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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 9, 2024 | 12:39 PM IST
SYNVISC HYLAN GF 20MG INJECTION 2ML is used in the treatment of knee pain due to osteoarthritis in patients who have failed to respond adequately to simple painkillers or physical therapy and exercise. It contains Sodium hyaluronate, which works by restoring synovial fluid in the knee that helps to lubricate and cushion the joint during movement. Thereby it reduces pain. In some cases, you may experience certain common side effects such as pain, swelling, redness, and warmth at the injection site or fluid in the joint. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Prescription drug

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Manufacturer/Marketer

Nicholas Piramal India Ltd

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About SYNVISC HYLAN GF 20MG INJECTION 2ML

SYNVISC HYLAN GF 20MG INJECTION 2ML belongs to the class of medicines called non-steroidal anti-inflammatory drugs (NSAIDs)  used in the treatment of knee pain due to osteoarthritis in patients who have failed to respond adequately to simple painkillers or physical therapy and exercise. Osteoarthritis is a degenerative joint disease in which the two ends of the joints come together due to the breakdown of a protective covering of cartilage. Due to the absence of this protective covering, the joints rub against each other, leading to pain and stiffness.

SYNVISC HYLAN GF 20MG INJECTION 2ML contains Sodium hyaluronate, which works by restoring synovial fluid in the knee that helps to lubricate and cushion the joint during movement. Thereby it reduces pain.

SYNVISC HYLAN GF 20MG INJECTION 2ML will be administered by a healthcare professional; do not self-administer. In some cases, you may experience certain common side effects such as pain, swelling, redness, and warmth at the injection site or fluid in the joint. Most of these side effects do not require medical attention and will resolve gradually over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Sodium hyaluronate or products from birds such as eggs, feathers and poultry, inform your doctor before receiving SYNVISC HYLAN GF 20MG INJECTION 2ML. If you are a pregnant or breastfeeding woman, inform your doctor before receiving SYNVISC HYLAN GF 20MG INJECTION 2ML. SYNVISC HYLAN GF 20MG INJECTION 2ML is not recommended for children as safety and effectiveness have not been established. SYNVISC HYLAN GF 20MG INJECTION 2ML should be used with caution in patients with pre-existing chondrocalcinosis (accumulation of calcium salts in hyaline cartilage or fibrocartilage) as it may lead to an acute attack of the condition.

Uses of SYNVISC HYLAN GF 20MG INJECTION 2ML

Treatment of Osteoarthritis

Medicinal Benefits

SYNVISC HYLAN GF 20MG INJECTION 2ML contains Sodium hyaluronate, a non-steroidal anti-inflammatory drug (NSAID) used in the treatment of knee pain due to osteoarthritis in patients who have failed to respond adequately to simple painkillers or physical therapy and exercise. It works by restoring synovial fluid in the knee that helps to lubricate and cushion the joint during movement. Thereby it reduces pain by decreasing friction in the joints.

Directions for Use

SYNVISC HYLAN GF 20MG INJECTION 2ML will be administered by a healthcare professional; do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of SYNVISC HYLAN GF 20MG INJECTION 2ML

  • Pain, swelling, redness, and warmth at the injection site
  • Fluid in the joint

Drug Warnings

If you are allergic to Sodium hyaluronate or products from birds such as eggs, feathers and poultry, inform your doctor before receiving SYNVISC HYLAN GF 20MG INJECTION 2ML. If you are a pregnant or breastfeeding woman, inform your doctor before receiving SYNVISC HYLAN GF 20MG INJECTION 2ML. SYNVISC HYLAN GF 20MG INJECTION 2ML is not recommended for children as safety and effectiveness have not been established. SYNVISC HYLAN GF 20MG INJECTION 2ML should be used with caution in patients with pre-existing chondrocalcinosis (accumulation of calcium salts in hyaline cartilage or fibrocartilage) as it may lead to an acute attack of the condition. Avoid activities such as tennis, heavy lifting, jogging, or standing on your feet for a long time immediately after receiving SYNVISC HYLAN GF 20MG INJECTION 2ML and for the next 48 hours.

Drug Interactions

Drug-Drug Interaction: Inform your doctor if you take any other prescription or non-prescription medicines, vitamins, or herbal supplements.

Drug-Food Interaction: No interactions found.

