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Written By ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Nov 30, 2024 | 3:18 PM IST

Xtrant Capsule is used to treat prostate cancer. It contains Estramustine, an antimicrotubule agent that works by blocking DNA replication (genetic material) in cancer cells. Hence, this stops the further growth and multiplication of the cancer cells. Common side effects of Xtrant Capsule may include nausea, dizziness, heartburn, headache, diarrhoea, muscle weakness, joint pain, hot flushes, nausea, vomiting, thirst, flatulence, edema, and GI bleeding.

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Prescription drug

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Prescription drug
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Manufacturer/Marketer

Natco Pharma Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Xtrant Capsule

Xtrant Capsule is an antineoplastic medicine used in the treatment of prostate cancer. It is used to treat metastatic or progressive prostate cancer (a condition where cancer does not get cured) in men. Prostate cancer is a condition that occurs when the number of prostate gland cells increases abnormally. Symptoms may include difficulty in urinating, pain, numbness, etc.

Xtrant Capsule contains Estramustine, which belongs to the class of antimicrotubule agents. It works by blocking the replication of DNA (genetic material) in the cancer cells. Hence, this stops the further growth and multiplication of the cancer cells.

Xtrant Capsule may cause certain side effects such as nausea, dizziness, heartburn, headache, diarrhoea, muscle weakness, joint pain, hot flushes, nausea, vomiting, thirst, flatulence, edema, and GI bleeding. These side effects usually disappear without any medical attention. However, if these side effects persist or worsen, consult your doctor. Take this medicine as advised by your doctor. It should be taken on an empty stomach at least 2 hours before or post meals. Your doctor will decide the dose of the medicine based on the severity of your disease.

Xtrant Capsule should be avoided if you are allergic to estradiol, nitrogen mustard or any component present in this medicine. Inform your doctor about medications you use to avoid interactions. Inform your doctor if you have any pre-existing or a history of liver/kidney disease, hypocalcemia, thrombophlebitis, fluid retention, coronary artery disease, diabetes, gynecomastia, or impotence before taking Xtrant Capsule . Xtrant Capsule is not recommended for use in women and children as this medicine is recommended for men. Xtrant Capsule is known to cause thrombosis, fatal and nonfatal myocardial infarction, glucose intolerance and elevated blood pressure in some patients. Hence, close monitoring should be done during the treatment.

Uses of Xtrant Capsule

Treatment of metastatic prostate cancer

Medicinal Benefits

Xtrant Capsule contains Estramustine, which belongs to the class of antimicrotubule agents. It works by blocking the replication of DNA (genetic material) in the cancer cells. Hence, this stops the further growth and multiplication of the cancer cells.

Directions for Use

Xtrant Capsule should be taken on an empty stomach at least two hours before or after a meal. It is advised not to take more than the recommended dose of medicine. Swallow the medicine as a whole with a glass of water. Do not chew, crush or break the medicine.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Xtrant Capsule

  • Dizziness
  • Heartburn
  • Headache
  • Diarrhoea
  • Loss of Appetite
  • Nausea
  • Vomiting
  • GI bleeding
  • Thirst
  • Edema

Drug Warnings

Xtrant Capsule should be avoided if you are allergic to it or either estradiol or nitrogen mustard. Keep a note of all your ongoing medications to avoid interactions. Inform your doctor if you have any pre-existing or a history of liver/kidney disease, hypocalcemia, thrombophlebitis, fluid retention, coronary artery disease, diabetes, Gynecomastia, or impotence before taking Xtrant Capsule . Xtrant Capsule is not recommended for use in women and children as the safety and efficacy of this medicine are not established. Xtrant Capsule is known to cause thrombosis, fatal and nonfatal myocardial infarction, glucose intolerance and elevated blood pressure in some patients. Hence, close monitoring should be done during the entire treatment course. Do not take Xtrant Capsule with milk or any other dairy products.

Drug Interactions

Drug-drug interactions: Xtrant Capsule may interact with antifungal medicine (ketoconazole, itraconazole), antacids (magnesium hydroxide, aluminium hydroxide), vitamins, herbal supplements and many other medicines.

Drug-food interactions: No interactions found. 

Drug-disease interactions: Xtrant Capsule should be used with caution in patients with severe liver and kidney failure, adrenal or pituitary gland problems, heart failure, an irregular heartbeat, increased blood pressure, and hypoglycemia.

Drug-Drug Interactions Checker List

  • MAGNESIUM HYDROXIDE
  • ALUMINIUM HYDROXIDE
  • KETOCONAZOLE
  • ITRACONAZOLE

Habit Forming

No

Diet & Lifestyle Advise

  • Try to take vegetables like cauliflower, cabbage, broccoli, spinach and kale. This food slows the growth of prostate cancer and even reduces the risk of prostate cancer.
  • It is advised to consume fewer dairy products as these foods may increase the risk of prostate cancer.
  • Physical activity helps strengthen muscles, reduces fatigue, helps with weight loss, and gives strength.
  • Maintain a healthy weight by doing regular simple exercises and yoga.
  • Getting adequate sleep as resting helps improve your health and mental ability and improves attention.
  • Avoid including red meat high amounts of meat in your diet. When meat is cooked, it may increase the risk of developing prostate cancer.

Special Advise

  • Xtrant Capsule is not recommended for use in patients suffering from severe kidney disease.
  • Regular checkups on your calcium, potassium, blood sugar, and blood pressure levels are advised.

Disease/Condition Glossary

Prostate cancer: The prostate gland is a small walnut-sized gland present under the bladder which is responsible for the production of seminal fluid. Prostate cancer is a carcinogenic condition that occurs when the prostate gland cells increase out of control. The main cause of this condition is unknown. However, a few underlying reasons that increase the risk for this condition include age, family history, ethnic group, genetic factors, obesity, etc.

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Alcohol

Consult your doctor

Interaction of Xtrant Capsule with alcohol is unknown. It is advisable to consult your doctor if you have concerns.

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Pregnancy

Not applicable

Not intended for women. Xtrant Capsule has the potential to harm a fetus. If there is a chance that your partner will become pregnant while you are on estramustine, you should utilize effective birth control.

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Breast Feeding

Not applicable

Not intended for women.

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Driving

Unsafe

Xtrant Capsule may decrease alertness or make you feel sleepy and dizzy. So, do not drive or operate heavy machinery after taking Xtrant Capsule until your vision improves.

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Liver

Caution

Xtrant Capsule should be used with caution, especially if you have a history of liver diseases/conditions. Your doctor may adjust the dose based on your condition.

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Kidney

Caution

Xtrant Capsule should be used with caution, especially if you have a history of kidney diseases/conditions. This medicine causes fluid retention and edema which can be worsened by kidney impairment. Your doctor may adjust the dose based on your condition.

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Children

Not applicable

Intended for use in adult men.

Country of origin

INDIA

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - XTR0012

FAQs

Xtrant Capsule is used to treat metastatic prostate cancer.
Xtrant Capsule contains Estramustine, which belongs to the class of antimicrotubule agents. It works by blocking the replication of DNA (genetic material) in the cancer cells. Hence, this stops the further growth and multiplication of the cancer cells.
No, do not stop taking Xtrant Capsule without consulting your doctor. It is recommended to take this medicine for the entire prescribed duration, even when symptoms improve or resolve.
Xtrant Capsule is an antineoplastic medicine that contains the active ingredient Estramustine, which is used in the treatment of prostate cancer in men.
The common side effects of Xtrant Capsule include nausea, dizziness, heartburn, headache, diarrhea, muscle weakness, joint pain, hot flushes, vomiting, thirst, flatulence, edema, and stomach bleeding. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

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