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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Jan 1, 2025 | 2:47 PM IST

Samplus Capsule is used to treat liver disease, depression, and osteoarthritis. It works by protecting the liver from toxins, regulating mood and stimulating the production of cartilage. In some cases, this medicine may cause side effects such as headache, vomiting, diarrhoea, and dizziness. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Synonym :

S ADENOSYL L METHIONINE

Composition :

ADEMETIONINE-100MCG

Manufacturer/Marketer :

Elder Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Jan-27

About Samplus Capsule

Samplus Capsule is used to treat various medical conditions, including depression, reduce pain and swelling in the joints, and conditions such as osteoarthritis, biliary cholangitis (an autoimmune disease of the liver), and excess cholesterol in bile and biliary and liver diseases caused by cystic fibrosis. It is also used to treat liver disease during pregnancy, improve symptoms in people with fibromyalgia, and treat nerve problems in people with AIDS or sexual dysfunction in men with depression.

Samplus Capsule contains Ademetionine, a naturally occurring substance found in cells, tissue, and body fluids. It is produced from methionine (amino acid) and is used to treat liver disease, depression, and osteoarthritis. Samplus Capsule ensures sufficient levels of glutathione in the liver are maintained to minimize liver damage. It also prevents the increase of lipids associated with cirrhosis outside the liver. It also affects certain chemical messengers (serotonin) in the brain, which communicate between brain cells, regulating mood and treating depression. It stimulates the production of parts of cartilage, reduces the inflammatory mediator, and has painkilling properties.

Take Samplus Capsule as recommended by your doctor. In some cases, you may experience common side effects such as abdominal discomfort, abdominal pain, diarrhoea, nausea, dizziness, and insomnia. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not discontinue Samplus Capsule without consulting your doctor. Consult the doctor if you are pregnant or breastfeeding. Samplus Capsule can be given to children with extreme caution if recommended by the doctor. Avoid consuming alcohol with Samplus Capsule as it could lead to increased drowsiness and liver damage. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Samplus Capsule

Treatment of Depression, Primary biliary cholangitis, Osteoarthritis.

Medicinal Benefits

The Samplus Capsule contains Ademetionine, a naturally occurring substance in cells, tissue, and body fluids. It is produced from methionine (amino acid) and is used to treat liver disease, depression, and osteoarthritis. In liver disease, Samplus Capsule ensures sufficient glutathione levels in the liver to minimize liver damage. It also prevents the increase of lipids associated with cirrhosis outside the liver. In depression, it affects certain chemical messengers (serotonin) in the brain, which communicate between brain cells, thereby regulating mood and treating depression. In osteoarthritis, It stimulates the production of cartilage parts, reduces the inflammatory mediator, and has painkilling properties. Samplus Capsule is also effective in treating liver disease during pregnancy, improving symptoms in fibromyalgia, treating nerve problems in people with AIDS, or sexual dysfunction in men with depression.

Side Effects of Samplus Capsule

  • Headache
  • Dizziness
  • Feeling anxious
  • Vomiting
  • Stomach upset
  • Diarrhoea
  • Constipation
  • Insomnia (sleep problem)
  • Increased sweating

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take Samplus Capsule if you are allergic to any of its contents, if you have used an MAO inhibitor in the past 14 days, if the inflammation of gall bladder and bile ducts, narrowing or blockage of bile ducts, biliary colic, calcified gallstones, improper constriction of the gallbladder, gastric or duodenal ulcer. Inform your doctor if you have heart disease, seizure disorders, bone marrow suppression, diabetes, schizophrenia, bipolar disorder, acute alcohol intoxication, glaucoma, thyroid problems, or kidney and liver problems. Do not take Samplus Capsule if you are pregnant or breastfeeding unless advised by your doctor. Samplus Capsule can be given to children with caution if recommended by the doctor. Avoid consuming alcohol along with Samplus Capsule as it could lead to increased drowsiness and liver damage. Keep your doctor informed about your health condition and medicines to rule out any unpleasant side effects.

Therapeutic Class

NUTRITIONAL SUPPLEMENT

Diet & Lifestyle Advise

Liver disease:

  • Include foods such as bell peppers, citrus fruits, leafy vegetables, tomatoes, milk, fish, low-fat dairy, beans, nuts, lentils, tofu, and tempeh in your diet.
  • Foods rich in vitamins B and C and calcium are good for the gallbladder.
  • Plant-based protein foods such as beans, nuts, lentils, tofu, and tempeh help prevent gallbladder disease.
  • Avoid high-fat, trans-fat, processed foods, white bread, white pasta, and sugars.
  • Avoid tobacco and alcohol consumption.

