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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Nov 23, 2024 | 4:27 PM IST

Dorpivib 500 Injection is used to treat bacterial infections, such as complicated intra-abdominal infections and complicated urinary tract infections (including pyelonephritis). It contains doripenem, an antibacterial drug that works by inhibiting bacterial enzymes called penicillin-binding proteins (PBPs) and shows a bactericidal effect. Thus, it treats bacterial infections.

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Prescription drug

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Composition

DORIPENEM-500MG

Manufacturer/Marketer

Vibcare Pharma Pvt Ltd

Consume Type

PARENTERAL

Return Policy

Not Returnable

for this medicine

About Dorpivib 500 Injection

Dorpivib 500 Injection belongs to the group of antibiotic medicines called carbapenems. It is indicated in treating bacterial infections such as complicated intra-abdominal infections and complicated urinary tract infections (including pyelonephritis). Bacterial infections are illnesses or conditions caused by bacterial growth or toxins (poisons).

Dorpivib 500 Injection contains doripenem. Doripenem is an antibacterial drug. It works by inhibiting bacterial enzymes called penicillin-binding proteins (PBPs) and shows a bactericidal effect. Thus, Dorpivib 500 Injection treats bacterial infections.

Dorpivib 500 Injection will be administered by a healthcare professional; do not self-administer. Sometimes, Dorpivib 500 Injection may cause injection site reactions, headaches, nausea, diarrhoea, rash, and phlebitis (vein inflammation). Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, consult your doctor.

Inform your doctor if you are allergic to any component in Dorpivib 500 Injection. If you are pregnant or breastfeeding, inform your doctor before taking Dorpivib 500 Injection. It is not recommended for use in children below 18 as safety and effectiveness have not been established. Keep your doctor up to date on your medical condition and medications to rule out any potential adverse effects or interactions.

Uses of Dorpivib 500 Injection

Treatment of Bacterial infections (Complicated intra-abdominal infections and complicated urinary tract infections including pyelonephritis)

Medicinal Benefits

Dorpivib 500 Injection contains doripenem. Doripenem is an antibacterial drug. It works by killing bacteria. Thus, Dorpivib 500 Injection helps treat bacterial infections. It is indicated in treating bacterial infections such as complicated intra-abdominal infections and complicated urinary tract infections (including pyelonephritis).

Directions for Use

A healthcare professional will administer Dorpivib 500 Injection. Do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Dorpivib 500 Injection

  • Redness, pain, or swelling at the injection site
  • Headaches
  • Nausea
  • Diarrhoea
  • Rash
  • Phlebitis (vein inflammation)

Drug Warnings

Dorpivib 500 Injection is contraindicated in patients with known serious hypersensitivity to doripenem, other drugs in the same class, or patients who have demonstrated anaphylactic reactions to beta-lactams. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Dorpivib 500 Injection should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. If symptoms worsen or persist or new symptoms appear, patients should stop using the medicine and consult a doctor. Valproic acid lowers serum valproic acid concentrations. Patients with seizure disorders treated with valproic acid or sodium valproate are at a higher risk of having a seizure.

Drug Interactions

Drug-Drug Interactions: Dorpivib 500 Injection may interact with vaccines (BCG vaccine, cholera vaccine live, typhoid vaccine live) and anticonvulsants (valproic acid, divalproex sodium).

Drug-Food Interactions: Avoid the consumption of alcohol or alcoholic beverages.

Drug-Disease Interactions: Inform your doctor if you have colitis (inflammation in the colon's lining), renal dysfunction, CNS disorders (Seizures) and hemodialysis (dialysis).

Drug-Drug Interactions Checker List

  • BCG VACCINE
  • CHOLERA VACCINE LIVE
  • TYPHOID VACCINE LIVE
  • VALPROIC ACID
  • DIVALPROEX SODIUM

Habit Forming

No

Diet & Lifestyle Advise

  • It would be best to take probiotics after taking the full course of Dorpivib 500 Injection to restore some healthy bacteria in the intestine that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yoghurt, cheese, sauerkraut and kimchi can help restore the intestine's good bacteria.
  • Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria, which helps stimulate their growth. Thus fibre foods may help restore healthy gut bacteria after taking a course of antibiotics. Whole grains, like whole-grain bread and brown rice, should be included in your diet.
  • Avoid taking too many calcium-enriched foods and drinks as it might affect the working of Dorpivib 500 Injection.
  • Avoid intake of alcoholic beverages with Dorpivib 500 Injection as it can make you dehydrated and affect your sleep. This can make it harder for your body to aid the Dorpivib 500 Injection in fighting off infections.

