apollo
0
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Dec 7, 2024 | 2:18 PM IST

Carfilnat 60Mg Inj is used to treat Multiple Myeloma. It contains Carfilzomib, which suppresses proteasomes that prevent protein breakdown in MM (multiple myeloma) cells. When proteasome function is stopped within the MM cell, a protein build-up occurs within the MM cell, which destroys the malignant cells. Sometimes, Carfilnat 60Mg Inj may cause side effects such as fatigue (feeling overtired), anaemia, nausea, thrombocytopenia (low platelet level), dyspnea (feeling short of breath), diarrhoea, and pyrexia (fever).

Read more
Prescription drug

Whats That

tooltip
Prescription drug
 Trailing icon
Consult Doctor

Composition

CARFILZOMIB-60MG

Manufacturer/Marketer

Natco Pharma Ltd

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Carfilnat 60Mg Inj

Carfilnat 60Mg Inj belongs to the group of proteasome inhibitors (anti-cancer medicines). It is used alone and in combination with other medications to treat people with multiple myeloma (a type of cancer of the bone marrow) who have already been treated with other medicines. Multiple myeloma, also known as myeloma, is a type of bone marrow cancer that affects several areas of the body, such as the spine, skull, pelvis, and ribs.

Carfilnat 60Mg Inj contains Carfilzomib, which suppresses proteasomes that prevent protein breakdown in MM (multiple myeloma) cells. When proteasome function is stopped within the MM cell, a protein build-up occurs within the MM cell, which destroys the malignant cells.

Carfilnat 60Mg Inj is administered in a hospital setting by a physician qualified by training and experience to administer cancer chemotherapeutic agents. Sometimes, you may experience common side effects, such as fatigue (feeling overtired), anaemia, nausea, thrombocytopenia (low platelet level), dyspnea (feeling short of breath), diarrhoea, and pyrexia (fever). Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if any of these side effects persist or worsen.

Before taking the Carfilnat 60Mg Inj, inform your doctor about all your allergic or hypersensitivity reactions to medicines or food. Carfilnat 60Mg Inj can cause fetal harm when administered to a pregnant woman. It is critical not to become pregnant while undergoing therapy and for several months afterwards. Before beginning treatment, discuss effective contraception with your healthcare professional. Inform them immediately if you or your partner becomes pregnant while undergoing therapy. Breastfeeding is usually not advised during this treatment since it is unknown whether this medication passes into breast milk. Do not skip any laboratory checks because Thrombocytopenia, Hepatic Toxicity and Hepatic Failure may occur. If it happens, reduce or interrupt dosing as clinically indicated.

Uses of Carfilnat 60Mg Inj

Treatment of Multiple Myeloma

Medicinal Benefits

Carfilzomib, a proteasome inhibitor, is present in Carfilnat 60Mg Inj. It suppresses proteasomes, preventing protein breakdown in MM (multiple myeloma) cells. When proteasome function is stopped within the MM cell, a protein build-up occurs within the MM cell, which destroys the malignant cells.

Directions for Use

Carfilnat 60Mg Inj will be administered in a hospital setting under the supervision of a physician qualified by training and experience to administer cancer chemotherapeutic agents.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Carfilnat 60Mg Inj

  • Fatigue (feeling overtired)
  • Anaemia (lack of blood)
  • Nausea
  • Thrombocytopenia (low platelet level)
  • Dyspnea (feeling short of breath)
  • Diarrhea
  • Pyrexia (fever)
  • Increased risk of infection
  • Breathlessness and looking pale
  • Bruising, bleeding gums or nosebleeds
  • Low potassium levels in the blood
  • Decreased appetite
  • Difficulty sleeping (insomnia)
  • Headache and dizziness
  • Numbness or tingling in hands and feet
  • High blood pressure
  • Shortness of breath
  • Cough
  • Constipation
  • Feeling sick or being sick
  • Tummy (abdomen) Pain
  • Joint, muscle or bone pain

