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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 30, 2024 | 5:59 AM IST

Zyposa Tablet 10's is used to prevent and treat fungal infections. It contains posaconazole which works by inhibiting fungal cell growth and causing cell death. In some cases, this medicine may cause side effects such as diarrhoea, nausea, fever, vomiting, headache, and cough. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Manufacturer/Marketer

Zydus Cadila

Consume Type

ORAL

Return Policy

Not Returnable

for this medicine

About Zyposa Tablet 10's

Zyposa Tablet 10's is in a class of medications called azole antifungals. It is used to prevent and treat fungal infections when other antifungal medicines have not worked, or you have had to stop taking them. It is also indicated for preventing invasive Aspergillus and Candida infections in patients at high risk of developing these infections due to being severely immunocompromised, such as hematopoietic stem cell transplant (HSCT) recipients with graft-versus-host disease (GVHD) or those with hematologic malignancies with prolonged neutropenia from chemotherapy.

Zyposa Tablet 10's contains a medicine called posaconazole. It is a triazole antifungal agent and exerts its antifungal activity through the blockage of certain enzymes (P-450 dependent enzyme, sterol 14α-demethylase). This leads to inhibiting the synthesis of ergosterol, a key component of the fungal cell membrane, and the accumulation of methylated sterol precursors. This results in the inhibition of fungal cell growth and cell death. Thus, it treats infections.

Take Zyposa Tablet 10's as prescribed by your doctor. You are advised to take Zyposa Tablet 10's for as long as your doctor has prescribed it based on your medical condition. In some cases, you may experience diarrhoea, nausea, fever, vomiting, headache, coughing and low potassium levels in the blood. Most of these side effects of Zyposa Tablet 10's do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Inform your doctor if you are allergic or hypersensitive to any component present in Zyposa Tablet 10's or if you are pregnant, suspect you are pregnant, plan to have a baby or are breastfeeding; your doctor will prescribe Zyposa Tablet 10's only if the benefits outweigh the risk. Before taking the Zyposa Tablet 10's, inform your doctor about your medical history and ongoing therapies to rule out any potential adverse effects or interactions.

Uses of Zyposa Tablet 10's

Zyposa Tablet 10's is used in the treatment of Fungal infections and prophylaxis of invasive Aspergillus and Candida infections in severely immunocompromised patients.

Medicinal Benefits

Posaconazole is an antifungal medication present in Zyposa Tablet 10's. It is effective in treating fungal infections in adults. It is also indicated for preventing invasive Aspergillus and Candida infections in patients who are severely immunocompromised and at high risk of developing these infections, such as hematopoietic stem cell transplant (HSCT) recipients with graft-versus-host disease (GVHD) or those with hematologic malignancies with prolonged neutropenia from chemotherapy.

Directions for Use

Tablet/Capsule: Swallow it as a whole with water; do not crush, break or chew it.Oral Suspension/syrup: Shake the bottle well before each use. Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Zyposa Tablet 10's

  • Diarrhoea
  • Nausea
  • Fever
  • Vomiting
  • Headache
  • Coughing
  • Low potassium levels in the blood

Drug Warnings

Inform your doctor if you are allergic or hypersensitive to any component present in Zyposa Tablet 10's or if you are pregnant, suspect you are pregnant, plan to have a baby or are breastfeeding; your doctor will prescribe Zyposa Tablet 10's only if the benefits outweigh the risk. Before taking the Zyposa Tablet 10's, inform your doctor about your medical history and ongoing therapies to rule out any potential adverse effects or interactions. And also, let your doctor know before prescribing Zyposa Tablet 10's if you have Arrhythmias and QTc Prolongation, liver problems, or low potassium, magnesium, or calcium levels in your blood.

Drug Interactions

Drug-Drug Interactions: Zyposa Tablet 10's may interact with various drugs, including medicines used to treat allergies (terfenadine, astemizole), drug used to treat stomach problems (cisapride), medicine used to treat symptoms of Tourette's and mental illness (pimozide), antimalarial drug (halofantrine), and medicine used to treat abnormal heart rhythms (quinidine).

Drug-Food Interactions: There are no studies indicating food interactions with Zyposa Tablet 10's. However, it is advised to take non-starchy vegetables and gluten-free foods and limit alcohol and caffeine intake.

Drug-Disease Interactions: Tell your doctor before taking Zyposa Tablet 10's if you have a medical history of allergic reactions to medicines, heart diseases, liver or kidney problems, blood disorders and low levels of magnesium and potassium.

