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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Nov 30, 2024 | 3:18 PM IST
Posafung 300 mg Injection 16.7 ml is used to prevent and treat fungal infections. It contains a medicine called posaconazole. It is a triazole antifungal agent and exerts its antifungal activity through the blockage of certain enzymes (P-450 dependent enzyme, sterol 14α-demethylase). This leads to inhibiting the synthesis of ergosterol, a key component of the fungal cell membrane, and the accumulation of methylated sterol precursors. This results in the inhibition of fungal cell growth and cell death. Thus, it treats infections.
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Prescription drug
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Manufacturer/Marketer

Gufic Bioscience Ltd

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Posafung 300 mg Injection 16.7 ml

Posafung 300 mg Injection 16.7 ml is in a class of medications called azole antifungals. It is used to prevent and treat fungal infections in adults and children two years of age and older with a weakened ability to fight infection. Besides this, it is also used to treat invasive aspergillosis (a serious fungal infection that begins in the lungs and spreads through the bloodstream to other organs) in adults and teenagers 13 years of age and older. Any disease caused by a fungus is known as a fungal infection.

Posafung 300 mg Injection 16.7 ml contains a medicine called posaconazole. It is a triazole antifungal agent and exerts its antifungal activity through the blockage of certain enzymes (P-450 dependent enzyme, sterol 14α-demethylase). This leads to inhibiting the synthesis of ergosterol, a key component of the fungal cell membrane, and the accumulation of methylated sterol precursors. This results in the inhibition of fungal cell growth and cell death. Thus, it treats infections.

Posafung 300 mg Injection 16.7 ml will be administered by a qualified healthcare professional. You may sometimes experience injection site reactions, fever, headache, chills or shaking, stomach pain, constipation, diarrhoea, nosebleeds and coughing. Most of these side effects of Posafung 300 mg Injection 16.7 ml do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Inform your doctor if you are allergic or hypersensitive to any component present in Posafung 300 mg Injection 16.7 ml or if you are pregnant, suspect you are pregnant, plan to have a baby or are breastfeeding; your doctor will prescribe Posafung 300 mg Injection 16.7 ml only if the benefits outweigh the risk. Before taking the Posafung 300 mg Injection 16.7 ml, inform your doctor about your medical history and ongoing therapies to rule out any potential adverse effects or interactions.

Uses of Posafung 300 mg Injection 16.7 ml

Treatment of Fungal infections

Medicinal Benefits

It is used to prevent and treat fungal infections in adults and children two years of age and older with a weakened ability to fight infection. It is also used to treat invasive aspergillosis (a serious fungal infection that begins in the lungs and spreads through the bloodstream to other organs) in adults and teenagers 13 years of age and older. Posafung 300 mg Injection 16.7 ml contains a medicine called posaconazole. It is a triazole antifungal agent and exerts its antifungal activity through the blockage of certain enzymes (P-450 dependent enzyme, sterol 14α-demethylase). This leads to inhibiting the synthesis of ergosterol, a key component of the fungal cell membrane, and the accumulation of methylated sterol precursors. This results in the inhibition of fungal cell growth and cell death. Thus, it treats infections.

Directions for Use

Posafung 300 mg Injection 16.7 ml will be administered by a qualified healthcare professional. Kindly do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Posafung 300 mg Injection 16.7 ml

  • Injection site reactions
  • Fever
  • Headache
  • Chills or shaking
  • Constipation
  • Stomach pain
  • Diarrhoea
  • Nosebleeds
  • Coughing

Drug Warnings

Keep your doctor informed about your health condition and medicines to rule out any side effects. Posafung 300 mg Injection 16.7 ml is restricted to people sensitive to product constituents or other antifungal medicines. During pregnancy and lactation, posaconazole should only be used after careful risk/benefit considerations, so before taking Posafung 300 mg Injection 16.7 ml, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. It is unknown whether it is safe to consume alcohol with Posafung 300 mg Injection 16.7 ml. However, as a precautionary measure, it is advisable not to take or limit alcohol.

Drug Interactions

Drug-Drug Interactions: Posafung 300 mg Injection 16.7 ml may interact with anticoagulant medication (e.g. apixaban).

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: No interactions found/established.

