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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Dec 13, 2024 | 11:25 AM IST
Triplixam 4mg/1.25mg/5mg Tablet is used to treat hypertension (high blood pressure). It works by relaxing and widening the blood vessels, thereby improving blood flow and making it easier for the heart to pump blood through them. It also increases the amount of urine produced by the kidneys. Thereby, this medicine helps lower blood pressure, thus, reducing the chances of heart problems such as heart attack and stroke.
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Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Triplixam 4mg/1.25mg/5mg Tablet

Triplixam 4mg/1.25mg/5mg Tablet is used to treat high blood pressure (hypertension). High blood pressure is a condition in which the blood exerts increased pressure on the walls of blood vessels. Triplixam 4mg/1.25mg/5mg Tablet helps lower blood pressure, thereby reducing the chances of heart problems such as heart attack and stroke.  
 
Triplixam 4mg/1.25mg/5mg Tablet contains Indapamide, Amlodipine, and Perindopril erbumine. Indapamide lowers blood pressure by increasing the amount of urine produced by the kidneys. Amlodipine relaxes the blood vessels, thereby improving blood flow. Perindopril erbumine widens the blood vessels, making it easier for the heart to pump blood through them. Together, Triplixam 4mg/1.25mg/5mg Tablet helps treat hypertension.
 
You are advised to take Triplixam 4mg/1.25mg/5mg Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects such as oedema, headache, dizziness, flushing, and abdominal pain. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if the side effects persist or worsen.
 
Triplixam 4mg/1.25mg/5mg Tablet is not recommended during early pregnancy and should not be taken when more than 3 months pregnant as it may cause serious harm to the baby. Triplixam 4mg/1.25mg/5mg Tablet is not recommended for breastfeeding mothers and children. Triplixam 4mg/1.25mg/5mg Tablet may cause dizziness, so drive with caution. Avoid consuming alcohol as it might cause increased dizziness. Inform your doctor about all the medicines you are taking and your health condition to rule out any unpleasant side effects.

Uses of Triplixam 4mg/1.25mg/5mg Tablet

Treatment of Hypertension (high blood pressure).

Medicinal Benefits

Triplixam 4mg/1.25mg/5mg Tablet is a combination of three drugs, namely: Indapamide, Amlodipine, and Perindopril erbumine. Triplixam 4mg/1.25mg/5mg Tablet belongs to the group of anti-hypertensive medicines used to treat high blood pressure (hypertension). Triplixam 4mg/1.25mg/5mg Tablet helps lower blood pressure, thereby reduces the chances of heart problems such as heart attack and stroke. Indapamide is a diuretic that lowers blood pressure by increasing the amount of urine produced by the kidneys. Amlodipine is a calcium channel blocker that relaxes the blood vessels, thereby improving blood flow. Perindopril erbumine is an angiotensin-converting enzyme inhibitor that widens the blood vessels; this makes it easier for the heart to pump blood through them. Together, Triplixam 4mg/1.25mg/5mg Tablet helps treat hypertension.

Directions for Use

Take Triplixam 4mg/1.25mg/5mg Tablet before a meal. Swallow Triplixam 4mg/1.25mg/5mg Tablet as a whole with water; do not crush, break or chew it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Triplixam 4mg/1.25mg/5mg Tablet

  • Oedema
  • Headache
  • Dizziness
  • Flushing
  • Tiredness
  • Weakness
  • Nausea
  • Vomiting

Drug Warnings

Do not take Triplixam 4mg/1.25mg/5mg Tablet if you are allergic to any of its contents; if you have angioedema, severe liver/kidney problems, liver encephalopathy, severe water retention, low blood pressure, or low blood potassium. Inform your doctor if you have diabetes, heart problems, gout, parathyroid gland problems, heart failure, collagen disease, atherosclerosis (hardening of arteries), excess acid in the blood, liver/kidney problems, if you are on a low-salt diet, if you are taking lithium/potassium-sparing diuretics, low blood pressure in the brain, or if you are taking any other blood pressure-lowering medicines. Triplixam 4mg/1.25mg/5mg Tablet is not recommended during early pregnancy and should not be taken when more than 3 months pregnant as it may cause serious harm to the baby. Triplixam 4mg/1.25mg/5mg Tablet is not recommended for breastfeeding mothers and children. Triplixam 4mg/1.25mg/5mg Tablet may cause dizziness, so drive with caution. Keep your doctor informed about your health condition and medications to rule out any interactions.

Drug Interactions

Drug-Drug Interactions: Triplixam 4mg/1.25mg/5mg Tablet may interact with anti-maniac drug (lithium), muscle relaxer (dantrolene), anti-cancer (estramustine), drugs used to treat heart failure (sacubitril+valsartan), potassium-sparing drugs (triamterene, amiloride), immunosuppressant (cyclosporin), anti-hypertensive (aliskiren).

Drug-Food Interactions: Avoid consuming grapefruit and grapefruit juice whilst taking Triplixam 4mg/1.25mg/5mg Tablet as it might increase the blood levels of amlodipine; this can lead to an unpredictable increase in the blood pressure-lowering effect of Triplixam 4mg/1.25mg/5mg Tablet . Inform your doctor if you are taking St. John's wort (a herbal supplement).

Drug-Disease Interactions: Inform your doctor if you have angioedema, severe liver/kidney problems, liver encephalopathy, severe water retention, low blood pressure, heart failure, or low blood potassium.

Drug-Drug Interactions Checker List

  • LITHIUM
  • DANTROLENE
  • ESTRAMUSTINE
  • SACUBITRIL+VALSARTAN
  • TRIAMTERENE
  • AMILORIDE
  • CICLOSPORIN
  • ALISKIREN

Habit Forming

No

Diet & Lifestyle Advise

  • You are advised to consume low salt and low-fat diet. 
  • Exercise regularly.
  • Eat a diet rich in whole grains, vegetables, and fruits.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight with proper diet and exercise.
  • Practice meditation or yoga as it helps in managing stress.

