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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Nov 23, 2024 | 4:47 PM IST
Enphene 25 mg Tablet is used to treat female infertility. It contains Clomiphene and Ubiquinone which work by stimulating the production of hormones that are responsible for the ovulation process and protects the body from free radical damage. This medicine may sometimes cause side effects such as flushing, night sweats, hot flushes, abdominal bloating or discomfort, nausea, vomiting, headache, and breast pain. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Manufacturer/Marketer

Xeno Pharmaceuticals

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Enphene 25 mg Tablet

Enphene 25 mg Tablet belongs to the group of medications called ‘ovulation stimulants’ used to treat infertility in women who are not ovulating (producing an egg) properly or have irregular or no menstrual cycle. The problem with ovulation is a common cause of infertility in women.

Enphene 25 mg Tablet is a combination of two drugs: Clomiphene (estrogen agonist) and Ubiquinone (nutritional supplements). Clomiphene works by stimulating the production of hormones that are responsible for the ovulation process. Ubiquinone is an antioxidant that protects the body from damage by chemicals (free radicals) that cause infertility. Together, Enphene 25 mg Tablet is used to induce ovulation (egg production) in a woman who has problems with ovulation and wishes to get pregnant.

Take Enphene 25 mg Tablet as prescribed by your doctor. The common side-effects of Enphene 25 mg Tablet are flushing (reddening of the skin, especially the face), vasomotor symptoms (night sweats and hot flushes), abdominal bloating or discomfort, nausea (feeling sick), vomiting (being sick), headache, vision problems, and breast pain. Most of these side effects of Enphene 25 mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Enphene 25 mg Tablet or its inactive components, please inform your doctor. Do not take Enphene 25 mg Tablet if you have liver disease, unexplained abnormal vaginal bleeding, an uncontrolled adrenal gland or thyroid disorder, or an ovarian cyst (unrelated to polycystic ovary syndrome). It is not recommended to use in pregnant women. So, it is advised to take a pregnancy test before using this medicine. It is also not recommended for use in children, adolescents, men, and post-menopausal women. Inform your doctor if you are breastfeeding as this medicine may affect the amount of breast milk produced.  Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Enphene 25 mg Tablet

Treatment of Female infertility.

Medicinal Benefits

Enphene 25 mg Tablet is a combination of two drugs, namely; Clomiphene (estrogen agonist) and Ubiquinone (nutritional supplements) used for fertility enhancement in women who are experiencing infertility due to problems with ovulation (production and release of an egg from the ovary). Clomiphene is a partial estrogen agonist which works by stimulating the hormones that are necessary for the ovulation process. Ubiquinone (coenzymeQ10 (CoQ10) ) is a naturally occurring quinone that is found in most aerobic organisms from bacteria to mammals. It is an antioxidant that protects the body from damage by chemicals (free radicals) that cause infertility. Collectively, Enphene 25 mg Tablet improves ovulation in women who cannot get pregnant because they are not ovulating and have a condition called polycystic ovary syndrome (a hormonal disorder in females causing enlarged ovaries with small cysts).

Directions for Use

Take Enphene 25 mg Tablet as advised by the doctor. Swallow it as a whole with a glass of water. Do not break, chew, or crush it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Enphene 25 mg Tablet

  • Flushing (reddening of the skin, especially face)
  • Vasomotor symptoms (night sweats and hot flushes)
  • Metrorrhagia (menstrual bleeding at irregular intervals)
  • Abdominal discomfort
  • Nausea (feeling sick)
  • Vomiting (being sick)
  • Headache
  • Visual disturbances
  • Breast tenderness

Drug Warnings

Before taking Enphene 25 mg Tablet , inform your doctor if you are having an early menopause, diagnosed as infertile, stopped menstrual periods due to being underweight, have previously diagnosed with fits or seizures (fits), uterine fibroids (non-cancerous tumors in the womb), polycystic ovaries (presence of small cysts on the enlarged ovaries), swollen ovaries, or hypertriglyceridemia (increased fat levels in the body) or a family history of hypertriglyceridemia. Your doctor may also check for other causes of infertility before prescribing this medicine. Enphene 25 mg Tablet contains lactose and sucrose, so inform your doctor if you have any intolerance to sugars. Enphene 25 mg Tablet may cause problems with your eyesight. Cautions should be required before driving or operating heavy machinery. Do not start using a new medication without telling your doctor. Let your doctor know if you use any prescription and non-prescription medications you are taking, including other vitamins, before starting Enphene 25 mg Tablet .

Drug Interactions

Drug-Drug Interactions: Enphene 25 mg Tablet should not be used along with an anti-cancer agent (bexarotene), or blood thinners (warfarin, dicumarol, anisindione).

Drug-Food Interactions: Alcohol may increase the risk of side-effects of Enphene 25 mg Tablet .

Drug-Disease Interactions: Enphene 25 mg Tablet should be used with caution in patients with abnormal uterine bleeding, liver failure, hyperlipidemia (increased fat levels), uncontrolled adrenal gland dysfunction, thyroid problems and pituitary tumors.

Drug-Drug Interactions Checker List

  • BEXAROTENE
  • WARFARIN
  • DICUMAROL
  • ANISINDIONE

Habit Forming

No

Diet & Lifestyle Advise

  • Consume a healthy diet that is rich in fiber, and proteins, and low in carbohydrates and fats. 
  • Avoid processed or high-sugar foods. 
  • Stay active and shed excess weight if you are overweight or obese. Do not perform intense exercises as they may negatively impact your reproductive health. Increase the intensity of exercise gradually.
  • Being underweight may also reduce your chances of getting pregnant. So, prepare a diet chart that can you to gain weight healthily. 
  • Avoid stress as it may decrease your chances of getting pregnant. Try relaxation techniques and receive support and counseling if necessary. 
  • Limit alcohol and caffeine intake and quit smoking.

