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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Nov 23, 2024 | 4:48 PM IST
Zobiphos 4 mg Injection 1's is used to treat osteoporosis (weak and brittle bones), Paget’s disease of bone and high calcium levels caused by cancer. It contains Zoledronic acid which works by preventing the bones from breaking down and keeps them strong. In some cases, this medicine may cause side effects such as headache, fever, nausea, dizziness, vomiting, diarrhoea, swelling, or pain at the infusion site. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Manufacturer/Marketer

Bhardwaj India Pvt Ltd

Consume Type

PARENTERAL

Return Policy

Not Returnable

for this medicine

About Zobiphos 4 mg Injection 1's

Zobiphos 4 mg Injection 1's belongs to the class of medicines called 'bisphosphonates' used to treat osteoporosis (weak and brittle bones) caused by menopause or long-term steroid use. Zobiphos 4 mg Injection 1's also treats Paget’s bone and high calcium levels caused by cancer. Osteoporosis is a bone disease that weakens and thins bones by decreasing bone density, common in post-menopausal women.  As the density of bones decreases, they weaken and are more likely to break. 

Zobiphos 4 mg Injection 1's contains Zoledronic acid that works by binding to the bone tightly and preventing the removal of calcium by osteoclasts (a type of bone cell that destroys bone tissue). This prevents osteoclasts from breaking down the bone and keeps the bones strong and minimizes the risk of bones breaking.

A doctor or nurse will administer Zobiphos 4 mg Injection 1's. In some cases, you may experience headache, fever, nausea, dizziness, vomiting, back pain, diarrhea, pain in the muscles, joints, or bones, swelling, or pain at the infusion site. Most of these side effects of Zobiphos 4 mg Injection 1's do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Zobiphos 4 mg Injection 1's or any other medicines, please tell your doctor. Avoid taking Zobiphos 4 mg Injection 1's if you are pregnant or breastfeeding and consult a doctor. Zobiphos 4 mg Injection 1's is not recommended for children below 18 years as the safety and effectiveness were not established. Avoid taking Zobiphos 4 mg Injection 1's if you have hypocalcemia (low calcium levels in the blood) and severe kidney problems. Drive only if you are alert as Zobiphos 4 mg Injection 1's may cause dizziness. Zobiphos 4 mg Injection 1's may cause osteonecrosis of the jaw (ONJ) in some patients. Therefore, if you experience any problems with teeth or mouth such as loose teeth, swelling or pain, non-healing of sores, or discharge, consult your doctor and dentist as these might be signs of osteonecrosis of the jaw.

Uses of Zobiphos 4 mg Injection 1's

Treatment of Postmenopausal osteoporosis, Pagets disease, Hypercalcemia (high level of calcium) in cancer

Medicinal Benefits

Zobiphos 4 mg Injection 1's contains Zoledronic acid used to treat postmenopausal osteoporosis, Paget’s disease, and hypercalcemia of malignancy (bone cancer in which excess of calcium exits). Zobiphos 4 mg Injection 1's binds to the bone tightly and prevents calcium removal by osteoclasts (a type of bone cell that destroy bone tissue). This prevents osteoclasts from breaking down the bone, strengthening bones, and minimizing the risk of bones breaking. Also, Zobiphos 4 mg Injection 1's may reduce calcium levels in the blood by preventing calcium reabsorption from bones to the blood. Thus, it helps in treating high calcium levels in the blood caused by cancer.

Directions for Use

Zobiphos 4 mg Injection 1's will be administered by a healthcare professional; do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Zobiphos 4 mg Injection 1's

  • Headache
  • Fever
  • Nausea
  • Dizziness
  • Vomiting
  • Back pain
  • Diarrhoea
  • Flu-like symptoms (chills, tiredness, muscle, and joint pain)
  • Pain in the muscles, joints, or bones
  • Swelling or pain at the infusion site

