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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Nov 23, 2024 | 4:28 PM IST
Sayana Press 104mg/0.65ml Injection is used in the treatment of amenorrhea (the unusual cessation of menstrual periods) and abnormal uterine bleeding. It is also used for the Prevention of endometrial hyperplasia (thickening of the uterine or womb lining) in women who take conjugated estrogen. It contains medroxyprogesterone acetate (DMPA), which is similar to (but not the same as) the natural hormone progesterone produced in the ovaries during the second half of your menstrual cycle. During your menstrual cycle, it prevents an egg from fully maturing and being discharged from the ovaries. If an egg is not released, it cannot be fertilised by sperm.
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Prescription drug

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Prescription drug
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Synonym

DEPOT MEDROXYPROGESTERONE ACETATE

Manufacturer/Marketer

Pfizer Ltd

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Sayana Press 104mg/0.65ml Injection

Sayana Press 104mg/0.65ml Injection belongs to a group of medicines called progestogens used as a long-acting contraceptive. Contraception is a procedure that aims to prevent unwanted pregnancy for safe family planning.

Sayana Press 104mg/0.65ml Injection contains medroxyprogesterone acetate (DMPA), which is similar to (but not the same as) the natural hormone progesterone, which is produced in the ovaries during the second half of your menstrual cycle. During your menstrual cycle, Sayana Press 104mg/0.65ml Injection prevents an egg from fully maturing and being discharged from the ovaries. If an egg is not released, it cannot be fertilised by sperm and result in pregnancy.

Sayana Press 104mg/0.65ml Injection will be administered by your doctor or healthcare professional. In some cases, you may have nervousness, headache, stomach pain or discomfort, weight increase or decrease, libido decreased (reduced sex drive), dizziness, and feeling sick and depressed. Most of these side effects of Sayana Press 104mg/0.65ml Injection do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Let your doctor know before prescribing Sayana Press 104mg/0.65ml Injection if you have, or had migraine headaches, diabetes, Severe pain or swelling in the calf, eye disorders, depression, liver or kidney disorders, osteoporosis, asthma, or epilepsy. And also inform your doctor if you are pregnant or expecting pregnancy or breastfeeding or taking if you are using certain medicines such as high-dose glucocorticoids (steroids).

Uses of Sayana Press 104mg/0.65ml Injection

i. Treatment of amenorrhea (the unusual cessation of menstrual periods) and abnormal uterine bleeding. ii. Prevention of endometrial hyperplasia (thickening of the uterine or womb lining) in women who take conjugated estrogen

Medicinal Benefits

Sayana Press 104mg/0.65ml Injection contains medroxyprogesterone acetate (DMPA), which is close to (but not the same as) progesterone, a natural hormone secreted in the ovaries during the second half of your menstrual cycle. Sayana Press 104mg/0.65ml Injection prevents an egg from fully developing and being released from the ovaries during your menstrual cycle. An egg that is not released cannot be fertilised by sperm and result in pregnancy. On the other hand, it also induces changes in the lining of your womb, making conception less likely. It also thickens the mucus at the womb's opening, making sperm entry more difficult.

Directions for Use

Sayana Press 104mg/0.65ml Injection will be administered by a qualified healthcare professional. Kindly do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Sayana Press 104mg/0.65ml Injection

  • Nervousness
  • Headache
  • Stomach pain or discomfort
  • Weight increase or decrease
  • Depression
  • Libido decreased (reduced sex drive)
  • Dizziness
  • Feeling sick
  • Feeling bloated
  • Hair loss
  • Acne
  • Rash
  • Back pain
  • Vaginal discharge
  • Breast tenderness
  • Fluid retention
  • Weakness

Drug Warnings

Sayana Press 104mg/0.65ml Injection should not be used if you are allergic to any of its components. Inform your doctor if you are allergic to any of the substances. Before taking Sayana Press 104mg/0.65ml Injection, inform your healthcare provider if you have or have had migraine headaches, vaginal bleeding, blood disorders (such as deep vein thrombosis), diabetes, severe pain or swelling in the calf, eye diseases, depression, liver (such as jaundice) or kidney disorders, osteoporosis, asthma, or epilepsy and hormone-dependent cancer of the breast or sex organs. Also, tell your doctor if you are pregnant, expecting a pregnancy, breastfeeding, or using certain medications, such as high-dose glucocorticoids (steroids).

Drug Interactions

Drug-Drug Interactions: Sayana Press 104mg/0.65ml Injection may have an interaction with medicines, including aminoglutethimide, or other medicines that thin your blood (anticoagulants such as warfarin) and anti-seizure medicines (e.g. topiramate).

Drug-Food Interactions: Sayana Press 104mg/0.65ml Injection may interact with grapefruit.

Drug-Disease Interactions: Inform your doctor if you have abnormal genital bleeding, low level of bone minerals, breast cancer, liver disease, and thromboembolism (blood clot problem).

