Arthopan 500 Tablet belongs to a group of medicines called Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) or pain killers used to reduce and relieve pain, redness and inflammation (swelling) in patients suffering from osteoarthritis, rheumatoid arthritis and ankylosing spondylitis, cervical spondylitis (wear and tear of spinal discs in neck), dysmenorrhea, mild migraine and acute gout (severe pain due to an excess of uric acid) in adult and children. Rheumatoid arthritis is an autoimmune disease in which the immune system of the body attacks its cells and causes damage, thereby causing joint pain with inflammation.

Arthopan 500 Tablet is a combination of two drugs: Naproxen (painkiller) and Pantoprazole (antacid). Naproxen is an anti-inflammatory drug that works by blocking the action of the cyclo-oxygenase (COX) enzyme in the body that is involved in the production of certain chemical substances (prostaglandins) that cause pain and swelling. This helps in reducing mild to moderate pain and inflammation at the injured or damaged site decreasing stiffness in joints. It is also used to treat low back pain, strains, and sprains. Naproxen has been reported to cause gastric discomfort, acidity, and risk of stomach ulcers. Hence, it is combined with Pantoprazole (proton pump inhibitors) which reduces the amount of acid made by the stomach, thus preventing damage to the stomach. Thus, the combination helps alleviate pain with minimal gastric irritation caused due to Naproxen alone.

Take Arthopan 500 Tablet as prescribed by your doctor. You are advised to take Arthopan 500 Tablet for as long as your doctor has prescribed it for you based on your medical condition. You may experience indigestion, stomach pain, constipation, dizziness, nausea, and diarrhea in some cases. Most of these side effects of Arthopan 500 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Before taking this medicine, inform your doctor if you have any known allergy to naproxen, pantoprazole, other NSAIDs or other medications. If you are pregnant or breastfeeding, please inform your doctor before taking Arthopan 500 Tablet . Also, inform the doctor if you have a history of heart rhythm problems or ulcers due to painkillers. Patients with age above 65 years, with pre-existing cardiac diseases such as heart failure, hypertension or stroke, gastrointestinal bleeding (due to pain killers), gastric ulcers, respiratory diseases such as asthma, liver diseases, kidney diseases, or bleeding disorders should use Arthopan 500 Tablet only when prescribed by a doctor.

Arthopan 500 Tablet is a combination of two drugs, namely: Naproxen is an anti-inflammatory (reduces inflammation) and an analgesic (reduces pain) agent, and Pantoprazole (antacid). Naproxen works by blocking the action of the cyclo-oxygenase (COX) enzyme in the body that is involved in the production of certain chemical substances (prostaglandins) that cause pain and swelling. This helps in reducing mild to moderate pain and inflammation at the injured or damaged site decreasing stiffness in joints. It is also used to treat fibrositis (muscle pain and stiffness), tenosynovitis (swelling of tendons), low back pain, strains and sprains. NSAIDs such as Naproxen have been reported to cause gastric discomfort, acidity, and risk of stomach ulcers. To reduce gastric discomfort and stomach ulceration risk, it is combined with Pantoprazole (a proton pump inhibitor that inhibits gastric acid secretion) to reduce stomach acid production during long-term treatment for people with pre-existing stomach ulcers or for people having a history of developing stomach ulcers while using NSAIDs. Thus, the combination helps alleviate pain with minimal gastric irritation caused due to Naproxen alone.

• Indigestion
• Stomach pain
• Constipation
• Dizziness
• Nausea
• Vomiting
• Kidney dysfunction
• Diarrhoea

Do not take Arthopan 500 Tablet if you are allergic to Arthopan 500 Tablet . Long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as naproxen may increase the risk of heart attack or stroke and stomach ulcers. The risk of developing ulcers is higher if you have a history of ulcers, have bleeding disorders, older in age, alcoholic or have multiple diseases. Elderly patients are at greater risk for gastrointestinal bleeding problems so the doctor can limit their dose. It should not be used by a patient who has undergone recent heart bypass surgery or going to have it. Arthopan 500 Tablet is not recommended for pregnant women especially in the third trimester as it may cause harm to the baby. Therefore, pregnant or breastfeeding women are advised to consult a doctor before taking Arthopan 500 Tablet . Consult your doctor before giving Arthopan 500 Tablet to children. Do not take any other NSAIDs for pain relief along with Arthopan 500 Tablet unless prescribed. Prolonged intake of PPIs or proton pump inhibitors like pantoprazole may cause brittle bones so intake of Vitamin D and calcium can be additionally given by your doctor while using Arthopan 500 Tablet . Do not consume alcohol with Arthopan 500 Tablet as it may increase the risk of stomach bleeding or ulcer.

