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Written By , M Pharmacy
Reviewed By , MPharma., PhD
Last Updated Jan 1, 2025 | 9:31 AM IST

Zextra 600Mg Tablet is used to treat pain, swelling and inflammation in osteoarthritis and rheumatoid arthritis. Besides this, it can also be used to relieve pain, tenderness, swelling, and stiffness caused by juvenile rheumatoid arthritis in children two years of age and older. It contains Tolmetin, which works by blocking the release of a chemical messenger called prostaglandin, produced by COX-2, which is responsible for pain, swelling and inflammation. Thus, it effectively helps to manage pain in various conditions.

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Prescription drug

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Composition :

TOLMETIN-600MG

Manufacturer/Marketer :

Dr Reddy's Laboratories Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Zextra 600Mg Tablet

Zextra 600Mg Tablet is used to treat pain, swelling and inflammation in osteoarthritis and rheumatoid arthritis. Besides this, it can also be used to relieve pain, tenderness, swelling, and stiffness caused by juvenile rheumatoid arthritis in children two years of age and older. 

Zextra 600Mg Tablet contains Tolmetin, which works by blocking the release of a chemical messenger called prostaglandin, produced by COX-2, which is responsible for pain, swelling and inflammation. Thus, Zextra 600Mg Tablet effectively helps to manage pain in various conditions.

You should take this medicine exactly as the doctor prescribed it. The common side-effects of Zextra 600Mg Tablet are diarrhoea, constipation, gas, weight gain or loss, headache, depression, skin irritation, ringing in the ears, ulcers, bleeding, or holes in the stomach or intestine. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Before taking the Zextra 600Mg Tablet, let your doctor know about all your medical conditions, sensitivities, and medications you are using. Inform your doctor if you have ulcers or bleeding in your stomach, severe liver and/or kidney impairment, colitis (inflammation of the large intestine), uncontrolled blood pressure, or heart problems. Also, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Zextra 600Mg Tablet should not be taken around or after 20 weeks of pregnancy unless directed by your doctor. Zextra 600Mg Tablet may harm the fetus and create complications during delivery if taken about 20 weeks or later during pregnancy.

Uses of Zextra 600Mg Tablet

Treatment of Osteoarthritis, Rheumatoid arthritis, Juvenile rheumatoid arthritis (in children 2 years of age and older)

Medicinal Benefits

Zextra 600Mg Tablet contains ‘Tolmetin’, which is a non-steroidal anti-inflammatory drug (NSAID). It acts as both an analgesic (reduces pain) and an anti-inflammatory (reduces inflammation) agent. It is a selective COX-2 inhibitor. COX-2 enzymes are responsible for converting arachidonic acid to prostaglandins, which are inflammatory mediators. The blocking of COX-2 reduces the production of prostaglandins, eventually decreasing pain and inflammation.

Side Effects of Zextra 600Mg Tablet

  • Diarrhea
  • Constipation
  • Gas
  • Weight gain or loss
  • Headache
  • Dizziness
  • Depression
  • Skin irritation
  • Ringing in the ears
  • Ulcers, bleeding, or holes in the stomach or intestine

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Before taking Zextra 600Mg Tablet, inform your doctor if you have a history of stomach ulcers or bleeding, asthma, oedema (fluid retention), GI toxicity, rash, renal toxicities, and thrombosis (blood clots block your blood vessels). If you have recently had a heart attack, do not take an NSAID such as tolmetin unless your doctor tells you to. Inform your doctor if you or someone in your family has or has ever had heart disease, a heart attack, or a stroke, if you smoke, and if you have or have ever had high cholesterol, high blood pressure, or diabetes. If you have any of the following symptoms, seek emergency medical attention right away: chest pain, shortness of breath, weakness in one area or side of the body, or slurred speech.

Therapeutic Class

NON-STEROIDAL DRUG

Drug-Drug Interactions

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TolmetinKetorolac
Critical
TolmetinApixaban
Severe

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Diet & Lifestyle Advise

  • Maintain a healthy body weight because obesity can lead to joint pain. Please avoid strenuous exercise as it may aggravate your arthritis-related joint pain. Instead, you can stretch and engage in low-impact aerobic exercises such as treadmill walking, biking, and swimming. Lifting light weights can also help to improve your muscle strength.
  • Increase your intake of glucosamine, chondroitin sulphate, vitamin D, and calcium-rich supplements. Turmeric and fish oils can also help reduce tissue inflammation.
  • If you have arthritis or joint pain, include fish such as salmon, trout, tuna, and sardines in your diet. These fish are high in omega-3 fatty acids, which aid in reducing inflammation (redness and swelling) and protecting the heart.
  • Your sitting posture is critical, especially if you suffer from pain or inflammation. Try to sit as little as possible and only for a short period of time (10-15 min). Place a rolled-up towel at the back of your curve to alleviate pain. In addition, a footrest can be used if necessary.
  • Follow heat or cold therapy by regularly applying a cold or hot compress to the joints for 15-20 minutes.
  • Relax by meditating, reading, taking a bubble bath, or listening to calming music.
  • Avoid drinking alcohol and quit smoking.

