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Written By , M Pharmacy
Reviewed By , M Pharmacy
Last Updated Jan 1, 2025 | 2:48 PM IST
Spifen MR 50mg/4mg Tablet is used to treat osteoarthritis, rheumatoid arthritis, gouty arthritis, ankylosing spondylitis, acute pain, chronic low back pain, and muscle spasms. It contains Ketoprofen and Thiocolchicoside which work by blocking the chemical messengers that cause pain and relieving muscle stiffness. In some cases, this medicine may cause side effects such as nausea, heartburn, indigestion, dizziness, sleepiness, nervousness, and diarrhoea. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Prescription drug

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Consume Type :

ORAL

Return Policy :

Not Returnable

About Spifen MR 50mg/4mg Tablet

Spifen MR 50mg/4mg Tablet belongs to a group of medicines called pain killer/Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) used for the treatment of osteoarthritis, rheumatoid arthritis, gouty arthritis and ankylosing spondylitis, acute pain, chronic low back pain, and muscle spasms. It relieves the pain and relaxes the muscles. Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Muscle spasm is the sudden involuntary contractions of the muscle, which can be painful and uncomfortable.

Spifen MR 50mg/4mg Tablet is a combination of two drugs: Ketoprofen (NSAID) and Thiocolchicoside (Muscle relaxant). Ketoprofen blocks the effect of a chemical messenger known as cyclo-oxygenase (COX) enzyme that makes other chemical prostaglandins (PG). By blocking the effect of chemical messenger ketoprofen helps in reducing mild to moderate pain and inflammation at the injured or damaged site. Thiocolchicoside is a muscle relaxant and works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements, thereby helping relieve pain due to muscle spasms.

Take Spifen MR 50mg/4mg Tablet as prescribed by your doctor. You are advised to take Spifen MR 50mg/4mg Tablet for as long as your doctor has prescribed it for you depending on your medical conditions. You may experience nausea, heartburn, indigestion and stomach pain, dizziness, sleepiness, nervousness, diarrhea, ringing in the ear. Most of these side effects of Spifen MR 50mg/4mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Spifen MR 50mg/4mg Tablet should not be taken if you are known to be allergic to Spifen MR 50mg/4mg Tablet or any other medicines. Spifen MR 50mg/4mg Tablet should not be taken in the conditions like kidney or heart disease. If you are pregnant or breastfeeding, please inform your doctor before starting Spifen MR 50mg/4mg Tablet. Spifen MR 50mg/4mg Tablet should not be used in children as safety and efficacy have not established. Spifen MR 50mg/4mg Tablet may cause reduced body movements, drowsiness, sleepiness and dizziness it is advisable to you do not drive unless you are alert.

Uses of Spifen MR 50mg/4mg Tablet

Treatment of Osteoarthritis, Rheumatoid arthritis, Gouty arthritis, Ankylosing spondylitis, Acute pain, Chronic low back pain, Muscle spasms.

Medicinal Benefits

Spifen MR 50mg/4mg Tablet is a combination of two drugs: Ketoprofen (pain killer) and Thiocolchicoside (Muscle relaxant). Spifen MR 50mg/4mg Tablet is used for the treatment of osteoarthritis, rheumatoid arthritis, gout and ankylosing spondylitis, acute pain, chronic low back pain, and muscle spasms. Ketoprofen blocks the effect of a chemical messenger known as cyclo-oxygenase (COX) enzyme that makes another chemical 'prostaglandin' (PG). These chemicals are produced at injury sites and cause pain and swelling. By blocking the effect of chemicals, ketoprofen helps in reducing mild to moderate pain and inflammation at the injured or damaged site. Thiocolchicoside works on the centers of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements, thereby helping relieve pain due to muscle spasms.

Side Effects of Spifen MR 50mg/4mg Tablet

  • Nausea
  • Heartburn
  • Indigestion
  • Stomach pain
  • Dizziness
  • Sleepiness
  • Nervousness
  • Diarrhea
  • Ringing in ear

