Regonat 40 mg Tablet is an anti-cancer medicine used in the treatment of colorectal carcinoma. Colorectal cancer is a disease in which the cancer or the malignant cells grow out of control in the colon or rectum.

Regonat 40 mg Tablet contains Regorafenib as an active ingredient, which belongs to the class of medicines known as kinase inhibitors. It works by inhibiting the action of an enzyme (tyrosine kinase) and thus stops the abnormal growth of cancer cells.

Regonat 40 mg Tablet may cause certain side effects such as diarrhea, rash, tiredness, decreased appetite, nausea, weight loss, fatigue, stomach pain, loss of appetite, hoarseness, and dizziness. These side effects do not require medical attention and gradually resolve over time. Regonat 40 mg Tablet should be taken as advised by your doctor.

Avoid taking Regonat 40 mg Tablet if you are allergic to it or any other components of it. Before taking this medicine, inform your doctor if you have/had liver or kidney disease, gastrointestinal disorders, hypertension, heart problems, blood disorders, plan of any surgery, or any skin disorders. This medicine is not recommended for use in pregnant and breastfeeding mothers due to embryo-fetal toxicity.

Regonat 40 mg Tablet contains, Regorafenib which used in the treatment of colorectal cancer (CRC) in patients who have previously been treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an antiVEGF therapy, and, if KRAS wild type, an anti-EGFR therapy. It works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body. In this way, Regonat 40 mg Tablet stops the body's production, spread and growth of cancerous cells.

• Nausea
• Diarrhea
• Loss of appetite
• Skin rash
• Hoarseness
• Tiredness
• Chest pain
• Dizziness
• Weakness

To treat your condition effectually, continue taking Regonat 40 mg Tablet for the period that your doctor has prescribed. Avoid taking Regonat 40 mg Tablet if you are allergic to it or any other components present in it. Breastfeeding should be discontinued in nursing mothers during the treatment as it passes into breast milk and may cause a possible risk to the infant. This medicine is not recommended for use in children below 18 years of age as the safety and efficacy are not established. Regonat 40 mg Tablet may cause hypertension, heart attack, hand-foot skin reaction, gastrointestinal perforation, haemorrhage, hepatotoxicity, and Reversible Posterior Leukoencephalopathy Syndrome (RPLS) in some patients. Hence, inform your doctor about your complete medication and medical history before taking Regonat 40 mg Tablet . Inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment, as this medicine is known to cause embryo-fetal toxicity. Avoid driving and operating machines, as this medicine may cause dizziness.

Drug-Drug Interactions: Regonat 40 mg Tablet may have interaction with strong CYP3A4 inhibitors (clarithromycin, diltiazem, erythromycin, itraconazole, ketoconazole, ritonavir), strong CYP3A4 inducers (carbamazepine, rifampicin, phenytoin, phenobarbitone).

Drug-Food Interactions: Avoid alcohol consumption and smoking.

Dug-Disease Interactions: Tell your doctor if you have liver or kidney disease, heart problems, GI perforation, or lung toxicity before starting the treatment.

• CLARITHROMYCIN
• RITONAVIR
• KETOCONAZOLE
• ITRACONAZOLE
• RIFAMPICIN
• PHENYTOIN

• Physical activity helps strengthen muscles, reduces fatigue, helps in weight loss, and gives strength. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
• Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
• Getting adequate sleep as resting helps improve your health and mental ability and improves attention.
• De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
• Eat food rich in antioxidants such as berries, spinach, etc.
• Foods containing fibre help in better digestion. These include beans, peas, lentils, whole grains, nuts, and seeds.
• Avoid smoking and alcohol consumption.
• Maintain a healthy weight.
• Avoid fast food, fried food, processed meats, refined carbs and added sugars.

• Your doctor may suggest periodic liver function tests to monitor the function of the liver due to the use of Regonat 40 mg Tablet .
• It is advised to use contraceptive pills while using Regonat 40 mg Tablet to prevent pregnancy.
• Seek medical attention immediately if you have swelling in your lower legs, fast heartbeats, or trouble breathing as it may be a sign of a heart problem.

Colorectal cancer: Also known as colon cancer (growth of cancer cells in the colon) or rectal cancer (cancer cells grow in the rectum area) is a condition in which the cancerous or the malignant cells grow out of control in the colon or rectum. Symptoms may include diarrhoea, constipation, bloody stools, change in the bowel habits, abdominal discomfort, etc.