Drug Warnings

Before taking Carfilnat 60Mg Inj, inform your doctor about your medical history and other medications you are currently taking to rule out any potential negative effects. Avoid taking Carfilnat 60Mg Inj if you are pregnant or breastfeeding or allergic to any component present in Carfilnat 60Mg Inj. Both women and men using this Carfilnat 60Mg Inj should use birth control to avoid pregnancy. Inform your doctor right away if you or your partner become pregnant during treatment with Carfilnat 60Mg Inj. Inform your doctor if you have a history of heart failure and ischemia, Pulmonary Hypertension, Thrombocytopenia, low blood pressure or hepatic toxicity; your doctor will closely monitor and manage it. Carfilzomib injection may induce serious or life-threatening responses for up to 24 hours following administration. Before each dose of carfilzomib, you will be given specific drugs to assist in preventing a reaction. If you develop any of the following symptoms after your treatment, contact your doctor right away: fever, chills, joint or muscle pain, flushing or swelling of the face, swelling or tightening of the throat, vomiting, weakness, shortness of breath, disorientation or fainting, or chest tightness or pain.

Drug Interactions

Drug-Drug Interactions: Carfilnat 60Mg Inj may interact with monoclonal antibodies (e.g. adalimumab), immunomodulatory medication (e.g. baricitinib, fingolimod), vaccines (e.g. BCG Vaccine, Denue vaccine), and antipsychotic medication (e.g. clozapine), and anabolic steroid hormone (methyltestosterone).

Drug-Food Interactions: Avoid the consumption of alcoholic beverages.

Drug-Disease Interactions: Carfilnat 60Mg Inj may interact with various disease conditions, including tumour lysis syndrome (a condition that occurs when a large number of cancer cells die within a short period, releasing their contents into the blood), heart disease, pulmonary impairment, bleeding disorders, low or high blood pressure, renal or hepatic impairment and infections (bacterial/fungal/protozoal/viral).

Drug-Drug Interactions Checker List

  • ADALIMUMAB
  • BARICITINIB
  • FINGOLIMOD
  • BCG VACCINE
  • DENGUE VACCINE
  • CLOZAPINE
  • METHYLTESTOSTERONE

Habit Forming

No

Diet & Lifestyle Advise

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugars.

Special Advise

  • Pregnancy testing is recommended for females of reproductive potential prior to initiating treatment with Carfilnat 60Mg Inj.
  • Keep all appointments with your doctor and the laboratory. Your doctor will order laboratory tests before, during and after your treatment to check your body's response to Carfilnat 60Mg Inj to see if your blood cells are affected by this drug.
  • Do not donate sperm during treatment with Carfilnat 60Mg Inj and for three months after your last dose.

Disease/Condition Glossary

Myeloma, also called multiple myeloma, is a cancer of the plasma cells. Plasma cells are white blood cells that make antibodies that protect us from infection. In myeloma, the cells grow too much, crowding out normal cells in the bone marrow that make red blood cells, platelets, and other white blood cells. Multiple myeloma, the most common type of plasma cell tumour, develops in the bone marrow and can spread throughout the body.

bannner image

Alcohol

Caution

Avoid alcohol consumption while on treatment with Carfilnat 60Mg Inj.

bannner image

Pregnancy

Unsafe

Carfilnat 60Mg Inj should not be taken during pregnancy as it might cause fetal harm. Inform your doctor immediately if you are conceiving while on therapy.

bannner image

Breast Feeding

Unsafe

Do not breastfeed while you are receiving Carfilnat 60Mg Inj and for two weeks after your final dose.

bannner image

Driving

Caution

Carfilnat 60Mg Inj may cause fatigue, dizziness, fainting, and/or a drop in blood pressure. So, if you have any of these symptoms while in therapy, you should not operate machinery or drive a car.

bannner image

Liver

Caution

Extreme caution is exercised while using Carfilnat 60Mg Inj in patients with liver impairment. Inform your doctor if you have liver impairment. Your doctor monitors liver enzymes and withholds dosing if suspected.

bannner image

Kidney

Caution

Limited information is available. Please inform your doctor before prescribing Carfilnat 60Mg Inj if you have kidney impairment. Your doctor will weigh the benefits and potential risks before prescribing Carfilnat 60Mg Inj.

bannner image

Children

Caution

The safety and effectiveness of Carfilnat 60Mg Inj in pediatric patients have not been established.

