Zyzu MR 100/4 Capsule is a combination medication used to reduce and relieve pain due to muscle spasms (painful muscular contractions) associated with degenerative vertebral disorders, vertebral static problems, dorsal pain, low back pain, and torticollis (neck muscle contractions).

Zyzu MR 100/4 Capsule is a combination of two drugs: Thiocolchicoside (muscle relaxant) and Aceclofenac (a non-steroidal anti-inflammatory drug). Thiocolchicoside is a muscle relaxant that works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements, thereby relieving pain due to muscle spasms. Aceclofenac is a non-steroidal anti-inflammatory drug (pain killer) that works by blocking the action of cyclo-oxygenase (COX) enzyme in the body involved in the production of certain chemical substances, such as prostaglandins, that cause pain and swelling.

Take Zyzu MR 100/4 Capsule as prescribed. Your doctor will advise you on how often you take your tablets based on your medical condition. You may experience diarrhoea, dizziness, nausea, vomiting, stomach pain, or increased liver enzymes in the blood in some cases. Most of these side effects of Zyzu MR 100/4 Capsule do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Zyzu MR 100/4 Capsule or any other medicines, please tell your doctor. Zyzu MR 100/4 Capsule is not recommended for children below 18 years of age. Avoid taking Zyzu MR 100/4 Capsule if you are pregnant, as it may cause harm to the foetus. Zyzu MR 100/4 Capsule is excreted in breast milk. Therefore, Zyzu MR 100/4 Capsule is contraindicated in breastfeeding women as it may cause adverse effects on the baby. If you have asthma, diabetes, high blood pressure, stomach ulcer, high cholesterol, chickenpox, porphyria (rare inherited disorder), systemic lupus erythematosus (an autoimmune disease), ulcerative colitis or Crohn’s disease (conditions causing swelling of the bowel, diarrhoea, bowel pain, vomiting and weight loss), galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption, G-6-PD deficiency (a hereditary condition resulting in low red blood cell counts), fits, muscular hypotonia (decreased muscle tone), flaccid paresis (loose and floppy limbs), bleeding or blood clotting disorders, kidney, liver or heart diseases, inform your doctor before taking Zyzu MR 100/4 Capsule .

Zyzu MR 100/4 Capsule is a combination of two drugs, namely, Thiocolchicoside and Aceclofenac, used to treat pain due to muscle spasms. Thiocolchicoside is a muscle relaxant that works on the centers of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements, thereby relieving pain due to muscle spasms. Aceclofenac is a non-steroidal anti-inflammatory drug (pain killer) that works by blocking the action of the cyclo-oxygenase (COX) enzyme in the body that is involved in the production of certain chemical substances such as prostaglandins that cause pain and swelling.

• Diarrhoea

• Dizziness
• Nausea
• Vomiting
• Stomach pain
• Increased liver enzymes in the blood

If you are allergic to Zyzu MR 100/4 Capsule or any other medicines, please tell your doctor. Zyzu MR 100/4 Capsule is not recommended for children below 18 years of age. Avoid taking Zyzu MR 100/4 Capsule if you are pregnant as it may cause harm to the fetus. Zyzu MR 100/4 Capsule is excreted in breast milk. Therefore, Zyzu MR 100/4 Capsule is contraindicated in breastfeeding women as it may cause adverse effects on the baby. Do not consume alcohol with Zyzu MR 100/4 Capsule as it may increase the risk of severe adverse effects. If you have asthma, diabetes, high blood pressure, stomach ulcer, high cholesterol, chickenpox, porphyria (rare inherited disorder), systemic lupus erythematosus (an autoimmune disease), ulcerative colitis or Crohn’s disease (conditions causing swelling of the bowel, diarrhoea, bowel pain, vomiting, and weight loss), galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption, G-6-PD deficiency (a hereditary condition resulting in low red blood cell counts), fits, muscular hypotonia (decreased muscle tone), flaccid paresis (loose and floppy limbs), bleeding or blood clotting disorders, kidney, liver or heart diseases, inform your doctor before taking Zyzu MR 100/4 Capsule .