Disease/Condition Glossary

Bacterial infections: A bacterial infection is a condition in which harmful bacteria enter, multiply, and infect the body. Infectious or harmful bacteria can make you sick and reproduce quickly in the body. These harmful bacteria produce toxins, damaging tissue and making you sick. It can target any body part and multiply very quickly. When infected with bacteria, you can experience generalized symptoms like fever, chills, and fatigue. Anyone can become infected with a bacterial infection. But, people with weak immune systems or taking immunosuppressive medicine are more prone to bacterial infection.

Pyelonephritis: Pyelonephritis is caused by an ascending urinary tract infection that travels from the bladder to the kidneys. Fever, flank discomfort, nausea, vomiting, burning with urine, increased frequency, and urgency are common symptoms.

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Alcohol

Caution

Consuming alcohol with Dorpivib 500 Injection is not advisable as it may cause unpleasant side effects.

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Pregnancy

Consult your doctor

Please visit your doctor. There are no adequate and well-controlled studies in pregnant women. Your doctor will only provide a prescription if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Consult your doctor; there has been no significant research on the use of Dorpivib 500 Injection in breastfeeding women.

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Driving

Caution

It is unclear whether Dorpivib 500 Injection affects driving abilities, so don't drive or operate machinery if you're having trouble concentrating or reacting.

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Liver

Caution

Limited information was available about using Dorpivib 500 Injection in patients with liver disease. Inform your doctor before receiving Dorpivib 500 Injection if you have a history of liver diseases/conditions. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Inform your doctor before receiving Dorpivib 500 Injection if you have had a kidney impairment/disorder history. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Safe if prescribed

It is not recommended for use in children below 18 years.

Country of origin

India

Manufacturer/Marketer address

SCO 42, 1st Floor, Swastic Vihar, Mansa Devi Complex, Sector 5, Panchkula, Haryana 134109, India
Other Info - DO99469

Author Details

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FAQs

Dorpivib 500 Injection is used to treat Bacterial infections (Complicated intra-abdominal infections and complicated urinary tract infections including pyelonephritis).
Dorpivib 500 Injection contains doripenem. Doripenem is an antibacterial drug. It works by killing bacteria. Thus, Dorpivib 500 Injection helps treat bacterial infections.
Caution should be exercised. Patients with seizure disorders who are being treated with valproic acid or sodium valproate are at a higher risk of having a seizure. It has been demonstrated that administering Dorpivib 500 Injection together with valproic acid lowers its (valproic acid) serum levels.
In some cases, Dorpivib 500 Injection may lead to Clostridium difficile-associated diarrhoea (ranging from mild to fatal colitis): in major cases, it gradually resolves over time. In case this condition persists, consult your doctor immediately.
Inform your doctor if you do not feel better even after finishing the full course of treatment. If the symptoms worsen while using this medicine, consult your doctor.
To reduce the development of antibiotic resistance and maintain the effectiveness of Dorpivib 500 Injection, it should only be used to treat or prevent infections that are proven or highly suspected to be caused by bacteria.
Usually, Dorpivib 500 Injection starts working soon after taking it. However, it may take a few days to kill all the harmful bacteria and make you feel better.
A healthcare professional will administer Dorpivib 500 Injection through an intravenous (IV) infusion. It is given over a specific duration, depending on the infection being treated and the patient's condition. Do not self-administer it.
Yes, Dorpivib 500 Injection is an antibiotic medication. It belongs to the carbapenem class of antibiotics and is used to treat a variety of bacterial infections (such as complicated intra-abdominal infections and urinary tract infections) by inhibiting the growth of bacteria.
No, Dorpivib 500 Injection is an antibiotic used to treat bacterial infections, not viral infections. It does not directly targets the SARS-CoV-2 virus that causes COVID-19.
Dorpivib 500 Injection is not available as an over-the-counter medication. It is a prescription medication used to treat serious bacterial infections and must be prescribed by a healthcare provider.
Taking too much of Dorpivib 500 Injection may lead to an overdose, potentially causing serious side effects such as seizures, difficulty breathing, and severe allergic reactions (like itching, rash, or blisters on the skin, mouth, nose, and eyes). If an overdose is suspected, seek immediate medical help.
While taking Dorpivib 500 Injection, you should avoid certain medications that may interact with it, such as vaccines (e.g., BCG vaccine, live cholera vaccine, live typhoid vaccine) and anticonvulsants (e.g., valproic acid, divalproex sodium). Always consult your doctor before taking Dorpivib 500 Injection with other medications.
Dorpivib 500 Injection should be stored in a cool and dry place, away from direct sunlight. Do not freeze the medication. Keep it out of reach of children.

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