Pirtine Plus 100mg/325mg Tablet is a combination medication that belongs to the analgesic medication class. It is widely used in the treatment of acute and chronic pain, fever, headache, joint pains, dysmenorrhea (period pain), postoperative pain, toothache after dental extraction, and myalgia (muscle pain). Pain is a widely used term used to describe an unpleasant feeling or discomfort. It ranges from mild to severe. The severity of the pain depends on the underlying condition. Inflammation is the immune system's natural response to injury or infection.

Pirtine Plus 100mg/325mg Tablet contains flupirtine and paracetamol. Flupirtine is an analgesic (non-opioid analgesic) which works by blocking the transmission of pain signals to the brain to lower pain perception. Paracetamol is an analgesic (pain reliever) and an antipyretic (fever reducer), which works by blocking the release of certain chemical messengers that cause fever and pain. Thus Pirtine Plus 100mg/325mg Tablet alleviates pain and other associate conditions.

Use Pirtine Plus 100mg/325mg Tablet as directed by the physician only. The dose and duration of the medication depend on your condition and its severity. The common side effects of Pirtine Plus 100mg/325mg Tablet include nausea, vomiting, wind, abdominal discomfort, diarrhoea, constipation, heartburn, drowsiness, dizziness, headache, and depression. Most of these side effects of Pirtine Plus 100mg/325mg Tablet are temporary, do not require medical attention, and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Before taking Pirtine Plus 100mg/325mg Tablet, inform your doctor if you are allergic to flupirtine, paracetamol, or other ingredients. Besides, inform your doctor if you are pregnant, breastfeeding, or have any pre-existing conditions such as liver diseases such as hepatic encephalopathy (loss of brain function due to liver damage), chronic alcoholism, or cholestasis (reduced bile flow), renal impairment, myasthenia gravis (chronic neuromuscular disease), or heart diseases. If Pirtine Plus 100mg/325mg Tablet is given in patients with liver diseases, liver function should be monitored closely. Pirtine Plus 100mg/325mg Tablet causes drowsiness and dizziness, so drive only if you are alert. Pirtine Plus 100mg/325mg Tablet is not recommended for children younger than six years old.

Pirtine Plus 100mg/325mg Tablet contains flupirtine (non-opioid analgesic) and paracetamol (analgesic and antipyretic). Flupirtine works by blocking the glutamate receptors that are involved in producing pain signals. It also has muscle relaxant properties. Paracetamol acts as an analgesic and antipyretic by inhibiting the release of prostaglandins (chemical mediators) that cause pain, inflammation, and fever. Altogether provide relief from pain and associated symptoms.

• Nausea
• Vomiting
• Colic/wind
• Gastric
• Abdominal discomfort
• Diarrhea
• Constipation
• Heartburn
• Drowsiness
• Dizziness
• Headache
• Depression

Avoid using Pirtine Plus 100mg/325mg Tablet if you are allergic to analgesics or painkillers. People with liver diseases, kidney diseases, and elderly people above 65 years of age may require dose adjustments. If Pirtine Plus 100mg/325mg Tablet is given to patients with liver impairment, liver function should be closely monitored. It is advised to discontinue use if you notice any signs of liver damage such as nausea, vomiting, yellowed skin and eyes (jaundice), abdominal pain, loss of appetite, itchy skin, and dark-coloured urine, etc.

Drug-drug interactions: Pirtine Plus 100mg/325mg Tablet may interact with anticoagulants such as warfarin.

Drug-food interactions:  The use of alcohol with Pirtine Plus 100mg/325mg Tablet is restricted as alcohol may worsen the side effects of the medicine.

Drug-disease interactions: Pirtine Plus 100mg/325mg Tablet should not be given in patients with alcoholism, liver disease and phenylketonuria (excess of protein – phenylalanine in the body).

• WARFARIN

• Do not take alcohol.
• Include more glucosamine, chondroitin sulphate, vitamin D, and calcium-enriched supplements. Besides this, turmeric and fish oils can help reduce inflammation in the tissue.
• Please do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do stretching, low impact aerobic exercises like walking on a treadmill, bike riding and swimming. You can also strengthen your muscles by lifting light weights.
• In the chronic condition of arthritis or joint pain, try to include fish like salmon, trout, tuna, and sardines. These fishes are enriched with omega-3 fatty acids that minimum level of chemical called cytokines, which ramp up inflammation.
• Your sitting posture is important, especially when you have pain and inflammation. Try to sit as little as possible and only for a short time. Long-term immobility is harmful in conditions like arthritis. Use back support like a rolled-up towel to minimise pain at the back of your spine curve. Keep your knees and hips at a right angle. Besides this, you can also use a footrest if required.

• Flupirtine may interact with anticoagulants such as warfarin. A blood test called the PT is needed to monitor this potential interaction. 

Pain is a widely used term used to describe an unpleasant feeling or discomfort. It ranges from mild to severe. The severity of the pain depends on the underlying condition. It is also classified as acute (short-term) and chronic (long-term), depending on the duration of the pain. Acute pain, if left untreated, can result in chronic pain in some conditions.