Sine 10mg Tablet is used to treat and prevent Raynaud's phenomenon, cerebral vascular insufficiency (poor blood flow to the brain), arteriosclerosis (hardening of the arteries), and other conditions involving poor blood flow in the blood vessels (veins and arteries). Besides this, it is also used to relax uterine muscles to prevent premature labour (when the uterus starts contracting for birth earlier than usual).

Sine 10mg Tablet contains Isoxsuprine, which relaxes and widens the blood vessels (artery/veins) and muscles (like uterine muscle), thereby increasing the blood flow to the muscles and blocking nerves, delaying contraction in premature labour pains, and poor blood flow to organs and other body parts.

Sine 10mg Tablet should be taken regularly in dose and duration as advised by the doctor. It would be best to take it at a fixed time every day. Your doctor will advise you on the exact dosage and how often you have to take Sine 10mg Tablet based on your medical condition. In some cases, you may experience chest pain (angina), irregular heartbeat, nausea, vomiting, and weakness. Most of these side effects of Sine 10mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Sine 10mg Tablet should not be stopped abruptly without consulting the doctor as it may lead to unpleasant side effects. Also, it is not suitable for some people. Inform your doctor before starting Sine 10mg Tablet if you have any bleeding disorders or heart problems. Do not do strenuous activities to avoid premature labour. Sine 10mg Tablet may cause sudden falls in blood pressure, so if you are driving or operating a motor vehicle or doing any hazardous task, avoid it. Do not stand suddenly from a lying position, as you may feel dizzy. Alcohol intake with Sine 10mg Tablet can also cause dizziness, so one should avoid its intake.

Sine 10mg Tablet contains Isoxsuprine, which is a vasodilator. It relaxes and widens the blood vessels (artery/veins) and muscles (like uterine muscle), thereby relaxing them and increasing blood circulation to these parts. It is recommended to avoid strenuous exercise and work for the best results of Sine 10mg Tablet. So, it is prescribed for the treatment of cerebrovascular insufficiency (poor blood flow to the brain), peripheral vascular disease (blocked veins of the leg), Buerger's disease (blood clot in arm and legs) and Raynaud's disease (numb and cold sensation due to blocked nerves of hand). It helps in the prevention of preterm labour in pregnant women.

• Weakness
• Dizziness
• Flushing (feeling of warmth)
• Upset stomach
• Vomiting
• Stomach pain

Sine 10mg Tablet should not be given to people allergic to Sine 10mg Tablet, have low blood pressure (less than 90 mm of Hg), or have a heart or bleeding problem. Tell your doctor you are using the Sine 10mg Tablet before undergoing dental or other surgery. Your doctor might stop this medicine before the surgery. Sine 10mg Tablet should not be stopped abruptly without consulting the doctor as it may lead to unpleasant side-effects. Also, lifestyle changes should be continued with Sine 10mg Tablet for best results and a speedy recovery. Sine 10mg Tablet may cause dizziness, so if you are sitting, rise slowly to avoid falling and not driving or operating a car. Also, any strenuous exercise or work should be avoided to avoid delivery complications.

Drug-Drug Interactions: Sine 10mg Tablet interacts with some medicines, so it should be used with caution with antibiotics (erythromycin, clarithromycin or rifampicin), antifungal  (ketoconazole), anti-hypertensive (diltiazem, lovastatin, simvastatin, atorvastatin),  anti-migraine (ergotamine, dihydroergotamine), sedatives or hypnotics (buspirone), certain antidepressants (fluoxetine and lithium), medicines to lower blood pressure (methyldopa), anti-Parkinson’s (levodopa, pramipexole, ropinirole), anti-epilepsy (phenobarbital, carbamazepine, phenytoin, rifampicin, primidone, oxcarbazepine, ethosuximide, valproate).

Drug-Food Interactions: Please tell your doctor about all the Vitamins, herbs, and supplements you are taking as Sine 10mg Tablet may interact with them to produce unpleasant side effects. 

Drug-Disease Interactions: Sine 10mg Tablet should be taken with caution in people who have low blood pressure, a bleeding problem, especially arterial bleeding, have had a heart attack or any heart problem.

• KETOCONAZOLE
• ERYTHROMYCIN
• LEVODOPA
• ROPINIROLE
• PHENOBARBITAL
• LITHIUM
• FLUOXETINE
• VALPROATE
• PRAMIPEXOLE
• BUSPIRONE
• DIHYDROERGOTAMINE
• SIMVASTATIN
• ATORVASTATIN

• Keep your weight under control with a body mass index (BMI) of 19.5-24.9.

• Opt for a diet rich in whole grains, fruits, veggies, and low-fat dairy products.

• Limit sodium chloride (table salt) intake in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.

• If you are taking alcohol, then only one serving for women and two servings is advisable.

• Quitting smoking is the best strategy to lower the risk of heart disease.

• Avoid chronic stress as it can raise your blood pressure. Try to enjoy and spent time with your loved ones to cope with stress and practice mindfulness techniques.

• Monitor your blood pressure daily and if there is too much fluctuation, then immediately contact your doctor.

• Try to include heart-healthy omega-3 fatty acid-containing food drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.

• Use caution while driving a motor vehicle, operating machinery, or performing other hazardous activities as, Sine 10mg Tablet may cause dizziness, so if you experience dizziness or drowsiness, avoid these activities. Try to rise slowly from a sitting or lying position to avoid falling.

• Notify your doctor if you experience skin rash or palpitations (irregular heartbeats) after using Sine 10mg Tablet.

• Do not use Sine 10mg Tablet immediately after bleeding from childbirth (postpartum) and artery (blood vessel).

Premature labour: Also known as preterm labour, occurs when regular contractions and relaxations of the uterus result in the opening of your cervix after week 20 and before week 37 of pregnancy. It can lead to premature birth and other greater risks to the baby.

Cerebrovascular insufficiency: It occurs when there is obstruction of one or more blood vessels (arteries) that supply blood to the brain. This obstruction leads to strokes or transient ischemic attacks (TIAs or 'mini-strokes').

Buerger's disease: Buerger's disease occurs commonly in the arms and legs, where blood vessels get swollen, thereby preventing blood flow and causing clots to form. This leads to pain, tissue damage, and the formation of gangrene (death of body tissues).

Raynaud's phenomenon: Raynaud's phenomenon occurs due to blocked nerves resulting in discolouration of the fingers and/or the toes after exposure to extreme cold or hot temperatures conditions. Skin discolouration shows a diminished blood supply to the local tissues.