Siz-LS Capsule is used to treat gastro-oesophageal reflux disease (GERD), acidity, heartburn, Zollinger-Ellison syndrome, Helicobacter pylori infection, irritable bowel syndrome, indigestion, duodenal and gastric ulcers. The stomach is usually protected from acid by a mucous layer. In some cases, due to excess acid production, the mucous layer gets eroded, which leads to acidity. 
 
Siz-LS Capsule is a combination of two drugs: Rabeprazole (proton pump inhibitor) and Levosulpiride (prokinetic agent). Rabeprazole works by blocking an enzyme called the gastric proton pump, which is responsible for acid production. Levosulpiride works by increasing the pressure of the inferior oesophageal (food pipe) sphincter, thereby preventing the backflow of food and acid into the mouth. Together, Siz-LS Capsule helps in preventing acid reflux, thereby providing relief from acidity and heartburn.
 
You are advised to take Siz-LS Capsule for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as headache, nausea, vomiting, gas, abdominal pain, dizziness, and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Inform your doctor if you have a history of gastrointestinal bleeding or intestinal obstruction. On long-term treatment, Siz-LS Capsule may cause osteoporosis and hypomagnesemia. Consult a doctor if you are pregnant or breastfeeding. Siz-LS Capsule may cause drowsiness and dizziness, so drive only if you are alert. Siz-LS Capsule is not recommended for children as safety and effectiveness have not been established. Avoid consuming alcohol along with Siz-LS Capsule as it could lead to increased drowsiness and elevate stomach acid production.

Siz-LS Capsule is a combination of two drugs: Rabeprazole and Levosulpiride. Siz-LS Capsule belongs to a group of medicines called gastrointestinal agents used to treat gastro-oesophageal reflux disease (GERD), acidity, heartburn, Zollinger-Ellison syndrome, Helicobacter pylori infection, irritable bowel syndrome, indigestion, duodenal and gastric ulcers. Rabeprazole is a proton pump inhibitor that works by blocking an enzyme called gastric proton pump, which is responsible for the production of acid. Levosulpiride is a prokinetic agent that increases the pressure of the inferior oesophageal (food pipe) sphincter, thereby preventing the backflow of food and acid into the mouth. Together, Siz-LS Capsule helps in preventing acid reflux, thereby providing relief from acidity and heartburn. 

• Headache
• Nausea
• Vomiting
• Flatulence
• Abdominal pain
• Dizziness
• Diarrhoea 

Do not take Siz-LS Capsule if you are allergic to any of its components. Inform your doctor if you have a history of pheochromocytoma (tumour of the adrenal gland), epilepsy, mania, gastrointestinal bleeding, intestinal obstruction, or severe kidney or liver impairment. Siz-LS Capsule may cause osteoporosis (weak and brittle bones) and hypomagnesemia (low magnesium levels) on long-term treatment. Consult a doctor if you are pregnant or breastfeeding. Siz-LS Capsule may cause dizziness and drowsiness, so drive only if you are alert. Siz-LS Capsule is not recommended for children as safety and effectiveness have not been established.

Drug-Drug Interactions: Siz-LS Capsule may interact with a blood thinner (warfarin), anti-cancer (methotrexate), cardiac glycoside (digoxin), immunosuppressant (mycophenolate mofetil, tacrolimus), antibiotic (amoxicillin, clarithromycin).

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform your doctor if you have gastrointestinal bleeding, intestinal obstruction, epilepsy, mania, Clostridium difficile-associated diarrhoea (CDAD), hyperprolactinemia (high levels of prolactin), bone fractures, or hypomagnesemia (low levels of magnesium).

• WARFARIN
• METHOTREXATE
• DIGOXIN
• MYCOPHENOLATE MOFETIL
• TACROLIMUS
• AMOXICILLIN
• CLARITHROMYCIN

• Eat smaller meals more often.

• Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increases acidity and heartburn.

• Maintain a healthy weight by regular exercising.

• Avoid lying down after eating to prevent acid reflux.

• Avoid tight-fitting clothes as it might increase the pressure on the abdomen leading to acid reflux.

• Practice relaxation techniques and avoid stress by doing yoga or meditation.

• Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea, and soda. 

• Avoid sitting continuously as it may trigger acidity. Take a break of 5 minutes every hour by doing brisk walking or stretching.

• Siz-LS Capsule might cause false-positive results for secretin stimulation test, prolactin test, and tests for tetrahydrocannabinol (THC). Inform the person doing the tests that you are taking Siz-LS Capsule .

• Regular blood tests for monitoring magnesium levels and bone density tests are advised if you are on long-term treatment with Siz-LS Capsule .

• Inform your doctor if you are due to have Chromogranin A test.

Acidity: The stomach is usually protected from acid by a mucous layer. In some cases, due to excess acid production, the mucous layer gets eroded, which leads to complications like GERD, acidity, heartburn, and peptic ulcers.

Gastroesophageal reflux disease (GERD): It occurs when stomach acid frequently flows into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn and acidity. Symptoms include heartburn, sour or bitter taste in the mouth, and difficulty swallowing. 

Stomach ulcers: Stomach ulcers are sores that develop on the stomach and intestine lining due to erosion of the protective stomach lining. Symptoms include nausea, changes in appetite, bloody or dark stools, unexplained weight loss, vomiting, and indigestion. 

Indigestion: Indigestion is the feeling of fullness. It occurs due to slow gastric emptying. Symptoms include stomach pain, bloating, heartburn, nausea, and vomiting.