Habit Forming

No

How Zextra 600Mg Tablet Works

Zextra 600Mg Tablet contains Tolmetin, which works by blocking the release of a chemical messenger called prostaglandin, produced by COX-2, which is responsible for pain, swelling and inflammation. Thus, Zextra 600Mg Tablet effectively helps to manage pain in various conditions.

What if I have taken an overdose of Zextra 600Mg Tablet

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Zextra 600Mg Tablet may include severe stomach pain, vomit, extreme drowsiness, slow/shallow breathing, and seizures. Seek immediate medical attention if you observe these symptoms or think you might have taken too much. Do this even if there are no signs of discomfort or poisoning.
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Alcohol

Unsafe

Consuming alcohol along with Zextra 600Mg Tablet is not advisable.

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Pregnancy

Caution

Zextra 600Mg Tablet should not be used when pregnancy unless clearly necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Zextra 600Mg Tablet.

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Breast Feeding

Caution

Inform your doctor if you are breastfeeding. A decision should be made whether to discontinue nursing or to discontinue the medicine, taking into account the importance of the medicine to the mother.

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Driving

Caution

Zextra 600Mg Tablet may cause dizziness. So, you should not drive or operate heavy machinery after taking Zextra 600Mg Tablet.

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Liver

Caution

Zextra 600Mg Tablet should be used with caution in patients with liver diseases. Your doctor will weigh the benefits and potential risks before prescribing Zextra 600Mg Tablet. So, do not take Zextra 600Mg Tablet unless instructed by the doctor if you have a liver impairment/disorder history.

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Kidney

Caution

Zextra 600Mg Tablet should be used with caution in patients with kidney diseases. Dosage adjustments may be necessary for patients with severe renal impairment. So, do not take Zextra 600Mg Tablet unless instructed by the doctor if you have a kidney impairment/disorder history.

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Children

Caution

Zextra 600Mg Tablet can be used in children two years and older to treat Juvenile rheumatoid arthritis.

Country of origin

India

Manufacturer/Marketer address

Dr. Reddy's Laboratories Ltd., 8-2-337, Road No. 3, Banjara Hills, Hyderabad, Telangana 500034, INDIA
Other Info - ZEX0005

Author Details

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FAQs

Zextra 600Mg Tablet is used to treat pain, swelling and inflammation in osteoarthritis and rheumatoid arthritis. Besides this, it can also be used to relieve pain, tenderness, swelling, and stiffness caused by juvenile rheumatoid arthritis in children two years of age and older.
Zextra 600Mg Tablet contains ‘Tolmetin’, which is a non-steroidal anti-inflammatory drug (NSAID). It is a COX-2 inhibitor. COX-2 enzyme produces prostaglandins that cause pain, swelling and inflammation.
Zextra 600Mg Tablet is not recommended for the longer term, especially in higher doses, as it increases the risk of heart attack and stroke.
Zextra 600Mg Tablet should not be taken before or after a coronary artery bypass graft (CABG; a form of cardiac surgery).
Zextra 600Mg Tablet is a pain reliever that helps in the relief of pain and inflammation associated with joint disorders. However, taking it without the advice of a doctor is not advised.
Zextra 600Mg Tablet is not recommended for the longer term, especially in higher doses, as it increases the risk of heart attack and stroke.
Inform your doctor before taking the Zextra 600Mg Tablet if you are going to take any immunizations/vaccinations. Your doctor will decide.
Zextra 600Mg Tablet is a nonsteroidal anti-inflammatory drug (NSAID) that contains the active ingredient Tolmetin. It is used to relieve pain, inflammation, and stiffness caused by conditions such as osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
No, Zextra 600Mg Tablet is not a narcotic drug. It is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and stiffness caused by various conditions.
The common side of Zextra 600Mg Tablet in some individuals may include diarrhea, constipation, gas, weight gain or loss, headache, depression, skin irritation, ringing in the ears, ulcers, bleeding, or holes in the stomach or intestine. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

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