Country of origin

INDIA

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - CAR1021

Author Details

Doctor imageWe provide you with authentic, trustworthy and relevant information

FAQs

Carfilnat 60Mg Inj is used to treat Multiple Myeloma.
Carfilnat 60Mg Inj contains Carfilzomib, which inhibits proteasomes and thereby prevents protein breakdown in MM (multiple myeloma) cells. When the proteasome action within the MM cell is disturbed, a protein accumulation occurs, destroying the cancerous cells.
No, it is unsafe to father a child while taking Carfilnat 60Mg Inj. It is recommended for sexually active men to use condoms while on treatment and for at least several months after their last dose of Carfilnat 60Mg Inj.
Based on the medical condition, Carfilnat 60Mg Inj may be given alone or together with other medicines used to treat multiple myeloma.
Tell your healthcare professional immediately if you get any signs of an infusion-related reaction during or after the infusion. Your doctor may give other medicines, or the infusion may need to be slowed down or stopped.
Carfilnat 60Mg Inj can cause a significant decrease in the number of blood cells and platelets. Your doctor may suggest laboratory tests before and during the treatment. Tell your healthcare provider if you develop a fever or have signs of bruising or bleeding.
Carfilnat 60Mg Inj treats multiple myeloma that has returned or no longer responds to treatment. It's often used with other medications. If you have questions or concerns, talk to your doctor. They will help you understand if Carfilnat 60Mg Inj is right for you.
Carfilnat 60Mg Inj is to be administered by intravenous infusion in a hospital setting under the supervision of a physician qualified to administer cancer chemotherapeutic agents.
Carfilnat 60Mg Inj is given on two consecutive days each week for three weeks followed by a 12-day rest period or it may be given once a week for 3 weeks followed by a 13-day rest period. However, the pattern and duration of treatment may vary. Please consult the doctor if you have any concerns.
You may experience nausea and extreme tiredness from Carfilnat 60Mg Inj. To cope with nausea, try eating small meals, avoiding strong smells, and staying hydrated. For tiredness, prioritize rest, break tasks into smaller chunks, and take regular breaks. Practice relaxation techniques like deep breathing, meditation, or yoga, and stay hydrated and energized with nutritious food. However, if these are bothering you consult your doctor immediately.
Carfilnat 60Mg Inj can lower your blood cell and platelet counts, increasing the risk of infections, anemia, and bleeding. To keep an eye on this, your doctor will likely order regular blood tests before and during treatment. Consult your doctor if you suspect any symptoms of low immunity like delayed healing or frequent infections.
If you experience any of the following, seek a doctor's advice right away: fever, infection signs, unusual bleeding, shortness of breath, chest pain, severe nausea, weakness, confusion, or severe headache. Also, consult your doctor if you have concerns or questions about your treatment, notice any health changes or side effects, miss a dose, or need to change your treatment schedule.
Carfilnat 60Mg Inj should not be taken during pregnancy as it might cause fetal harm. Inform your doctor immediately if you are pregnant or think you may be pregnant while on therapy.
Do not breastfeed while you are receiving Carfilnat 60Mg Inj and for two weeks after your final dose as it may pass into the breastmilk. Consult your doctor if you have any concerns regarding it.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
icon image

Keep Refrigerated. Do not freeze.Prepaid payment required.

Add to Cart