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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Nov 23, 2024 | 4:30 PM IST
Ronapreve 120 mg/ml Injection 2's (2 Vials Combip belongs to the class of monoclonal antibodies used in the post-exposure treatment of mild to moderate respiratory illness caused by coronavirus infection. This combination medicine works by blocking the spike protein of the virus from attaching to the human receptor cell, thereby arresting the progress of the disease. Common side effects include nausea, diarrhoea, indigestion, vomiting, pain and soreness at the injection site.
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Prescription drug

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Prescription drug
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Manufacturer/Marketer

Cipla Ltd

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Ronapreve 120 mg/ml Injection 2's (2 Vials Combip

Ronapreve 120 mg/ml Injection 2's (2 Vials Combip belongs to the group of monoclonal antibodies used in the post-exposure treatment of mild to moderate respiratory illness caused by COVID-19 in people aged 12 years or older, weighing at least 40kgs. Ronapreve 120 mg/ml Injection 2's (2 Vials Combip is used in non-hospitalised cases of COVID-19 that are at risk of progressing to severe disease. 

Ronapreve 120 mg/ml Injection 2's (2 Vials Combip contains Casirivimab and Imdevimab which work by using proteins (monoclonal antibodies) that mimic the natural immune system of the body and fight off the harmful virus. They block the virus attachment and entry into the human cells, thereby preventing the progression of the illness.

A qualified healthcare professional will administer Ronapreve 120 mg/ml Injection 2's (2 Vials Combip. Do not self-administer. Ronapreve 120 mg/ml Injection 2's (2 Vials Combip may cause certain common side effects such as redness, pain and soreness at the injection site. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if these side effects persist. 

It is advisable to inform the doctor if you are allergic to any of its components. Consult your doctor if you are pregnant, planning to get pregnant or are breastfeeding. Ronapreve 120 mg/ml Injection 2's (2 Vials Combip is not authorized for use in patients who require oxygen therapy or hospitalisation due to COVID-19.

Uses of Ronapreve 120 mg/ml Injection 2's (2 Vials Combip

Treatment of COVID-19

Medicinal Benefits

Ronapreve 120 mg/ml Injection 2's (2 Vials Combip contains monoclonal antibodies used in the post-exposure treatment of mild to moderate disease caused by SARS-CoV-2. Ronapreve 120 mg/ml Injection 2's (2 Vials Combip works by using monoclonal proteins to imitate the natural defence mechanism of the body. The COVID virus contains a capsid with spike proteins, through which it penetrates into the body cells to cause infection. Ronapreve 120 mg/ml Injection 2's (2 Vials Combip binds to the spike protein of the virus. Thereby blocking the spike protein of the virus from attaching to the human receptor cell and arresting the progress of the disease. Hence, Ronapreve 120 mg/ml Injection 2's (2 Vials Combip finds use in preventing the progression of mild to moderate covid cases to severe cases requiring hospitalisation. Thus, Ronapreve 120 mg/ml Injection 2's (2 Vials Combip finds use in reducing rates of hospitalisation. Ronapreve 120 mg/ml Injection 2's (2 Vials Combip may also be used as post-exposure prophylaxis of coronavirus disease in people who are not fully vaccinated against COVID-19, people with immunocompromising conditions, and in those who are at high risk of being exposed to someone with COVID-19.

Directions for Use

Ronapreve 120 mg/ml Injection 2's (2 Vials Combip will be administered by a qualified healthcare professional. Do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Ronapreve 120 mg/ml Injection 2's (2 Vials Combip

  • Redness, soreness and pain at the injection site

Drug Warnings

It is advisable to inform the doctor if you are allergic to any of its components. Keep your doctor informed if you suffer from any chronic diseasea such as HIV, asthma, cancer, liver disease, kidney problems, heart disease, neurodevelopmental disorders, sickle cell disease or if you have recently had surgery, gastrostomy, tracheostomy or positive pressure ventilation. Offer a detailed medical and vaccination history. Discuss any recent vaccinations with the doctor. Inform the doctor especially if you are on any radiotherapy, immunosuppressant drugs, blood thinners or any other medicines. Consult your doctor if you are planning to get pregnant or are breastfeeding. Ronapreve 120 mg/ml Injection 2's (2 Vials Combip is not meant for use as vaccination and in severe hospitalised cases.

