Duplat Depot 22.5 mg Combipack Injection belongs to the class of synthetic hormones used in the treatment of prostate cancer in men, endometriosis, and hormone-responsive breast cancer in women. Also, Duplat Depot 22.5 mg Combipack Injection is used to treat premature puberty in children. Prostate cancer is cancer of the prostate gland (a small gland under the bladder that produces semen) found only in men. The symptoms include difficulty in urination, pain, numbness, or sexual problems.

Duplat Depot 22.5 mg Combipack Injection contains Leuprorelin, a synthetic hormone that works similarly to the natural hormone, gonadotropin-releasing hormone (GnRH), by acting on the pituitary gland and decreasing the levels of testosterone in men and estrogen in women. Thereby, Duplat Depot 22.5 mg Combipack Injection is used in the treatment of prostate cancer by inhibiting the growth of the tumor or causing it to shrink.  

Use Duplat Depot 22.5 mg Combipack Injection as prescribed by your doctor. You are advised to take Duplat Depot 22.5 mg Combipack Injection for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience pain, redness, swelling, or skin hardening at the injection site, muscle weakness, bone pain, inability to have an erection, breast tenderness, headache, vaginal dryness, changes in breast size, acne, or mood swings. Most of these side effects of Duplat Depot 22.5 mg Combipack Injection do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Duplat Depot 22.5 mg Combipack Injection or any other medicines, please tell your doctor. Duplat Depot 22.5 mg Combipack Injection is contraindicated in pregnant and breastfeeding women. It is advised to use effective contraceptive measures to avoid pregnancy while taking Duplat Depot 22.5 mg Combipack Injection as it may cause birth defects. Duplat Depot 22.5 mg Combipack Injection should be used with caution in children. You are recommended to avoid or limit consumption of alcohol with Duplat Depot 22.5 mg Combipack Injection as it may increase the risk of bone density loss. Drive only if you are alert as Duplat Depot 22.5 mg Combipack Injection may cause dizziness, drowsiness, or vision disturbances.

Duplat Depot 22.5 mg Combipack Injection contains Leuprorelin which works similarly to the natural hormone, gonadotropin-releasing hormone (GnRH), by acting on the pituitary gland and decreasing the levels of testosterone in men and oestrogen in women. Thereby, Duplat Depot 22.5 mg Combipack Injection is used in the treatment of prostate cancer by inhibiting the growth of the tumour or causing it to shrink.  Also, Duplat Depot 22.5 mg Combipack Injection is used to treat hormone-responsive breast cancer in pre and postmenopausal women. By reducing testosterone and oestrogen levels, Duplat Depot 22.5 mg Combipack Injection delays the onset of puberty in children.

In men:

• Muscle weakness
• Bone pain
• Inability to have an erection
• Tiredness
• Decreased interest in sex

In women:

• Breast tenderness
• Difficulty in sleeping
• Headache
• Vaginal dryness
• Changes in breast size

In children:

• Acne
• Mood swings
• Vaginal bleeding
• Pain, redness, swelling or skin hardening at the injection site

If you are allergic to Duplat Depot 22.5 mg Combipack Injection or any other medicines, please tell your doctor. Duplat Depot 22.5 mg Combipack Injection is contraindicated in pregnant and breastfeeding women. It is advised to use effective non-hormonal contraceptives such as condoms to avoid pregnancy while taking Duplat Depot 22.5 mg Combipack Injection as it may cause birth defects. Duplat Depot 22.5 mg Combipack Injection should be used with caution in children. You are advised to quit smoking as it may increase the risk of prostate cancer. You are recommended to avoid or limit consumption of alcohol with Duplat Depot 22.5 mg Combipack Injection as it may increase the risk of bone density loss. Drive only if you are alert as Duplat Depot 22.5 mg Combipack Injection may cause dizziness, drowsiness or vision disturbances.

Drug-Drug Interaction: Duplat Depot 22.5 mg Combipack Injection may interact with antibiotics (moxifloxacin), heart-related medicines (procainamide, quinidine, sotalol, amiodarone), narcotic analgesics (methadone), antipsychotics (clozapine).

Drug-Food Interaction: No interactions found.

Drug-Disease Interaction: If you have abnormal vaginal bleeding, diabetes, osteoporosis (thinning of bones), depression, blood vessel disorder, seizures (fits), mental illness, spinal cord injury, brain tumor or heart disease, inform your doctor before taking Duplat Depot 22.5 mg Combipack Injection.

• MOXIFLOXACIN
• PROCAINAMIDE
• QUINIDINE
• SOTALOL
• AMIODARONE
• METHADONE
• CLOZAPINE

• Include fish, soy, tomatoes, Brussels sprouts, kale, broccoli, and oils containing omega-3 fatty acids such as olive oil as these foods may reduce the risk of prostate cancer.
• Avoid grilled meat, red meat, and saturated fat found in animal products, milk, and dairy products as they may increase the risk of prostate cancer.
• Exercise regularly to lose weight as obesity is also considered a risk factor for prostate cancer.
• Quit smoking to reduce the risk of prostate cancer.
• Avoid fast food, fried food, processed meats, refined carbs, and added sugar.

Duplat Depot 22.5 mg Combipack Injection may cause changes in blood cholesterol levels or affect values in liver functioning tests. Therefore, inform your doctor that you are taking Duplat Depot 22.5 mg Combipack Injection before undergoing any tests.

Prostate cancer: It is the cancer of the prostate gland (a small gland under the bladder that produces semen) found only in men. The symptoms include difficulty in urination, pain, numbness, or sexual problems. Certain factors increase the risk of prostate cancer, such as the family history of prostate cancer, older age, obesity, or genetic changes.

Breast cancer: It is a type of cancer that develops in breast cells that are stimulated by a female sex hormone called estrogen. Breast cancer may form in lobules (glands that produce milk), ducts of the breast (the pathway that brings milk from glands to the nipple), and in the fatty tissue or the fibrous connective tissue within the breast.

Endometriosis: It is a disorder in which the tissue lining the uterus (endometrium) grows on the ovaries, bowel, or tissues lining the pelvis. The most common symptom is pelvic pain. Other symptoms of endometriosis include lower back pain, painful periods, heavy menstrual bleeding, pain following sexual intercourse, or discomfort with bowel movements.  

Premature puberty: It is a condition in which the signs of puberty (physical changes in which a child’s body matures into an adult body) start early in children, i.e., before 9 years in girls and before 10 years in boys.