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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Dec 13, 2024 | 11:26 AM IST
Cofsiz-D Syrup is used to treat dry cough. It works by blocking the transmission of nerve signals from the cough centre in the brain to the muscles that produce cough. This medicine may sometimes cause side effects such as dry mouth, throat or nose, drowsiness, blurred vision, constipation, dizziness, and restlessness. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Prescription drug

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Manufacturer/Marketer

Nitro Organics Pvt Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Cofsiz-D Syrup

Cofsiz-D Syrup is primarily used to treat dry cough. Coughing (dry or productive) is the body's way of clearing irritants (like allergens, mucus or smoke) from airways and preventing infection. There are two types of coughs: dry cough and chesty cough. A dry cough is tickly and doesn't produce any vicious or thick mucus, while a chesty cough (wet cough) means mucous or sputum is produced to help clear your airways. 

Cofsiz-D Syrup is a combination of three drugs: Chlorpheniramine (antihistamine), Phenylephrine (decongestant) and Dextromethorphan (cough suppressant). Chlorpheniramine works by blocking the action of histamine, a substance responsible for causing allergic reactions. Phenylephrine helps shrink the blood vessels in the nasal passage, reducing a stuffy nose. Dextromethorphan works by blocking the transmission of nerve signals from the cough centre in the brain to the muscles that produce cough. Collectively, it helps to provide relief from dry cough.

Cofsiz-D Syrup should be taken as prescribed by the doctor. Your doctor will recommend how often you take Cofsiz-D Syrup based on your medical condition. Some people may experience dry mouth, throat or nose, drowsiness, blurred vision, constipation, dizziness, restlessness or excitation. Most of these side effects of Cofsiz-D Syrup do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Inform your doctor if you are allergic to Cofsiz-D Syrup or other medicines. If you are pregnant or breastfeeding, it is advised to inform your doctor before using the Cofsiz-D Syrup . Cofsiz-D Syrup is not recommended for children below 12 years of age. If you are about to undergo medical tests or surgery, please inform your doctor that you are taking Cofsiz-D Syrup . Avoid using Cofsiz-D Syrup if you have taken medicines such as linezolid, phenelzine, selegiline, rasagiline, isocarboxazid, tranylcypromine and methylene blue injection in the past 14 days. Drink plenty of fluids while taking Cofsiz-D Syrup to loosen mucus. If you have glaucoma, urinary problems, enlarged prostate, phenylketonuria (a congenital disability that causes accumulation of amino acid, phenylalanine in the body), cough with mucus or cough caused by asthma, smoking, chronic bronchitis or emphysema (a lung condition causing shortness of breath), inform your doctor before taking Cofsiz-D Syrup .

Uses of Cofsiz-D Syrup

Treatment of Dry Cough

Medicinal Benefits

Cofsiz-D Syrup is a combination drug belonging to a medication class called 'cough and cold preparations' primarily used to treat dry cough. Chlorpheniramine works by blocking the action of histamine, a substance responsible for causing allergic reactions. It helps relieve allergy symptoms such as sneezing, running nose, watery eyes, itching, swelling, congestion or stiffness. Phenylephrine is a 'decongestant' that helps shrink the blood vessels located in the nasal passage, thereby reducing stuffy nose. Dextromethorphan works by blocking the transmission of nerve signals from the cough centre in the brain to the muscles that produce cough. Thus, Cofsiz-D Syrup helps to relieve overall cough, cold and allergic symptoms.

Directions for Use

Shake the bottle well before use. Check the label for directions and take Cofsiz-D Syrup with or without food in doses as prescribed by your doctor with the help of a measuring cup provided with the pack.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Cofsiz-D Syrup

  • Dry mouth, throat or nose
  • Drowsiness
  • Dizziness
  • Blurred vision
  • Headache
  • Constipation
  • Restlessness or excitation
  • Loss of appetite

Drug Warnings

Inform your doctor if you are allergic to Cofsiz-D Syrup or other medicines. If you are pregnant or breastfeeding, it is advised to inform your doctor before using the Cofsiz-D Syrup . Cofsiz-D Syrup is not recommended for children below 12 years of age. If you are about to undergo medical tests or surgery, please inform your doctor that you are taking Cofsiz-D Syrup . Avoid using Cofsiz-D Syrup if you have taken medicines such as linezolid, phenelzine, selegiline, rasagiline, isocarboxazid, tranylcypromine and methylene blue injection in the past 14 days. Drink plenty of fluids while taking Cofsiz-D Syrup to loosen mucus. If you have glaucoma, urinary problems, enlarged prostate, phenylketonuria (a birth defect that causes accumulation of amino acid, phenylalanine in the body), cough with mucus or cough caused by asthma, smoking, chronic bronchitis or emphysema (a lung condition causing shortness of breath), inform your doctor before taking Cofsiz-D Syrup .

