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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Jan 1, 2025 | 9:32 AM IST

Bosuvi 400 mg Tablet is used to treat certain cancers such as Philadelphia chromosome-positive chronic myeloid leukaemia. It contains Bosutinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduces the spread of cancer to other parts of the body.

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Composition :

BOSUTINIB-400MG

Manufacturer/Marketer :

Glenmark Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Bosuvi 400 mg Tablet

Bosuvi 400 mg Tablet is an anti-cancer medicine used in the treatment of Leukemia. Leukemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. It causes excessive production of immature white blood cells by the bone marrow and reduces the body’s ability to fight infections. Bosuvi 400 mg Tablet is used in the treatment of chronic myelogenous leukemia (CML). This medicine is used in patients with chronic, accelerated, or blast phase Ph+ (Philadelphia chromosome-positive) chronic myelogenous leukemia who are resistant or intolerant to prior therapy.

Bosuvi 400 mg Tablet contains Bosutinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body.

Bosuvi 400 mg Tablet may cause certain side effects, such as rash, fatigue, headache, back pain, decreased platelet count, back pain, nausea, vomiting, diarrhea, abdominal pain, loss of appetite, and dizziness. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. Bosuvi 400 mg Tablet should be taken as advised by your doctor. Do not take more than the recommended dose of medicine. Your doctor will decide the dose of Bosuvi 400 mg Tablet based on the severity of your condition.

Bosuvi 400 mg Tablet should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before taking this medicine, inform your doctor if you have liver/kidney disease, gastrointestinal toxicity, myelosuppression, fluid retention, and hepatic toxicity, as may cause serious side effects or worsen such conditions. This medicine is known to cause embryo-fetal toxicity. Hence, inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment with Bosuvi 400 mg Tablet . Breastfeeding should be discontinued in nursing mothers during the treatment. Bosuvi 400 mg Tablet is not recommended for use in children below 18 years of age as the safety and efficacy are not established.

Uses of Bosuvi 400 mg Tablet

Treatment of Philadelphia chromosome-positive chronic myeloid leukemia

Medicinal Benefits

Bosuvi 400 mg Tablet contains Bosutinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body.

Side Effects of Bosuvi 400 mg Tablet

  • Nausea
  • Diarrhoea
  • Painful urination
  • Decreased platelet count
  • Fatigue
  • Edema
  • Vomiting
  • Diarrhea
  • Abdominal pain
  • Headache
  • Back pain
  • Cough
  • Dizziness
  • Skin rash

Directions for Use

Take Bosuvi 400 mg Tablet as advised by your doctor. Do not take more than the prescribed dose of medicine. Swallow the medicine as a whole with a glass of water. Do not chew crush or break the medicine.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Bosuvi 400 mg Tablet should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before taking, inform your doctor if you have liver/kidney disease, diabetes, cardiac problems, increased blood pressure, gastrointestinal toxicity, myelosuppression, fluid retention, and hepatic toxicity, as the use of Bosuvi 400 mg Tablet in these patients may cause serious side effects. This medicine is known to cause embryo-fetal toxicity. Hence, inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment. Breastfeeding should be discontinued in nursing mothers during the treatment. Bosuvi 400 mg Tablet is not recommended for use in children below 18 years of age as the safety and efficacy are not established. Avoid alcohol consumption and smoking, as it can lead to serious adverse effects.

Therapeutic Class

ANTINEOPLASTIC

Drug-Drug Interactions

verifiedApollotooltip
BosutinibYellow fever vaccine
Critical
BosutinibLeflunomide
Severe

Drug-Food Interactions

verifiedApollotooltip
BOSUTINIB-400MGGrapefruit and Grapefruit Juice
Moderate

Diet & Lifestyle Advise

  • After your treatment begins, several dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals to take during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans, and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast and fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

How Bosuvi 400 mg Tablet Works

Bosuvi 400 mg Tablet contains Bosutinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body.

What if I have taken an overdose of Bosuvi 400 mg Tablet

Do not take more than the prescribed dose. Using more medication will not improve your symptoms; instead, they may cause serious side effects or poisoning. If you suspect that you may have overdosed of Bosuvi 400 mg Tablet or observe any side effects, please go to the emergency department of the closest hospital or nursing home. No specific side effects have been reported under these circumstances.
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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Bosuvi 400 mg Tablet to prevent serious adverse effects.

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Pregnancy

Unsafe

Bosuvi 400 mg Tablet is not recommended for use in pregnancy as it may harm your fetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking Bosuvi 400 mg Tablet . Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

Limited data is available on the effect of Bosuvi 400 mg Tablet on breastfeeding. Bosuvi 400 mg Tablet should be avoided during breastfeeding. Hence, inform your doctor if you are breastfeeding. Your doctor may prescribe an alternative based on the symptoms and health condition.

