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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 9, 2024 | 12:40 PM IST
Prepixa 2.5 Tablet is used to prevent and treat deep vein thrombosis (blood clots in leg veins) and pulmonary embolism (blood clots in the lung). Additionally, it is used to prevent blood clots in patients with atrial fibrillation (irregular heartbeat). It contains Apixaban, which works by inhibiting the action of blood clotting factor and prevents the conversion of fibrinogen (soluble protein) to fibrin (insoluble protein). Thus, it helps in preventing blood clot formation. Some people may experience side effects such as nausea, anaemia (lack of blood), and unusual bleeding, including swelling and bruising. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition

APIXABAN-2.5MG

Manufacturer/Marketer

Emcure Pharmaceuticals Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Prepixa 2.5 Tablet

Prepixa 2.5 Tablet is used to prevent and treat deep vein thrombosis (blood clots in leg veins) and pulmonary embolism (blood clots in the lung). Additionally, Prepixa 2.5 Tablet is used to prevent blood clots in patients with atrial fibrillation (irregular heartbeat). Deep vein thrombosis is a condition in which blood clots form in deep veins, usually in the legs. Pulmonary embolism is a condition in which a blood clot blocks the arteries in the lungs. Atrial fibrillation is a condition that causes irregular, often fast heartbeat.

Prepixa 2.5 Tablet contains Apixaban, which works by inhibiting the action of blood clotting factor (X a), which is an important element of blood clotting. Thereby, it prevents the conversion of fibrinogen (soluble protein) to fibrin (insoluble protein) and helps in preventing blood clot formation.

Take Prepixa 2.5 Tablet as prescribed. Your doctor will advise you how often you take Prepixa 2.5 Tablet based on your medical condition. Some people may experience nausea, anaemia (lack of blood), and unusual bleeding, including swelling and bruising. Most of these side effects of Prepixa 2.5 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Prepixa 2.5 Tablet or any other medicines, please tell your doctor. If you are pregnant or a nursing mother, you are advised to consult a doctor before using Prepixa 2.5 Tablet . If you have a stomach ulcer, recent bleeding in the brain, kidney or liver problems, high blood pressure, or bleeding problems, inform your doctor before taking Prepixa 2.5 Tablet . Your doctor may suggest a blood test called the 'international normalized ratio' (INR) to check how quickly your blood is clotting. This test result will help your doctor to decide exactly when you should start taking Prepixa 2.5 Tablet .

Uses of Prepixa 2.5 Tablet

Treatment of Prevention of blood clot.

Medicinal Benefits

Prepixa 2.5 Tablet is primarily used to prevent and treat blood clots in the body by inhibiting the action of clotting factor Xa, which is an important element of blood clotting. Thereby, it prevents the conversion of fibrinogen to fibrin (a protein that binds platelets together and forms a clot) and helps in preventing blood clot formation.

Directions for Use

Take Prepixa 2.5 Tablet with or without food as advised by the doctor. Swallow it as a whole with a glass of water. Do not chew or break it. If you have difficulty swallowing the whole tablet, crush it and mix it with water, 5 % dextrose in water, apple puree, or juice.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Prepixa 2.5 Tablet

  • Nausea
  • Anaemia (lack of blood)
  • Bleeding, including swelling and bruising

Drug Warnings

Prepixa 2.5 Tablet should not be used in children. Blood tests are advised before and while taking Prepixa 2.5 Tablet to monitor kidney and liver functioning. If you are pregnant or breastfeeding, please inform your doctor before taking Prepixa 2.5 Tablet . If you have a stomach ulcer, recent bleeding in the brain, kidney or liver problems, high blood pressure or bleeding problems, antiphospholipid syndrome (an immune system disorder that causes an increased risk of blood clots), inform your doctor before taking Prepixa 2.5 Tablet .

Drug Interactions

Drug-Drug Interaction: Prepixa 2.5 Tablet may have interaction with pain killers (acetylsalicylic acid, naproxen, ibuprofen), heart-related medicines (diltiazem), antidepressants (nortriptyline, amitriptyline), antifungal drugs (ketoconazole), antibiotics (rifampicin), epilepsy or fits related medicines (phenytoin), anti-HIV/AIDS drugs (ritonavir) and blood thinners (warfarin, enoxaparin, heparin, clopidogrel, rivaroxaban, dabigatran).

Drug-Food Interaction: Prepixa 2.5 Tablet may interact with St John’s Wort (herbal supplement for depression). Limit intake of alcohol and do not exceed 14 units per week as it may increase the risk of bleeding.

Drug-Disease Interaction: If you have a stomach ulcer, recent bleeding in the brain, kidney or liver problems, high blood pressure or bleeding problems, antiphospholipid syndrome (an immune disorder of bleeding),  inform your doctor before taking Prepixa 2.5 Tablet .

Drug-Drug Interactions Checker List

  • ASPIRIN
  • CLOPIDOGREL
  • DILTIAZEM
  • HEPARIN
  • IBUPROFEN
  • NAPROXEN
  • RIVAROXABAN

Habit Forming

No

Diet & Lifestyle Advise

  • Avoid vitamin K rich foods such as coriander, cabbage, spinach, broccoli, collard greens, kale (leaf cabbage), black liquorice, turnip greens, avocados, Brussels sprouts as they may decrease the effectiveness of Prepixa 2.5 Tablet .

