CLOSED PLUSE TABLET is used to treat anxiety disorders. Anxiety is a mental health disorder characterized by feelings of intense, excessive and persistent worry or fear that are strong enough to interfere with one’s daily activities. Anxiety symptoms include rapid breathing, increased heart rate, restlessness, trouble concentrating, and difficulty falling asleep.

CLOSED PLUSE TABLET is a combination of two drugs: clonazepam and escitalopram. Clonazepam produces a calming effect by suppressing the abnormal activity of nerve cells. Escitalopram increases the serotonin hormone levels that improve mood, behaviour, and cognition in patients with anxiety.

CLOSED PLUSE TABLET should be taken as prescribed by the doctor. Common side-effects of CLOSED PLUSE TABLET are nausea, headache, dizziness, confusion, drowsiness, fatigue, sleeping problems, breathlessness, poor coordination of movements, stomach upset, decreased libido (low sexual desire), and memory problems. Consult your doctor if any of these side effects persist or worsen.

Do not take CLOSED PLUSE TABLET if you are allergic to any of its components. Inform your doctor if you have seizures, liver problems, sleep disorders, lung problems, and alcohol or drug abuse. Do not consume alcohol, as it can increase the risk of side effects. Consult your doctor if you are pregnant or breastfeeding before taking this medicine. CLOSED PLUSE TABLET may cause dizziness and drowsiness, so avoid driving vehicles or operating machinery unless you are alert.

CLOSED PLUSE TABLET is a combination of two medicines: clonazepam and escitalopram. It is used to treat anxiety disorders. Clonazepam increases the effect of gamma-aminobutyric acid (GABA) and produces a calming effect by suppressing the abnormal activity of nerve cells. Escitalopram is a selective serotonin reuptake inhibitor (SSRI); it increases the serotonin levels in the brain, thereby improving mood and behaviour.

• Nausea

• Vomiting

• Diarrhoea

• Dizziness

• Confusion

• Uncoordinated body movements

• Drowsiness

• Fatigue

• Delayed ejaculation

• Decreased libido (low sexual desire)

• Memory problems

Do not take CLOSED PLUSE TABLET if you are allergic to any ingredients. Tell your doctor if you are taking antidepressants, antipsychotic medication, antihypertensives, or antibiotics. Talk to your doctor if you have a history of seizures, bipolar disorder, or schizophrenia. Patients with liver diseases, diabetes, heart disease, and bleeding disorders should use the CLOSED PLUSE TABLET with caution. Please do not stop taking CLOSED PLUSE TABLET abruptly, as it can cause withdrawal symptoms. CLOSED PLUSE TABLET may cause suicidal thoughts and worsen anxiety.

Drug-drug interactions: CLOSED PLUSE TABLET may interact with other antianxiety drugs, monoamine oxidase inhibitors (selegiline and moclobemide), opioids or strong pain killers, sedatives, anti-arrhythmic drugs, a medication used to treat heartburn (cimetidine) and antibiotics (rifampicin and linezolid).

Drug-food interactions: Avoid alcohol as it may increase the risk of side effects when taken along with CLOSED PLUSE TABLET.

Drug-disease interactions: CLOSED PLUSE TABLET should be used with caution in patients with seizures, schizophrenia, liver diseases, diabetes, heart diseases, sleep disorders and bleeding disorders.

• SELEGILINE
• MOCLOBEMIDE
• CIMETIDINE
• RIFAMPICIN
• LINEZOLID

• Attend therapy sessions regularly.

• Eat a healthy diet.

• Try to stay active and exercise regularly.

• Take ample rest. Get enough sleep.

• Meditate regularly as it helps in easing anxiety.

• Avoid smoking, caffeine, and alcohol consumption.

• Foods and drinks like salmon, chamomile, turmeric, dark chocolate, green tea, and yoghurt may help with anxiety.

• Your doctor may advise regular eye checkups as using CLOSED PLUSE TABLET may worsen the symptoms in patients with open-angle glaucoma.

• Consult your doctor immediately if there is any change in behaviour or if you have any suicidal thoughts.

Anxiety: Anxiety is a feeling of fear, worry or uneasiness. It is usually a normal emotion. However, if a person experiences repeated episodes of anxiety that worsen over time or interfere with daily activities, the condition is called anxiety disorder. Symptoms include irritability, lack of concentration, nervousness, fatigue, rapid heartbeat and trembling.