ROSUSIGN 10MG TABLET belongs to the class of medicines known as statins, which reduces bad cholesterol (low-density lipoprotein-LDL) and glyceride level, thereby reducing the risk of heart attack and stroke in the future. High cholesterol, known as hyperlipidemia or dyslipidemia, occurs when there is an excess of the unhealthy balance of cholesterol in the blood. When there is a high cholesterol level in the blood, your arteries get narrowed and clogged, finally contributing to heart diseases like stroke and heart attack. 

ROSUSIGN 10MG TABLET works by blocking liver enzymes, causing the liver to make less cholesterol. ROSUSIGN 10MG TABLET increases the uptake and breakdown by the liver of cholesterol already in the blood. Thus, ROSUSIGN 10MG TABLET lowers the levels of lipids known as cholesterol and triglycerides in the blood when lifestyle changes (like a low-fat diet) on their own have failed. ROSUSIGN 10MG TABLET reduces the ‘bad’ cholesterol and increases the ‘good’ cholesterol by blocking our body’s production of ‘bad’ cholesterol. It also improves your body’s ability to remove it from your blood.

The possible side effects of ROSUSIGN 10MG TABLET may include myalgia (muscle pain), asthenia (lack of energy), nausea, headache, abdominal pain, muscle pain, weakness, and daytime drowsiness. Most of these side effects of ROSUSIGN 10MG TABLET do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor. It is important to have your lipid profile checked regularly.

This medicine is only one part of a treatment program that should include a healthy low-fat diet, regular exercise, smoking cessation, moderation of alcohol intake and weight reduction. You can normally eat while taking this medicine, but avoid high-fat foods. Before starting the dose of ROSUSIGN 10MG TABLET , tell your doctor if you have kidney problems, are pregnant or breastfeeding, have diabetes, severe lung disease, or have musculoskeletal disorders (like myopathy and rhabdomyolysis). You should avoid taking ROSUSIGN 10MG TABLET with immune system affecting medicine (cyclosporine) or anti-HIV medicines (lopinavir, ritonavir, or atazanavir) as it might have a serious effect.

ROSUSIGN 10MG TABLET lowers the risk of cardiovascular disease and coronary events like heart attack, stroke, and heart-related chest pain (angina). ROSUSIGN 10MG TABLET is beneficial in patients who are at high risk of these events. It is also prescribed in children (aged eight years or more) suffering from familial hypercholesterolemia (a genetic disease resulting in high cholesterol) along with lipid-lowering pills and other dietary measures. ROSUSIGN 10MG TABLET plays a vital role in slowing atherosclerosis progress (blocked artery walls of heart due to fat/lipid deposition leading to heart attack and stroke) in adult patients.

• Myalgia (muscle pain)

• Asthenia (lack of energy)
• Nausea
• Headache
• Abdominal pain
• Muscle pain
• Weakness
• Daytime drowsiness

A prolonged intake of ROSUSIGN 10MG TABLET may cause muscular disorders like myopathy and rhabdomyolysis with kidney damage. A person taking excess alcohol and affected with liver disease should consult a doctor before its intake. Caution should be exercised if you are taking any blood thinner or anticoagulants like warfarin or coumarin. At least 2 hours gap should be maintained between intake of ROSUSIGN 10MG TABLET and antacids like magnesium hydroxide and aluminium hydroxide. Increases in HbA1c and fasting glucose levels can be observed if a person regularly takes ROSUSIGN 10MG TABLET . So you should tell the doctor before having these diabetes tests. Patients with proteinuria (protein in urine) or haematuria (blood in urine) should tell the doctor before taking the ROSUSIGN 10MG TABLET , as it might require dose adjustment. It is recommended that you should have a liver enzyme test regularly if you are regularly taking ROSUSIGN 10MG TABLET .

Drug-Drug Interactions: ROSUSIGN 10MG TABLET is known to contra-indicate when taken along with cyclosporine (organ transplants medicine), warfarin or clopidogrel (blood thinner), fibrates (gemfibrozil, fenofibrate), a medicine used to lower cholesterol (ezetimibe), antacid (aluminium hydroxide, magnesium hydroxide), antibiotics (erythromycin, fusidic acid), oral contraceptive pills, regorafenib (anti-cancer), anti-viral or anti-HIV drug (ritonavir, lopinavir, atazanavir, simeprevir, ombitasvir, paritaprevir, dasabuvir, velpatasvir, grazoprevir, elbasvir, glecaprevir, and pibrentsavir). 

Drug-Food Interactions: Alcoholic beverages should be avoided with ROSUSIGN 10MG TABLET .

Drug-Disease Interactions: ROSUSIGN 10MG TABLET may interact with disease conditions, including neuromuscular disorders (Myopathy, Myoneural Disorder), thyroid gland problems (Hypothyroidism), and Renal Dysfunction.

• CYCLOSPORINE
• WARFARIN
• CLOPIDOGREL
• GEMFIBROZIL
• FENOFIBRATE
• EZETIMIBE
• ALUMINIUM HYDROXIDE
• MAGNESIUM HYDROXIDE
• ERYTHROMYCIN
• FUSIDIC ACID
• REGORAFENIB
• RITONAVIR
• LOPINAVIR
• ATAZANAVIR
• SIMEPREVIR
• OMBITASVIR
• PARITAPREVIR
• DASABUVIR
• VELPATASVIR
• GRAZOPREVIR
• ELBASVIR
• GLECAPREVIR
• PIBRENTASVIR

• Keep your weight under control with a BMI of 19.5-24.9.

• Do regular physical activity or exercise.

• Opt for a diet rich in whole grains, fruits, veggies, and low-fat dairy products. 

• Quitting smoking is the best strategy to lower the risk of heart disease. 

• Avoid chronic stress. Try to enjoy and spend time with your loved ones to cope with stress and practice mindfulness techniques. 

• Including heart-healthy omega-3 fatty acid-containing food drinks in your daily diet.

• Your doctor may advise on regular monitoring of liver function tests to monitor the liver enzymes.

High cholesterol: There are two types of cholesterol found in our body, good cholesterol (high-density lipoprotein) and bad cholesterol (low-density lipoprotein). Good cholesterol is good for our heart and helps in reducing the bad cholesterol from our body. On the other hand, excess of bad cholesterol (LDL) leads to the risk of heart diseases like heart attack and stroke. High cholesterol known as hyperlipidaemia or dyslipidaemia occurs when there is an excess of the unhealthy balance of cholesterol in the blood. When there is a high level of cholesterol in the blood, your arteries get narrowed and clogged that finally contributes to heart diseases, like stroke and heart attack. Eating high-fat or high-cholesterol-containing food/drinks and genetic factors are the primary causes of high cholesterol.