  • Do regular exercise as it helps to dissolve blood clots especially in obese people.

  • Do not consume more than 14 units of alcohol per week as excess alcohol intake may increase the risk of bleeding and quit smoking.

Special Advise

Complete blood count (CBC), INR test, prothrombin tests are advised before and while taking Prepixa 2.5 Tablet .

Disease/Condition Glossary

Deep vein thrombosis (blood clots in the legs) is a medical condition in which blood clots form in deep veins, usually in the legs. The symptoms include leg pain or swelling.

Pulmonary embolism (blood clots in the lungs) is a condition which occurs as the blood clots break and travel to the lungs from deep veins in the legs or other parts of the body. The symptoms of pulmonary embolism include cough, chest pain and shortness of breath. Quick medication is advised to reduce the risk of serious conditions due to blood clots.

Atrial fibrillation is a condition that causes irregular, often fast heartbeat. In atrial fibrillation condition, blood clots are formed as blood is pooled in the upper chambers of the heart.

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Alcohol

Caution

You are recommended not to consume more than 14 units per week as exceeding this may increase the risk of bleeding.

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Pregnancy

Caution

Prepixa 2.5 Tablet is a Category B pregnancy drug and is given to pregnant women only if doctor thinks benefits outweigh risks.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Prepixa 2.5 Tablet as it may be excreted in breast milk and cause adverse effects in the baby.

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Driving

Safe if prescribed

Prepixa 2.5 Tablet usually does not affect your ability to drive or operate machinery.

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Liver

Caution

Take Prepixa 2.5 Tablet with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Prepixa 2.5 Tablet with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Unsafe

Prepixa 2.5 Tablet is not recommended for children below 18 years of age.

Country of origin

India

Manufacturer/Marketer address

A €“ 504, Shapath-4, B/S Hotel Crowne Plaza, Opp. Karnavati Club, S. G. Highway ,Ahmedabad 380 051 Gujarat
Other Info - PRE1640

Author Details

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FAQs

Prepixa 2.5 Tablet is used to prevent and treat deep vein thrombosis (blood clots in leg veins) and pulmonary embolism (blood clots in the lung). Additionally, it is used to prevent blood clots in patients with atrial fibrillation (irregular heartbeat). Prepixa 2.5 Tablet works by inhibiting the action of blood clotting factor (X a), which is an important element of blood clotting.
No, you are not recommended to take ibuprofen with Prepixa 2.5 Tablet as co-administration of these two medicines may increase the risk of bleeding more easily. However, if you notice blood in urine or stools, dizziness, unusual bleeding or bruising, red or black tarry stools, vomiting, weakness or headache, please consult a doctor immediately. If you are supposed to use these medicines together, you are advised to contact your doctor so that the dose may be adjusted appropriately to use safely.
No, you are usually not advised to have a tattoo or body piercing while taking Prepixa 2.5 Tablet as it may increase the risk of bleeding and infection. If you still wish to proceed further, contact your doctor so that the dose may be adjusted or any antibiotics may be prescribed and let the piercer or tattooist know in advance that you are on treatment with a blood thinner.
Yes, you are advised to stop taking Prepixa 2.5 Tablet a few days before surgery or procedure as Prepixa 2.5 Tablet may increase the risk of bleeding. Therefore, before having any procedure or any surgery, please inform your doctor that you are taking Prepixa 2.5 Tablet .
Yes, Prepixa 2.5 Tablet helps in reducing the risk of stroke and heart attack by preventing blood clots. Stroke is caused as blood clots break off and travel to brain.
No, you are not recommended to stop taking Prepixa 2.5 Tablet without consulting your doctor as it may worsen the condition. Therefore, take Prepixa 2.5 Tablet for as long as your doctor has prescribed it.
If you have difficulty swallowing the tablet whole, please consult your doctor about alternative methods for taking Prepixa 2.5 Tablet . The tablet can be crushed and mixed with water, 5% glucose in water, apple juice, or apple puree just before consumption.
If you miss a dose of Prepixa 2.5 Tablet , take it as soon as you remember. Take the next dose of Prepixa 2.5 Tablet at the usual time and then continue as normal.
Side effects of Prepixa 2.5 Tablet include nausea, anaemia (lack of blood), and unusual bleeding, including swelling and bruising. Most of these side effects may not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
If you have atrial fibrillation (a condition in which the heart beats irregularly) and are taking Prepixa 2.5 Tablet to help prevent strokes or serious blood clots, in that case, you may be at a higher risk of having a stroke if you stop taking this medication. Besides this, you may be at risk of having a blood clot form in or around your spine that could cause paralysis if you have epidural or spinal anaesthesia or a spinal puncture while taking a blood thinner such as Prepixa 2.5 Tablet .
Yes, Prepixa 2.5 Tablet is a blood thinner. It belongs to the class of medicines known as factor Xa inhibitors which help prevent the formation of blood clots.
Symptoms of Prepixa 2.5 Tablet overdose are unusual bleeding or bruising; red, brown, or pink urine; red or black, tarry stools; and coughing up or vomiting blood or material that looks like coffee grounds. Consult the doctor if you experience these symptoms or if you have taken an overdose.

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