Zextra 600Mg Tablet is used to treat pain, swelling and inflammation in osteoarthritis and rheumatoid arthritis. Besides this, it can also be used to relieve pain, tenderness, swelling, and stiffness caused by juvenile rheumatoid arthritis in children two years of age and older. 

Zextra 600Mg Tablet contains Tolmetin, which works by blocking the release of a chemical messenger called prostaglandin, produced by COX-2, which is responsible for pain, swelling and inflammation. Thus, Zextra 600Mg Tablet effectively helps to manage pain in various conditions.

You should take this medicine exactly as the doctor prescribed it. The common side-effects of Zextra 600Mg Tablet are diarrhoea, constipation, gas, weight gain or loss, headache, depression, skin irritation, ringing in the ears, ulcers, bleeding, or holes in the stomach or intestine. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Before taking the Zextra 600Mg Tablet, let your doctor know about all your medical conditions, sensitivities, and medications you are using. Inform your doctor if you have ulcers or bleeding in your stomach, severe liver and/or kidney impairment, colitis (inflammation of the large intestine), uncontrolled blood pressure, or heart problems. Also, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Zextra 600Mg Tablet should not be taken around or after 20 weeks of pregnancy unless directed by your doctor. Zextra 600Mg Tablet may harm the fetus and create complications during delivery if taken about 20 weeks or later during pregnancy.

Zextra 600Mg Tablet contains ‘Tolmetin’, which is a non-steroidal anti-inflammatory drug (NSAID). It acts as both an analgesic (reduces pain) and an anti-inflammatory (reduces inflammation) agent. It is a selective COX-2 inhibitor. COX-2 enzymes are responsible for converting arachidonic acid to prostaglandins, which are inflammatory mediators. The blocking of COX-2 reduces the production of prostaglandins, eventually decreasing pain and inflammation.

• Diarrhea
• Constipation
• Gas
• Weight gain or loss
• Headache
• Dizziness
• Depression
• Skin irritation
• Ringing in the ears
• Ulcers, bleeding, or holes in the stomach or intestine

Before taking Zextra 600Mg Tablet, inform your doctor if you have a history of stomach ulcers or bleeding, asthma, oedema (fluid retention), GI toxicity, rash, renal toxicities, and thrombosis (blood clots block your blood vessels). If you have recently had a heart attack, do not take an NSAID such as tolmetin unless your doctor tells you to. Inform your doctor if you or someone in your family has or has ever had heart disease, a heart attack, or a stroke, if you smoke, and if you have or have ever had high cholesterol, high blood pressure, or diabetes. If you have any of the following symptoms, seek emergency medical attention right away: chest pain, shortness of breath, weakness in one area or side of the body, or slurred speech.

Drug-Drug interactions: Zextra 600Mg Tablet may interact with other NSAID medications (e.g. naproxen, meloxicam, nabumetone), anticoagulants (e.g. warfarin, aspirin), and immunosuppressants (e.g. methotrexate).

Drug-Food interactions: Consumption of alcoholic beverages should be avoided.

Drug-Disease interactions: Zextra 600Mg Tablet may interact with various disease conditions, including stomach ulcers or bleeding, asthma, fluid retention, GI toxicity, rash, renal toxicities, and thrombosis (blood clots block your blood vessels).

• NAPROXEN
• MELOXICAM
• NABUMETONE
• WARFARIN
• ASPIRIN

• Maintain a healthy body weight because obesity can lead to joint pain. Please avoid strenuous exercise as it may aggravate your arthritis-related joint pain. Instead, you can stretch and engage in low-impact aerobic exercises such as treadmill walking, biking, and swimming. Lifting light weights can also help to improve your muscle strength.
• Increase your intake of glucosamine, chondroitin sulphate, vitamin D, and calcium-rich supplements. Turmeric and fish oils can also help reduce tissue inflammation.
• If you have arthritis or joint pain, include fish such as salmon, trout, tuna, and sardines in your diet. These fish are high in omega-3 fatty acids, which aid in reducing inflammation (redness and swelling) and protecting the heart.
• Your sitting posture is critical, especially if you suffer from pain or inflammation. Try to sit as little as possible and only for a short period of time (10-15 min). Place a rolled-up towel at the back of your curve to alleviate pain. In addition, a footrest can be used if necessary.
• Follow heat or cold therapy by regularly applying a cold or hot compress to the joints for 15-20 minutes.
• Relax by meditating, reading, taking a bubble bath, or listening to calming music.
• Avoid drinking alcohol and quit smoking.

• Inform your doctor before taking the Zextra 600Mg Tablet if you have a history of a heart attack, bypass surgery or peripheral arterial disease.

Osteoarthritis: Osteoarthritis is the common type of arthritis in which the cartilage that cushions the ends of the bones erodes due to wear and tear over time. Common symptoms are joint pain and stiffness.

Rheumatoid arthritis (RA): Rheumatoid arthritis (RA) is an autoimmune disease in which the immune cells attack the joints and cause bone erosion, leading to severe pain and swelling. It may lead to joint deformity if left untreated.