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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Nov 10, 2024 | 7:18 PM IST
Colstim Injection 1 ml is used to treat neutropenia (lack of certain white blood cells) caused by cancer, bone marrow transplant, chemotherapy, bacterial infections or other conditions. It contains Filgrastim, which stimulates the bone marrow (the tissue where new blood cells are made) to produce more white blood cells that help fight infection.
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Prescription drug

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Prescription drug
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Manufacturer/Marketer

Zydus Cadila

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Colstim Injection 1 ml

Colstim Injection 1 ml belongs to the class of medicine called 'hematopoietic agent' used to treat neutropenia, a lack of certain white blood cells caused by cancer, bone marrow transplant, receiving chemotherapy, bacterial infections or other conditions. Neutropenia is a condition in which the number of neutrophils (a type of white blood cell) in the blood is decreased. White blood cells (neutrophils) protect the body from infections. Without enough neutrophils, the body can not fight off bacteria which increases the risk of many types of infections.

Colstim Injection 1 ml contains ' Filgrastim ' that stimulates the bone marrow (the tissue where new blood cells are made) to produce more white blood cells that help fight infection. Colstim Injection 1 ml is used to improve white blood cells during cancer treatment (chemotherapy), bone marrow transplantation, severe chronic neutropenia (low number of a type of white blood cells), neutropenia in patients with HIV infection, and before stem cell donation.

You are advised to take Colstim Injection 1 ml for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects such as thrombocytopenia (low platelets level), anaemia (low red blood cell), headache, diarrhoea, vomiting, nausea, alopecia (unusual hair loss), tiredness, soreness, swelling of the digestive tract, fever. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking Colstim Injection 1 ml for as long as your doctor has prescribed. To avoid recurring symptoms, do not stop it midway. Do not take Colstim Injection 1 ml if you are pregnant or planning for pregnancy. Colstim Injection 1 ml should not be taken by breastfeeding mothers unless prescribed. Colstim Injection 1 ml should be given to children under strict medical supervision. Please tell your doctor before using Colstim Injection 1 ml if you have sickle cell anaemia, as Colstim Injection 1 ml may cause sickle cell crisis and osteoporosis (bone disease). Regular blood tests will be taken to monitor the number of white blood cells in the body. Inform your doctor about your health condition and medicines to rule out unpleasant side effects. Colstim Injection 1 ml is a cold chain medicine, and so it has to be stored in the refrigerator between 2-8 degrees celsius else its efficacy might get lost. Do not store in the freezer or the fridge.

Uses of Colstim Injection 1 ml

Treatment of Neutropenia (low number of white blood neutropenia cells), Neutropenia during Chemotherapy, Neutropenia after Bone marrow transplantation, Neutropenia in patients with HIV infection, peripheral blood stem cell mobilisation (to stimulate stem cells to enter the bloodstream to be collected and used in bone marrow transplantation).

Medicinal Benefits

Colstim Injection 1 ml contains ‘Filgrastim’ is a white blood cell growth factor. It belongs to a group of proteins called cytokines and is very similar to a natural protein (granulocyte-colony stimulating factor) produced by your body. Colstim Injection 1 ml works by stimulating the bone marrow (the tissue where new blood cells are made) to produce more white blood cells that help fight infection. Colstim Injection 1 ml is used to improve white blood cells during cancer treatment (chemotherapy), bone marrow transplantation, severe chronic neutropenia (low number of a type of white blood cells), neutropenia in patients with HIV infection and before stem cell donation.

Directions for Use

Colstim Injection 1 ml will be administered by a healthcare professional; do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Colstim Injection 1 ml

  • Thrombocytopenia (low platelets level)
  • Anaemia (low red blood cell)
  • Headache
  • Diarrhoea
  • Vomiting
  • Nausea
  • Alopecia (unusual hair loss)
  • Tiredness
  • Soreness and swelling of the digestive tract
  • Fever

Drug Warnings

Do not take Colstim Injection 1 ml if you are allergic to Colstim Injection 1 ml or any of its ingredients it may contain inactive ingredients (such as dry natural rubber/latex in the needle cover on the prefilled syringe), which can cause allergic reactions or other problems. Before starting treatment with Colstim Injection 1 ml, inform your doctor if you have sickle cell anaemia, osteoporosis (bone disease), kidney disease, liver disease, spleen problems, heart problems, and radiation treatment. Colstim Injection 1 ml can cause the spleen to become enlarged, and it could rupture (tear). Inform your doctor right away if you have sudden or severe pain in your left upper stomach spreading up to your shoulder. If you receive chemotherapy or bone marrow transplant, do not use Colstim Injection 1 ml within 24 hours before or 24 hours after you receive chemotherapy or bone marrow transplant.  Do not take Colstim Injection 1 ml if you are pregnant or breastfeeding unless prescribed by the doctor. Colstim Injection 1 ml can be given safely to children only when prescribed. Colstim Injection 1 ml may cause dizziness, so drive only if you are alert. Avoid consuming alcohol along with Colstim Injection 1 ml as it could lead to increased drowsiness. Keep your doctor informed about all the medicines you are taking, including prescription, non-prescription medicines and herbal supplements. 

