Bigatra 75mg Tablet belongs to a class of drugs known as anticoagulants or blood thinners. Bigatra 75mg Tablet is primarily used to prevent and treat the risk of stroke and heart attack by reducing blood clot formation. Besides this, it also reduces the risk of getting clots in people who have undergone knee or hip replacement surgeries. Bigatra 75mg Tablet works by stopping the action of clotting factor (thrombin). This prevents the conversion of fibrinogen (soluble protein) to fibrin (insoluble protein), thereby preventing blood clots formation.

• Stomach pain
• Vomiting
• Bleeding
• Anaemia (low number of red blood cells)
• Nausea
• Diarrhoea

If you are known to be allergic to Bigatra 75mg Tablet or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to consult a doctor before using Bigatra 75mg Tablet. Bigatra 75mg Tablet is not recommended for children less than 18 years of age as the Safety and effectiveness have not been established. If you have an artificial heart valve, stomach ulcer, kidney/liver problems, high blood pressure, or bleeding problems, inform your doctor before taking Bigatra 75mg Tablet. You should inform the doctor that you are taking Bigatra 75mg Tablet if you are due to undergo surgery. Avoid consumption of alcohol while taking Bigatra 75mg Tablet as it may increase the risk of stomach bleeding.

Drug-Drug Interactions: Bigatra 75mg Tablet may interact with medicines to reduce blood clotting (warfarin, phenprocoumon, acenocoumarol, heparin, clopidogrel, prasugrel, ticagrelor, rivaroxaban), medicines to treat abnormal heartbeats  (amiodarone, dronedarone, quinidine, verapamil), medicines to treat fungal infections (ketoconazole, itraconazole), medicines to prevent organ rejection after transplantation (tacrolimus, cyclosporine) antiviral or HIV medicines (ritonavir, glecaprevir, pibrentasvir), antibiotics (rifampicin, clarithromycin), pain reliever (aspirin, ibuprofen, diclofenac), antiepileptic drugs (carbamazepine, phenytoin).

Drug-Food Interactions: Bigatra 75mg Tablet may interact with St. John’s wort, herbal medicine for depression.

Drug-Disease Interactions: Bigatra 75mg Tablet should be used with caution in patients with kidney, liver, or bleeding problems, heart problems, and unstable blood pressure.

• WARFARIN
• PHENPROCOUMON
• ACENOCOUMAROL
• HEPARIN
• CLOPIDOGREL
• PRASUGREL
• TICAGRELOR
• RIVAROXABAN
• AMIODARONE
• DRONEDARONE
• QUINIDINE
• VERAPAMIL
• ITRACONAZOLE
• KETOCONAZOLE
• TACROLIMUS
• CYCLOSPORINE
• INDINAVIR
• RITONAVIR
• RIFAMPICIN
• CLARITHROMYCIN
• GLECAPREVIR
• PIBRENTASVIR
• IBUPROFEN
• DICLOFENAC
• PHENYTOIN
• CARBAMAZEPINE

• Keep your cholesterol and triglyceride levels under control.

• Eat at regular intervals, and maintain a healthy diet that includes fresh fruits, vegetables.

• Limit alcohol intake since it raises blood pressure and increases the risk of heart diseases.

• Keep a check on your weight and exercise regularly to keep your heart healthy.

• You should have regular platelet count, factor V assay, fibrinogen level test, prothrombin time test (PT or PT-INR), and the INR (international normalized ratio) to analyze your blood clotting time.

• In case you miss a dose of Bigatra 75mg Tablet, take it as soon as possible. However, if it is too close to the next dose, revert to the original schedule.

Thrombosis/Blood Clot: A blood clot can occur in any part of the body and can lead to a heart attack, stroke, or damage to organs. Blood clots can reach the arteries or veins in the organs like the brain, kidney, heart, lungs, and limbs. Conditions like atherosclerosis, diabetes, heart failure, irregular heartbeat (arrhythmia), and obesity/overweight can trigger excessive blood clotting in the brain and heart. 

Deep vein thrombosis (blood clots in legs): It is a medical condition in which blood clots form in deep veins, usually in the legs. The symptoms include leg pain or swelling. 

Pulmonary embolism (blood clots in the lung): It is a chronic condition that occurs as the blood clots break and travel to the lungs from deep veins in the legs or other parts of the body. The symptoms of pulmonary embolism include cough, chest pain, and shortness of breath.

Stroke (blood clots in the brain): It occurs when the supply of blood to part of your brain is stopped or reduced. This prevents brain tissue from getting nutrients and oxygen leading to the death of brain cells.

Heart attack: A heart attack means the death of heart tissue due to a shortage of blood supply to the heart muscles. This can occur when there is an accumulation of cholesterol or fat narrowing the heart's major veins or when other substances like a blood clot are blocking the flow of blood.