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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Jan 1, 2025 | 2:48 PM IST
Ryfate O Oral Suspension is used to treat acidity, heartburn, and gastrointestinal ulcers. It contains Sucralfate and Oxetacaine which work by forming a protective barrier and exerting a numbing effect. This medicine may sometimes cause side effects such as constipation, dizziness, sleepiness, dry mouth, blurred vision, and diarrhoea. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Prescription drug

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Manufacturer/Marketer :

Syndicate Life Sciences Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Ryfate O Oral Suspension

Ryfate O Oral Suspension is used to treat peptic ulcers or gastrointestinal ulcers. It also treats hyperacidity, heartburn, indigestion, and gastritis (inflammation of the stomach). The stomach is usually protected from acid by a mucous layer. In some cases, due to excess acid production, the mucous layer gets eroded, which leads to complications like acidity and heartburn. A peptic ulcer is a sore on the stomach's lining or the first part of the small intestine (duodenum). Ulcers or sores of the stomach region are called gastric ulcers, while the duodenum ulcer is known as a duodenal ulcer.

Ryfate O Oral Suspension is a combination of two medicines: Sucralfate and Oxetacaine. Sucralfate is a gastrointestinal protectant that works by forming a protective barrier or coat over the ulcer so that digestive enzymes, acid and bile salts cannot further irritate the lining of the stomach duodenum. This protects the ulcer from the acid of the stomach, allowing it to heal. Besides this, Oxetacaine is a local anaesthetic that exerts a numbing effect, thereby providing relief from pain due to ulcers or acidic injury in the stomach.

It is better to take Ryfate O Oral Suspension an hour before a meal or without a meal for its best results. Your doctor will advise you on how often you take Ryfate O Oral Suspension based on your medical condition. Some people may experience common side effects like constipation, dizziness, sleepiness, dry mouth, blurred vision, and diarrhoea. Most of these side effects of Ryfate O Oral Suspension do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Ryfate O Oral Suspension or active and inactive ingredients present on it, please tell your doctor. If you are pregnant or breastfeeding, it is advised to consult a doctor before using Ryfate O Oral Suspension. Ryfate O Oral Suspension should not be given to children as safety has not been established. Try not to stop taking Ryfate O Oral Suspension of your own. Stopping a sudden intake of Ryfate O Oral Suspension will not influence the frequency or severity of future ulceration. Avoid taking aluminium and magnesium-containing antacids with Ryfate O Oral Suspension. Aluminium-containing antacids and Ryfate O Oral Suspension could lead to constipation and intestinal obstruction, whereas magnesium-containing antacids might cause diarrhoea.  Avoid consuming alcohol along with Ryfate O Oral Suspension as it could lead to increased acidity.

Uses of Ryfate O Oral Suspension

Treatment of Acidity, Heartburn, Stomach ulcer, Duodenal ulcer.

Medicinal Benefits

Ryfate O Oral Suspension belongs to a group of anti-ulcerants used to treat acidity, heartburn, gas and stomach ulcers. Ryfate O Oral Suspension is a combination of two medicines: Sucralfate (anti-ulcer) and Oxetacaine (Local anaesthetic). Sucralfate works by forming a protective barrier or coat over the ulcer to pepsin and bile and inhibiting gastric acid diffusion. This protects the ulcer from the acid of the stomach, allowing it to heal. It exhibits a cytoprotective effect and forms a viscous, adhesive barrier on the intact intestinal mucosa and stomach surface. It also stimulates the synthesis and release of gastric mucosal prostaglandins and bicarbonate and the epidermal growth factor that stimulates healing and formation of new healthy skin. On the other hand, Oxetacaine exerts a numbing effect, thereby providing relief from pain due to ulcers or acidic injury in the stomach. It does not lose its activity even in strongly acidic conditions and provides prolonged anaesthetic action.

Side Effects of Ryfate O Oral Suspension

  • Constipation

  • Dizziness

  • Sleepiness

  • Dry Mouth

  • Nausea

Directions for Use

Take Ryfate O Oral Suspension one hour before a meal or as advised by the doctor. Shake the bottle well before use. Take the prescribed dose by mouth using the measuring cup provided with the pack. Avoid drinking anything immediately after taking Ryfate O Oral Suspension as it can reduce the effectiveness of this medicine.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

You should avoid taking Ryfate O Oral Suspension if you are allergic to Ryfate O Oral Suspension or other ingredients present in it.  Inform your doctor before taking Ryfate O Oral Suspension if you have a history of appendicitis, blockage of the bowel, rectal bleeding, kidney problems, low-magnesium diet, or if you have undergone recent bowel surgery. Caution is required before giving Ryfate O Oral Suspension to elderly patients. Sucralfate in Ryfate O Oral Suspension contains aluminium, which is normally removed by your kidney. Therefore, older adults and people who have kidney problems may be at greater risk for developing high aluminium levels while using this drug with other products that contain aluminium (e.g. antacids). Do not take Ryfate O Oral Suspension if you are pregnant or breastfeeding unless prescribed by the doctor. The safety and effectiveness in children are not established, please consult your doctor before giving them Ryfate O Oral Suspension. Avoid consuming alcohol along with Ryfate O Oral Suspension as it could lead to increased acidity. 