Drug Interactions

Drug-Drug Interaction: Colstim Injection 1 ml may have interaction with other hematopoietic agents (pegfilgrastim), medicines used to treat cancer (altretamine, bendamustine, carboplatin, busulfan, cladribine, alemtuzumab, bevacizumab, dinutuximab, gemtuzumab, procarbazine, dacarbazine. ) 

Drug-Food Interaction: Avoid alcohol consumption while taking Colstim Injection 1 ml as it may increase dizziness and side effects.

Drug-Disease Interaction: Colstim Injection 1 ml may cause interactions with disease conditions such as leukocytosis (high levels of white blood cells), sepsis (a life-threatening complication of an infection), glomerulonephritis (kidney impairment), thrombocytopenia (low number of platelets in the blood), have any unusual bleeding or bruising liver dysfunction, myeloid tumours (a solid composed of immature white blood cells), sickle cell disease (red blood cells to become misshapen and break down).

Drug-Drug Interactions Checker List

  • ALTRETAMINE
  • BUSULFAN
  • CLADRIBINE
  • PROCARBAZINE
  • PEGFILGRASTIM
  • DACARBAZINE
  • GEMTUZUMAB
  • DINUTUXIMAB
  • BEVACIZUMAB
  • ALEMTUZUMAB
  • CARBOPLATIN
  • BENDAMUSTINE

Habit Forming

No

Diet & Lifestyle Advise

  • Eat a well-balanced and healthy diet, as it helps you to recover quickly. A dietitian will help you to create a diet plan based on your health condition. 

  • Avoid eating raw or undercooked food. 

  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.

  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes, and green tea.

  • Limit alcohol consumption and quit smoking. 

Special Advise

  • Constantly monitors the number of blood cells in your blood, and your bone density level while you are receiving treatment with Colstim Injection 1 ml.

  • Do not take any kind of immunization or vaccination without your doctor's approval while using Colstim Injection 1 ml.

Disease/Condition Glossary

Neutropenia is a condition in which the number of neutrophils (a type of white blood cell) in the blood is decreased. White blood cells (neutrophils) protect the body from infections. Without enough neutrophils, the body can not fight off bacteria which increases the risk of many types of infections. It can be caused by diseases that damage the bone marrow like cancer chemotherapy, HIV or AIDS, infections or deficiencies in vitamins or minerals, such as vitamin B12, folate, or copper, and autoimmune diseases, including Crohn's disease, lupus, and rheumatoid arthritis. Severe chronic neutropenias arise from the failure of the bone marrow to produce adequate numbers of neutrophils that circulate in the blood. It appears that patients with severe chronic neutropenias are at greater risk of developing leukaemia (blood cancer) than are other people.

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Alcohol

Caution

Avoid alcohol consumption while taking Colstim Injection 1 ml. It could lead to increased dizziness and drowsiness.

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Pregnancy

Caution

It is not known whether this Colstim Injection 1 ml will harm an unborn baby. Inform your doctor if you are pregnant or plan to become pregnant.

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Breast Feeding

Caution

It is unknown whether Colstim Injection 1 ml passes over into the breast milk. Please inform your doctor if you are breastfeeding before taking Colstim Injection 1 ml.

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Driving

Caution

Colstim Injection 1 ml may cause dizziness, drowsiness, and tiredness; do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

If you have liver problems, inform your doctor before receiving Colstim Injection 1 ml. Your doctor may adjust the dose based on your condition or prescribe a suitable alternative.

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Kidney

Caution

Colstim Injection 1 ml should be used with caution in patients with kidney diseases. Dose adjustments may be necessary. In some case, Colstim Injection 1 ml cause kidney injury. Inform your doctor immediately if you experience puffiness in your face or ankles, blood in your urine, or brown-coloured urine, or you notice you urinate less than usual.

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Children

Safe if prescribed

Colstim Injection 1 ml is used to treat children who are receiving chemotherapy or who suffer from severe low white blood cell count (neutropenia). The doctor will decide the dose of Colstim Injection 1 ml based on the age, body weight and condition of your child.