Drug-Drug Interactions: Arthopan 500 Tablet may have interaction with pain killers (ibuprofen, diclofenac, paracetamol, aspirin), high blood pressure-lowering medicines (propranolol, enalapril, cilazapril, losartan, candesartan, eprosartan), water pills (furosemide), blood thinners (heparin, warfarin, clopidogrel), fits related medicines (phenytoin), antidiabetic drugs (glimepiride, glipizide), antibiotics (moxifloxacin, ciprofloxacin, ampicillin, rifampicin), HIV/AIDS medicines (zidovudine, atazanavir, nelfinavir), antifungal (ketoconazole, voriconazole, itraconazole, posaconazole), heart medicine (digoxin) and anti-cancer drug (methotrexate).

Drug-Food Interactions: Arthopan 500 Tablet may interact with alcohol. Therefore, avoid alcohol intake while taking Arthopan 500 Tablet as it may increase the risk of stomach bleeding and drowsiness, and dizziness.

Drug-Disease Interactions: People with diabetes, stomach ulcer, gastrointestinal bleeding, asthma, kidney, liver, or heart problems, and an autoimmune condition, such as systemic lupus erythematosus (joint pain, fever, and skin rashes), colitis or Crohn’s disease (conditions causing swelling of the bowel, diarrhoea, bowel pain, vomiting, and weight loss) should consult a doctor before taking Arthopan 500 Tablet .

• IBUPROFEN
• DICLOFENAC
• PARACETAMOL
• ASPIRIN
• PROPRANOLOL
• ENALAPRIL
• LOSARTAN
• CANDESARTAN
• FUROSEMIDE
• HEPARIN
• WARFARIN
• CLOPIDOGREL
• PHENYTOIN
• GLIMEPIRIDE
• GLIPIZIDE
• MOXIFLOXACIN
• CIPROFLOXACIN
• AMPICILLIN
• RIFAMPICIN
• ZIDOVUDINE
• ATAZANAVIR
• NELFINAVIR
• KETOCONAZOLE
• VORICONAZOLE
• ITRACONAZOLE
• POSACONAZOLE
• DIGOXIN
• METHOTREXATE
• CILAZAPRIL
• EPROSARTAN

• Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
• Performing yoga may also help in improving joint flexibility and pain management.
• Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
• Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.
• Follow heat or cold therapy, and apply a cold or hot compress on the joints for 15-20minutes regularly.
• Acupuncture, massage, and physical therapy may also be helpful.
• Foods containing flavonoids such as soy, berries, broccoli, grapes, and green tea help in reducing inflammation.
• Include high-fiber-containing foods, berries, cherries, leafy green veggies, and black peppers in your meal. These foods are full of antioxidants, calcium, and vitamin B12 that can help cope with the long-term effects of the medicine. Fermented dairy products like miso, sauerkraut, and kimchi contain probiotics which help in the prevention of excess stomach acid production.
• Avoid intake of acid or heartburn-triggering foods or drinks like onions, peppermint, chocolate, caffeinated beverages, citrus fruits or juices, tomatoes, and high-fat and spicy foods.
• Avoid smoking and alcohol consumption.

• If you are elderly, a smoker, had stroke previously, or have high blood pressure, diabetes, or high cholesterol, please inform your doctor as these conditions may increase the risk of heart problems.
• Your doctor may monitor liver function and kidney function if you are taking Arthopan 500 Tablet for long-term.
• Individuals at risk for osteoporosis-related fractures should receive an adequate intake of calcium and vitamin D.
• Pantoprazole in Arthopan 500 Tablet  may interfere with certain laboratory tests (including urine test for tetrahydrocannabinol-THC, and a blood test to find certain tumors), possibly causing false test results. Make sure laboratory personnel and all your doctors know you are using Arthopan 500 Tablet .
• Regular monitoring of vitamin B-12, rarely, Pantoprazole in Arthopan 500 Tablet have caused vitamin B-12 deficiency. The risk is increased if they are taken Arthopan 500 Tablet every day for a long time.

Osteoarthritis: It is a degenerative joint disease in which the two ends of the joints come together due to breakdown of a protective covering of cartilage. Due to the absence of this protective covering, the joints rub against each other, leading to pain and stiffness. Symptoms of osteoarthritis include pain, stiffness, inflammation and tenderness. The main reason for osteoarthritis is age, the older you are, the more likely you could get osteoarthritis, thus known as degenerative disease, meaning that the joints wear out as a person ages. Other reasons include a past injuries such as torn cartilage, dislocated joints, and ligament injuries. 

Rheumatoid arthritis: It is an auto-immune disease (the body's immune system attacks its tissue) that leads to joint pain and damage. Symptoms of rheumatoid arthritis include pain, swelling, stiffness, deformities, and loss of joint function. 

Ankylosing spondylitis: It causes pain and stiffness in the spine. The pain usually starts in the lower back and can spread to the neck, damaged joints, or other parts of the body. Symptoms of ankylosing spondylitis include decreased flexibility which usually leads to a hunched-forward posture, pain, and back and joints.

Dysmenorrhea: Menstrual cramps are throbbing, aching cramps you get in your lower belly just before and during your period.

Migraine: A headache of varying intensity, often accompanied by nausea and sensitivity to light and sound.

Gout: A form of arthritis characterized by severe pain, redness, and tenderness in joints. Pain and inflammation occur when too much uric acid crystallizes and deposits in the joints.