Drug Interactions

Drug-Drug Interactions: No interactions found.

Drug-Food Interactions: No interactions found.

Drug-Disease Interactions: No interactions found.

Habit Forming

No

Diet & Lifestyle Advise

  • Keep a healthy state of mind. Fear is one of the biggest causes of decreased immunity. See a therapist when you feel overwhelmed.
  • Meditation, music and yoga have also proven very effective in helping with mental health.
  • Keep yourself at a safe distance from people.
  • Always sneeze or cough into your elbow and keep a handkerchief on you.
  • Wash your hands with soap and water and keep yourself clean.
  • Eat more lean meats, healthy fats, fruits, vegetables and whole-grain foods to give you more energy. Load up on Vitamin-C rich citrus fruit for enhanced immunity.
  • Do not forget to take your Vitamin B complex and Vitamin C supplements every day as these are essential for the body and immunity.
  • Steam inhalation for 3-5 minutes every day and salt-water gargle with warm water has been proven very effective in keeping respiratory infections at bay and in promoting health. 
  • Stay hydrated by drinking plenty of water as dehydration is often seen in pneumonia.
  • Taking a stroll in the garden, or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid tobacco use as smoking hampers lung health and makes breathing even more difficult.

Special Advise

  • In case of a fever or rash following Ronapreve 120 mg/ml Injection 2's (2 Vials Combip, do not use any antipyretic or anti-allergic medicines without consulting the doctor.
  • In case of worsening symptoms such as changes in BP, wheezing, hives, shortness of breath, weakness or confusion, call your doctor immediately.

Disease/Condition Glossary

Coronavirus Disease: Coronavirus disease is an infection caused by the SARS-CoV-2 virus. It can range from a mild cold, cough and fever to full-blown pneumonia. Coronavirus belongs to a group of RNA viruses and has crown-like projections on the surface of the pathogen. The virus transmits through droplets generated from an infectious person’s cough, sneeze or heavy breathing. The common symptoms of coronavirus disease are dry cough, tiredness, breathlessness, fever, loss of sense of taste and smell, diarrhoea, body pains, headache, and sore throat.

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Alcohol

Caution

It is not recommended to consume alcohol with Ronapreve 120 mg/ml Injection 2's (2 Vials Combip. Please consult your doctor if you have any concerns.

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Pregnancy

Caution

Not enough studies exist to ascertain the effect of Ronapreve 120 mg/ml Injection 2's (2 Vials Combip on pregnancy. Please consult your doctor if you have any concerns.

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Breast Feeding

Caution

Not enough studies exist to ascertain the effect of Ronapreve 120 mg/ml Injection 2's (2 Vials Combip on nursing. Please consult your doctor in case of any concerns.

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Driving

Caution

It is not known if Ronapreve 120 mg/ml Injection 2's (2 Vials Combip affects your ability to drive. Drive only if you are alert.

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Liver

Caution

Exercise caution before using Ronapreve 120 mg/ml Injection 2's (2 Vials Combip in case of established liver disease. Please consult your doctor to address any concerns.

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Kidney

Caution

Exercise caution before using Ronapreve 120 mg/ml Injection 2's (2 Vials Combip in case of established kidney disease. Please consult your doctor to address any concerns.

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Children

Caution

Ronapreve 120 mg/ml Injection 2's (2 Vials Combip is not recommended for use in children below 12years. Please consult your doctor if you have any concerns.

