Topcef O 100 Tablet belongs to a group of medications called 'cephalosporin antibiotics' primarily used for the treatment of a wide range of bacterial infections of the skin, ears, lungs, prostate and urinary tract. Besides this, it also treats typhoid fever and STDs (sexually transmitted diseases) like chlamydia and gonorrhoea. A bacterial infection happens when harmful bacteria enter inside the body and start multiplying. These harmful bacteria are responsible for producing toxins that can cause diseases like strep throat, urinary tract infection (UTI), bacterial food poisoning, gonorrhoea, bacterial meningitis, cellulitis, Lyme disease, and tetanus. Topcef O 100 Tablet does not work against viral infections like flu and colds.

Topcef O 100 Tablet contains 'Cefixime' (cephalosporin antibiotic) and 'Ofloxacin' (fluoroquinolone antibiotic) that works by preventing the formation of the outer covering of the bacteria (cell wall) required for their survival. Topcef O 100 Tablet prevents the release of a chemical messenger (mucopeptides) by the bacteria, thereby weakening and destroying the bacterial cell wall. Topcef O 100 Tablet is a broad range antibiotic that works against a wide range of both gram-positive and gram-negative bacteria.

Take Topcef O 100 Tablet as prescribed. Your doctor will recommend how often you take Topcef O 100 Tablet based on your medical condition. Topcef O 100 Tablet may cause some common side effects that include diarrhoea, indigestion, nausea, loose stools, abdominal pain, and vomiting. However, some of these side effects do not require medical attention and will pass within a couple of days. If side effects become get worse with time or do not pass within a couple of days, then one should consult their doctor. 

Topcef O 100 Tablet is not allowed to use in patients who are already taking any of the other antibiotics or having kidney or liver problems. This medicine can only be used in pregnant or breastfeeding women if strongly suggested by the doctor. Ofloxacin present in Topcef O 100 Tablet may cause and aggravate symptoms of existing peripheral neuropathy (nerve damage in legs), tendinitis (swelling or tearing of a tendon), myasthenia gravis (skeletal muscle weakness), and respiratory issues like bronchitis, sinusitis. People with diabetes should contact a doctor before taking Topcef O 100 Tablet as Topcef O 100 Tablet can lower your blood sugar level in some cases. Patient with central nervous system disorder or epilepsy (fits) should avoid intake of Topcef O 100 Tablet as its use is contraindicated for them.

Topcef O 100 Tablet is a combination of cephalosporin and fluoroquinolone antibiotics that works by killing the bacteria (bactericidal). Cefixime works by stopping the growth of bacteria by inhibiting the formation of a protective layer required by the bacteria or its growth. At the same time, Ofloxacin acts by blocking the action of a chemical messenger, which helps the genetic material of bacteria to survive. The doctor usually prescribes Topcef O 100 Tablet for the treatment of typhoid fever and urinary tract infections. Besides this, it also treats bacterial infections of the prostate, skin, lungs, sexually transmitted infections like gonorrhoea (cervical/urethral), ear infections (acute otitis media), upper respiratory tract infections (URTI), lower respiratory tract infection, tonsillitis (inflammation of the tonsils) and pharyngitis (inflammation of the pharynx). 

• Diarrhoea
• Nausea
• Dyspepsia (Indigestion)
• Loose stools
• Abdominal pain
• Vomiting

You should avoid taking Topcef O 100 Tablet if you are hypersensitive to ofloxacin, cefixime or other macrolide antibiotics as it may lead to overdose and toxicity. The use of Topcef O 100 Tablet is only allowed in pregnancy or breastfeeding if clearly suggested by the doctor. Tell your doctor if you are pregnant, or breastfeeding before using Topcef O 100 Tablet . Ofloxacin present in Topcef O 100 Tablet may cause and aggravate symptoms of existing peripheral neuropathy (nerve damage in legs), tendinitis (swelling or tearing of a tendon), myasthenia gravis (skeletal muscle weakness), and respiratory issues like bronchitis, sinusitis. People with diabetes should contact a doctor before taking Topcef O 100 Tablet as Topcef O 100 Tablet can lower your blood sugar level in some cases. Patient with central nervous system disorder or epilepsy (fits) should avoid intake of Topcef O 100 Tablet as its use is contraindicated for them. 

Drug-Drug Interaction: Topcef O 100 Tablet should be avoided to be taken with vaccines including typhoid vaccine, cholera vaccine, and Bacillus Calmette Guerin (BCG vaccine), antiepileptic (carbamazepine), blood thinner (warfarin), antacid and ulcer treating medicine (aluminium hydroxide, magnesium hydroxide, cimetidine, sucralfate), medicine to treat excess uric acid (probenecid), medicines for arthritis (methotrexate), diuretics/water pills (furosemide), asthma medicine (theophylline) and pain killers (fenbufen, ibuprofen). 

Drug-Food Interaction: A person should limit the consumption of eating a high-fat meal as this makes it harder for your body to absorb Topcef O 100 Tablet . Do not consume grapefruit during antibiotics treatment can prevent the body from utilizing Topcef O 100 Tablet properly. So, prevent intake of grapefruit or grapefruit juice with the antibiotic. Avoid consuming calcium enriched foods and drinks as it might affect the working of Topcef O 100 Tablet . 

Drug-Disease Interaction: People affected with diabetes mellitus, renal dysfunction, liver disease, seizure disorders, colitis (bowel disease that affects the large intestine, causing irritation, inflammation, and ulcers in the colon) should not take Topcef O 100 Tablet .

• FUROSEMIDE
• BACILLUS CALMETTE-GUERIN(BCG) VACCINE
• CHOLERA VACCINE
• TYPHOID VACCINE
• CARBAMAZEPINE
• WARFARIN
• CIMETIDINE
• SUCRALFATE
• METHOTREXATE
• THEOPHYLLINE
• IBUPROFEN
• MAGNESIUM HYDROXIDE
• ALUMINUM HYDROXIDE
• LORATADINE

• Include probiotics in your diet as probiotics contain healthy bacteria that are good for the intestines and can recover the killed bacteria.
• Taking probiotics after completing the antibiotics course can minimize the chances of antibiotic-associated diarrhoea. Foods that are high in probiotics include yoghurt, cheese, sauerkraut, and kimchi so consume them to restore the good bacteria of the intestine. 
• Try to take more fibre-enriched food as it will help the food to digest properly and helps to stimulate the growth of gut bacteria.
• Include whole grains like whole-grain bread, brown rice to include fibre in your diet.
• Try to consume less calcium, iron-enriched foods, and drinks as it may slow down the working of Topcef O 100 Tablet . 
• Try to limit the consumption of alcoholic beverages as it can cause worsening of side effects and make your body dehydrated and affect your sleep. This also makes it difficult for your body to aid the Topcef O 100 Tablet in fighting off infections.

If you experience diarrhoea or CDAD (C. difficile-associated disease) immediately contact a doctor or nearby clinic as you might require sufficient electrolyte and other interventions for preventing water loss or dehydration. 

Bacterial infection: The bacterial infection occurs when harmful bacteria enter, and get multiplied, and cause sickness inside the body. Common symptoms of bacterial infection may vary depending upon the type of infection and bacteria, causing it. Some other symptoms of a bacterial infection include fever, feeling tired, swollen lymph nodes, headache, nausea, or vomiting. Bacteria are single-celled small microorganisms found in different shapes and structures like spherical, rod, and spiral-shaped.  Some harmful bacteria that can affect a human's body include Streptococcus, Staphylococcus, and E. coli. Bacterial infection can infect anyone persons with a weak immune system or already taking immunosuppressive drugs are at higher risk of bacterial infection.