Drug-Drug Interaction: Zyzu MR 100/4 Capsule may have interaction with medicines used to lower high blood pressure (lisinopril, enalapril, candesartan, losartan, clonidine, moxonidine, hydralazine, methyldopa, propranolol), antibiotics (ciprofloxacin, moxifloxacin, ofloxacin, levofloxacin), water pills (furosemide, amiloride), blood thinners (heparin, warfarin, clopidogrel), anticancer drug (methotrexate), HIV drug (zidovudine), antidiabetic drugs (gliclazide, tolbutamide, glibenclamide), pain killers (ibuprofen, naproxen, aspirin, celecoxib, etoricoxib), steroids (hydrocortisone, prednisolone), medicines used for abortion (mifepristone), immunosuppressants (ciclosporin, tacrolimus), antimanic drug (lithium), heart-related medicines (digoxin), and antidepressants (fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram, escitalopram).

Drug- Food Interaction: Avoid the intake of alcohol with Zyzu MR 100/4 Capsule as it may increase the risk of severe adverse effects.

Drug-Disease Interaction: If you have asthma, diabetes, high blood pressure, stomach ulcer, high cholesterol, chickenpox, porphyria (rare inherited disorder), systemic lupus erythematosus (an autoimmune disease), ulcerative colitis or Crohn’s disease (conditions causing swelling of the bowel, diarrhoea, bowel pain, vomiting and weight loss), galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption, G-6-PD deficiency (a hereditary condition resulting in low red blood cell counts), fits, muscular hypotonia (decreased muscle tone), flaccid paresis (loose and floppy limbs), bleeding or blood clotting disorders, kidney, liver or heart diseases, inform your doctor before taking Zyzu MR 100/4 Capsule .

• LISINOPRIL
• ENALAPRIL
• CANDESARTAN
• LOSARTAN
• CLONIDINE
• MOXONIDINE
• METHYLDOPA
• PROPRANOLOL
• CIPROFLOXACIN
• MOXIFLOXACIN
• OFLOXACIN
• LEVOFLOXACIN
• FUROSEMIDE
• AMILORIDE
• HEPARIN
• WARFARIN
• CLOPIDOGREL
• METHOTREXATE
• ZIDOVUDINE
• GLICLAZIDE
• TOLBUTAMIDE
• GLIBENCLAMIDE
• IBUPROFEN
• NAPROXEN
• ASPIRIN
• CELECOXIB
• ETORICOXIB
• HYDROCORTISONE
• PREDNISOLONE
• MIFEPRESTONE
• CICLOSPORIN
• TACROLIMUS
• LITHIUM
• DIGOXIN
• FLUOXETINE
• PAROXETINE
• SERTRALINE
• FLUVOXAMINE
• CITALOPRAM
• ESCITALOPRAM
• HYDRALAZINE

• Regular exercise helps in muscle stretching so that they are less likely to spasm, tear and sprain. Mild exercises such as jogging and walking are helpful for muscle stretching.

• Massages can also be helpful.

• Avoid freezing and hot temperatures.

• Avoid wearing tight-fitting clothes, instead, wear loose garments.

• Rest well, and get plenty of sleep.

• To avoid developing pressure sores, change your position at least every two hours.

• Hot or cold therapy can help treat muscle spasms. Apply an ice pack or hot-pack on the muscle for 15-20minutes.

• Stay hydrated, drink plenty of water.

Regular tests are recommended to monitor liver functioning and liver enzymes while taking Zyzu MR 100/4 Capsule .

Pain: It is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Muscle spasm is the sudden involuntary contractions of the muscle, which can be painful and uncomfortable. When the nerve impulses that control the muscle movements are damaged or interrupted, it could lead to muscle spasms. Symptoms include muscle tightness, joint stiffness, unusual posture, difficulty in moving, and pain in affected muscles and joints. Fatigue (weakness), stress, extreme heat or cold, infection, and tight clothing can trigger muscle spasms. Muscle relaxants and exercise can treat muscle spasms. Muscle relaxants sedate the muscle and help in inhibiting painful contractions. Whereas, exercise helps in muscle stretching to be less likely to spasm, tear and sprain.