Drug Warnings

If you are allergic to Zobiphos 4 mg Injection 1's or any other medicines, please tell your doctor. Avoid taking Zobiphos 4 mg Injection 1's if you are pregnant or breastfeeding and consult a doctor. Zobiphos 4 mg Injection 1's is not recommended for children below 18 years as the safety and effectiveness were not established. Avoid taking Zobiphos 4 mg Injection 1's if you have hypocalcemia (low calcium levels in the blood) and severe kidney problems. Drive only if you are alert as Zobiphos 4 mg Injection 1's may cause dizziness. If you are not able to take daily calcium supplements, have had sections of the intestine or some or all of the parathyroid glands in the neck surgically removed, have cancer, gum disease, poor dental health, or planned tooth extraction or kidney problem, inform your doctor before taking Zobiphos 4 mg Injection 1's. If you are a smoker, inform your doctor before receiving Zobiphos 4 mg Injection 1's as it may increase the risk of dental problems. Zobiphos 4 mg Injection 1's may cause osteonecrosis of the jaw (ONJ) in some patients. Therefore, if you experience any problems with teeth or mouth such as loose teeth, swelling or pain, non-healing of sores, or discharge, consult your doctor and dentist as these might be signs of osteonecrosis of the jaw. You are recommended to drink at least 2 glasses of fluids before and after treatment with Zobiphos 4 mg Injection 1's as advised by your doctor to prevent dehydration. Take calcium and vitamin D supplements as prescribed by your doctor as Zobiphos 4 mg Injection 1's may reduce calcium levels in the blood.

Drug Interactions

Drug-Drug Interaction: Zobiphos 4 mg Injection 1's may interact with antibiotics (gentamicin) and water pills (furosemide).

Drug-Food Interaction: No interactions found.

Drug-Disease Interaction: Avoid taking Zobiphos 4 mg Injection 1's if you have hypocalcemia (low calcium levels in the blood) and severe kidney problems. If you have cancer, gum disease, poor dental health, or planned tooth extraction or kidney problem, inform your doctor before taking Zobiphos 4 mg Injection 1's.

Drug-Drug Interactions Checker List

  • GENTAMICIN
  • FUROSEMIDE

Habit Forming

No

Diet & Lifestyle Advise

  • Include dairy products like milk, yoghurt, cheese, or milk-based custard in your diet.
  • Eat daily a serving of broccoli, cabbage, bok choy (Chinese white cabbage), spinach, and other green leafy vegetables.
  • Snack on calcium-rich nuts like Brazil nuts or almonds.
  • Sprinkle sesame seeds over your food, vegetables, and salads. Sesame seeds are high in calcium.
  • Avoid or reduce the intake of caffeine, soft drinks, and alcohol that inhibit calcium absorption.
  • Replace the meat with tofu or tempeh for extra calcium in your food.

Special Advise

  • A preventive dental check-up is required before using Zobiphos 4 mg Injection 1's as it has been reported to cause osteonecrosis of the jaw. 
  • A blood test is recommended before taking each dose of Zobiphos 4 mg Injection 1's to monitor kidney functioning. 
  • Regular intake of calcium and vitamin D may be recommended by your doctor while taking treatment with Zobiphos 4 mg Injection 1's. 
  • While using Zobiphos 4 mg Injection 1's, you may experience musculoskeletal pain, in this case, stop taking Zobiphos 4 mg Injection 1's and consult a doctor. 

Disease/Condition Glossary

Osteoporosis: It is a bone disease that weakens and thins bones by decreasing bone density.  As the density of bones decreases, they weaken and are more likely to break. Post-menopausal women are more likely to develop osteoporosis than men because, at menopause, women’s ovaries stop producing estrogen (a female hormone) essential to keeping bones healthy. Following menopause, bone loss occurs, making bones weak and more likely to break. Also, long-term use of steroids may affect bone strength and cause osteoporosis in both men and women. Signs and symptoms include back pain caused by a fractured or collapsed vertebra, loss of height over time, a stooped posture, and a bone that breaks much more easily than expected.

Paget’s disease: In Paget’s disease, bone remodeling (removal of old bone and replacement with new bone material) is too quick, and new bone is formed in a disordered manner making it weaker than normal. If left untreated, the bone may become deformed, painful, and broken.

Hypercalcemia in cancer: In some cancers like breast cancer, lung cancer, or blood cancer, there is too much calcium level in the bloodstream. A patient suffering from a high level of calcium might include nausea, vomiting, constipation, headache, and loss of appetite. 

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Alcohol

Caution

Interaction of alcohol with Zobiphos 4 mg Injection 1's is unknown. Please consult a doctor before consuming alcohol with Zobiphos 4 mg Injection 1's.

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Pregnancy

Unsafe

Zobiphos 4 mg Injection 1's is a category D pregnancy drug and is not recommended for pregnant women as it may harm an unborn baby. Please consult a doctor if you are pregnant.

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Breast Feeding

Unsafe

Zobiphos 4 mg Injection 1's is contraindicated in breastfeeding mothers. Therefore, please consult a doctor if you are breastfeeding.

