Zisavel 200 mg Infusion 1's belongs to the class of medicines called antifungals used to treat fungal infections such as invasive aspergillosis and mucormycosis (in patients for whom Amphotericin B is not suitable). Invasive aspergillosis is an infection caused by Aspergillus fungus. It occurs by breathing and spreads from the lungs to the kidneys, brain, heart or skin. Mucormycosis is a rare but serious fungal infection of the skin or respiratory system that occurs in people with weakened immune systems.

Zisavel 200 mg Infusion 1's contains Isavuconazole which works by fungicidal actions by disrupting the biosynthesis of ergosterol,which are essential for their survival and kills fungus that causes infection.

Zisavel 200 mg Infusion 1's will be administered by a healthcare professional; do not self-administer. Some people may experience headache, decreased appetite, sleepiness, nausea, vomiting, stomach pain, diarrhoea or chest pain. Most of these side effects of Zisavel 200 mg Infusion 1's do not require medical attention and gradually resolve over time. However, if the side effects worsen or persist, please consult your doctor.

If you are allergic to Zisavel 200 mg Infusion 1's or any other medicines, please tell your doctor. Zisavel 200 mg Infusion 1's is not recommended for children below 18 years as the safety and effectiveness were not established. If you are pregnant, it is advised to consult a doctor before using Zisavel 200 mg Infusion 1's. Avoid breastfeeding while taking Zisavel 200 mg Infusion 1's. Drive only if you are alert after taking Zisavel 200 mg Infusion 1's as it may cause drowsiness, confusion or dizziness. Avoid alcohol consumption while taking Zisavel 200 mg Infusion 1's as it may increase the risk of liver damage.

Zisavel 200 mg Infusion 1's contains Isavuconazole, a broad-spectrum antifungal that is effective against a wide variety of microorganisms. It inhibits the synthesis of fungal cell membranes that are essential for their survival. Thereby, Zisavel 200 mg Infusion 1's kills or stops the growth of the fungus.

• Headache
• Decreased appetite
• Sleepiness
• Nausea
• Vomiting
• Stomach pain
• Diarrhoea
• Chest pain

If you are allergic to Zisavel 200 mg Infusion 1's or any other medicines, please tell your doctor. Zisavel 200 mg Infusion 1's is not recommended for children below 18 years as the safety and effectiveness were not established. If you are pregnant, it is advised to consult a doctor before using Zisavel 200 mg Infusion 1's. Avoid breastfeeding while taking Zisavel 200 mg Infusion 1's. Drive only if you are alert after taking Zisavel 200 mg Infusion 1's as it may cause drowsiness, confusion or dizziness. Avoid alcohol consumption while taking Zisavel 200 mg Infusion 1's as it may increase the risk of liver damage. If you experience severe blistering of the eyes, mouth, skin or genitals, seek immediate medical help.

Drug-Drug Interaction: Inform your doctor if you are taking anti-HIV drugs (ritonavir, efavirenz, etravirine), antibiotics (nafcillin), antitubercular drugs (rifabutin, rifampicin), medicine for rheumatoid arthritis (prednisone), immunosuppressants (tacrolimus, sirolimus, ciclosporin), antidiabetics (pioglitazone, metformin), anticonvulsants (carbamazepine, phenobarbital, phenytoin), antifungal (ketoconazole) or any other medicines before taking Zisavel 200 mg Infusion 1's.

Drug-Food Interaction: Zisavel 200 mg Infusion 1's may interact with St. John’s wort (herbal medicine to treat depression).

Drug-Disease Interaction: If you have liver or heart problems, inform your doctor before taking Zisavel 200 mg Infusion 1's.

• RITONAVIR
• EFAVIRENZ
• ETRAVIRINE
• RIFABUTIN
• RIFAMPICIN
• PREDNISONE
• TACROLIMUS
• SIROLIMUS
• CICLOSPORIN
• PIOGLITAZONE
• CARBAMAZEPINE
• PHENOBARBITAL
• PHENYTOIN
• KETOCONAZOLE
• METFORMIN

• Try to avoid areas with a lot of dust like excavation or construction sites. If you can’t avoid it, wear an N95 mask while going to such places.
• Clean skin injuries with soap and water, especially if they have been exposed to dust or soil to decrease the chances of developing a skin infection.
• Bandage all wounds until they heal to prevent fungal infections.
• Wash your hands frequently and keep your hands clean to prevent the spread of germs.
• Avoid dusty activities and digging in the soil.
• Wear shoes, a long-sleeved t-shirt, long pants and a mask while doing outdoor activities such as yard work, gardening or vising wooded areas to protect from fungus commonly present in the environment.
• Maintain a diet that is low in sugar, refined carbohydrates, mould-containing foods and yeast.

Regular blood tests are recommended while taking Zisavel 200 mg Infusion 1's to monitor liver functioning.

Invasive aspergillosis: It is an infection carried on by the fungus Aspergillus. When the infection moves from the lungs to the kidneys, brain, heart, or skin, it manifests itself. It mostly affects people whose immune systems have been compromised by chemotherapy or other illnesses like cancer or AIDS. The signs include coughing, fever, chest pain, and shortness of breath (sometimes with blood).

Mucormycosis: People with compromised immune systems are more susceptible to this uncommon but severe fungal infection of the skin or respiratory system. It can lead to death if not treated. Nasal congestion, headaches, coughs, fevers, and pain in the sinuses are some of the signs of respiratory infections. The signs of a skin infection include blisters or ulcers, redness, swelling, tenderness, and blackened skin tissue.