Bonitar 400 Tablet 10's

Bonitar 400 Tablet is an anti-cancer medicine used in the treatment of Leukemia. Leukemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. It causes excessive production of immature white blood cells by the bone marrow and reduces the body’s ability to fight infections. Bonitar 400 Tablet is used in the treatment of chronic myelogenous leukemia (CML). This medicine is used in patients with chronic, accelerated, or blast phase Ph+ (Philadelphia chromosome-positive) chronic myelogenous leukemia who are resistant or intolerant to prior therapy.

Bonitar 400 Tablet contains Bosutinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body.

Bonitar 400 Tablet may cause certain side effects, such as rash, fatigue, headache, back pain, decreased platelet count, back pain, nausea, vomiting, diarrhea, abdominal pain, loss of appetite, and dizziness. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. Bonitar 400 Tablet should be taken as advised by your doctor. Do not take more than the recommended dose of medicine. Your doctor will decide the dose of Bonitar 400 Tablet based on the severity of your condition.

Bonitar 400 Tablet should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before taking this medicine, inform your doctor if you have liver/kidney disease, gastrointestinal toxicity, myelosuppression, fluid retention, and hepatic toxicity, as may cause serious side effects or worsen such conditions. This medicine is known to cause embryo-fetal toxicity. Hence, inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment with Bonitar 400 Tablet . Breastfeeding should be discontinued in nursing mothers during the treatment. Bonitar 400 Tablet is not recommended for use in children below 18 years of age as the safety and efficacy are not established.

Bonitar 400 Tablet contains Bosutinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body.

• Nausea
• Diarrhoea
• Painful urination
• Decreased platelet count
• Fatigue
• Edema
• Vomiting
• Diarrhea
• Abdominal pain
• Headache
• Back pain
• Cough
• Dizziness
• Skin rash

Bonitar 400 Tablet should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before taking, inform your doctor if you have liver/kidney disease, diabetes, cardiac problems, increased blood pressure, gastrointestinal toxicity, myelosuppression, fluid retention, and hepatic toxicity, as the use of Bonitar 400 Tablet in these patients may cause serious side effects. This medicine is known to cause embryo-fetal toxicity. Hence, inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment. Breastfeeding should be discontinued in nursing mothers during the treatment. Bonitar 400 Tablet is not recommended for use in children below 18 years of age as the safety and efficacy are not established. Avoid alcohol consumption and smoking, as it can lead to serious adverse effects.

Drug-Drug Interactions: Bonitar 400 Tablet may interact with vaccines, proton pump inhibitors (pantoprazole, esomeprazole), CYP3A inhibitors (ritonavir, itraconazole, ketoconazole, clarithromycin, erythromycin), CYP3A inducers (rifampin, phenytoin, phenobarbitone, carbamazepine).

Drug-Food Interactions: Avoid alcohol consumption and smoking. 

Drug-Disease Interactions: Inform your doctor if you have kidney or liver disease, gastrointestinal disorders, diabetes, hepatotoxicity, and cardiac disorders before taking Bonitar 400 Tablet .

• PANTOPRAZOLE
• ESOMEPRAZOLE
• RITONAVIR
• ITRACONAZOLE
• KETOCONAZOLE
• CLARITHROMYCIN
• ERYTHROMYCIN
• RIFAMPICIN
• PHENYTOIN
• PHENOBARBITAL
• CARBAMAZEPINE

• After your treatment begins, several dietary adjustments can help you control side effects.
• Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
• Plant-based proteins are among the greatest meals to take during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans, and legumes.
• Eat a healthy diet and exercise regularly to maintain proper weight.
• Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
• De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
• Get optimal sleep; rest well.
• Avoid smoking and alcohol consumption.
• Avoid fast and fried food, processed meats, refined carbs and added sugars.

• Bonitar 400 Tablet should be administered only by a trained and experienced oncologist.
• A blood test should be performed such as LFT and RFT, to check for liver/kidney function.
• Weekly blood tests should be done during the treatment to check for CBC (Complete blood count).

Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia: Leukemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. It causes excessive production of immature white blood cells by the bone marrow and reduces the body’s ability to fight infections. Chronic Myelogenous Leukemia is a type of blood cancer that originates in the myeloid cells or stem cells in your bone marrow. Ph+ chronic myeloid leukemia is a common form of CML that occurs when specific chromosomes swap position. This causes a chromosome abnormality, creating the Philadelphia chromosome. The abnormal chromosomes produce an abnormal protein called Bcr-Abl tyrosine kinase, which then triggers a signal to produce abnormal white blood cells in the bone marrow. Symptoms may include fatigue, fever, weight loss, and loss of appetite.