Drug Interactions

Drug-Drug Interactions: Cofsiz-D Syrup may have interaction with anti-allergic drugs (diphenhydramine), anti-psychotic (escitalopram, desvenlafaxine, vilazodone), pain killer (aspirin), cold medicines (acetaminophen), antibiotics (amoxicillin), anti-depressants (linezolid, phenelzine, selegiline, rasagiline, isocarboxazid, tranylcypromine), beta-blockers (metoprolol, atenolol), muscle relaxants (carisoprodol, cyclobenzaprine).

Drug-Food Interactions: Cofsiz-D Syrup may interact with alcohol. Therefore, avoid alcohol consumption with Cofsiz-D Syrup as it may increase the risk of adverse effects such as drowsiness, dizziness or difficulty in concentrating.

Drug-Disease Interactions: Cofsiz-D Syrup is known to interact in patients with liver or kidney disease, asthma, diabetes, glaucoma, cardiovascular diseases, enlarged prostate gland, chronic bronchitis or emphysema (a lung condition causing shortness of breath).

Drug-Drug Interactions Checker List

  • DIPHENHYDRAMINE
  • ESCITALOPRAM
  • DESVENLAFAXINE
  • VILAZODONE
  • ACETAMINOPHEN
  • AMOXICILLIN
  • LINEZOLID
  • PHENELZINE
  • SELEGILINE
  • RASAGILINE
  • ISOCARBOXAZID
  • TRANYLCYPROMINE
  • METOPROLOL
  • ATENOLOL
  • CARISOPRODOL
  • CYCLOBENZAPRINE
  • CETIRIZINE

Habit Forming

No

Diet & Lifestyle Advise

  • Avoid dairy products such as milk as it may increase mucus production. Also, avoid processed or refined foods to have relief from cough. 
  • Drink plenty of fluids to avoid dry throat while you have a cough and loosen mucus.
  • Avoid citrus fruits as it may worsen the cough. Eat fruits rich in water content such as pears, watermelon, peaches and pineapples.

Special Advise

  • Cofsiz-D Syrup may contain phenylalanine, so check the medication label if you have phenylketonuria (PKU).
  • Do not use Cofsiz-D Syrup only to make a child sleepy. 
  • Contact a doctor if your symptoms do not improve even after 7 days.
  • Contact a doctor immediately if you develop fever, rash or headaches after taking Cofsiz-D Syrup . 

Disease/Condition Glossary

Cough: Coughing is the body’s way of clearing irritants (like allergens, mucus or smoke) from airways and preventing infection. Coughs may be dry or productive. A productive cough (wet cough) brings up sputum (phlegm, mucus and other matter) from the lungs. Cough is commonly caused as a response to allergy or viral infection but coughing up mucus is possibly an infection in the respiratory tract. If you are coughing thick, solid white mucus, you may have a bacterial infection in the airways. If the mucus is clear or light-coloured, you may have allergies or a minor infection in the respiratory tract, and yellow or green mucus indicates a respiratory infection.

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Alcohol

Caution

Avoid consumption of alcohol with Cofsiz-D Syrup as it may increase drowsiness. Please consult a doctor before consuming alcohol with Cofsiz-D Syrup .

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Pregnancy

Caution

The safety of Cofsiz-D Syrup in pregnant women is unknown. Therefore, it is given to pregnant women only if the doctor thinks the benefits outweigh the risks.

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Breast Feeding

Caution

It is unknown whether Cofsiz-D Syrup is excreted in human milk. Cofsiz-D Syrup is given to breastfeeding mothers only if the doctor thinks benefits are greater than risks.

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Driving

Caution

Cofsiz-D Syrup may cause dizziness or drowsiness in some people. Therefore, drive only if you are alert after taking Cofsiz-D Syrup .

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Liver

Caution

Take Cofsiz-D Syrup with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Cofsiz-D Syrup with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Caution

Cofsiz-D Syrup is not recommended for children below 12 years of age. However, please consult a doctor before using Cofsiz-D Syrup in children.