Drug-Drug Interactions Checker List

  • TERFENADINE
  • ASTEMIZOLE
  • CISAPRIDE
  • PIMOZIDE
  • HALOFANTRINE
  • QUINIDINE

Habit Forming

No

Diet & Lifestyle Advise

  • Take the medication as directed by the doctor and at regular intervals if you take Zyposa Tablet 10's for more than one day.
  • Do not use other over-the-counter medications, herbal or vitamin supplements without informing your pharmacist or doctor when you take Zyposa Tablet 10's.
  • Continue taking your normal regular diet unless your doctor prescribes a specific diet.
  • It is advisable to follow a candida diet during yeast infections. This diet excludes sugar, gluten, certain dairy products, alcohol and switches to low-sugar fruits, non-starchy vegetables, and gluten-free foods.
  • A very high sugar or high-carbohydrate diet may increase the count of Candida in some people. It is better to avoid or limit alcohol and caffeine intake during Zyposa Tablet 10's treatment to enhance a healthy lifestyle practice.

Special Advise

  • Regular blood tests are recommended before and while taking Zyposa Tablet 10's to monitor liver functioning, especially if you have any liver problems.

Disease/Condition Glossary

Fungal infection: Fungal infection occurs when a fungus enters, infects, and multiplies in the body. Fungi can live in water, soil, air, and plants. Fungi affect any body part, including the mouth, throat, oesophagus, lungs, bladder, genital area, and blood. Mild fungal skin infections are common and can cause rashes. Fungal infections affecting body organs like the lungs can cause flu or tuberculosis. Some fungal diseases like cryptococcal meningitis and blood infections can be fatal. A few common fungal infections are yeast infections that affect the genital area, oesophagus, and urinary tract caused by Candida.

Invasive aspergillosis: Invasive aspergillosis occurs when Aspergillus causes serious infection and usually affects people with weakened immune systems, such as those who have had an organ transplant or a stem cell transplant. Invasive aspergillosis most commonly affects the lungs but can also spread to other body parts.

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Alcohol

Consult your doctor

The interaction of Zyposa Tablet 10's with alcohol is unknown. If you have any concerns regarding this, please discuss with your doctor.

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Pregnancy

Consult your doctor

Zyposa Tablet 10's should not be used when pregnancy unless clearly necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Zyposa Tablet 10's.

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Breast Feeding

Consult your doctor

There is no substantial research yet on using Zyposa Tablet 10's in breastfeeding/nursing mothers. Inform your doctor if you are a nursing mother before taking Zyposa Tablet 10's; your doctor will decide whether Zyposa Tablet 10's can be taken by breastfeeding mothers.

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Driving

Caution

It is unknown whether Zyposa Tablet 10's alters the ability to drive, so do not drive or operate machinery if you experience any symptoms affecting your ability to concentrate and react.

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Liver

Consult your doctor

Inform your doctor before taking the Zyposa Tablet 10's if you have a liver impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Consult your doctor

Inform your doctor before taking the Zyposa Tablet 10's if you have a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Consult your doctor

Please consult a doctor before using Zyposa Tablet 10's for children.

Country of origin

India

Manufacturer/Marketer address

Zydus Tower, Satellite Cross Roads,Ahmedabad 380015 Gujarat, India.
Other Info - ZYP0069

Author Details

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FAQs

Zyposa Tablet 10's is used to treat fungal infections and prophylaxis of invasive Aspergillus and Candida infections in severely immunocompromised patients.
Zyposa Tablet 10's contains a medicine called posaconazole. It is a triazole antifungal agent and exerts its antifungal activity through the blockage of certain enzymes (P-450 dependent enzyme, sterol 14α-demethylase). This leads to inhibiting the synthesis of ergosterol, a key component of the fungal cell membrane, and the accumulation of methylated sterol precursors. This results in inhibiting fungal cell growth and, ultimately, cell death. Thus, it treats infections.
Zyposa Tablet 10's is not recommended for coadministration with anticoagulants, So if you are under anticoagulant therapy, inform your doctor before prescribing Zyposa Tablet 10's.
If you are allergic to posaconazole or similar antifungals such as fluconazole, itraconazole, ketoconazole, or voriconazole, you should not use it. When combined with certain medications, posaconazole can have unfavourable or dangerous side effects.
Like all medicines, this medicine may cause side effects such as diarrhoea, nausea, fever, vomiting, headache, coughing and low potassium levels in the blood, although not everybody gets them. Most of these side effects of Zyposa Tablet 10's do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
Take Zyposa Tablet 10's as prescribed by your doctor. You are advised to take Zyposa Tablet 10's for as long as your doctor has prescribed it for you based on your medical condition.

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