pressure (hypotension), coronary heart disease, liver or kidney disease, heart failure, high serum potassium (hyperkalemia), diabetes mellitus type 2 and patients with nil urine output (anuria).

Drug-Drug Interactions Checker List

  • METOPROLOL
  • RAMIPRIL
  • HYDROCHLOROTHIAZIDE
  • ASPIRIN
  • WARFARIN
  • CARBAMAZEPINE
  • PHENOBARBITAL
  • CYCLOSPORINE
  • IBUPROFEN
  • ITRACONAZOLE
  • KETOCONAZOLE
  • RITONAVIR
  • NELFINAVIR
  • CLARITHROMYCIN
  • TELITHROMYCIN
  • LITHIUM

Habit Forming

No

Diet & Lifestyle Advise

  • Consume antioxidant-rich food. Blueberries, cherries, tomatoes, squash, and bell peppers are highly antioxidants.
  • Eat natural diuretic foods. Asparagus, beets, green beans, grapes, onion, leafy greens, pineapple, leeks, pumpkin, and garlic are all-natural diuretic foods.
  • Use healthy cooking oils like soybean, olive, canola, and coconut oil.
  • You should avoid refined foods such as white bread, spaghetti, sugar, and red meat.
  • Reduce or eliminate Trans fatty acids, which are found in commercially baked items such as cookies, cakes, crackers, French fries, onion rings, doughnuts, and processed foods.
  • Avoid the consumption of too much salt or salty food.
  • Keep your weight under control with a BMI of 19.5-24.9.
  • Regular physical activity or exercise like walking improves your blood flow.
  • Elevate your legs or the swollen area on a chair or pillow.
  • Avoid standing or sitting for extended periods.
  • Avoid chronic stress, as it can raise your blood pressure.
  • Spend time with your loved ones to cope with stress and practice mindfulness techniques.
  • Quitting smoking and alcohol consumption is the best strategy to lower the risk of many health complications.

Special Advise

  • Treatment with Eplerenone 25mg Tablet requires regular monitoring of serum potassium and creatinine levels.
  • Monitor your blood pressure daily, and if there is too much fluctuation, immediately contact your doctor.
  • Monitor your blood sugar level daily, and if there is too much fluctuation, immediately contact your doctor.

Disease/Condition Glossary

Hypertension: The blood exerts increased pressure on the walls of blood vessels, leading to hypertension. High blood pressure is expressed as systolic/diastolic pressure. Systolic pressure is the pressure in the arteries when the heart beats or pumps out blood. Diastolic pressure is the pressure in the arteries between the heartbeats. Blood pressure is measured in millimetres of mercury (mmHg) by a blood pressure monitor called a sphygmomanometer. Some of the symptoms are headache, dizziness, nosebleeds, altered vision, chest pain, weakness, and shortness of breath. However, most of the time, there are no signs or symptoms of hypertension.

Oedema: Oedema, also known as fluid overload, occurs due to fluid build-up in spaces between the cells. Oedema can result from a variety of factors. Some oedema reasons are caused by your lifestyle, while an underlying medical problem causes others. Shortness of breath, chest pain (angina), abnormal heart rhythms (arrhythmia), and swelling in hands or abdominal areas are the symptoms of oedema.

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Alcohol

Unsafe

You are recommended not to consume alcohol along with Eplerenone 25mg Tablet to avoid unpleasant side effects.

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Pregnancy

Caution

Eplerenone 25mg Tablet should be used in pregnant women only if clinically needed, and the benefits outweigh the risks.

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Breast Feeding

Caution

Breast-feeding must be avoided during treatment with Eplerenone 25mg Tablet. It is only if prescribed by a doctor and if the benefits outweigh the harms.

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Driving

Unsafe

It is not recommended to drive after taking Eplerenone 25mg Tablet as it may occasionally cause drowsiness due to orthostatic hypotension (sudden drop in blood pressure on standing from lying position).