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Spifen MR 50mg/4mg Tablet should not be taken if you are known to be allergic to Spifen MR 50mg/4mg Tablet or any other medicines. Do not take Spifen MR 50mg/4mg Tablet if you are allergic to any of its contents, if you have stomach ulcers, have suffered bleeding problems, clotting problems, inflammatory bowel disease, severe heart, liver or kidney problems. Spifen MR 50mg/4mg Tablet can increase your risk of fatal heart attack or stroke. So, if you have had any recent heart surgery, do not take Spifen MR 50mg/4mg Tablet. Inform your doctor before taking Spifen MR 50mg/4mg Tablet if you have or had stomach bleeding or ulcers, heart failure, high blood pressure, high cholesterol, kidney or liver impairment. Spifen MR 50mg/4mg Tablet may cause a visual disturbance in few patients, inform your doctor and discontinue the Spifen MR 50mg/4mg Tablet immediately if you observe this symptom. This Spifen MR 50mg/4mg Tablet may increase the potassium level, regular monitoring of potassium level may need. Do not take Spifen MR 50mg/4mg Tablet if you are pregnant, planning for pregnancy or breastfeeding. If you are pregnant or breastfeeding, please inform your doctor before starting Spifen MR 50mg/4mg Tablet. Spifen MR 50mg/4mg Tablet should not be used in children as safety and efficacy have not established. Spifen MR 50mg/4mg Tablet may cause reduced body movements, drowsiness, sleepiness and dizziness it is advisable to you do not drive unless you are alert.

Therapeutic Class

ANALGESICS

Drug-Drug Interactions

verifiedApollotooltip
KetoprofenKetorolac
Critical
KetoprofenEverolimus
Severe

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.
  • Follow heat or cold therapy, apply a cold or hot compress on the joints for 15-20minutes regularly.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listen to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

How Spifen MR 50mg/4mg Tablet Works

Spifen MR 50mg/4mg Tablet is a combination of two drugs: Ketoprofen (NSAID) and Thiocolchicoside (Muscle relaxant). Ketoprofen blocks the effect of a chemical messenger known as cyclo-oxygenase (COX) enzyme that makes other chemical prostaglandins (PG). By blocking the effect of chemical messenger ketoprofen helps in reducing mild to moderate pain and inflammation at the injured or damaged site. Thiocolchicoside is a muscle relaxant and works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements, thereby helping relieve pain due to muscle spasms.

What if I have taken an overdose of Spifen MR 50mg/4mg Tablet

Avoid exceeding the recommended dose as it might cause an overdose. Seek immediate medical attention if you experience any unusual symptoms.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Spifen MR 50mg/4mg Tablet as it may increase drowsiness. It can also increase the risk of stomach bleeding.

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Pregnancy

Unsafe

Spifen MR 50mg/4mg Tablet is not recommended for use in pregnant women. Please consult your doctor if you have any concerns regarding this.

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Breast Feeding

Caution

Please consult your doctor before taking Spifen MR 50mg/4mg Tablet, your doctor will prescribe only if the benefits outweigh the risks.

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Driving

Caution

Spifen MR 50mg/4mg Tablet may cause dizziness, sleepiness and reduced body movements. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Spifen MR 50mg/4mg Tablet should not be given to children as the safety and effectiveness were not established.

Country of origin

India
Other Info - SP51573

Author Details

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FAQs

Spifen MR 50mg/4mg Tablet is used to relieve pain in conditions like osteoarthritis, rheumatoid arthritis, gouty arthritis, ankylosing spondylitis, low back pain, and muscle spasms.
Spifen MR 50mg/4mg Tablet is a combination of two drugs: Ketoprofen and Thiocolchicoside. Ketoprofen blocks the effect of a chemical messenger known as cyclo-oxygenase (COX) enzyme that makes another chemical 'prostaglandin' (PG). These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the effect of chemicals ketoprofen helps in reducing mild to moderate pain and inflammation at the injured or damaged site. Thiocolchicoside is a muscle relaxant that works on the centers of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements, thereby helping relieve pain due to muscle spasms. This Spifen MR 50mg/4mg Tablet is thus better efficient in relieving inflammation and pain.
Spifen MR 50mg/4mg Tablet is used to reduce and relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis, gouty arthritis and ankylosing spondylitis. Arthritis is the tenderness and swelling in the joints.
Diarrhea might be a side-effect of Spifen MR 50mg/4mg Tablet. Drink enough fluids and eat fiber-rich food if you experience diarrhea. If you find blood in stools (tarry stools) or if you experience excess diarrhea consult your doctor. Do not take anti-diarrheal medicine on your own.
Spifen MR 50mg/4mg Tablet might cause swelling of feet and hands due to fluid retention (edema). While lying down, raise your legs above by putting a pillow below them. Follow a low-salt diet as it might help in reducing fluid build-up.
In some patients, this Spifen MR 50mg/4mg Tablet may cause a visual disturbance. Immediately discontinue the Spifen MR 50mg/4mg Tablet in case of visual difficulties and contact your doctor.

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