Spifen MR 50mg/4mg Tablet belongs to a group of medicines called pain killer/Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) used for the treatment of osteoarthritis, rheumatoid arthritis, gouty arthritis and ankylosing spondylitis, acute pain, chronic low back pain, and muscle spasms. It relieves the pain and relaxes the muscles. Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Muscle spasm is the sudden involuntary contractions of the muscle, which can be painful and uncomfortable.

Spifen MR 50mg/4mg Tablet is a combination of two drugs: Ketoprofen (NSAID) and Thiocolchicoside (Muscle relaxant). Ketoprofen blocks the effect of a chemical messenger known as cyclo-oxygenase (COX) enzyme that makes other chemical prostaglandins (PG). By blocking the effect of chemical messenger ketoprofen helps in reducing mild to moderate pain and inflammation at the injured or damaged site. Thiocolchicoside is a muscle relaxant and works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements, thereby helping relieve pain due to muscle spasms.

Take Spifen MR 50mg/4mg Tablet as prescribed by your doctor. You are advised to take Spifen MR 50mg/4mg Tablet for as long as your doctor has prescribed it for you depending on your medical conditions. You may experience nausea, heartburn, indigestion and stomach pain, dizziness, sleepiness, nervousness, diarrhea, ringing in the ear. Most of these side effects of Spifen MR 50mg/4mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Spifen MR 50mg/4mg Tablet should not be taken if you are known to be allergic to Spifen MR 50mg/4mg Tablet or any other medicines. Spifen MR 50mg/4mg Tablet should not be taken in the conditions like kidney or heart disease. If you are pregnant or breastfeeding, please inform your doctor before starting Spifen MR 50mg/4mg Tablet. Spifen MR 50mg/4mg Tablet should not be used in children as safety and efficacy have not established. Spifen MR 50mg/4mg Tablet may cause reduced body movements, drowsiness, sleepiness and dizziness it is advisable to you do not drive unless you are alert.

Spifen MR 50mg/4mg Tablet is a combination of two drugs: Ketoprofen (pain killer) and Thiocolchicoside (Muscle relaxant). Spifen MR 50mg/4mg Tablet is used for the treatment of osteoarthritis, rheumatoid arthritis, gout and ankylosing spondylitis, acute pain, chronic low back pain, and muscle spasms. Ketoprofen blocks the effect of a chemical messenger known as cyclo-oxygenase (COX) enzyme that makes another chemical 'prostaglandin' (PG). These chemicals are produced at injury sites and cause pain and swelling. By blocking the effect of chemicals, ketoprofen helps in reducing mild to moderate pain and inflammation at the injured or damaged site. Thiocolchicoside works on the centers of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements, thereby helping relieve pain due to muscle spasms.

• Nausea
• Heartburn
• Indigestion
• Stomach pain
• Dizziness
• Sleepiness
• Nervousness
• Diarrhea
• Ringing in ear

Spifen MR 50mg/4mg Tablet should not be taken if you are known to be allergic to Spifen MR 50mg/4mg Tablet or any other medicines. Do not take Spifen MR 50mg/4mg Tablet if you are allergic to any of its contents, if you have stomach ulcers, have suffered bleeding problems, clotting problems, inflammatory bowel disease, severe heart, liver or kidney problems. Spifen MR 50mg/4mg Tablet can increase your risk of fatal heart attack or stroke. So, if you have had any recent heart surgery, do not take Spifen MR 50mg/4mg Tablet. Inform your doctor before taking Spifen MR 50mg/4mg Tablet if you have or had stomach bleeding or ulcers, heart failure, high blood pressure, high cholesterol, kidney or liver impairment. Spifen MR 50mg/4mg Tablet may cause a visual disturbance in few patients, inform your doctor and discontinue the Spifen MR 50mg/4mg Tablet immediately if you observe this symptom. This Spifen MR 50mg/4mg Tablet may increase the potassium level, regular monitoring of potassium level may need. Do not take Spifen MR 50mg/4mg Tablet if you are pregnant, planning for pregnancy or breastfeeding. If you are pregnant or breastfeeding, please inform your doctor before starting Spifen MR 50mg/4mg Tablet. Spifen MR 50mg/4mg Tablet should not be used in children as safety and efficacy have not established. Spifen MR 50mg/4mg Tablet may cause reduced body movements, drowsiness, sleepiness and dizziness it is advisable to you do not drive unless you are alert.

Drug-Drug Interactions: Spifen MR 50mg/4mg Tablet may have interaction with a blood thinner (warfarin), pain killer (ketorolac), antiallergic (prednisolone), blood pressure-lowering pills (captopril, enalapril), antidiabetic (glimepiride), medicines used in migraine (amitriptyline).

Drug-Food Interactions: Avoid alcohol consumption while taking Spifen MR 50mg/4mg Tablet as it might cause increased dizziness and risk of stomach bleeding.

Drug-Disease Interactions: Spifen MR 50mg/4mg Tablet may have interactions with stomach ulcers, blood disorders, stomach disorders, high blood pressure, edema (swelling in hand and feet) heart, kidney and liver problems.

• WARFARIN
• KETOROLAC
• PREDNISOLONE
• CAPTOPRIL
• ENALAPRIL
• GLIMEPIRIDE
• AMITRIPTYLINE

• Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
• Performing yoga may also help in improving joint flexibility and pain management.
• Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
• Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.
• Follow heat or cold therapy, apply a cold or hot compress on the joints for 15-20minutes regularly.
• De-stress yourself by meditating, reading books, taking a warm bubble bath or listen to soothing music.
• Acupuncture, massage and physical therapy may also be helpful.
• Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
• Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
• Avoid smoking and alcohol consumption.

• Spifen MR 50mg/4mg Tablet is not recommended for use in patients with a history of gastrointestinal ulcers or bleeding since it may worsen the patient's condition.
• Spifen MR 50mg/4mg Tablet may cause an impairment of fertility in men and women. Consult your doctor before using Spifen MR 50mg/4mg Tablet.

Pain: Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Pain may be dull or sharp, it might be constant or may come and go. The tolerance level of pain might vary from person to person. Pain can be generalized (overall body aches) or localized (affecting a specific area of the body). Pain can be considered a good thing as it helps us know that something is wrong in the body and thereby helps diagnose the condition. The common causes of pain include headache, muscle strain, cramps, cuts, bone fractures, and arthritis.

Osteoarthritis: It is a joint disease in which the two ends of the joints come together due to the breakdown of a protective covering of cartilage. Due to the absence of this protective covering, the joints rub against each other, leading to pain and stiffness. Symptoms include pain, stiffness, inflammation and tenderness.

Rheumatoid arthritis: It is an auto-immune disease (the body's immune system attacks its tissue), leading to joint pain and damage. Symptoms of rheumatoid arthritis include pain, swelling, stiffness, deformities and loss of joint function. 

Ankylosing spondylitis: It causes pain and stiffness in the spine. The pain generally starts in the lower back and can spread to the neck, damaged joints or other body parts. Ankylosing spondylitis includes decreased flexibility which usually leads to hunched-forward posture, pain and back and joints.

Gout: It is caused due to deposits of uric acid crystals in the joints, which leads to pain and inflammation in the joints. Symptoms include pain, swelling and redness in the joints, mostly the big toe.