Country of origin

United States

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - RON0117

Author Details

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FAQs

Ronapreve 120 mg/ml Injection 2's (2 Vials Combip belongs to the group of monoclonal antibodies used in the post-exposure treatment of mild to moderate respiratory illness caused by COVID-19 in people aged 12 years or older, weighing at least 40kgs. Ronapreve 120 mg/ml Injection 2's (2 Vials Combip is used in non-hospitalised cases of COVID-19 that are at risk of progressing to severe disease.
Ronapreve 120 mg/ml Injection 2's (2 Vials Combip works by inducing an antibody response in the body by instilling monoclonal antibodies that mimic the natural defences of the body and block the spike protein of the virus from attaching to body cells, thus arresting the progression of the disease.
Advanced age, obesity, chronic kidney disease, lung disease, sickle cell disease, neurodevelopmental disorders (for example cerebral palsy) and diseases of metabolism are high-risk factors for disease progression.
Not enough literature exists to ascertain the effects of Ronapreve 120 mg/ml Injection 2's (2 Vials Combip on fertility. Please consult your doctor in case of any concerns.
Covid-19 spreads through respiratory droplets when in close or direct contact with an infected person. The virus can spread through an infected person’s sneeze or cough. The virus can also be transmitted by touching any contaminated surfaces and then touching the nose, mouth or eyes without washing the hands.
Vaccines stimulate the body to make its own antibodies against infection. On the other hand, monoclonal antibodies deliver lab-made antibodies against the virus.
Patients with a high risk of developing COVID-19 disease means, those who have certain underlying medical conditions or factors that make them more likely to experience serious illness if they contract COVID-19. These conditions include advanced age, obesity, chronic kidney disease, lung disease, sickle cell disease, neurodevelopmental disorders (for example cerebral palsy) and diseases of metabolism.
An antibody cocktail is a combination of two or more monoclonal antibodies which are separately available but are mixed together. Hence, the name cocktail.
Before taking Ronapreve 120 mg/ml Injection 2's (2 Vials Combip, inform your doctor if you are allergic to Ronapreve 120 mg/ml Injection 2's (2 Vials Combip, if you are using prescription and non-prescription medications, vitamins, nutritional supplements, and herbal products. Also, inform your doctor if you have been vaccinated against COVID-19. Discuss the severity and duration of your COVID-19 symptoms to ensure the treatment is appropriate for your condition and also let your doctor know if you are breastfeeding, pregnancy or planning pregnancy.
Monoclonal antibodies are proteins made in a laboratory meant to stimulate immune system. Ronapreve 120 mg/ml Injection 2's (2 Vials Combip is a treatment that contains two monoclonal antibodies. These antibodies work together to neutralize the SARS-CoV-2 virus by binding to different parts of the virus's spike protein, preventing it from entering human cells.
Monoclonal antibodies neutralize SARS-CoV-2 by binding to its spike protein, preventing virus entry into human cells and reducing viral load, potentially alleviating symptoms and reducing disease severity.
Monoclonal antibody therapy for COVID-19 should be administered as soon as possible and within 5-7 days of symptom onset. Starting the treatment early in the course of the infection is crucial for it to be effective in reducing the risk of severe illness, hospitalization, and death.
Certain individuals should avoid monoclonal antibody therapy for COVID-19, including those who, are allergic to monoclonal antibody treatment, having severe or critical COVID-19 requiring hospitalization, who are seropositive for SARS-CoV-2 antibodies, indicating previous infection. And inform your doctor if you are breastfeeding, pregnant or planning pregnancy. It's important to discuss your medical history and any concerns with your doctor before starting treatment. They can help determine if monoclonal antibody therapy is safe and appropriate for you.
Ronapreve 120 mg/ml Injection 2's (2 Vials Combip can be administered either intravenously (into a vein) or subcutaneously (under the skin) by a trained healthcare professional in a hospital. Do not self-administer.
If you have high blood pressure and diabetes, you are recommended to take the advice of your doctor before taking Ronapreve 120 mg/ml Injection 2's (2 Vials Combip. To avoid potential interactions.
The common side effects of Ronapreve 120 mg/ml Injection 2's (2 Vials Combip are redness, pain and soreness at the injection site. If any of these side effects persist or worsen, please consult your doctor.

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