Zayo 50 Tablet is used in the treatment of heart failure. It helps to reduce the risk of death and hospitalization in adults with chronic heart failure. Also, it can be used in children 1 to less than 18 years old to treat heart failure. Heart failure is a chronic condition in which the heart cannot pump blood as effectively as it should.

Zayo 50 Tablet is a combination of two medicines: Valsartan and sacubitril. Valsartan belongs to the class of drugs called angiotensin receptor blockers (ARBs) that block the effect of angiotensin II receptors that tighten the blood vessels. By blocking the effect of angiotensin II receptors, Valsartan makes it easier for the heart to pump blood to all body parts by relaxing and widening the blood vessels. Sacubitril belongs to the class of drugs known as neprilysin inhibitors, which work by relaxing and widening the blood vessels and making it easier for the heart to pump blood to all body parts. Together, Zayo 50 Tablet helps in the treatment of heart failure.

Take Zayo 50 Tablet with or without food or as directed by your doctor. Do not crush, chew or break the tablet; swallow it as a whole with a glass of water. You are advised to take Zayo 50 Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as cough, dizziness, nausea, diarrhoea, and weakness. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking Zayo 50 Tablet for as long as your doctor has prescribed it. Try not to stop taking it on your own as it may cause a sudden increase the blood pressure, chest pain, or heart attack.  Do not be reluctant to speak with your doctor if you experience any difficulty while taking Zayo 50 Tablet . Do not take Zayo 50 Tablet with ACE inhibitors (such as captopril or enalapril) since the risk of side effects may increase. Do not take Zayo 50 Tablet for at least 36 hours before or after taking an ACE inhibitor drug. Inform your doctor before taking Zayo 50 Tablet if you have kidney or liver problems, if you are pregnant or breastfeeding, or if you have a history of hereditary angioedema (rapid oedema or swelling beneath the area of skin).

• Cough

• Dizziness

• Diarrhea

• Fainting

• Headache

• Nausea

• Stomach pain

• Vertigo (sensation of feeling off-balance)

• Weakness

Drug-Drug Interaction: Pain medication (aspirin), a medicine used to lower cholesterol  (rosuvastatin, atorvastatin), medicine to treat both type 1 and type 2 diabetes (insulin detemir), blood pressure medication (metoprolol), a medication used in the management of asthma (budesonide/formoterol).

Drug-Food Interaction: Maintain low salt and low-fat diet while taking Zayo 50 Tablet . Avoid consuming food rich in potassium, such as potassium-containing salt substitutes or over-the-counter potassium supplements. Avoid smoking and alcohol consumption.

Drug-Disease Interaction: Hypotension (low blood pressure), diabetes, angioedema (rapid edema or swelling beneath the skin), hyperkalemia (high potassium in the blood), renal artery stenosis, renal/liver disease, renal impairment.

• You are advised to consume low salt and low-fat diet while taking Zayo 50 Tablet .

• Regular exercise is also recommended to complement treatment with Zayo 50 Tablet .

• Eat a diet rich in whole grains, vegetables, fruits.

• Avoid smoking and alcohol consumption.

• Maintain a healthy weight with proper diet and exercise.

• Managing stress with meditation, yoga, massage would also help in treating high blood pressure.

• Regularly monitor blood pressure levels to prevent hypotension (low blood pressure).

• Get up slowly while rising from a lying or sitting position as Zayo 50 Tablet may cause dizziness.

• Keep your doctor informed about your health/disease conditions and the medicines you are taking.