Drug-Drug Interactions Checker List

  • APIXABAN

Habit Forming

No

Diet & Lifestyle Advise

  • Take the medication as directed by the doctor and at regular intervals if you take Posafung 300 mg Injection 16.7 ml for more than one day.
  • Do not use other over-the-counter medications, herbal or vitamin supplements without informing your pharmacist or doctor when you take Posafung 300 mg Injection 16.7 ml.
  • Continue taking your normal regular diet unless your doctor prescribes a specific diet.
  • It is advisable to follow a candida diet during yeast infections. This diet excludes sugar, gluten, certain dairy products, and alcoholic beverages and switches to low-sugar fruits, non-starchy vegetables, and gluten-free foods.
  • A very high sugar or high-carbohydrate diet may increase the count of Candida in some people. It is better to avoid or limit alcohol and caffeine intake during the Posafung 300 mg Injection 16.7 ml treatment to enhance a healthy lifestyle practice.

Disease/Condition Glossary

Fungal infection: Fungal infection occurs when a fungus enters, infects, and multiplies in the body. Fungi can live in water, soil, air, and plants. Fungi affect any body part, including the mouth, throat, oesophagus, lungs, bladder, genital area, and blood. Mild fungal skin infections are common and can cause rashes. Fungal infections affecting body organs like the lungs can cause flu or tuberculosis. Some fungal diseases like cryptococcal meningitis and blood infections can be fatal. A few common fungal infections are yeast infections that affect the genital area, oesophagus, and urinary tract caused by the species Candida.

Invasive aspergillosis: Invasive aspergillosis occurs when Aspergillus causes serious infection and usually affects people with weakened immune systems, such as those who have had an organ transplant or a stem cell transplant. Invasive aspergillosis most commonly affects the lungs but can also spread to other body parts.

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Alcohol

Caution

Limit or avoid consumption of alcohol while on treatment with Posafung 300 mg Injection 16.7 ml as it may increase the risk of serious side effects.

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Pregnancy

Caution

Posafung 300 mg Injection 16.7 ml is not recommended for use in pregnancy unless clearly necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Posafung 300 mg Injection 16.7 ml.

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Breast Feeding

Caution

There is no substantial research yet on using Posafung 300 mg Injection 16.7 ml in breastfeeding women. Inform your doctor if you are a nursing mother before taking Posafung 300 mg Injection 16.7 ml; your doctor will decide whether Posafung 300 mg Injection 16.7 ml can be taken by breastfeeding mothers.

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Driving

Caution

It is unknown whether Posafung 300 mg Injection 16.7 ml alters the ability to drive, so do not drive or operate machinery if you experience any symptoms affecting your ability to concentrate and react.

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Liver

Caution

Inform your doctor before receiving the Posafung 300 mg Injection 16.7 ml if you have a liver impairment/disorder history. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Kidney

Caution

Inform your doctor before receiving the Posafung 300 mg Injection 16.7 ml if you have a kidney impairment/disorder history. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Consult your doctor

Please consult your doctor. Your doctor will prescribe a suitable dose based on your child's age and condition.

Country of origin

India

Manufacturer/Marketer address

37,1St Floor, Kamala Bhavan Ii, Swami Nityanand Road, Andheri (East), Mumbai - 400 069. (India)
Other Info - POS0080

Author Details

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FAQs

Posafung 300 mg Injection 16.7 ml is used to treat Fungal infections.
Posafung 300 mg Injection 16.7 ml contains a medicine called posaconazole. It is a triazole antifungal agent and exerts its antifungal activity through the blockage of certain enzymes (P-450 dependent enzyme, sterol 14α-demethylase). This leads to inhibiting the synthesis of ergosterol, a key component of the fungal cell membrane, and the accumulation of methylated sterol precursors. This results in inhibiting fungal cell growth and, ultimately, cell death. Thus, it treats infections.
Posafung 300 mg Injection 16.7 ml is not recommended for coadministration with anticoagulants, So if you are under anticoagulant therapy, inform your doctor before prescribing Posafung 300 mg Injection 16.7 ml.
If you are allergic to posaconazole or similar antifungals such as fluconazole, itraconazole, ketoconazole, or voriconazole, you should not use it. When combined with certain medications, posaconazole can have unfavourable or dangerous side effects.
Posafung 300 mg Injection 16.7 ml may cause side effects like injection site reactions, diarrhoea, nausea, fever, vomiting, headache and coughing, although not everybody gets them. Most of these side effects of Posafung 300 mg Injection 16.7 ml do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
In some cases, using Posafung 300 mg Injection 16.7 ml may lead to nosebleeds as a side effect. It does not require medical attention and gradually resolves over time. However, if the side effects persist or worsen, please consult your doctor.
Posafung 300 mg Injection 16.7 ml will be administered by a qualified healthcare professional. Please do not self-administer.
Yes, Posafung 300 mg Injection 16.7 ml is effective in the treatment of fungal infections and prevention of invasive aspergillosis (a serious fungal infection that begins in the lungs and spreads through the bloodstream to other organs).

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