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Liver

Caution

Inform your doctor before receiving the Eplerenone 25mg Tablet if you have a history of liver diseases/conditions. Your doctor may adjust your dose depending on your current kidney conditions.

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Kidney

Caution

Inform your doctor before receiving the Eplerenone 25mg Tablet if you have a history of kidney diseases/conditions. Your doctor may adjust your dose depending on your current kidney conditions.

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Children

Caution

Eplerenone 25mg Tablet is not recommended for children below 12 years of age.

Country of origin

India
Other Info - EP71536

Author Details

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FAQs

Eplerenone 25mg Tablet is used to treat hypertension (high blood pressure) and oedema.
Eplerenone 25mg Tablet works by increasing the amount of urine passed out from the kidneys. It effectively reduces excess fluid levels in the body. This reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Thus, it also helps lower high blood pressure, reducing the chances of any future heart attack, stroke, or angina (chest pain) in the future.
It is not common, but Eplerenone 25mg Tablet can sometimes increase blood sugar levels. Therefore, it is crucial to monitor your blood sugar level to check for any fluctuations. Also, the use of Eplerenone 25mg Tablet should be avoided in patients with type 2 diabetes and some kidney problems.
Yes, Eplerenone 25mg Tablet can cause increased potassium levels (hyperkalemia), especially in patients with kidney problems or if you are taking potassium supplements along with Eplerenone 25mg Tablet. Please monitor your electrolyte level regularly to avoid increased blood potassium levels.
It is a medical term for fluid retention or overload. Due to oedema, the legs, hands, and other body parts start swelling, increasing blood pressure. If it does not subside, please consult your doctor immediately.
The main side effect of Eplerenone 25mg Tablet is peeing (urination) more often than normal. Most people need to pee about 30 minutes after taking Eplerenone 25mg Tablet and again within a few hours. Do not take Eplerenone 25mg Tablet before going to bed, or you may have to wake up at night to go for urination frequently.
No, it is not recommended to take Eplerenone 25mg Tablet along with lithium. It might increase lithium's level in the blood and lead to unpleasant side effects like visual impairment, loss of appetite, and muscle weakness. So, inform your doctor before starting Eplerenone 25mg Tablet if you take lithium is recommended.
No, Eplerenone 25mg Tablet is not a blood thinner. It is a diuretic used to treat high blood pressure and swelling.
Eplerenone 25mg Tablet contains Eplerenone. It is an aldosterone antagonist type of potassium-sparing diuretic.
Eplerenone 25mg Tablet may take up to 4 weeks to show its full effect. Keep taking Eplerenone 25mg Tablet for the prescribed duration.
No, Eplerenone 25mg Tablet is not known to cause erectile dysfunction. It does not have any effect on fertility.
Do not discontinue Eplerenone 25mg Tablet without consulting the doctor. To treat your condition effectively, keep taking Eplerenone 25mg Tablet for the prescribed duration.
Potassium-sparing diuretics increase urine production without depleting potassium reserves. Eplerenone 25mg Tablet permits the body to lose sodium while retaining potassium. The amounts of potassium may rise as a result. Therefore, your doctor may regularly check your potassium levels.
Your doctor might have recommended Eplerenone instead of Losartan as a blood pressure medication because losartan may have been insufficient in lowering your blood pressure. However, Eplerenone increases the risk of elevated potassium levels, which may not be suitable for you. Hence, the doctor has prescribed Eplerenone 25mg Tablet along with hydrochlorothiazide to prevent the rise in potassium levels.
Before starting Eplerenone 25mg Tablet, let the doctor know if you are taking aspirin. Taking aspirin with Eplerenone 25mg Tablet may decrease the effects of Eplerenone 25mg Tablet. Contact your doctor if you experience signs of high blood pressure such as headache, blurred vision, trouble concentrating, or dizziness.
Side effects of Eplerenone 25mg Tablet include dehydration, electrolyte disturbances (calcium, magnesium, and sodium), constipation, itching, and increased uric acid. If the side effects are persistent, reach out to your doctor.

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