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Driving

Unsafe

Bosuvi 400 mg Tablet may cause dizziness and may make you feel drowsy. Hence, avoid driving or operating machines after taking Bosuvi 400 mg Tablet or until you become alert.

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Liver

Caution

Bosuvi 400 mg Tablet is known to cause hepatotoxicity. Hence, inform your doctor if you have a pre-existing or a history of liver disease. A dose adjustment may be needed based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before taking Bosuvi 400 mg Tablet . Your doctor may reduce the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Bosuvi 400 mg Tablet is not recommended for use in children below 18 years of age as the safety and efficacy are not established.

Country of origin

India

Manufacturer/Marketer address

Glenmark Pharmaceuticals Limited, B/2, Mahalaxmi Chambers, 22, Bhulabhai Desai Road, Mumbai €“ 400 026.
Other Info - BOS0080

Author Details

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FAQs

Bosuvi 400 mg Tablet is used to treat Philadelphia chromosome-positive chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia.
Bosuvi 400 mg Tablet contains Bosutinib, which works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells.
Bosuvi 400 mg Tablet is known to cause embryo-fetal toxicity; hence, it is contraindicated for use in pregnancy. A woman needs to have a negative pregnancy test before starting treatment with this medicine. It is better to use effective birth control methods to prevent pregnancy while taking this medicine or at least six months after completion of the treatment.
You should call your doctor right away if you experience any of the following symptoms such as severe dizziness or fainting, difficulty breathing or shortness of breath, persistent nausea or vomiting, severe stomach pain or cramps, unusual bleeding or bruising, severe skin rash or itching and signs of an allergic reaction (such as swelling of the face, lips, or tongue).
Regular scans will determine whether your tumour is responding to the treatment. Your doctor will decide when those scans should be done. Until your doctor advises you to stop taking Bosuvi 400 mg Tablet , continue taking it.
Bosuvi 400 mg Tablet increases the risk of bleeding or infection since it reduces the number of platelets and white blood cells in your blood. In order to prevent, avoid people who have infections. Check with your doctor immediately if you think you may be getting an infection, or if you get fever, chills, cough.
Yes, Bosuvi 400 mg Tablet can affect your lungs. One of the potential side effects is pulmonary toxicity, which can lead to symptoms such as severe shortness of breath, dry cough, dizziness, and extreme tiredness. If you experience any of these symptoms, please consult your doctor immediately.
Bosuvi 400 mg Tablet does not cause hair loss. However, if you notice hair loss while taking Bosuvi 400 mg Tablet , please consult your doctor.
Avoid sitting or standing in one position for too long. Change your posture frequently to relieve pressure on nerves Regular exercise can improve circulation and reduce the risk of nerve compression and ensure your diet includes essential vitamins and minerals, especially B vitamins, which are crucial for nerve health. However, consult your doctor for proper guidance.
Changes in your skin such as rashes, dryness, or itching can be a side effect of Bosuvi 400 mg Tablet . Use a gentle, fragrance-free moisturizer to keep your skin hydrated. Stay away from harsh soaps, detergents, and other potential skin irritants. If the skin changes are severe or persistent, please consult your doctor.
To relieve constipation during treatment with Bosuvi 400 mg Tablet , you can include more fibre-rich foods in your diet, such as fruits, vegetables, whole grains, and legumes. Drink plenty of water. Engage in regular physical activity to help stimulate bowel movements. However, if it persists, please consult your doctor.
Yes, nausea and extreme tiredness are known side effects of Bosuvi 400 mg Tablet . Take some rest and avoid certain foods such as salty, spicy, fried, or fatty foods that can aggravate nausea and stay hydrated by drinking plenty of water. Eat and drink often in small amounts. These side effects can occur as your body adjusts to Bosuvi 400 mg Tablet . However, if they become severe or persistent, please consult your doctor.
Changes in taste, such as a metallic taste or loss of taste, are common side effects of Bosuvi 400 mg Tablet . To overcome this side effect, rinse your mouth with a solution of salt and bicarbonate of soda before meals to neutralize bad tastes, use extra seasonings, herbs, and spices to enhance the flavour of your food. Stay hydrated by drinking plenty of water to help cleanse your palate. However, if this side effect persists please consult your doctor.
The common side effects of Bosuvi 400 mg Tablet are rash, fatigue, headache, back pain, decreased platelet count, back pain, nausea, vomiting, diarrhoea, abdominal pain, loss of appetite, and dizziness. If any of these side effects persist or worsen, please consult your doctor.

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