Dorific 500mg Injection belongs to the group of antibiotic medicines called carbapenems. It is indicated in treating bacterial infections such as complicated intra-abdominal infections and complicated urinary tract infections (including pyelonephritis). Bacterial infections are illnesses or conditions caused by bacterial growth or toxins (poisons).

Dorific 500mg Injection contains doripenem. Doripenem is an antibacterial drug. It works by inhibiting bacterial enzymes called penicillin-binding proteins (PBPs) and shows a bactericidal effect. Thus, Dorific 500mg Injection treats bacterial infections.

Dorific 500mg Injection will be administered by a healthcare professional; do not self-administer. Sometimes, Dorific 500mg Injection may cause injection site reactions, headaches, nausea, diarrhoea, rash, and phlebitis (vein inflammation). Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, consult your doctor.

Inform your doctor if you are allergic to any component in Dorific 500mg Injection. If you are pregnant or breastfeeding, inform your doctor before taking Dorific 500mg Injection. It is not recommended for use in children below 18 as safety and effectiveness have not been established. Keep your doctor up to date on your medical condition and medications to rule out any potential adverse effects or interactions.

Dorific 500mg Injection contains doripenem. Doripenem is an antibacterial drug. It works by killing bacteria. Thus, Dorific 500mg Injection helps treat bacterial infections. It is indicated in treating bacterial infections such as complicated intra-abdominal infections and complicated urinary tract infections (including pyelonephritis).

• Redness, pain, or swelling at the injection site
• Headaches
• Nausea
• Diarrhoea
• Rash
• Phlebitis (vein inflammation)

Dorific 500mg Injection is contraindicated in patients with known serious hypersensitivity to doripenem, other drugs in the same class, or patients who have demonstrated anaphylactic reactions to beta-lactams. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Dorific 500mg Injection should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. If symptoms worsen or persist or new symptoms appear, patients should stop using the medicine and consult a doctor. Valproic acid lowers serum valproic acid concentrations. Patients with seizure disorders treated with valproic acid or sodium valproate are at a higher risk of having a seizure.

Drug-Drug Interactions: Dorific 500mg Injection may interact with vaccines (BCG vaccine, cholera vaccine live, typhoid vaccine live) and anticonvulsants (valproic acid, divalproex sodium).

Drug-Food Interactions: Avoid the consumption of alcohol or alcoholic beverages.

Drug-Disease Interactions: Inform your doctor if you have colitis (inflammation in the colon's lining), renal dysfunction, CNS disorders (Seizures) and hemodialysis (dialysis).

• BCG VACCINE
• CHOLERA VACCINE LIVE
• TYPHOID VACCINE LIVE
• VALPROIC ACID
• DIVALPROEX SODIUM

• It would be best to take probiotics after taking the full course of Dorific 500mg Injection to restore some healthy bacteria in the intestine that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yoghurt, cheese, sauerkraut and kimchi can help restore the intestine's good bacteria.
• Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria, which helps stimulate their growth. Thus fibre foods may help restore healthy gut bacteria after taking a course of antibiotics. Whole grains, like whole-grain bread and brown rice, should be included in your diet.
• Avoid taking too many calcium-enriched foods and drinks as it might affect the working of Dorific 500mg Injection.
• Avoid intake of alcoholic beverages with Dorific 500mg Injection as it can make you dehydrated and affect your sleep. This can make it harder for your body to aid the Dorific 500mg Injection in fighting off infections.

Bacterial infections: A bacterial infection is a condition in which harmful bacteria enter, multiply, and infect the body. Infectious or harmful bacteria can make you sick and reproduce quickly in the body. These harmful bacteria produce toxins, damaging tissue and making you sick. It can target any body part and multiply very quickly. When infected with bacteria, you can experience generalized symptoms like fever, chills, and fatigue. Anyone can become infected with a bacterial infection. But, people with weak immune systems or taking immunosuppressive medicine are more prone to bacterial infection.

Pyelonephritis: Pyelonephritis is caused by an ascending urinary tract infection that travels from the bladder to the kidneys. Fever, flank discomfort, nausea, vomiting, burning with urine, increased frequency, and urgency are common symptoms.