Special Advise

  • Regular monitoring of blood pressure levels, kidney function and electrolyte levels while taking Triplixam 4mg/1.25mg/5mg Tablet is advised.
  • If you are due to have any surgery, inform the doctor that you are taking Triplixam 4mg/1.25mg/5mg Tablet

Disease/Condition Glossary

High blood pressure (hypertension): It is a condition in which the blood exerts increased pressure on the walls of blood vessels leading to hypertension. This condition can lead to hardened arteries (blood vessels), decreasing the blood and oxygen flow to the heart. Raised blood pressure can cause chest pain (angina) and heart attack (when the blood supply to the heart is blocked). High blood pressure also causes brain damage (stroke) and kidney failure. Symptoms of high blood pressure include headache, dizziness, nose bleed, changes in vision, chest pain, weakness and dyspnoea (shortness of breath). However, most of the time, the signs and symptoms of hypertension are none.

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Alcohol

Caution

Avoid consuming alcohol as it might cause increased dizziness.

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Pregnancy

Caution

Triplixam 4mg/1.25mg/5mg Tablet is not recommended during early pregnancy and should not be taken when more than 3 months pregnant as it may cause serious harm to the baby. Please consult your doctor if you are pregnant, think you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Triplixam 4mg/1.25mg/5mg Tablet is not recommended for breastfeeding mothers. Talk to your doctor if you have any concerns.

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Driving

Caution

Triplixam 4mg/1.25mg/5mg Tablet may cause dizziness, do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Dose adjustment may be needed. Please consult your doctor if you have liver problems or any concerns regarding this. Avoid taking Triplixam 4mg/1.25mg/5mg Tablet if you have severe liver disease or hepatic encephalopathy.

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Kidney

Caution

Dose adjustment may be needed. Avoid taking Triplixam 4mg/1.25mg/5mg Tablet if you have severe kidney problems. Please consult your doctor if you have kidney problems or any concerns regarding this.

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Children

Unsafe

Triplixam 4mg/1.25mg/5mg Tablet is not recommended for children as safety and effectiveness have not been established.

Country of origin

India

Manufacturer/Marketer address

Serdia House, Off Dr. S S Rao Road, Behind M G Hospital Parel, Mumbai 400012
Other Info - TRI1450

Author Details

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FAQs

Triplixam 4mg/1.25mg/5mg Tablet belongs to the group of anti-hypertensive medicines used to treat high blood pressure (hypertension).
Triplixam 4mg/1.25mg/5mg Tablet contains Indapamide, Amlodipine, and Perindopril erbumine. Indapamide lowers blood pressure by increasing the amount of urine produced by the kidneys. Amlodipine relaxes the blood vessels, thereby improving blood flow. Perindopril erbumine widens the blood vessels; this makes it easier for the heart to pump blood through them. Together, Triplixam 4mg/1.25mg/5mg Tablet helps treat high blood pressure.
Triplixam 4mg/1.25mg/5mg Tablet may cause palpitations, a sensation that the heart is racing, pounding, or fluttering. A minor fluctuation should not be a worry; however, if palpitations continue or you begin to feel unwell, speak with your doctor.
High blood pressure increases the workload on the arteries and heart. If untreated, it could damage the blood vessels of the heart, brain, kidney and might result in stroke, heart failure or kidney failure. Hypertension increases the risk of heart attacks. Therefore, anti-hypertensives such as Triplixam 4mg/1.25mg/5mg Tablet are used to lower the blood pressure to normal; this reduces the risk of developing these disorders.
Do not stop taking Triplixam 4mg/1.25mg/5mg Tablet without consulting your doctor, as it may lead to a rise in blood pressure. To treat your condition effectually, continue taking Triplixam 4mg/1.25mg/5mg Tablet for as long as your doctor has prescribed it. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Triplixam 4mg/1.25mg/5mg Tablet .
Light-headedness could be a side-effect of Triplixam 4mg/1.25mg/5mg Tablet . It occurs due to low blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking; instead, lie down and get up slowly only when you feel better. People taking Triplixam 4mg/1.25mg/5mg Tablet are advised to regularly monitor their blood pressure levels to avoid unpleasant events.
Avoid consuming grapefruit and grapefruit juice whilst taking Triplixam 4mg/1.25mg/5mg Tablet as it might increase the blood levels of amlodipine; this can lead to an unpredictable increase in the blood pressure-lowering effect of Triplixam 4mg/1.25mg/5mg Tablet . Inform your doctor if you are on a salt-restricted diet, use salt substitutes or if you are taking potassium supplements.
Triplixam 4mg/1.25mg/5mg Tablet may cause diarrhoea as a common side effect in some individuals. If you experience this symptom, drink plenty of water to stay hydrated, eat the BRAT diet, which includes bananas, rice, applesauce, and toast, and limit your intake of high-fibre foods, fatty foods and spicy foods.
Triplixam 4mg/1.25mg/5mg Tablet is usually taken with or without food. However, it is often recommended to take it before a meal for optimal effectiveness. It's important to follow the instructions provided by the doctor for the best results.
Triplixam 4mg/1.25mg/5mg Tablet is not known to cause weight gain. However, if you experience any weight changes, manage it with lifestyle changes like exercising regularly, eating nutritious-rich food, staying hydrated, limiting your intake of sugary foods and cutting down on carbs.
The side effects of Triplixam 4mg/1.25mg/5mg Tablet include headache, oedema, dizziness, flushing, and abdominal pain. Consult the doctor if any of these symptoms persist or worsen.

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