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Driving

Caution

Zobiphos 4 mg Injection 1's may cause dizziness. Therefore, avoid driving or operating machinery if you feel dizzy after taking Zobiphos 4 mg Injection 1's.

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Liver

Caution

Take Zobiphos 4 mg Injection 1's with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Zobiphos 4 mg Injection 1's with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required. Avoid taking Zobiphos 4 mg Injection 1's if you have severe kidney problems.

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Children

Unsafe

Zobiphos 4 mg Injection 1's is not recommended for children below 18 years as the safety and effectiveness were not established.

Country of origin

India

Manufacturer/Marketer address

C-145, Okhla Industrial Area, New Delhi-110020, Delhi, India
Other Info - ZOB0027

Author Details

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FAQs

Zobiphos 4 mg Injection 1's is used to treat osteoporosis (weak and brittle bones) and Paget's bone.
Zobiphos 4 mg Injection 1's contains Zoledronic acid that works by binding to the bone tightly and preventing the removal of calcium by osteoclasts (a type of bone cells that destroy bone tissue). This prevents osteoclasts from breaking down the bone and keeps the bones strong and minimizes the risk of bones breaking.
You are not recommended to take Zobiphos 4 mg Injection 1's if you have hypocalcemia (low levels of calcium in the blood) as it may worsen the condition. However, the levels of calcium and vitamin D may be checked before starting treatment with Zobiphos 4 mg Injection 1's.
Zobiphos 4 mg Injection 1's may cause osteonecrosis (bone damage) of the jaw. Therefore, to prevent such condition, maintain good oral hygiene and have regular dental check-ups while taking Zobiphos 4 mg Injection 1's. Also, is you wear dentures, make sure they fit properly. However, if you experience any problems with teeth or mouth such as loose teeth, swelling or pain, non-healing of sores or discharge, consult your doctor and dentist as these might be signs of osteonecrosis of the jaw.
You are not recommended to take Zobiphos 4 mg Injection 1's with gentamicin as co-administration of these two medicines may increase the risk of very low calcium levels in the blood. However, please consult a doctor before taking Zobiphos 4 mg Injection 1's with other medicines.
Zobiphos 4 mg Injection 1's may reduce calcium levels in the blood by preventing calcium reabsorption from bones to the blood. Therefore, your doctor may prescribe calcium and vitamin D supplements, and you may be advised to take them for at least 10 days after receiving Zobiphos 4 mg Injection 1's.
Zobiphos 4 mg Injection 1's may cause flu-like symptoms (chills, tiredness, muscle and joint pain) in some patients as a common side effect. However, if the symptoms persist or worsen even after 2 weeks, please consult a doctor.
Osteonecrosis of the jaw (ONJ) is a condition where part of the jawbone doesn't get enough blood, causing it to die. This can happen after dental work or on its own, often linked to certain medications used for osteoporosis and cancer. Symptoms include pain, swelling, exposed bone, and trouble chewing.
In Paget’s disease, bone remodeling (removal of old bone and replacement with new bone material) is too quick, and new bone is formed in a disordered manner making it weaker than normal. If left untreated, the bone may become deformed, painful, and broken.
No, Zobiphos 4 mg Injection 1's is not a habit-forming medication. It is used to treat osteoporosis and high blood calcium levels, and it does not cause physical or psychological dependence.
Zobiphos 4 mg Injection 1's belongs to the class of medicines called 'bisphosphonates' that contains Zolendronic acid.
Your doctor will evaluate your individual needs and determine the appropriate treatment duration, confirming personalized care and best results. Zobiphos 4 mg Injection 1's will be administered by a healthcare professional in a clinical setting. Always follow your doctor's instructions regarding treatment duration.
Zobiphos 4 mg Injection 1's is administered through an intravenous (IV) infusion by a healthcare professional. This medication is given directly into your vein, and self-administration is not allowed.
Zobiphos 4 mg Injection 1's is generally considered safe when we exactly follow our doctor's instructions. However, like all medications, it can have side effects and potential interactions with other drugs. It's important to follow your doctor's instructions and inform them of any pre-existing and existing medical conditions or medication history to avoid negative complications.
To keep your bones healthy, you should exercise regularly, eat a diet rich in calcium and vitamin D, stop smoking, limit alcohol, stay hydrated, and make your home safer to prevent falls. These simple changes can make a big difference in maintaining strong bones.
The common side effects of the Zobiphos 4 mg Injection 1's are headache, fever, nausea, dizziness, vomiting, back pain, diarrhea, pain in the muscles, joints, or bones, swelling, or pain at the infusion site. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

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