Country of origin

India

Manufacturer/Marketer address

B-37, Rajiv Nagar, Oppo, Sector 22, Rohini, Delhi, 110086
Other Info - COF0117

Author Details

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FAQs

Cofsiz-D Syrup is used to treat dry cough.
Cofsiz-D Syrup is a combination drug, primarily used to treat dry cough. Chlorpheniramine works by blocking the action of histamine, a substance responsible for causing allergic reactions. Phenylephrine is a 'decongestant' that helps in shrinking the blood vessels located in the nasal passage, thereby reducing stuffy nose. Dextromethorphan works by blocking the transmission of nerve signals from the cough center in the brain to the muscles that produce cough.
Consuming alcohol, along with Cofsiz-D Syrup , may potentiate some of the pharmacologic effects of CNS-active agents. If used together, it may lead to symptoms like confusion, central nervous system depression, impairment of thinking and judgment.
No, you should not take Cofsiz-D Syrup if you need to undergo surgery as it may lead to excessive drowsiness and sleepiness when given along with anesthesia. Please inform your doctor before surgery if you are taking Cofsiz-D Syrup as the doctor may stop it 72 hours before the surgery.
It is not recommended to take Cofsiz-D Syrup along with any anti-depressant medication, especially MAO inhibitors (linezolid, phenelzine, selegiline, rasagiline, isocarboxazid, tranylcypromine), as it may lead to unpleasant side-effects or any drug interaction. Also, Cofsiz-D Syrup should be taken at least 15 days after your last dose of anti-depressants.
Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take Cofsiz-D Syrup and skip the missed dose. Do not take extra medicine to make up the missed dose.
Cofsiz-D Syrup should be used with caution and only when prescribed by a doctor in patients with glaucoma. As Cofsiz-D Syrup may rarely worsen the symptoms of glaucoma.
Yes, Cofsiz-D Syrup can cause sleepiness or drowsiness as a common side effect. Cofsiz-D Syrup contains dextromethorphan and phenylephrine, which can lead to drowsiness, dizziness, and other side effects like nausea, dry mouth, and headache. Therefore, avoid activities that requires mental alertness until you know how Cofsiz-D Syrup affects you.
No, taking Cofsiz-D Syrup in a dose higher than recommended will not make it more effective but can actually be harmful. Overdosing can lead to severe side effects and toxicity. Therefore, follow your doctor’s instructions carefully.
It is unknown whether Cofsiz-D Syrup passes into human milk. Therefore, please consult your doctor if you are supposed to breastfeed while taking Cofsiz-D Syrup . Your doctor will prescribe Cofsiz-D Syrup only if the benefits outweigh risks.
Store at a temperature not exceeding 30°C in a cool and dry place. Protect it from sunlight and moisture. Keep out of reach of children.
Cofsiz-D Syrup is primarily used to treat dry cough and relieve allergy symptoms such as a runny nose, stuffy nose, sneezing, and watery eyes. However, it is not typically recommended for chronic cough or asthma. Therefore, please consult your doctor for appropriate medications and treatments for chronic cough or asthma.
Both Cofsiz-D Syrup and other cold or allergy medicines may contain dextromethorphan, phenylephrine, and chlorpheniramine as active components. Therefore, combining cold or allergy medicines with Cofsiz-D Syrup increases the chance of side effects. So always consult your doctor before combining other medicines along with Cofsiz-D Syrup .
Avoid alcohol that can increase the drowsiness and dizziness caused by Cofsiz-D Syrup . Inform your doctor if you have any pre-existing conditions, such as heart, kidney, lung, liver, thyroid problems, diabetes, glaucoma, or prostate issues. Inform your doctor if you are taking other medications, or if you are breastfeeding, pregnant or planning pregnancy. Drink plenty of fluids while taking Cofsiz-D Syrup to loosen mucus. Take Cofsiz-D Syrup exactly as prescribed by your doctor. Do not exceed the recommended dose.
It is not known whether Cofsiz-D Syrup can cause fetal harm. Therefore, please consult your doctor if you are pregnant before taking Cofsiz-D Syrup . Your doctor will prescribe Cofsiz-D Syrup only if the benefits outweigh risks.
The duration for using Cofsiz-D Syrup depends on the severity of your symptoms and your doctor's advice. Generally, it is meant for short-term use to relieve symptoms like dry cough, runny nose, and sneezing. Follow your doctor's instructions on how long to use it and consult your doctor if you have any concerns.
The common side effects of Cofsiz-D Syrup are dry mouth, throat or nose, drowsiness, blurred vision, constipation, dizziness, restlessness or excitation. If any of these side effects persist or worsen, please consult your doctor.

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