Country of origin

India

Manufacturer/Marketer address

Zydus Tower, Satellite Cross Roads,Ahmedabad – 380015 Gujarat, India.
Other Info - COL0587

Author Details

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FAQs

Colstim Injection 1 ml is used to treat neutropenia (lack of certain white blood cells) caused by cancer, bone marrow transplant, chemotherapy, bacterial infections or other conditions.
Colstim Injection 1 ml contains 'Filgrastim' is a growth factor that stimulates the bone marrow to produce white blood cells. These cells protect the body against infections.
No, Colstim Injection 1 ml is not recommended to patients with spleen disorder. It may cause your spleen to become enlarged, and it could rupture. If you experience pain in the left upper stomach/abdominal area or left shoulder, contact your doctor immediately.
If you are being treated for severe chronic neutropenia for a longer period, Colstim Injection 1 ml may cause blood in your urine (haematuria). Your doctor may regularly test your urine if you experience this side effect or if a protein is found in your urine (proteinuria).
Colstim Injection 1 ml should be used with caution in patients with kidney diseases. Dose adjustments may be necessary. Colstim Injection 1 ml cause breathlessness (dyspnoea), tachycardia & wheeze, and even death. If you have had a history of asthma, the more possibility of these systemic allergic-like reactions. Please inform your doctor.
Colstim Injection 1 ml to be taken with caution, especially if you have had heart problems. The dose may have to be adjusted by your doctor. In some cases, Colstim Injection 1 ml causes inflammation of the aorta (the large blood vessel which transports blood from the heart to the body) symptoms can include fever, abdominal pain, malaise, back pain, and increased inflammatory markers. Tell your doctor if you experience those symptoms. Please inform your doctor before taking Colstim Injection 1 ml.
Yes, Colstim Injection 1 ml may interfere with certain lab tests such as bone imaging and blood tests (elevation in lactate dehydrogenase and alkaline phosphate), possibly causing false test results. Make sure your doctor and laboratory staff know you use Colstim Injection 1 ml.
Colstim Injection 1 ml is generally safe when used as prescribed by your doctor. However, like all medications, it can cause side effects, some of which may be serious. Common side effects are usually mild and temporary. Still, following your doctor's instructions and attending regular check-ups to monitor your health is essential. If you experience any unusual or persistent symptoms, contact your doctor promptly. Additionally, inform your doctor about your medical history, allergies, and other medications to minimize the risk of adverse reactions. You can minimize potential risks and ensure safe treatment by using Colstim Injection 1 ml as directed and under medical supervision.
There is no clear evidence that Colstim Injection 1 ml causes cancer. Sharing your medical history and risk factors with your doctor is crucial. They'll explain the benefits and potential risks of taking Colstim Injection 1 ml, including any long-term effects. If you have concerns about cancer or other health issues, consult your doctor or a qualified healthcare professional for personalized advice.
Colstim Injection 1 ml stimulates the bone marrow to generate a large number of white blood cells, which might cause bone pain. This pain is frequently felt in the bones of the thighs, hips, and upper arms. The pain is usually temporary and resolves once treatment is stopped or the dose is adjusted. Inform your doctor if you are experiencing heavy pain, and your doctor may prescribe medications to manage discomfort.
Colstim Injection 1 ml is used to treat children receiving chemotherapy or suffering from severe low white blood cell count (neutropenia). The doctor will decide the dose of Colstim Injection 1 ml based on your child's age, body weight and condition. Follow your doctor's directions to achieve better results.
Colstim Injection 1 ml should be used with caution if you have kidney disease. It may increase the risk of kidney problems, so your doctor will monitor you closely. They may adjust your dose or watch for signs of kidney issues. If you have kidney disease, tell your doctor before taking Colstim Injection 1 ml, and they'll help you use it safely.
Colstim Injection 1 ml may cause dizziness, drowsiness, and tiredness.do not drive or operate heavy machinery if you feel dizzy.
Common side effects of Colstim Injection 1 ml may include thrombocytopenia (low platelets level), anaemia (low red blood cell), headache, diarrhoea, vomiting, nausea, alopecia (unusual hair loss), tiredness, soreness, swelling of the digestive tract, fever. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
Colstim Injection 1 ml should only be used during pregnancy and breastfeeding if clearly needed and under a doctor's guidance. If you're pregnant or breastfeeding, consult your doctor before taking Colstim Injection 1 ml to discuss the benefits and risks and make an informed decision for you and your baby.

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