Rapilif-M 50 Combipack is used for the treatment of Benign prostatic hyperplasia (BPH), a condition in men that causes the enlargement of the prostate gland. It is complicated by an overactive bladder and symptoms of urge urinary incontinence (involuntary leakage of urine), urgency, and frequency.

Rapilif-M 50 Combipack contains Mirabegron and Silodosin. Mirabegron works by reducing the activity of an overactive bladder and treats related symptoms. Silodosin works by relaxing the muscles around the bladder exit and prostate gland. Thus, it makes it easier to pass urine and helps relieve urinary symptoms.

Take Rapilif-M 50 Combipack as prescribed. Your doctor will advise you on how often you should take it based on your medical condition. Rapilif-M 50 Combipack may cause common side effects such as abnormal ejaculation, increased heart rate, dizziness, nausea, constipation, urinary tract infections, and runny or blocked nose. Most of these side effects of Rapilif-M 50 Combipack do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.

If you are allergic to Mirabegron, Silodosin, or any other medicines, please tell your doctor. Rapilif-M 50 Combipack is not recommended for children and adolescents under 18 years of age. Drive only if you are alert after taking Rapilif-M 50 Combipack, as it may cause dizziness. If you are about to undergo cataract eye surgery, inform your eye specialist that you are taking Rapilif-M 50 Combipack, as it may cause complications during the surgery.

Rapilif-M 50 Combipack contains Mirabegron and Silodosin. Mirabegron is a bladder muscle relaxant which works by reducing the activity of an overactive bladder and treats related symptoms such as frequent urination, urgency incontinence (an uncontrollable urge to urinate) and sudden need to empty the bladder. Silodosin works by relaxing the muscles around the bladder exit and prostate gland. Thus, it makes it easier to pass urine and helps relieve urinary symptoms such as incomplete bladder emptying, frequent urination at night and difficulty urinating. Thus, together, they help treat benign prostatic hyperplasia (BPH) symptoms.

• Abnormal ejaculation
• Increased heart rate
• Dizziness
• Nausea
• Constipation
• Urinary tract infections
• Runny or blocked nose
   

If you are allergic to Mirabegron, Silodosin or any other medicines, please tell your doctor. Rapilif-M 50 Combipack is not recommended for children and adolescents below 18 years of age. Drive only if you are alert after taking Rapilif-M 50 Combipack as it may cause dizziness. If you are about to undergo cataract eye surgery, inform your eye specialist that you are taking Rapilif-M 50 Combipack as it may cause complications during the surgery. Inform your doctor if you take other medicines for overactive bladder treatment. If you get headaches, especially sudden, migraine-like (throbbing) headaches, tell your doctor, as these may be signs of severe high blood pressure.

Drug-Drug Interaction: Inform your doctor if you are taking antipsychotics (thioridazine), medicines for abnormal heart rhythm (propafenone, flecainide), antidepressants (desipramine, imipramine), blood thinners (dabigatran etexilate), medicines used to lower blood pressure (doxazosin, prazosin), antifungals (ketoconazole, itraconazole), medicines used for HIV-AIDS (ritonavir), and immunosuppressants (cyclosporine).
Drug-Food Interaction: No interactions found.
Drug-Disease Interaction: If you have ever fainted or felt dizzy when standing up suddenly, have trouble emptying your bladder or have a weak urine stream, kidney or liver problems or an ECG abnormality known as QT prolongation, inform your doctor before taking Rapilif-M 50 Combipack.

• THIORIDAZINE
• PROPAFENONE
• FLECAINIDE
• DESIPRAMINE
• IMIPRAMINE
• DABIGATRAN ETEXILATE
• DOXAZOSIN
• PRAZOSIN
• KETOCONAZOLE
• ITRACONAZOLE
• RITONAVIR
• CYCLOSPORINE

• Avoid caffeine and alcohol, especially in the hours after dinner.
• Urinate as soon as you feel the urge.
• Go to the washroom even when you don’t feel the urge.
• Reduce your stress levels, as nervousness may increase urination frequency.
• Keep yourself warm since being cold may worsen symptoms.
   

Benign prostatic hyperplasia (BPH): It is a condition in men in which age-related prostate gland enlargement occurs, which may cause urination difficulty. It occurs when the prostate gland's cells start to multiply. Your prostate gland swells due to these extra cells, which squeeze the urethra and decrease urine flow. The exact cause is unknown, but age-related changes in male sex hormones may be a factor. Any testicular abnormalities or a family history of prostate issues could increase the risk of developing BPH. The symptoms include excessive urination at night, dribbling (to move downwards in a thin flow) after urination, a sense of incomplete bladder emptying, an urge to urinate and leaking, frequent urination and a weak urinary stream.