Special Advise

Enphene 25 mg Tablet may cause multiple pregnancies (pregnant with more than one child at the same time) or ectopic pregnancy (growing of fetus outside the womb). These conditions may also occur if you are not taking this medicine. However, discuss with your doctor the possible risks before taking Enphene 25 mg Tablet .

Disease/Condition Glossary

Female Infertility: A woman is said to have fertility problems when she cannot become pregnant within a year of trying. If a woman gets pregnant but experiences miscarriages or stillbirths, it is also included in infertility. The most common cause of infertility is a problem with ovulation or damage to the uterus.

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Alcohol

Caution

Alcohol consumption may worsen your condition and increase the risk of side-effects.

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Pregnancy

Caution

Clomiphene in Enphene 25 mg Tablet is a category X drug. It should not be given to pregnant women as Enphene 25 mg Tablet doesn't benefit this population and may also cause birth defects/congenital disabilities in the unborn baby.

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Breast Feeding

Caution

Enphene 25 mg Tablet decreases the supply of breast milk. So, it should be used with caution in breastfeeding mothers.

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Driving

Caution

Enphene 25 mg Tablet may cause vision problems, so do not drive or operate heavy machinery after taking Enphene 25 mg Tablet until your vision gets normal.

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Liver

Caution

Enphene 25 mg Tablet should be used with extreme caution in patients with liver disease as the liver metabolizes this medicine. Dose adjustments may be necessary.

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Kidney

Caution

Enphene 25 mg Tablet can be used in patients with kidney diseases if clinically required.

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Children

Unsafe

Enphene 25 mg Tablet is not recommended for use in children.

Country of origin

India

Manufacturer/Marketer address

plot no- 87a, 8th street, shree kumaran nagar, kovur, chennai- 600128
Other Info - ENP0005

Author Details

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FAQs

Enphene 25 mg Tablet is used to treat infertility in women who are not ovulating (producing an egg) properly or have irregular or no menstrual cycle.
Enphene 25 mg Tablet contains clomiphene and ubiquinone. clomiphene can induce ovulation in women who have problems with fertility. It enhances fertility by stimulating the production of hormones that are necessary for ovulation. Ubiquinone is an antioxidant that protects the body from damage by chemicals (free radicals).
After taking Enphene 25 mg Tablet , this medicine may (1) induce ovulation, and you may get your period, or (2) induce ovulation, and you get pregnant and not have a period, or (3) fail to induce ovulation. So, if you have not had your period, take a pregnancy test at home or in the doctor's office to confirm pregnancy.
Enphene 25 mg Tablet is not a cure for infertility. It can only enhance your chance of getting pregnant by inducing ovulation. In most cases, the women ovulate within 7 to 10 days after taking this medicine. So, ask your doctor if you have any questions regarding the benefits of Enphene 25 mg Tablet .
Enphene 25 mg Tablet is given to women who cannot become pregnant due to problems with ovulation. It is not recommended for children, adolescents, men, pregnant women and post-menopausal women.
Enphene 25 mg Tablet can only enhance your chances of fertility. The reason for not getting pregnant after taking this medicine may be low dosage, other underlying causes of infertility are any comorbid conditions that interfere with Enphene 25 mg Tablet action. Consult your doctor to know the exact reason.
It is advised to keep taking Enphene 25 mg Tablet for the duration suggested by the doctor. Your doctor may recommend repeating your treatment with Enphene 25 mg Tablet until you become pregnant. However, to avoid serious side effects or toxicity, the treatment with Enphene 25 mg Tablet should not be repeated for more than 6 menstrual cycles.
To improve your chances of getting pregnant with Enphene 25 mg Tablet , make sure you take the medication exactly as prescribed by your doctor. It is typically taken once a day for 5 days, usually starting on day 5 of your menstrual cycle. Additionally, track your ovulation using an ovulation test kit from 5 to 10 days after starting treatment with Enphene 25 mg Tablet for the best results.
Enphene 25 mg Tablet should not be used in individuals who are allergic to any of its components. It should not be used in individuals with liver disease, ovarian cysts (except polycystic ovary syndrome), or uncontrolled thyroid or adrenal disorders. Enphene 25 mg Tablet is also contraindicated during pregnancy, as it may cause birth defects/congenital disabilities in the unborn baby.
No, Enphene 25 mg Tablet is not considered habit-forming. It is an ovulation stimulant used primarily for fertility treatment, and its effects are temporary, typically ending once the treatment stops. It does not lead to dependence or addiction.
Take Enphene 25 mg Tablet as advised by the doctor. Take it once a day for 5 days in a row, starting on the 5th day of your menstrual cycle, unless your doctor advises otherwise. Enphene 25 mg Tablet should be swallowed as a whole with water; do not crush or chew it. To help you remember, try to take Enphene 25 mg Tablet at the same time each day.
After starting Enphene 25 mg Tablet , ovulation typically occurs 5–10 days after the last dose. To maximize your chances of pregnancy, you should have sex during your fertile window, which is generally 5 days after ovulation. However, your doctor may monitor you regularly during the treatment and suggest the best possible days for conception.
Enphene 25 mg Tablet is typically prescribed for 3 to 6 cycles to stimulate ovulation. If there is no pregnancy after this period, please consult your doctor.
The common side effects you may experience while taking Enphene 25 mg Tablet include flushing (reddening of the skin, especially the face), vasomotor symptoms (night sweats and hot flushes), abdominal bloating or discomfort, nausea (feeling sick), vomiting (being sick), headache, vision problems, and breast pain. If these side effects persist or worsen, please consult your doctor.

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