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Composition

CARMUSTINE-100MG

Manufacturer/Marketer

Zydus Healthcare Ltd

Consume Type

PARENTERAL

Return Policy

Not Returnable

for this medicine

About Carstim 100 mg Combipack Injection 1's

Carstim 100 mg Combipack Injection 1's is a chemotherapeutic medicine used in the treatment of brain tumors. A tumor is defined as the formation of solid mass tissue due to the abnormal growth of cells. A brain tumor is a serious condition where the cells (cancerous or non-cancerous) grow abnormally in the brain. Carstim 100 mg Combipack Injection 1's is also used in the treatment of multiple myeloma in combination with prednisone, Hodgkin’s Disease, and non-Hodgkin’s Disease in combination with other approved drugs.

Carstim 100 mg Combipack Injection 1's contains Carmustine, which belongs to the alkylating agents class. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis. This causes shrinkage of tumor cells and thereby prevents the growth and further spread of cancerous or non-cancerous cells.

Carstim 100 mg Combipack Injection 1's may cause certain side effects, such as nausea, vomiting, headache, pale skin, dizziness, stomach upset, tiredness, loss of balance, and pain at the site of injection. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. Carstim 100 mg Combipack Injection 1's is a parenteral preparation. A trained healthcare professional will administer it. Hence, do not self-administer.

Carstim 100 mg Combipack Injection 1's should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before administration, inform your doctor if you have liver/kidney disease, cardiac disorders, or respiratory conditions. Carstim 100 mg Combipack Injection 1's may cause pulmonary toxicity, bone marrow suppression, gastrointestinal toxicity, nephrotoxicity and hepatotoxicity in some patients. Hence, careful monitoring should be done during the entire treatment. This medicine is known to cause fetal harm in pregnant women. Hence, inform your doctor if you are pregnant or are planning to become pregnant. Breastfeeding should be discontinued in nursing mothers during the treatment.

Uses of Carstim 100 mg Combipack Injection 1's

Treatment of Brain Tumors, Multiple Myeloma, Hodgkin's Disease and Non-Hodgkin's Disease

Medicinal Benefits

Carstim 100 mg Combipack Injection 1's contains Carmustine, which belongs to the alkylating agents class. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis. This causes shrinkage of tumor cells and thereby prevents the growth and further spread of cancerous or non-cancerous cells.

Side Effects of Carstim 100 mg Combipack Injection 1's

  • Nausea
  • Dizziness
  • Stomach upset
  • Headache
  • Vomiting
  • Pale skin
  • Tiredness
  • Loss of balance
  • Diarrhoea
  • Cough
  • Decreased platelet count
  • Bruising or bleeding gums
  • Pain at the site of injection

Directions for Use

Carstim 100 mg Combipack Injection 1's will be administered by a trained healthcare professional. Hence, do not self-administer. 

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Carstim 100 mg Combipack Injection 1's should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before administration, inform your doctor if you have liver/kidney disease, cardiac disorders, or respiratory conditions. Carstim 100 mg Combipack Injection 1's may cause pulmonary toxicity, bone marrow suppression, gastrointestinal toxicity, nephrotoxicity and hepatotoxicity in some patients. Hence careful monitoring should be done during the entire treatment. This medicine is known to cause fetal harm in pregnant women. Hence, inform your doctor if you are pregnant or are planning to become pregnant. Breastfeeding should be discontinued in nursing mothers during the treatment. It is unknown whether Carstim 100 mg Combipack Injection 1's can be administered in children or not. If administered, close monitoring of the child is needed. Avoid alcohol consumption and smoking as it can lead to serious adverse effects.

Therapeutic Class

CHEMOTHERAPY

Drug Interactions

Drug-Drug Interactions: Carstim 100 mg Combipack Injection 1's may interact with vaccines, antiretroviral drugs (Abacavir, Zidovudine, adefovir), immunomodulators (abatacept, etanercept), anticoagulants (acenocoumarol, warfarin), anticonvulsant drugs (phenytoin, phenobarbitone).

Drug-Food Interactions: Avoid alcohol consumption and smoking. 

Drug-Disease Interactions: Inform your doctor if you have kidney or liver disease, gastrointestinal disorders,  and pulmonary disorders before receiving Carstim 100 mg Combipack Injection 1's.