Drug-Disease Interaction: SYNVISC HYLAN GF 20MG INJECTION 2ML is not recommended in patients with infections, knee joint infections, or skin disease in the area at the injection site. Inform your doctor if you have blood clots or blood circulation problems in your leg before receiving SYNVISC HYLAN GF 20MG INJECTION 2ML.

Habit Forming

No

Diet & Lifestyle Advise

  • Physical activity helps strengthen muscles and relieves joint stiffness. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.
  • Follow heat or cold therapy, and apply a cold or hot compress on the joints for 15-20 minutes regularly.
  • Acupuncture, massage, and physical therapy may also be helpful.
  • Eat foods rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids, such as soy, berries, broccoli, grapes, and green tea, help reduce inflammation.
  • Avoid smoking and alcohol consumption.

Disease/Condition Glossary

Osteoarthritis: It is a degenerative joint disease that occurs when the concentration of sodium hyaluronate in joints decreases. Hyaluronic acid is found in the joints, which lubricates and provides a cushion between two bones. When Hyaluronic acid gets reduced, it causes the bones to rub together, leading to pain, stiffness, and other osteoarthritis symptoms. This disease can occur in any joint, but commonly affected areas of the body are hands, fingertips, knees, hips, and spine, typically at the neck or lower back. The most common osteoarthritis symptoms include pain, tenderness (discomfort when pressing on the area with fingers), stiffness,  and inflammation. The main reason for osteoarthritis is age, the older you are, the more likely you could get osteoarthritis, thus known as degenerative disease, meaning that the joints wear out as a person ages. Other reasons include a past injury such as torn cartilage, dislocated joints and ligament injuries.

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Alcohol

Consult your doctor

The interaction of SYNVISC HYLAN GF 20MG INJECTION 2ML with alcohol is unknown. If you have any concerns regarding this, please discuss them with your doctor.

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Pregnancy

Consult your doctor

The safety and effectiveness of SYNVISC HYLAN GF 20MG INJECTION 2ML in pregnant women have not been established. Therefore, if you are pregnant or planning for pregnancy, please inform your doctor before receiving SYNVISC HYLAN GF 20MG INJECTION 2ML.

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Breast Feeding

Consult your doctor

The safety and effectiveness of SYNVISC HYLAN GF 20MG INJECTION 2ML in breastfeeding women have not been established. Therefore, please inform your doctor if you are breastfeeding before receiving SYNVISC HYLAN GF 20MG INJECTION 2ML.

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Driving

Caution

Drive only if you are alert after receiving SYNVISC HYLAN GF 20MG INJECTION 2ML.

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Liver

Consult your doctor

If you have a pre-existing or a history of liver disease, please inform your doctor before receiving SYNVISC HYLAN GF 20MG INJECTION 2ML.

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Kidney

Consult your doctor

If you have a pre-existing or a history of kidney disease, please inform your doctor before receiving SYNVISC HYLAN GF 20MG INJECTION 2ML.

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Children

Unsafe

SYNVISC HYLAN GF 20MG INJECTION 2ML is not recommended for children and adolescents (age 21 years or younger) as the safety and effectiveness of SYNVISC HYLAN GF 20MG INJECTION 2ML have not been established in that age group.

Country of origin

INDIA

Manufacturer/Marketer address

401, LSC, C-Block, Mohan Place Saraswati Vihar Delhi DL 110034 In
Other Info - SYN0050

Author Details

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FAQs

SYNVISC HYLAN GF 20MG INJECTION 2ML is used in the treatment of knee pain due to osteoarthritis in patients who have failed to respond adequately to simple painkillers or physical therapy and exercise.
SYNVISC HYLAN GF 20MG INJECTION 2ML contains Sodium hyaluronate, a non-steroidal anti-inflammatory drug (NSAID) which works by restoring synovial fluid in the knee that helps to lubricate and cushion the joint during movement. Thereby it reduces knee pain due to osteoarthritis.
You are recommended to avoid activities such as tennis, heavy lifting, jogging, or standing on your feet for a long time immediately after receiving SYNVISC HYLAN GF 20MG INJECTION 2ML and for the next 48 hours. Discuss with your doctor regarding the appropriate time to resume these activities.
SYNVISC HYLAN GF 20MG INJECTION 2ML should not be used in patients with infections, knee joint infections, or skin disease in the area at the injection site. Also, SYNVISC HYLAN GF 20MG INJECTION 2ML should not be administered to patients with known allergies to Sodium hyaluronate.

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