Trinexovas 40 Tablet belongs to a group of medications called 'anti-hypertensives primarily used to treat high blood pressure (hypertension). High blood pressure is a chronic (long-term) condition in which blood pressure is elevated persistently in higher than normal levels. This condition can also cause fluid retention, leading to peripheral oedema (swelling of legs and hands). If left untreated, this condition can increase the risk of heart-related diseases like heart attack, heart failure, stroke, irregular heartbeat, and other complications.

Trinexovas 40 Tablet contains Olmesartan, Cilnidipine, and Chlorthalidone. Olmesartan is an angiotensin-II receptor blocker (ARB). Angiotensin narrows the blood vessels increasing the blood pressure, therefore blocking angiotensin can result in widening of the narrowed blood vessels. Cilnidipine is a calcium channel blocker. It acts by relaxing the blood vessels and improving the blood flow. Chlorthalidone is a diuretic or water pill that acts by expelling excess water and salt from the body. It helps in decreasing fluid accumulation and oedema (fluid overload).

You should take this medicine exactly as prescribed by the doctor. The common side-effects of Trinexovas 40 Tablet are dizziness, low blood pressure, flushing (reddening of the skin, especially face), headache, palpitations (pounding heartbeat), increased micturition (frequency of urination), and lethargy (feeling weak). These side-effects usually resolve without requiring any medical attention. However, if any of these side-effects persist or get worse, inform your doctor immediately.

It is not recommended to take Trinexovas 40 Tablet if you are allergic to any contents of it. It is not advised to take Trinexovas 40 Tablet if you are allergic to sulfa drugs, unable to urinate, taking aliskiren, and have diabetes or kidney disease. It is not recommended for use in children, pregnant women, and breastfeeding mothers. It should be used with caution in elderly people. Alcohol consumption may increase the risk of side-effects. Trinexovas 40 Tablet may cause dizziness, so do not drive or operate heavy machinery if you feel dizzy.

Trinexovas 40 Tablet is used to treat hypertension (high blood pressure) in adults. It works by lowering the body’s production of substances that could increase heart rate and also widens narrowed blood vessels. It allows the blood to flow more smoothly in the blood vessels. It also helps to reduce oedema or fluid overload. Trinexovas 40 Tablet is a combination of medicines, so it shows greater efficacy and tolerability when compared to monotherapies. It helps to reduce serious complications of hypertension such as heart attack, stroke, and end-stage kidney disease.

• Dizziness
• Low blood pressure
• Flushing (reddening of the skin, especially face)
• Headache
• Palpitations (pounding heartbeat)
• Increased micturition (frequency of urination)
• Lethargy (feeling weak)

Before taking Trinexovas 40 Tablet , inform your doctor if you have liver or kidney disease, heart failure, are on a low-salt diet, gout, high cholesterol, diabetes, and severe hypotension (low blood pressure). Do not get overheated in hot weather or by doing heavy exercise. Make sure to get hydrated by drinking fluids in these conditions. Trinexovas 40 Tablet may cause imbalances in the electrolyte levels. Trinexovas 40 Tablet may cause low blood pressure, so inform your doctor if you experience vomiting, diarrhoea, or excessive sweating.

Drug-Drug Interactions: Trinexovas 40 Tablet may interact with other blood pressure medicines, medicines used to treat heart disease (digoxin and quinidine), antidiabetic medicine (insulin), oral diabetes medicines, steroid medicines, anti-psychotic drugs, antibiotics (rifampicin and erythromycin), and medicine used to treat fits (phenytoin).

Drug-Food Interactions: No interactions found.

Drug-Disease Interactions: Trinexovas 40 Tablet should be used with caution in patients with liver or kidney disease, heart failure, are on a low-salt diet, gout, high cholesterol, diabetes, and severe hypotension (low blood pressure).

• DIGOXIN
• QUINIDINE
• INSULIN
• RIFAMPICIN
• ERYTHROMYCIN
• PHENYTOIN

• Keep your weight under control with a body mass index (BMI) 19.5-24.9.

• Do regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week. Doing this can help you to lower your raised blood pressure by about 5 mm of Hg.

• Limit intake of sodium chloride (table salt) in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.

• Limit alcohol intake. One serving for women and two servings for men is advisable.

• Quit smoking as it is the best strategy to lower the risk of heart disease.

• Avoid chronic stress as it can raise your blood pressure. Try to enjoy and spent time with your loved ones to cope with stress and practice mindfulness techniques.

• Monitor your blood pressure daily and if there is too much fluctuation, then immediately contact your doctor.

• Try to include heart-healthy omega 3 fatty acids-containing food drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.

• Your doctor may monitor kidney function, blood pressure, and electrolyte levels at regular intervals while using Trinexovas 40 Tablet .

• Trinexovas 40 Tablet may cause orthostatic hypotension (sudden drop in blood pressure on standing), so rise slowly while standing up from a sitting or lying position.

• Do not stop taking this medicine even if you feel better unless advised by the doctor.

Hypertension: It is a chronic (long-term) condition in which blood pressure is elevated persistently at higher than normal levels. It occurs when the blood’s force against the wall of blood vessels is too high. This condition can cause chest pain (angina) and heart attack (when blood supply to the heart is blocked). Additionally, high blood pressure also causes damage to the brain, kidneys, and eyes. The risk of high blood pressure complications increases with the following: obesity, smoking, diabetes, alcohol intake, lack of physical inactivity, stress, and kidney diseases.