Zerodol S Tablet belongs to a group of medicines called 'Non-Steroidal Anti-Inflammatory Drugs' (NSAIDs) used to provide pain relief in various conditions including post-traumatic pain, low back pain, cervical pain, spondylitis, osteoarthritis, rheumatoid arthritis. Pain can be temporary (acute) or prolonged period (chronic) in nature. Acute pain is for a short time caused by damage to the tissues of the muscle, bone or organs. Chronic pain lasts for life long caused due to nerve damage, osteoarthritis and dental pain due to damage to the tooth nerve, infection, extraction or injury. 

Zerodol S Tablet contains two medicines, namely Aceclofenac and Serratiopeptidase. Aceclofenac works by blocking the release of a chemical messenger called prostaglandin, produced by COX-2, responsible for pain, swelling and inflammation. On the other hand, Serratiopeptidase is a proteolytic enzyme that helps break the insoluble protein (fibrin) by-product of blood clot into smaller units. It also causes thinning of the fluids in the body due to injury, thereby making fluid drainage smoother in the swollen tissue. Together Zerodol S Tablet is effective for relieving pain, especially in joint condition. 

You are advised to take Zerodol S Tablet for as long as your doctor has prescribed it for you depending on your medical conditions. You may experience nausea, vomiting, loss of appetite (feeling not hungry), heartburn, stomach pain, indigestion, diarrhoea. Most of these side effects of Zerodol S Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Do not take Zerodol S Tablet if you are pregnant or breastfeeding unless prescribed by the doctor. Zerodol S Tablet may cause drowsiness and dizziness, so drive with caution. Zerodol S Tablet should not be given to children as safety and efficacy have not been established. Avoid consuming alcohol, and Zerodol S Tablet as it could lead to increased drowsiness and dizziness; it might also increase stomach bleeding risk. Zerodol S Tablet should not be given to children as the safety and effectiveness were not established. 

Zerodol S Tablet is used to provide pain relief in various conditions including post-traumatic pain, low back pain, cervical pain, spondylitis (inflammation in spinal bones), osteoarthritis (lifelong joint pain and stiffness), rheumatoid arthritis (joint pain and damage throughout the body), and migraine. Zerodol S Tablet plays a vital role in reducing pain and inflammation by blocking the release of chemical messengers that cause pain and inflammation. This helps in reducing mild to moderate pain and inflammation at the injured or damaged site. Serratiopeptidase is a proteolytic enzyme that helps break the insoluble protein (fibrin) by-product of blood clots into smaller units. It also causes thinning of the fluids in the body due to injury, thereby making fluid drainage smoother in the swollen tissue.

• Nausea
• Vomiting
• Loss of appetite
• Heartburn
• Stomach pain
• Indigestion
• Diarrhoea

Do not take Zerodol S Tablet if you are allergic to Zerodol S Tablet or other painkillers. Zerodol S Tablet should not be taken in the conditions like stomach ulcers, bleeding problems, clotting problems, or severe heart, liver, or kidney problems. Inform your doctor before taking Zerodol S Tablet if you have or had disorders of the stomach, blood circulation problems to the brain, asthma, angioedema (swelling under the skin), skin rashes, diabetes, high blood pressure, auto-immune diseases, and connective tissue diseases. Stop taking Zerodol S Tablet and consult your doctor immediately if you have stomach pain or any signs of bleeding in the intestine or stomach, such as blood in stools. Inform your doctor if you are recovering from major surgery or if you are more than 65 years of age. Do not take Zerodol S Tablet if you are pregnant or breastfeeding unless prescribed. Zerodol S Tablet may cause drowsiness and dizziness, so drive only if you are alert. Zerodol S Tablet should not be given to children as safety has not been established. Avoid consuming alcohol along with Zerodol S Tablet as it could lead to increased drowsiness and can increase the risk of stomach bleeding.

Drug-Drug Interaction: Zerodol S Tablet may have interaction with pain killers (aspirin, ibuprofen, naproxen, celecoxib, etoricoxib), anti-depressants (citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, lithium), cardiac glycoside (digoxin), anti-hypertensives (enalapril, lisinopril, losartan, candesartan, hydralazine, methyldopa, clonidine, moxonidine, propranolol), blood thinners (warfarin, heparin, clopidogrel), anti-rheumatoid (methotrexate), steroids (mifepristone).

Drug-Food Interaction: Drinking alcohol should be avoided while taking Zerodol S Tablet as it can cause unpleasant effects.

Drug-Disease Interaction: Zerodol S Tablet should be used with caution in patients with stomach ulcers or bleeding, severe kidney disease, liver diseases, and colitis (inflammation of the large intestine).

• ASPIRIN
• IBUPROFEN
• NAPROXEN
• CELECOXIB
• ETORICOXIB
• CITALOPRAM
• ESCITALOPRAM
• FLUOXETINE
• FLUVOXAMINE
• PAROXETINE
• SERTRALINE
• LITHIUM
• DIGOXIN
• LISINOPRIL
• ENALAPRIL
• LOSARTAN
• CANDESARTAN
• HYDRALAZINE
• METHYLDOPA
• CLONIDINE
• MOXONIDINE
• PROPRANOLOL
• WARFARIN
• HEPARIN
• CLOPIDOGREL
• METHOTREXATE
• MIFEPRISTONE

• Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
• Performing yoga may also help in improving joint flexibility and pain management.
• Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
• Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.
• Follow heat or cold therapy, apply a cold or hot compress on the joints for 15-20minutes regularly.
• De-stress yourself by meditating, reading books, taking a warm bubble bath, or listen to soothing music.
• Acupuncture, massage, and physical therapy may also be helpful.
• Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
• Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes, and green tea.
• Avoid smoking and alcohol consumption.

Musculoskeletal pain: Different types of musculoskeletal pain are caused due to soft tissues (muscle, tendon, and ligaments) injury. Extreme tissue pain and inflammation caused due to sprains, strains, trauma, or post-surgery may require a prolonged amount of time to heal. Different types of musculoskeletal pain are caused due to soft tissues (muscle, tendon, and ligaments). Extreme tissue pain and inflammation are caused due to sprains, strains, or trauma, or post-surgery. These types of injuries may require a prolonged amount of time to heal. 

Osteoarthritis: This is a common type of arthritis in which the cartilage that cushions the bones' ends erodes due to wear and tear over time. Common symptoms are joint pain and stiffness.

Rheumatoid arthritis (RA): It is an autoimmune disease in which the immune cells attack the joints and cause bone erosion leading to severe pain and swelling. It may lead to joint deformity if left untreated.

Ankylosing spondylitis: It is a type of arthritis in which inflammation is seen in the spine and large joints. It led to pain and stiffness in the back and affected joints.

Gout: An inflammatory condition in which uric acid deposits and crystallizes in the joints. It is characterized by acute, severe, and recurring pain attacks, especially at night; redness, and swelling in the affected joints.