Drug-Drug Interactions Checker List

  • WARFARIN
  • TOPIRAMATE

Habit Forming

No

Diet & Lifestyle Advise

  • Keep your weight under control with a body mass index (BMI) of 19.5-24.9.
  • Opt for a diet rich in whole grains, fruits, veggies, and low-fat dairy products.
  • Including heart-healthy omega-3 fatty acid-containing food drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.
  • Do regular exercise to maintain weight fluctuations caused due to Sayana Press 104mg/0.65ml Injection.
  • Avoid chronic stress and exercise like running, as it might increase vaginal bleeding.
  • Try to be stress-free to improve your mood swings due to hormonal fluctuations. 
  • Monitor your blood pressure daily and if there is too much fluctuation, immediately contact your doctor.
  • Monitor your blood sugar level and blood pressure regularly to avoid any complications.
  • Quitting smoking and not drinking alcohol is the best strategy to lower the risk of any complications.

Disease/Condition Glossary

Contraception: It is a procedure that aims to prevent pregnancy. A woman can only get pregnant if a man's sperm fertilizes her egg. Contraception aims to prevent this from happening by keeping egg and sperm apart by stopping egg production or not letting the uterus wall become thick. As a result, no fertilization takes place, so contraception is a safe method for family planning.

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Alcohol

Caution

It is not known whether it is safe to consume alcohol with Sayana Press 104mg/0.65ml Injection. However, as a precautionary measure, it is advisable not to take or limit alcohol.

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Pregnancy

Unsafe

Sayana Press 104mg/0.65ml Injection must not be taken if you are pregnant as hormonal medicines can affect the developing baby.

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Breast Feeding

Safe if prescribed

Sayana Press 104mg/0.65ml Injection can be safely used by nursing mothers. Your doctor or healthcare professional may advise that you wait until at least 6 weeks after your baby has been born before you start using Sayana Press 104mg/0.65ml Injection for contraception.

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Driving

Caution

Sayana Press 104mg/0.65ml Injection usually does not impact your ability to drive or operate machinery.

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Liver

Caution

Inform your doctor before receiving the Sayana Press 104mg/0.65ml Injection if you have a liver impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Inform your doctor before receiving the Sayana Press 104mg/0.65ml Injection if you have a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Unsafe

Sayana Press 104mg/0.65ml Injection is not recommended for children below 12 years of age.

Country of origin

INDIA

Manufacturer/Marketer address

The Capital, 1802, 18th Floor , Plot No. C-70, ‘G’ Block , Bandra Kurla Complex, Bandra East , Mumbai – 400051
Other Info - SAY0022

Author Details

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FAQs

Sayana Press 104mg/0.65ml Injection is used to treat amenorrhea (the unusual cessation of menstrual periods) and abnormal uterine bleeding. Besides that, it can also use to prevent endometrial hyperplasia (thickening of the uterine or womb lining) in women who take conjugated estrogen.
Sayana Press 104mg/0.65ml Injection prevents an egg from fully developing and being released from the ovaries during your menstrual cycle. An egg that is not released cannot be fertilised by sperm and result in pregnancy. On the other hand, it also induces changes in the lining of your womb, making conception less likely. It also thickens the mucus at the womb's opening, making sperm entry more difficult.
It is recommended not to take any other contraceptives with Sayana Press 104mg/0.65ml Injection without a doctor's prescription.
Yes, the Sayana Press 104mg/0.65ml Injection may cause hair loss. If you feel that you are experiencing a lot of hall falls while taking Sayana Press 104mg/0.65ml Injection, please consult your doctor.
Do not use Sayana Press 104mg/0.65ml Injection if you are allergic to medroxyprogesterone acetate, or any other similar hormonal medicines, if you have/had breast cancer, a blood clotting disorder such as deep vein thrombosis (blood clot in the legs) or pulmonary embolism (blood clot in the lung), severe liver disease such as jaundice, unexplained vaginal bleeding or if you are pregnant or think you may be pregnant or If you have not yet started your periods.
Sayana Press 104mg/0.65ml Injection can be used for just one or two occasions in a few cases such as if your partner is having a vasectomy, Sayana Press 104mg/0.65ml Injection can be used to protect you until the vasectomy takes place, or if you are being immunised against rubella, to prevent conception during the virus's active phase, or if you are awaiting sterilisation.
Sayana Press 104mg/0.65ml Injection is not primarily used as a contraceptive, but Medroxyprogesterone injections are commonly used as contraception.
Weight gain is a possible side effect of Sayana Press 104mg/0.65ml Injection, but it can often be managed with diet and exercise. The weight gain can vary from person to person, and it's more likely to occur with higher doses. By maintaining a healthy lifestyle, you can minimize the impact of weight gain while taking Sayana Press 104mg/0.65ml Injection.
Sayana Press 104mg/0.65ml Injection is a generally safe and effective medication when used as directed. However, as with any medication, it may not be suitable for everyone and can cause side effects in some individuals. To ensure safe and effective use, following your healthcare provider's instructions is essential.
Withdrawal bleeding usually occurs within 3 to 7 days after you stop taking Sayana Press 104mg/0.65ml Injection. Consult your doctor if your condition does not improve or if it worsens.
Take Sayana Press 104mg/0.65ml Injection at the same time every day, with or without food as directed, and swallow it whole with water. Don't crush, break, or chew it.
If you miss to take a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose. Do not take a double dose.
The common side effects of Sayana Press 104mg/0.65ml Injection include headache, nausea, dizziness, hair loss, acne, and unusual vaginal bleeding or spotting. Most of these side effects of Sayana Press 104mg/0.65ml Injection do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.

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