Therapeutic Class

ANTIULCERANTS

Drug-Drug Interactions

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SucralfateColecalciferol
Severe
SucralfateDoxercalciferol
Severe

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Diet & Lifestyle Advise

  • Avoid intake of acid or heartburn triggering foods or drinks like peppermint, chocolate, onions, caffeinated beverages, citrus fruits or juices, tomatoes, and high-fat and spicy foods.

  • Eating five or six smaller meals throughout the day rather than three large meals. It can help reduce the production of stomach acid.

  • Avoid taking alcohol and smoking cigarettes and red meat. It increases the production of stomach acid and makes symptoms worse. It can also cause erosion of the stomach lining.

  • Include the high fiber-containing foods, leafy green veggies (kale, spinach), green tea in your meal. Fermented dairy products like miso, sauerkraut, and kimchi contain probiotics which help in the prevention of excess acid production.

  • Cranberry juice can be beneficial in peptic ulcer and H. pylori infections.

Habit Forming

No

How Ryfate O Oral Suspension Works

Ryfate O Oral Suspension is a combination of two medicines: Sucralfate and Oxetacaine. Sucralfate is a gastrointestinal protectant that works by forming a protective barrier or coat over the ulcer so that digestive enzymes, acid and bile salts cannot further irritate the lining of the stomach duodenum. This protects the ulcer from the acid of the stomach, allowing it to heal. Besides this, Oxetacaine is a local anaesthetic that exerts a numbing effect, thereby providing relief from pain due to ulcers or acidic injury in the stomach.

What if I have taken an overdose of Ryfate O Oral Suspension

Avoid exceeding the recommended dose as it might cause an overdose. Seek immediate medical attention if you experience any unusual symptoms.
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Alcohol

Caution

Drinking alcohol with Ryfate O Oral Suspension may cause dehydration and elevate the level of stomach acid thereby decreasing Ryfate O Oral Suspension efficacy.

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Pregnancy

Caution

Ryfate O Oral Suspension is a pregnancy category B drug. It should not be taken until prescribed. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

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Breast Feeding

Caution

There is limited data on how Ryfate O Oral Suspension affects breastfeeding. Please consult your doctor, before taking Ryfate O Oral Suspension. your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Driving

Caution

Ryfate O Oral Suspension decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

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Liver

Caution

Ryfate O Oral Suspension to be taken with caution if you had or have a history of liver disease/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Consult your doctor before taking Ryfate O Oral Suspension if you have kidney impairment or any concerns regarding this. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Sucralfate in Ryfate O Oral Suspension contains aluminum, which is normally excreted by your kidney. Therefore, people who have kidney problems may be at greater risk for developing high aluminum toxicity in the body. The dose adjustment is necessary for patients with kidney disease.

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Children

Caution

The safety and effectiveness of Ryfate O Oral Suspension in children has not been established. Please consult your doctor before giving Ryfate O Oral Suspension to children.

Country of origin

India
Other Info - RY93562

Author Details

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FAQs

Ryfate O Oral Suspension is used to treat peptic ulcers or gastrointestinal ulcers. It also treats hyperacidity, heartburn, indigestion, and gastritis (inflammation of the stomach).
Ryfate O Oral Suspension is a combination of two medicines: Sucralfate and Oxetacaine. Sucralfate is an antiulcers covers the damaged ulcer tissue in the stomach and protects it from acid or injury to facilitate healing. Oxetacaine is a local anesthetic that shows numbing effect provides fast relief from pain caused due to ulcers or acidic injury in the stomach.
If you miss a dose of Ryfate O Oral Suspension, take the missed dose as soon as you remember it. However, if it's almost time for the next dose, do not take a double dose to make up for a missed one.
Do not take Ryfate O Oral Suspension for longer durations unless prescribed by the doctor. Talk to your doctor if you do not feel better even after taking Ryfate O Oral Suspension for a few days.
Do not stop taking Ryfate O Oral Suspension without consulting your doctor. The stomach ulcer and duodenal ulcer tends to be recurrent disease. If you stop taking Ryfate O Oral Suspension, it will not influence the frequency or severity of future ulceration.
Do not take aspirin and ibuprofen as a pain killer while taking Ryfate O Oral Suspension unless your doctor says it to take. These pain killers increase the secretion of stomach acid and exaggerate gastrointestinal bleeding. Besides this, avoid acid-containing food/drinks, coffee, tea, carbonated drinks and vegetables like lemon, tomato etc.
Ryfate O Oral Suspension is prescribed to treat gastrointestinal issues such as peptic ulcers, hyperacidity, heartburn, indigestion, and gastritis. It provides a protective barrier for the stomach lining and helps alleviate pain.
Take the prescribed dose one hour before a meal or as your doctor directs. Before using, shake the bottle well and administer the dose orally using the provided measuring cup. Afterwards, refrain from drinking anything to ensure the medication works optimally.
No, it is recommended that you avoid drinking water or any other liquid immediately after taking Ryfate O Oral Suspension. This helps ensure the medication works effectively.
Yes, the use of Ryfate O Oral Suspension can cause constipation in some individuals, which typically resolves on its own over time. To manage this side effect, try increasing your fluid intake, eating a fibre-rich diet, and engaging in regular physical activity. If the constipation persists or worsens, consult your doctor for further guidance.
Common side effects of Ryfate O Oral Suspension including constipation, dizziness, sleepiness, dry mouth, blurred vision, and diarrhea. These side effects usually resolve on their own. If they persist or worsen, consult your doctor.

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