Synapze-M Tablet is a combination medicine indicated for the management of diabetic neuropathy. Diabetic neuropathy is a condition in which nerve damage occurs due to high blood glucose levels. It primarily damages the nerves in the legs and feet. Diabetic neuropathic pain is common in patients with type 1 and type 2 diabetes.
 
Synapze-M Tablet contains Epalrestat and Methylcobalamin. Epalrestat works by inhibiting the aldose reductase enzyme, which catalyses the conversion of glucose to sorbitol, thereby preventing the accumulation of sorbitol. Accumulation of sorbitol occurs due to hyperglycaemia in patients suffering from diabetes which leads to nerve pain. Methylcobalamin helps in the rejuvenation and protection of damaged nerve cells by producing a substance called myelin. Together, Synapze-M Tablet helps in treating diabetic neuropathy.
 
You are advised to take Synapze-M Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as nausea, vomiting, diarrhoea, dizziness, and headache. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Consult your doctor if you are pregnant or breastfeeding. Synapze-M Tablet may cause drowsiness and dizziness, so drive only if you are alert. Synapze-M Tablet is not recommended for children as safety and effectiveness have not been established. Avoid consuming alcohol with Synapze-M Tablet as it could lead to increased drowsiness and dizziness. Keep your doctor informed about your health condition and medicines to rule out any side effects/interactions.

Synapze-M Tablet is a combination of two drugs, namely: Epalrestat and Methylcobalamin. Synapze-M Tablet is indicated for the management of diabetic neuropathy. Epalrestat works by inhibiting the aldose reductase enzyme, which catalyses the conversion of glucose to sorbitol. This prevents the accumulation of sorbitol. Accumulation of sorbitol occurs due to hyperglycaemia in patients suffering from diabetes which leads to nerve pain. Methylcobalamin helps in the rejuvenation and protection of damaged nerve cells by producing a substance called myelin. Together, Synapze-M Tablet helps in treating diabetic neuropathy.

• Dizziness
• Nausea
• Vomiting
• Headache
• Diarrhoea

Do not take Synapze-M Tablet if you are allergic to any of its components. Inform your doctor if you have liver or kidney problems. Consult your doctor if you are pregnant or breastfeeding. Synapze-M Tablet may cause drowsiness and dizziness, so drive only if you are alert. Synapze-M Tablet is not recommended for children as safety and effectiveness have not been established. Avoid consuming alcohol with Synapze-M Tablet as it could lead to increased drowsiness and sleepiness. 

Drug-Drug Interactions: Synapze-M Tablet may interact with antibiotic (chloramphenicol) and anti-diabetic (metformin).

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform your doctor if you have severe liver or kidney dysfunction.

• CHLORAMPHENICOL
• METFORMIN

• Include food rich in vitamin B and D in your diet.
• Include cayenne pepper in your diet as it can help in lowering neuropathic pain.
• Exercising regularly helps in improving overall health and combating pain. 
• Rest well, get plenty of sleep.
• Try taking a warm bath as it can be soothing.
• Avoid smoking and alcohol consumption.
• Meditation and yoga can help lower stress, decrease pain sensitivity and improves coping skills.
• Acupuncture can be helpful by stimulating pressure points.
• Using essential oils for massages can help increase circulation.

Diabetic neuropathy: Diabetic neuropathy is a condition in which nerve damage occurs due to high blood glucose levels. It mostly damages the nerves in the legs and feet. Diabetic neuropathic pain is common in patients with type1 and type2 diabetes, which usually develops slowly. The pain could be intermittent or continuous, which is felt as a prickling, stabbing, tingling or burning sensation. A feeling of numbness and loss of sensations is also common with neuropathic pain. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, difficulty with coordination when walking, difficulty resting or sleeping, and evoked pain (pain caused by events that are usually not painful).