Primazone Plus 1000mg/500mg Injection belongs to the group of medicines called antibiotics used to treat various bacterial infections such as respiratory tract (lungs) infection, urine infection, blood infection, meningitis (inflammation of the brain and spinal cord), gonorrhoea (sexually transmitted disease), skin, abdominal, bone, and joint infections. Bacterial infections are caused due to the multiplication of harmful bacteria inside or on the body. Infectious or harmful bacteria can make you sick and reproduce quickly in your body. These harmful bacteria produce chemicals known as toxins, which can damage tissue and make you sick. Primazone Plus 1000mg/500mg Injection does not work against infections caused by the virus, including cold and flu.

Primazone Plus 1000mg/500mg Injection is a combination of two antibiotics, namely: Cefoperazone (cephalosporin antibiotic) and sulbactam (beta-lactamase inhibitor). Cefoperazone works by preventing the formation of bacterial cell covering, which is necessary for their survival. Thereby, kills the bacteria. On the other hand, sulbactam works by decreasing bacterial resistance and enhancing the activity of cefoperazone against the bacteria. Together, Primazone Plus 1000mg/500mg Injection helps to treat bacterial infections.

You may experience diarrhoea, allergic reaction, abnormal liver function tests, and anaemia (low number of red blood cells). Most of these side effects of Primazone Plus 1000mg/500mg Injection do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Before starting Primazone Plus 1000mg/500mg Injection, please inform your doctor if you have any allergy (against any antibiotic), kidney or liver problems. Do not take Primazone Plus 1000mg/500mg Injection on your own as self-medication may lead to antibiotic-resistance in which antibiotics fail to act against specific bacterial infections. Consult your doctor before taking Primazone Plus 1000mg/500mg Injection if you are pregnant or planning for pregnancy. Avoid taking Primazone Plus 1000mg/500mg Injection if you are breastfeeding as Primazone Plus 1000mg/500mg Injection may pass into breast milk. Avoid alcohol consumption while taking Primazone Plus 1000mg/500mg Injection to prevent unpleasant side-effects.

Primazone Plus 1000mg/500mg Injection belongs to the group of medicines called antibiotics used to treat various bacterial infections such as respiratory tract (lungs) infection, urine infection, blood infection, meningitis (inflammation of the brain and spinal cord), gonorrhoea (sexually transmitted disease), skin, abdominal, bone, and joint infections. Primazone Plus 1000mg/500mg Injection is a combination of two antibiotics, namely: Cefoperazone (cephalosporin antibiotic) and sulbactam (beta-lactamase inhibitor). Cefoperazone works by preventing the formation of bacterial cell covering, which is necessary for their survival. Thereby, kills the bacteria. On the other hand, sulbactam works by decreasing bacterial resistance and enhancing the activity of cefoperazone against the bacteria. Together, Primazone Plus 1000mg/500mg Injection helps to treat bacterial infections.

• Diarrhoea
• Allergic reaction
• Abnormal liver function tests
• Anaemia (low number of red blood cells)

After taking Primazone Plus 1000mg/500mg Injection if you have allergy-like symptoms including rash, swelling of the face/lips/throat, difficulty in breathing, or tightness in the chest, immediately contact your doctor. Do not take Primazone Plus 1000mg/500mg Injection if you have an allergy to Primazone Plus 1000mg/500mg Injection, cephalosporins penicillin class of antibiotics as it may cause a skin rash, itching, and difficulty in breathing. People having liver disease or jaundice (yellowing of skin/eye) should not take Primazone Plus 1000mg/500mg Injection, as it can damage your liver severely. You may have diarrhoea in some cases which can be managed by taking it with any probiotics and plenty of fluids. Do not take antacids along with Primazone Plus 1000mg/500mg Injection; maintain a gap of 2-3 hours between both. Avoid alcohol consumption while taking Primazone Plus 1000mg/500mg Injection to prevent unpleasant side-effects. Primazone Plus 1000mg/500mg Injection may cause dizziness, so be cautious while driving. Inform your doctor about all the medicines you are taking and about your health condition to rule out any unpleasant side-effects.

Drug-Drug Interactions: Primazone Plus 1000mg/500mg Injection may have interaction with a diuretic (furosemide), anticoagulants (warfarin), other antibiotics (gentamicin).

Drug-Food Interactions: No interactions found/established.

Drug-disease interactions: Primazone Plus 1000mg/500mg Injection may have interactions with colitis (inflammation in the lining of the colon), seizures, dialysis, kidney, and liver dysfunction.

• FUROSEMIDE
• WARFARIN
• GENTAMICIN

• Probiotics should be taken after taking the full course of Primazone Plus 1000mg/500mg Injection in order to restore some healthy bacteria in the intestines that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yoghurt, cheese, sauerkraut, kombucha, and kimchi can help to restore the good bacteria of the intestine.

• Include more fibre-enriched food in your diet, as it can be easily digested by your gut bacteria, which helps stimulate their growth. Thus, fibre-rich foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains like whole-grain bread, brown rice should be included in your diet.

• Avoid intake of alcoholic beverages with Primazone Plus 1000mg/500mg Injection as it can make you dehydrated and may affect your sleep. This can make it harder for your body to aid the Primazone Plus 1000mg/500mg Injection in fighting off infections.

• Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection harder to treat.

• Discontinue Primazone Plus 1000mg/500mg Injection and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing.

• Diarrhoea may occur as a side effect but should stop when your course is complete. Inform your doctor if it does not stop or if you find blood in your stools.

• Primazone Plus 1000mg/500mg Injection is preferably taken with food to avoid an upset stomach.

• Some people may be allergic to Primazone Plus 1000mg/500mg Injection or other penicillin or cephalosporin group of antibiotics. So a prior sensitivity test may be necessary. Inform your doctor if you are allergic to any medicine particularly antibiotics belong to these groups.

• If you feel nauseous after taking Primazone Plus 1000mg/500mg Injection, stick to simple meals like porridge, khichdi, dal roti, and other home-cooked meals. Avoid spicy and fatty food.

Bacterial infections: A bacterial infection is a condition in which harmful bacteria enter, multiply, and infect our body. Infectious or harmful bacteria can make you sick and reproduce quickly in your body. These harmful bacteria produce chemicals known as toxins, which can damage tissue and make you sick. It can target any body part and multiply very quickly. When you get infected with bacteria, you can experience generalized symptoms, like fevers, chills, and fatigue. Bacteria are of various forms comprising commonly of spherical, rod, and spiral-shaped. Bacterial infections vary from minor illnesses like sore throat and ear infections to severe brain infections like meningitis and encephalitis. Anyone can become infected with a bacterial infection. But, people with weak immune systems or taking immunosuppressive medicine are more prone to bacterial infection.