Depression:

  • Maintaining a healthy diet and regular exercise helps improve overall health and boost self-esteem.
  • Perform meditation and yoga. This helps in relieving stress and provides relaxation.
  • Follow a regular sleep pattern to improve the amount and quality of sleep you get.
  • Include foods rich in omega fatty acids such as fish, nuts, fresh fruits, vegetables, and olive oils.
  • Neurotransmitters are made up of amino acids. Amino acid-rich foods such as meat, dairy products, and certain fruits and vegetables help properly maintain neurotransmitters. 
  • Avoid smoking and alcohol consumption.

Osteoarthritis:

  • Physical activity helps strengthen muscles and relieves joint stiffness. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Follow heat or cold therapy, and apply a cold or hot compress on the joints for 15-20 minutes regularly.

Habit Forming

No

How Samplus Capsule Works

Samplus Capsule contains Ademetionine, a naturally occurring substance found in cells, tissue, and body fluids. It is produced from methionine (amino acid) and is used to treat liver disease, depression, and osteoarthritis. Samplus Capsule ensures sufficient levels of glutathione in the liver are maintained to minimize liver damage. It also prevents the increase of lipids associated with cirrhosis outside the liver. It also affects certain chemical messengers (serotonin) in the brain, which communicate between brain cells, regulating mood and treating depression. It stimulates the production of parts of cartilage, reduces the inflammatory mediator, and has painkilling properties.

What if I have taken an overdose of Samplus Capsule

Take Samplus Capsule only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.
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Alcohol

Caution

Avoid consumption of alcohol while taking Samplus Capsule as it may cause increased dizziness and liver damage.

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Pregnancy

Caution

Avoid taking Samplus Capsule if you are pregnant unless advised by a doctor. Please consult your doctor if you have any concerns regarding this, your doctor will recommend only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor before taking Samplus Capsule, your doctor will decide whether Samplus Capsule can be taken by breastfeeding mothers or not.

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Driving

Caution

Samplus Capsule does not affect your ability to drive. However, you are advised to be cautious while driving if you experience dizziness.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Samplus Capsule can be given to children with caution only if recommended by the doctor.

Country of origin

India

Manufacturer/Marketer address

“Elder House” Plot No. C-9, Dalia Industrial Estate, Off Veera Desai Road, Andheri (W), Mumbai – 400053.
Other Info - SAM0047

Author Details

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FAQs

Samplus Capsule is used to treat various medical conditions, including depression, osteoarthritis, biliary cholangitis (an autoimmune disease of the liver), and excess cholesterol in bile and biliary and liver diseases caused by cystic fibrosis. It is also used to treat liver disease during pregnancy, improve symptoms in people with fibromyalgia, and treat nerve problems in people with AIDS or sexual dysfunction in men with depression.
Samplus Capsule contains Ademetionine is used in the treatment of liver disease, depression, and osteoarthritis. It is used in liver conditions associated with reduced bile formation (intrahepatic cholestasis). It restores the balance of serotonin, a natural chemical present in the brain. It also blocks the production of certain inflammatory chemical substances that cause pain and swelling in osteoarthritis.
If you miss a dose, take it as soon as you remember. However, if it is time for the next scheduled dose, skip the missed dose and follow your usual dosage.
Do not discontinue Samplus Capsule without consulting your doctor. To treat your condition effectively, continue taking Samplus Capsule for as long as advised. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Samplus Capsule.
Do not take Samplus Capsule if you have used MAO inhibitors (like isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others) in the last 14 days as the co-administration of Samplus Capsule and MAO inhibitor cause serious drug interaction. Let know doctor know about this.
No, the Samplus Capsule does not cure arthritis. Samplus Capsule is only used to relieve symptoms of arthritis, such as joint pain, swelling and stiffness.
Yes, Samplus Capsule is good for the liver. It aids liver function, minimises liver damage and treats liver disease.
Samplus Capsule contains Ademetionine, a naturally occurring substance found in cells, tissue, and body fluids. It is produced from methionine (amino acid).
Do not take Samplus Capsule if you are allergic to any of its components, if you have used an MAO inhibitor in the past 14 days, or if you have inflammation of gall bladder and bile ducts, narrowing or blockage of bile ducts, biliary colic, calcified gallstones, improper constriction of the gallbladder, gastric or duodenal ulcer.
Samplus Capsule may cause side effects such as abdominal discomfort, abdominal pain, diarrhoea, nausea, dizziness, and insomnia. Talk to your doctor if you experience these side effects persistently.
It is not known if Samplus Capsule is safe to use for the long term. Take Samplus Capsule for the duration prescribed by the doctor.

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