Trybofen AP 100mg/325mg Tablet is a combination medicine used to relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis, spondylosis, spondyloarthritis, and ortho-degenerative disorders. Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Arthritis, also known as joint inflammation, is the tenderness and swelling of the joints. Symptoms include swelling, pain, and stiffness. 
 
Trybofen AP 100mg/325mg Tablet is a combination of three drugs, namely: Aceclofenac, Paracetamol, and Trypsin chymotrypsin. Aceclofenac and Paracetamol work by blocking the effect of chemical messengers called prostaglandins by inhibiting cyclooxygenase (COX) enzymes, thereby reduces mild to moderate pain and inflammation at the injured or damaged site. Trypsin chymotrypsin breaks down the abnormal proteins at the site of inflammation, thereby reduces swelling and inflammation.
 
You are advised to take Trybofen AP 100mg/325mg Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as nausea, vomiting, stomach pain, loss of appetite, indigestion, and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Consult your doctor if you are pregnant or breastfeeding. Trybofen AP 100mg/325mg Tablet may cause drowsiness and dizziness, so drive with caution. Trybofen AP 100mg/325mg Tablet is not recommended for children as safety and efficacy have not been established. Avoid consuming alcohol with Trybofen AP 100mg/325mg Tablet as it could lead to increased drowsiness and dizziness; it might also increase the risk of stomach bleeding. Keep your doctor informed about your health condition and medicines to rule out any side effects/interactions.

Trybofen AP 100mg/325mg Tablet is a combination of three drugs, namely: Aceclofenac, Paracetamol, and Trypsin chymotrypsin. Trybofen AP 100mg/325mg Tablet is used to relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis, spondylosis, spondyloarthritis, and ortho-degenerative disorders. Aceclofenac is an NSAID (Non-Steroidal Anti-Inflammatory Drug) and Paracetamol is an analgesic. Aceclofenac and Paracetamol work by blocking the effect of chemical messengers called prostaglandins by inhibiting cyclooxygenase (COX) enzymes, thereby reducing mild to moderate pain and inflammation at the injured or damaged site. Trypsin chymotrypsin is a combination of enzymes that breaks down the abnormal proteins at the site of inflammation, thereby reducing swelling and inflammation by increasing the blood supply at the affected area.

• Nausea
• Vomiting
• Stomach pain
• Diarrhoea
• Indigestion
• Loss of appetite
• Heartburn

Do not take Trybofen AP 100mg/325mg Tablet if you are allergic to any of its contents; if you have/had severe heart problems, active or recurring peptic ulcer, gastrointestinal perforation, bleeding problems, inflammation of intestines, severe liver or kidney impairment. Inform your doctor if you have/had high blood pressure, heart problems, high cholesterol, diabetes, asthma, angina, bowel problems, blood clotting disorder, a habit of smoking, liver or kidney problems. Consult your doctor if you are pregnant or breastfeeding. Stop taking Trybofen AP 100mg/325mg Tablet and consult your doctor immediately if you have stomach pain or any signs of bleeding in the intestine or stomach, such as blood in stools. 

Drug-Drug Interactions: Trybofen AP 100mg/325mg Tablet may interact with pain killers (aspirin), anti-coagulant (warfarin, coumadin, heparin, clopidogrel), antibiotic (chloramphenicol), cardiac glycoside (digoxin), anti-maniac agent (lithium), immunosuppressant (methotrexate, tacrolimus, ciclosporin), antiprogestational steroids (mifepristone), anti-retroviral (zidovudine), anti-hypertensives, diuretics, and corticosteroids.

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform your doctor if you have/had severe heart problems, active or recurring peptic ulcer, gastrointestinal perforation, bleeding problems, inflammation of intestines, severe liver or kidney impairment.

• ASPIRIN
• WARFARIN
• COUMADIN
• HEPARIN
• CLOPIDOGREL
• CHLORAMPHENICOL
• DIGOXIN
• LITHIUM
• METHOTREXATE
• TACROLIMUS
• CICLOSPORIN
• MIFEPRISTONE
• ZIDOVUDINE

• Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
• Performing yoga may also help in improving joint flexibility and pain management.
• Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
• Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.
• De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
• Acupuncture, massage and physical therapy may also be helpful.
• Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
• Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
• Avoid smoking and alcohol consumption.

Pain: Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Pain may be dull or sharp; it might be constant or may come and go. The tolerance level of pain might vary from person to person. Pain can be generalized (overall body aches) or localized (affecting a specific area of the body). The common causes of pain include headache, muscle strain, cramps, cuts, bone fractures, and arthritis.

Osteoarthritis: It is a joint disease in which the two ends of the joints come together due to the breakdown of a protective covering called cartilage. Due to the absence of this protective covering, the joints rub against each other, leading to pain and stiffness. Symptoms include pain, stiffness, inflammation and tenderness.

Rheumatoid arthritis: It is an auto-immune disease (the body's immune system attacks its tissue), leading to joint pain and damage. Symptoms of rheumatoid arthritis include pain, swelling, stiffness, deformities and loss of joint function. 

Spondylosis: It is a degenerative condition of the spine due to the wear and tear of the spinal discs. It is osteoarthritis of the spine, a common condition which worsens with age.

Spondyloarthritis: It is an inflammatory disease that affects the pelvis, back, neck, chest, spine, fingers, knees, toes, and some larger joints.