Drug-Drug Interactions Checker List

  • ABACAVIR
  • ZIDOVUDINE
  • ADEFOVIR
  • ABATACEPT
  • ETANERCEPT
  • ACENOCOUMAROL
  • WARFARIN
  • PHENYTOIN

Diet & Lifestyle Advise

  • After your treatment begins, several dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals to take during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans, and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast and fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

What if I have taken an overdose of Carstim 100 mg Combipack Injection 1's

As Carstim 100 mg Combipack Injection 1's is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.

Special Advise

  • Carstim 100 mg Combipack Injection 1's should be administered only by a trained and experienced oncologist.
  • A blood test should be performed such as LFT, RFT, and PFT, to check for liver/kidney function, and pulmonary function.
  • Weekly blood tests should be done for at least six weeks after the dose is administered to check for CBC (Complete blood count).
  • Carstim 100 mg Combipack Injection 1's should be administered carefully without touching the skin as it can cause serious hyperpigmentation. Hence where gloves during administration.

Disease/Condition Glossary

Brain Tumors: It is a serious condition where the cells (cancerous or non-cancerous) grow abnormally in the brain. A tumor is defined as the formation of solid mass tissue due to the abnormal growth of cells. There are different types of brain tumors which can be either benign (non-cancerous) or malignant (cancerous). Carstim 100 mg Combipack Injection 1's is used in the treatment of glioblastoma (a malignant tumor that occurs in the brain and spinal cord), brainstem glioma (a tumor that affects the brain stem of the CNS), medulloblastoma (a cancerous tumor that mostly occurs in children affecting the cerebellum (lower back part of the brain)), astrocytoma (growth of cells in astrocytes which support and connect nerve cells), ependymoma (a tumor that occurs outside the CNS or within the brain parenchyma, and metastatic brain tumors.

Hodgkin’s Disease: Hodgkin’s disease or lymphoma is a blood cancer of a certain type of cells called WBCs, specifically lymphocytes. Lymphocytes normally help control infection and maintain the body's normal immunity. However, in a cancerous state, there is an abnormal multiplication of these blood cells, causing many problems such as fatigue, fever, loss of appetite, itching, night sweats and lymph node swelling.

Multiple myeloma: It is a type of cancerous tumor that affects the plasma cells of the bone marrow. These cells collect in the bone marrow and divide uncontrollably, leading to kidney and bone damage. Symptoms include bone pain, loss of appetite, fever, and frequent infections. Generally, multiple myeloma cannot be cured, but the signs and symptoms can be reduced greatly or disappear after a period of time.

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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Carstim 100 mg Combipack Injection 1's to prevent serious adverse effects.

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Pregnancy

Unsafe

Carstim 100 mg Combipack Injection 1's is not recommended for use in pregnancy as it may harm your fetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Carstim 100 mg Combipack Injection 1's. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

Limited data is available on the effect of Carstim 100 mg Combipack Injection 1's on breastfeeding. Hence, if you are a nursing mother, inform your doctor before receiving Carstim 100 mg Combipack Injection 1's. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Unsafe

Carstim 100 mg Combipack Injection 1's will be administered in the hospital setting. Hence, avoid driving.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Carstim 100 mg Combipack Injection 1's. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Carstim 100 mg Combipack Injection 1's. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition.

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Children

Consult your doctor

Limited information is available for the use of Carstim 100 mg Combipack Injection 1's in children. Hence, it will be given to the children only if needed. If administered, careful monitoring of the child is needed.

Country of origin

India

Manufacturer/Marketer address

D' Block, 3rd Floor, Gillander House, Netaji Subhas Road, Kolkata - 700001 (Wb)
Other Info - CAR1870

FAQs

Carstim 100 mg Combipack Injection 1's is used to treat Brain Tumors, Multiple Myeloma, Hodgkin’s Disease and Non-Hodgkin’s Disease.
Carstim 100 mg Combipack Injection 1's contains Carmustine, which belongs to the alkylating agents class. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis.
Carstim 100 mg Combipack Injection 1's may cause pulmonary toxicity, bone marrow suppression, gastrointestinal toxicity, nephrotoxicity and hepatotoxicity in some patients. Hence, inform your oncologist about your complete medical history, including current medication, to rule out any side effects/interactions.

Disclaimer

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